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  1. Article ; Online: Letter to the Editor Re: Yu Qing, Wang Hai-Jun, Wang Hong-Zhu, Li Yan, Liang Xiao-Min, Xu Chi, Jeppesen Erik Does the responses of Vallisneria natans (Lour.) Hara to high nitrogen loading differ between the summer high-growth season and the low-growth season? Science of the Total Environment 601-602(2017)1513-1521.

    Cao, Yu / Wang, Wei / Li, Wei

    The Science of the total environment

    2017  Volume 610-611, Page(s) 75–76

    Abstract: Yu et al.'s paper showed very interesting effects of high nitrogen (N) on the submerged macrophytes Vallisneria natans: active growth in the growing season enabled the macrophytes partly to overcome the ammonium stress. This result was evident in an ... ...

    Abstract Yu et al.'s paper showed very interesting effects of high nitrogen (N) on the submerged macrophytes Vallisneria natans: active growth in the growing season enabled the macrophytes partly to overcome the ammonium stress. This result was evident in an experiment using ten pond ecosystems; however, their conclusion that shading induced by high phytoplankton biomass together with the toxicity of high ammonium contributed to the decrease of macrophytes growth was not strongly supported by the data provided in the paper. Three factors influencing how submerged macrophytes respond to high ammonium, not addressed by Yu et al.'s paper, are toxicity of ammonium/ammonia (NH
    MeSH term(s) Ammonium Compounds ; Animals ; Biomass ; Hydrocharitaceae/growth & development ; Nitrogen/chemistry ; Phytoplankton ; Seasons
    Chemical Substances Ammonium Compounds ; Nitrogen (N762921K75)
    Language English
    Publishing date 2017-08-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2017.08.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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  2. Article ; Online: What is the impact of type 2 diabetes mellitus on CYP450 metabolic activities?

    Tomlinson, Brian / Li, Yan-Hong

    Expert opinion on drug metabolism & toxicology

    2024  Volume 19, Issue 12, Page(s) 867–870

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Cytochrome P-450 Enzyme System/metabolism ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease
    Chemical Substances Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Editorial
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2023.2288246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6264: Show issues Location:
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  3. Article ; Online: The Outcomes of Patients with Omicron Variant Infection who Undergo Elective Surgery: A Propensity-score-matched Case-control Study.

    Xiong, Xiaojuan / Li, Rui / Yan, Hong / Mao, Qingxiang

    International journal of medical sciences

    2024  Volume 21, Issue 5, Page(s) 817–825

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; Case-Control Studies ; Propensity Score ; Elective Surgical Procedures/adverse effects ; Hypoalbuminemia ; Intensive Care Units
    Language English
    Publishing date 2024-03-17
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.90695
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  4. Article ; Online: Retraction: Salidroside inhibits the proliferation and migration of gastric carcinoma cells and tumor growth

    Yan, Wei / Li, Kai / Buhe, Amin / Li, Tianxiong / Tian, Peirong / Hong, Jun

    RSC advances

    2024  Volume 14, Issue 19, Page(s) 13591

    Abstract: This retracts the article DOI: 10.1039/C9RA00044E.]. ...

    Abstract [This retracts the article DOI: 10.1039/C9RA00044E.].
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Retraction of Publication
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra90046d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Canagliflozin + metformin ER for the treatment of type 2 diabetes: the evidence to date.

    Tomlinson, Brian / Li, Yan-Hong

    Expert opinion on pharmacotherapy

    2024  Volume 24, Issue 18, Page(s) 1937–1947

    Abstract: Introduction: Patients with type 2 diabetes (T2D) usually show progressive deterioration in glycemic control and sequential additions of therapy are generally needed. Many new options for glucose lowering therapy have been introduced recently and it is ... ...

    Abstract Introduction: Patients with type 2 diabetes (T2D) usually show progressive deterioration in glycemic control and sequential additions of therapy are generally needed. Many new options for glucose lowering therapy have been introduced recently and it is becoming common practice to use fixed-dose combinations (FDCs) of glucose lowering agents from different classes. This article reviews the FDC of canagliflozin with metformin extended release.
    Areas covered: A literature search was performed to identify publications describing the efficacy and safety of canagliflozin and metformin when used separately and in combinations.
    Expert opinion: Canagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor which has shown benefits in reducing progression of renal disease and heart failure in patients with T2D. There was an increased incidence of amputation with canagliflozin in one study, but canagliflozin results in weight loss and reduction of blood pressure which contribute to the overall benefit. Metformin has been the first line oral hypoglycemic agent for many years and is thought to have many advantages, but it should be avoided in patients with severely decreased renal function because of the risk of lactic acidosis. The combination in a single tablet given once daily should help to simplify therapy and improve medication adherence in T2D.
    MeSH term(s) Humans ; Canagliflozin/adverse effects ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/adverse effects ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Glucosides/therapeutic use ; Metformin/therapeutic use ; Blood Glucose ; Glucose
    Chemical Substances Canagliflozin (0SAC974Z85) ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Glucosides ; Metformin (9100L32L2N) ; Blood Glucose ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2023.2276180
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5130: Show issues Location:
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  6. Article ; Online: Integrative analysis of homologous recombination repair patterns unveils prognostic signatures and immunotherapeutic insights in breast cancer.

