Article ; Online: The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes.
2020 Volume 9, Issue 11
Abstract: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic, with more than 50 million cases reported globally. Findings have consistently identified an increased severity of ... ...
Abstract | The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic, with more than 50 million cases reported globally. Findings have consistently identified an increased severity of SARS-CoV-2 infection in individuals with diabetes. Osteopontin, a cytokine-like matrix-associated phosphoglycoprotein, is elevated in diabetes and drives the expression of furin, a proprotein convertase implicated in the proteolytic processing and activation of several precursors, including chemokines, growth factors, hormones, adhesion molecules, and receptors. Elevated serum furin is a signature of diabetes mellitus progression and is associated with a dysmetabolic phenotype and increased risk of diabetes-linked premature mortality. Additionally, furin plays an important role in enhancing the infectivity of SARS-CoV-2 by promoting its entry and replication in the host cell. Here, we hypothesize that diabetes-induced osteopontin and furin protein upregulation results in worse outcomes in diabetic patients with SARS-CoV-2 infection owing to the roles of these protein in promoting viral infection and increasing metabolic dysfunction. Thus, targeting the osteopontin-furin axis may be a plausible strategy for reducing mortality in SARS-CoV-2 patients with diabetes. |
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MeSH term(s) | Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/virology ; Child ; Child, Preschool ; Comorbidity ; Diabetes Mellitus/blood ; Diabetes Mellitus/epidemiology ; Female ; Furin/blood ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Osteopontin/blood ; Renin-Angiotensin System ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Up-Regulation ; Virulence ; Young Adult |
Chemical Substances | Osteopontin (106441-73-0) ; Furin (EC 3.4.21.75) |
Language | English |
Publishing date | 2020-11-23 |
Publishing country | Switzerland |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review |
ZDB-ID | 2661518-6 |
ISSN | 2073-4409 ; 2073-4409 |
ISSN (online) | 2073-4409 |
ISSN | 2073-4409 |
DOI | 10.3390/cells9112528 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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