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Article ; Online: Retraction notice to "Enhancement of resistance to chemo-radiation by hsa-miR-1290 expression in glioblastoma cells" [Eur. J. Pharmacol. 880 (2020) 173144].

Khalighfard, Solmaz / Kalhori, Mohammad Reza / Haddad, Peiman / Khori, Vahid / Alizadeh, Ali Mohammad

2024 Volume 969, Page(s) 176349

Language	English
Publishing date	2024-03-07
Publishing country	Netherlands
Document type	Journal Article ; Retraction of Publication
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2024.176349
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Article ; Online: The Potential of miR-21 in Stem Cell Differentiation and its Application in Tissue Engineering and Regenerative Medicine.

Kalhori, Mohammad Reza / Soleimani, Masoud / Alibakhshi, Reza / Kalhori, Amir Ali / Mohamadi, Parisa / Azreh, Rasoul / Farzaei, Mohammad Hosien

Stem cell reviews and reports

2023 Volume 19, Issue 5, Page(s) 1232–1251

Abstract: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two important types of non-coding RNAs that are not translated into protein. These molecules can regulate various biological processes, including stem cell differentiation and self-renewal. One of ...

Abstract	MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two important types of non-coding RNAs that are not translated into protein. These molecules can regulate various biological processes, including stem cell differentiation and self-renewal. One of the first known miRNAs in mammals is miR-21. Cancer-related studies have shown that this miRNA has proto-oncogene activity and is elevated in cancers. However, it is confirmed that miR-21 inhibits stem cell pluripotency and self-renewal and induces differentiation by targeting various genes. Regenerative medicine is a field of medical science that tries to regenerate and repair damaged tissues. Various studies have shown that miR-21 plays an essential role in regenerative medicine by affecting stem cell proliferation and differentiation. In this review, we will discuss the function of miR-21 in regenerative medicine of the liver, nerve, spinal cord, wound, bone, and dental tissues. In addition, the function of natural compounds and lncRNAs will be analyzed as potential regulators of miR-21 expression in regenerative medicine.
MeSH term(s)	Animals ; Tissue Engineering ; Regenerative Medicine ; RNA, Long Noncoding ; Cell Differentiation/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mammals/metabolism
Chemical Substances	RNA, Long Noncoding ; MicroRNAs
Language	English
Publishing date	2023-03-11
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-023-10510-8
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Zs.A 6198: Show issues

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Article ; Online: MiR-1290: a potential therapeutic target for regenerative medicine or diagnosis and treatment of non-malignant diseases.

Kalhori, Mohammad Reza / Soleimani, Masoud / Yari, Kheirollah / Moradi, Mahmoudreza / Kalhori, Amir Ali

Clinical and experimental medicine

2022 Volume 23, Issue 3, Page(s) 737–750

Abstract: MicroRNAs are a set of small non-coding RNAs that could change gene expression with post-transcriptional regulation. MiRNAs have a significant role in regulating molecular signaling pathways and innate and adaptive immune system activity. Moreover, ... ...

Abstract	MicroRNAs are a set of small non-coding RNAs that could change gene expression with post-transcriptional regulation. MiRNAs have a significant role in regulating molecular signaling pathways and innate and adaptive immune system activity. Moreover, miRNAs can be utilized as a powerful instrument for tissue engineers and regenerative medicine by altering the expression of genes and growth factors. MiR-1290, which was first discovered in human embryonic stem cells, is one of those miRNAs that play an essential role in developing the fetal nervous system. This review aims to discuss current findings on miR-1290 in different human pathologies and determine whether manipulation of miR-1290 could be considered a possible therapeutic strategy to treat different non-malignant diseases. The results of these studies suggest that the regulation of miR-1290 may be helpful in the treatment of some bacterial (leprosy) and viral infections (HIV, influenza A, and Borna disease virus). Also, adjusting the expression of miR-1290 in non-infectious diseases such as celiac disease, necrotizing enterocolitis, polycystic ovary syndrome, pulmonary fibrosis, ankylosing spondylitis, muscle atrophy, sarcopenia, and ischemic heart disease can help to treat these diseases better. In addition to acting as a biomarker for the diagnosis of non-malignant diseases (such as NAFLD, fetal growth, preeclampsia, down syndrome, chronic rhinosinusitis, and oral lichen planus), the miR-1290 can also be used as a valuable instrument in tissue engineering and reconstructive medicine. Consequently, it is suggested that the regulation of miR-1290 could be considered a possible therapeutic target in the treatment of non-malignant diseases in the future.
MeSH term(s)	Pregnancy ; Female ; Animals ; Humans ; Infant, Newborn ; Regenerative Medicine ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Gene Expression Regulation ; Down Syndrome
Chemical Substances	MicroRNAs ; MIRN1290 microRNA, human
Language	English
Publishing date	2022-07-08
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-022-00854-9
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Zs.A 5481: Show issues