    Li, Yan-Shuang / Jiang, Hong-Chuan

    Journal of applied genetics

    2024  

    Abstract: Globally, breast cancer (BC) is the leading cause of female death and morbidity. Homologous recombination repair (HRR) is critical in BC. However, the prognostic role and immunotherapy response of HRR in BC remains to be clarified. Firstly, we identified ...

    Abstract Globally, breast cancer (BC) is the leading cause of female death and morbidity. Homologous recombination repair (HRR) is critical in BC. However, the prognostic role and immunotherapy response of HRR in BC remains to be clarified. Firstly, we identified HRR types in BC samples from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) dataset (GSE42568) based on 65 HRR genes (HRRGs). A differentially expressed gene (DEG) list for different HRR types was generated. Then, the influences of gene sets composed of these DEGs on biological pathways and BC prognosis were explored. Next, we identified gene clusters based on gene sets composed of DEGs. Genes associated with prognosis for DEGs were identified using univariate Cox regression. Finally, the HRR score was constructed based on genes associated with prognosis. We analyzed how HRR score correlates with tumor mutation burden (TMB), immune cell infiltration (ICI), and immunotherapy response. Three HRR clusters were discovered. HRR subtype A demonstrated decreased infiltration and a high number of immunosuppressive cells with a poor prognosis. DEGs among various HRR types were predominantly enriched in cell cycle and genomic stability-related pathways. The prognostic model based on sixteen DEGs accurately predicted BC prognosis. The HRRGs were differentially expressed in three DEG clusters. TMB, ICI, and immunotherapy responses differed significantly between the high and low HRR groups (HSG, LSG). The HSG was distinguished by a high degree of ICI and low TMB. LSG had a better response to anti-PD-1 or anti-PD-1 and anti-CTLA4 combination therapy. This work revealed that HRR patterns would contribute to predicting prognosis and immunotherapy response in BC, which may benefit patients.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1235302-4
    ISSN 2190-3883 ; 1234-1983
    ISSN (online) 2190-3883
    ISSN 1234-1983
    DOI 10.1007/s13353-024-00848-1
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    In stock of ZB MED Bonn / Germany

    Einzelsign.: Show issues

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  7. Article: Receptor-interacting protein kinase 2 is associated with tumor immune infiltration, immunotherapy-related biomarkers, and affects gastric cancer cells growth

    Yang, Qian / Hong, Kunqiao / Li, Yu / Shi, Pengshuang / Yan, Fang / Zhang, Peng

    Journal of Cancer

    2024  Volume 15, Issue 1, Page(s) 176–191

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.90008
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  8. Article ; Online: Photoredox-catalyzed radical-radical cross coupling of ketyl radicals with unstabilized primary alkyl radicals.

    Feng, Shishen / Liu, Hong / Li, Yan / Fang, Yewen

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 33, Page(s) 4431–4434

    Abstract: Herein, a novel protocol dealing with the preparation of sterically hindered alcohols has been successfully ... ...

    Abstract Herein, a novel protocol dealing with the preparation of sterically hindered alcohols has been successfully developed
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc00620h
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  9. Article ; Online: Salty treatment increased bioactive compounds accumulation during agarwood development in Aquilaria sinensis trees.

    Yan, Tingting / Zhang, Ningnan / Hong, Zhou / Chen, Yuan / Li, Gaiyun

    Fitoterapia

    2024  Volume 175, Page(s) 105901

    Abstract: To compare the bioactive compounds in agarwood induced by different methods in Aquilaria sinensis(Lour.) Gilg trees, a two dimensional thin layer chromatograph(2D-TLC) combined with effect directive analysis(EDA) was developed. Three antioxidants were ... ...

    Abstract To compare the bioactive compounds in agarwood induced by different methods in Aquilaria sinensis(Lour.) Gilg trees, a two dimensional thin layer chromatograph(2D-TLC) combined with effect directive analysis(EDA) was developed. Three antioxidants were found by 2D-TLC-DPPH and further identified as 2-(2-phenylethyl) chromones(PECs) with LC-MS/MS. The 3 antioxidants decreased along agarwood formation and their compositions in drilling induced agarwood differed with those in microbe culture induced agarwood. Further study showed NaCl treatment promoted antioxidants accumulation in agarwood induced by drilling or hot drilling. Hot drilling combined with salty stimulation was most efficient in some chemicals accumulation, which were identified as PECs with antioxidant, tyrosinase or β-glucosidase inhibiting activities by 2D-TLC-EDA-LC-MS/MS. This study provided a 2D-TLC-EDA-LC-MS/MS method for bioactive compounds screen and qualification of agarwood. Based on this method, non-conventional methods were found to accelerate the accumulation of some bioactive PECs in A. sinensis trees.
    Language English
    Publishing date 2024-03-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2024.105901
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    Zs.B 1873: Show issues Location:
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  10. Article ; Online: An Asynchronous Concerted Mechanism and Its Origin in Lewis Acid-Mediated Carbonyl-Olefin [2+2] Cycloaddition.

    Li, Yan-Yu / Zhang, Shuo-Qing / Hong, Xin

    Chemistry, an Asian journal

    2023  Volume 18, Issue 14, Page(s) e202300375

    Abstract: The concerted mechanism of thermal ... ...

    Abstract The concerted mechanism of thermal BBr
    Language English
    Publishing date 2023-06-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202300375
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