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Article ; Online: Effect of poly (lactic-co-glycolic acid) polymer nanoparticles loaded with vancomycin against Staphylococcus aureus biofilm.

Nouruzi, Ellahe / Hosseini, Seyed Mostafa / Asghari, Babak / Mahjoub, Reza / Zare, Ehsan Nazarzadeh / Shahbazi, Mohammad-Ali / Kalhori, Fereshte / Arabestani, Mohammad Reza

BMC biotechnology

2023 Volume 23, Issue 1, Page(s) 39

Abstract: Staphylococcus aureus is a unique challenge for the healthcare system because it can form biofilms, is resistant to the host's immune system, and is resistant to numerous antimicrobial therapies. The aim of this study was to investigate the effect of ... ...

Abstract	Staphylococcus aureus is a unique challenge for the healthcare system because it can form biofilms, is resistant to the host's immune system, and is resistant to numerous antimicrobial therapies. The aim of this study was to investigate the effect of poly (lactic-co-glycolic acid) (PLGA) polymer nanoparticles loaded with vancomycin and conjugated with lysostaphin (PLGA-VAN-LYS) on inhibiting S. aureus biofilm formation. Nano drug carriers were produced using the double emulsion evaporation process. we examined the physicochemical characteristics of the nanoparticles, including particle size, polydispersity index (PDI), zeta potential, drug loading (DL), entrapment efficiency (EE), Lysostaphin conjugation efficiency (LCE), and shape. The effect of the nano drug carriers on S. aureus strains was evaluated by determining the minimum inhibitory concentration (MIC), conducting biofilm formation inhibition studies, and performing agar well diffusion tests. The average size, PDI, zeta potential, DL, EE, and LCE of PLGA-VAN-LYS were 320.5 ± 35 nm, 0.270 ± 0.012, -19.5 ± 1.3 mV, 16.75 ± 2.5%, 94.62 ± 2.6%, and 37% respectively. Both the agar well diffusion and MIC tests did not show a distinction between vancomycin and the nano drug carriers after 72 h. However, the results of the biofilm analysis demonstrated that the nano drug carrier had a stronger inhibitory effect on biofilm formation compared to the free drug. The use of this technology for treating hospital infections caused by the Staphylococcus bacteria may have favorable effects on staphylococcal infections, considering the efficacy of the nano medicine carrier developed in this study.
MeSH term(s)	Humans ; Vancomycin/pharmacology ; Glycols ; Staphylococcus aureus ; Agar ; Lysostaphin ; Staphylococcal Infections ; Polymers ; Biofilms
Chemical Substances	Vancomycin (6Q205EH1VU) ; Glycols ; glycolic acid (0WT12SX38S) ; Agar (9002-18-0) ; Lysostaphin (EC 3.4.24.75) ; Polymers
Language	English
Publishing date	2023-09-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2052746-9
ISSN	1472-6750 ; 1472-6750
ISSN (online)	1472-6750
ISSN	1472-6750
DOI	10.1186/s12896-023-00811-8
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Article ; Online: Co-delivery of streptomycin and hydroxychloroquine by labeled solid lipid nanoparticles to treat brucellosis: an animal study.

Moez, Narjes Morovati / Hosseini, Seyed Mostafa / Kalhori, Fereshte / Shokoohizadeh, Leili / Arabestani, Mohammad Reza

Scientific reports

2023 Volume 13, Issue 1, Page(s) 14012

Abstract: Can brucellosis-related biochemical and immunological parameters be used as diagnostic and treatment indicators? The goal of this project was to look at biochemical parameters, trace elements, and inflammatory factors in the acute and chronic stages of ... ...

Abstract	Can brucellosis-related biochemical and immunological parameters be used as diagnostic and treatment indicators? The goal of this project was to look at biochemical parameters, trace elements, and inflammatory factors in the acute and chronic stages of brucellosis after treatment with streptomycin and hydroxychloroquine-loaded solid lipid nanoparticles (STR-HCQ-SLN). The double emulsion method was used for the synthesis of nanoparticles. Serum levels of trace elements, vitamin D, CRP, and biochemical parameters were measured in rats involved in brucellosis. The therapeutic effect of STR-HCQ-SLN was compared with that of free drugs. In both healthy and infected rats, serum concentrations of copper, zinc, iron, magnesium, potassium, and biochemical parameters of the liver were significantly different. By altering the serum levels of the aforementioned factors, treatment with STR-HCQ-SLN had a positive therapeutic effect on chronic brucellosis. Vitamin D levels declined (46.4%) and CRP levels rose (from 7.5 mg to less than 1 mg) throughout the acute and chronic stages of brucellosis. This study showed that by comparing the biochemical parameters and the levels of trace elements in the serum of healthy and diseased mice in the acute and chronic stages of brucellosis, it is possible to get help from other routine methods for diagnosis.
MeSH term(s)	Animals ; Mice ; Rats ; Streptomycin ; Hydroxychloroquine/therapeutic use ; Trace Elements ; Brucellosis/drug therapy ; Nanoparticles ; Animals, Laboratory ; Vitamins ; Vitamin D
Chemical Substances	Streptomycin (Y45QSO73OB) ; Lipid Nanoparticles ; Hydroxychloroquine (4QWG6N8QKH) ; Trace Elements ; Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2023-08-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41150-0
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Article: Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver.

Zobeiri, Mehdi / Parvizi, Fatemeh / Kalhori, Mohammad Reza / Majnooni, Mohammad Bagher / Farzaei, Mohammad Hosein / Abdollahi, Mohammad

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 6641031

Abstract: The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) as multifactorial chronic liver disease and the lack of a specific treatment have begun a new era in its treatment using gene expression changes and microRNAs. This study aimed to ... ...

Abstract	The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) as multifactorial chronic liver disease and the lack of a specific treatment have begun a new era in its treatment using gene expression changes and microRNAs. This study aimed to investigate the potential therapeutic effects of natural compounds in NAFLD by regulating miRNA expression. MicroRNAs play essential roles in regulating the cell's biological processes, such as apoptosis, migration, lipid metabolism, insulin resistance, and adipocyte differentiation, by controlling the posttranscriptional gene expression level. The impact of current NAFLD pharmacological management, including drug and biological therapies, is uncertain. In this context, various dietary fruits or medicinal herbal sources have received worldwide attention versus NAFLD development. Natural ingredients such as berberine, lychee pulp, grape seed, and rosemary possess protective and therapeutic effects against NAFLD by modifying the gene's expression and noncoding RNAs, especially miRNAs.
Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/6641031
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Article ; Online: Retraction Note: Gamma-radiated immunosuppressed tumor xenograft mice can be a new ideal model in cancer research.

Khodayari, Hamid / Khodayari, Saeed / Khalighfard, Solmaz / Tahmasebifar, Arash / Tajaldini, Mahboubeh / Poorkhani, Amirhoushang / Nikoueinejad, Hassan / Hamidi, Gholam Ali / Nosrati, Hassan / Kalhori, Mohammad Reza / Alizadeh, Ali Mohammad

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19952

Language	English
Publishing date	2023-11-15
Publishing country	England
Document type	Retraction of Publication
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-46583-1
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Article ; Online: Retraction Note: The toxicity and therapeutic effects of single-and multi-wall carbon nanotubes on mice breast cancer.

Kavosi, Arghavan / Noei, Saeideh Hosseini Ghale / Madani, Samaneh / Khalighfard, Solmaz / Khodayari, Saeed / Khodayari, Hamid / Mirzaei, Malihe / Kalhori, Mohammad Reza / Yavarian, Majid / Alizadeh, Ali Mohammad / Falahati, Mojtaba

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19953

Language	English
Publishing date	2023-11-15
Publishing country	England
Document type	Retraction of Publication
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-46596-w
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Article ; Online: The potential role of miR-1290 in cancer progression, diagnosis, prognosis, and treatment: An oncomiR or onco-suppressor microRNA?

Kalhori, Mohammad Reza / Soleimani, Masoud / Arefian, Ehsan / Alizadeh, Ali Mohammad / Mansouri, Kamran / Echeverria, Javier

Journal of cellular biochemistry

2021 Volume 123, Issue 3, Page(s) 506–531

Abstract: Cancer is one of the leading causes of death in humans because of the lack of early diagnosis, distant metastases, and the resistance to adjuvant therapies, including chemotherapy and radiotherapy. In addition to playing an essential role in tumor ... ...

Abstract	Cancer is one of the leading causes of death in humans because of the lack of early diagnosis, distant metastases, and the resistance to adjuvant therapies, including chemotherapy and radiotherapy. In addition to playing an essential role in tumor progression and development, microRNAs (miRNAs) can be used as a robust biomarker in the early detection of cancer. MiR-1290 was discovered for the first time in human embryonic stem cells, and under typical physiological situations, plays an essential role in neuronal differentiation and neural stem cell proliferation. Its coding sequence is located at the 1p36.13 regions in the first intron of the aldehyde dehydrogenase 4 gene member A1. miR-1290 is out of control in many cancers such as breast cancer, colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, lung cancer, pancreatic cancer, and plays a vital role in their development. Therefore, it is suggested that miR-1290 can be considered as a potential diagnostic and therapeutic target in many cancers. In addition to the importance of miR-1290 in the noninvasive diagnosis of various cancers, this systematic review study discussed the role of miR-1290 in altering the expression of different genes involved in cancer development and chemo-radiation resistance. Moreover, it considered the regulatory effect of natural products on miR-1290 expression and the interaction of lncRNAs by miR-1290.
MeSH term(s)	Breast Neoplasms/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Esophageal Neoplasms/genetics ; Esophageal Squamous Cell Carcinoma/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics
Chemical Substances	MIRN1290 microRNA, human ; MicroRNAs ; RNA, Long Noncoding
Language	English
Publishing date	2021-12-13
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.30191
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Zs.A 1114: Show issues

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Article ; Online: Targeting miRNA by Natural Products

Mehdi Zobeiri / Fatemeh Parvizi / Mohammad Reza Kalhori / Mohammad Bagher Majnooni / Mohammad Hosein Farzaei / Mohammad Abdollahi

Evidence-Based Complementary and Alternative Medicine, Vol

A Novel Therapeutic Approach for Nonalcoholic Fatty Liver

2021 Volume 2021

Abstract	The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) as multifactorial chronic liver disease and the lack of a specific treatment have begun a new era in its treatment using gene expression changes and microRNAs. This study aimed to investigate the potential therapeutic effects of natural compounds in NAFLD by regulating miRNA expression. MicroRNAs play essential roles in regulating the cell’s biological processes, such as apoptosis, migration, lipid metabolism, insulin resistance, and adipocyte differentiation, by controlling the posttranscriptional gene expression level. The impact of current NAFLD pharmacological management, including drug and biological therapies, is uncertain. In this context, various dietary fruits or medicinal herbal sources have received worldwide attention versus NAFLD development. Natural ingredients such as berberine, lychee pulp, grape seed, and rosemary possess protective and therapeutic effects against NAFLD by modifying the gene’s expression and noncoding RNAs, especially miRNAs.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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