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  1. Article ; Online: A sting in the tail-are antibodies against the C-terminus of Plasmodium falciparum circumsporozoite protein protective?

    Murdoch, Jem / Baum, Jake

    EMBO molecular medicine

    2023  Volume 15, Issue 6, Page(s) e17556

    Abstract: Malaria remains a huge burden on global public health. Annually there are more than 200 million cases with > 600,000 deaths worldwide, the vast majority of which occur within Sub-Saharan Africa (WHO; World Malaria Report, 2021). Malaria disease is the ... ...

    Abstract Malaria remains a huge burden on global public health. Annually there are more than 200 million cases with > 600,000 deaths worldwide, the vast majority of which occur within Sub-Saharan Africa (WHO; World Malaria Report, 2021). Malaria disease is the consequence of infection by a protozoan parasite from the genus Plasmodium with most morbidity and mortality caused by P. falciparum. With rates of infection plateauing and rebounding in some areas (in particular, as a result of the disruption caused by the COVID-19 pandemic), there have been increasing calls for new initiatives that can reduce malaria incidence towards local elimination or the hoped for goal of global eradication. In 2021, the World Health Organisation approved the first malaria vaccine RTS,S/AS01 (also called Mosquirix™), indicating it to be safe for use in young children and advocating its integration into routine immunisation programmes. Approval of this vaccine clearly represents a major landmark in global efforts towards malaria control and eradication aspirations. RTS,S modest efficacy, however, points at the need to better understand immune responses to the parasite if we hope to design next generation malaria vaccines with increased potency.
    MeSH term(s) Child ; Humans ; Child, Preschool ; Plasmodium falciparum ; Pandemics ; COVID-19/epidemiology ; Malaria, Falciparum/prevention & control ; Antibodies ; Malaria/epidemiology ; Malaria Vaccines ; Protozoan Proteins/genetics
    Chemical Substances Antibodies ; Malaria Vaccines ; Protozoan Proteins
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.15252/emmm.202317556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A sting in the tail—are antibodies against the C‐terminus of Plasmodium falciparum circumsporozoite protein protective?

    Jem Murdoch / Jake Baum

    EMBO Molecular Medicine, Vol 15, Iss 6, Pp n/a-n/a (2023)

    2023  

    Abstract: Malaria remains a huge burden on global public health. Annually there are more than 200 million cases with > 600,000 deaths worldwide, the vast majority of which occur within Sub‐Saharan Africa (WHO; World Malaria Report, 2021). Malaria disease is the ... ...

    Abstract Malaria remains a huge burden on global public health. Annually there are more than 200 million cases with > 600,000 deaths worldwide, the vast majority of which occur within Sub‐Saharan Africa (WHO; World Malaria Report, 2021). Malaria disease is the consequence of infection by a protozoan parasite from the genus Plasmodium with most morbidity and mortality caused by P. falciparum. With rates of infection plateauing and rebounding in some areas (in particular, as a result of the disruption caused by the COVID‐19 pandemic), there have been increasing calls for new initiatives that can reduce malaria incidence towards local elimination or the hoped for goal of global eradication. In 2021, the World Health Organisation approved the first malaria vaccine RTS,S/AS01 (also called Mosquirix™), indicating it to be safe for use in young children and advocating its integration into routine immunisation programmes. Approval of this vaccine clearly represents a major landmark in global efforts towards malaria control and eradication aspirations. RTS,S modest efficacy, however, points at the need to better understand immune responses to the parasite if we hope to design next generation malaria vaccines with increased potency.
    Keywords Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Subject code 572
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Enhanced Antimalarial and Antisequestration Activity of Methoxybenzenesulfonate-Modified Biopolymers and Nanoparticles for Tackling Severe Malaria.

    Najer, Adrian / Kim, Junyoung / Saunders, Catherine / Che, Junyi / Baum, Jake / Stevens, Molly M

    ACS infectious diseases

    2024  Volume 10, Issue 2, Page(s) 732–745

    Abstract: Severe malaria is a life-threatening condition that is associated with a high mortality. ... ...

    Abstract Severe malaria is a life-threatening condition that is associated with a high mortality. Severe
    MeSH term(s) Female ; Humans ; Pregnancy ; Plasmodium falciparum/metabolism ; Antimalarials/pharmacology ; Placenta ; Endothelial Cells ; Malaria, Cerebral ; Biopolymers/metabolism ; Heparin/pharmacology
    Chemical Substances Antimalarials ; Biopolymers ; Heparin (9005-49-6)
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.3c00564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bottoms up! Malaria parasite invasion the right way around.

    Andrews, Mia / Baum, Jake / Gilson, Paul R / Wilson, Danny W

    Trends in parasitology

    2023  Volume 39, Issue 12, Page(s) 1004–1013

    Abstract: A critical part of the malaria parasite's life cycle is invasion of red blood cells (RBCs) by merozoites. Inside RBCs, the parasite forms a schizont, which undergoes segmentation to produce daughter merozoites. These cells are released, establishing ... ...

    Abstract A critical part of the malaria parasite's life cycle is invasion of red blood cells (RBCs) by merozoites. Inside RBCs, the parasite forms a schizont, which undergoes segmentation to produce daughter merozoites. These cells are released, establishing cycles of invasion. Traditionally, merozoites are represented as nonmotile, egg-shaped cells that invade RBCs 'narrower end' first and pack within schizonts with this narrower end facing outwards. Here, we discuss recent evidence and re-evaluate previous data which suggest that merozoites are capable of motility and have spherical or elongated-teardrop shapes. Furthermore, merozoites invade RBCs 'wider end' first and pack within schizonts with this wider end facing outwards. We encourage the field to review this revised model and consider its implications for future studies.
    MeSH term(s) Animals ; Parasites ; Malaria/parasitology ; Schizonts ; Merozoites ; Life Cycle Stages
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The R

    Baum, Jake / Pasvol, Geoffrey / Carter, Richard

    Nature

    2020  Volume 582, Issue 7813, Page(s) 488

    MeSH term(s) Animals ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Culicidae ; Humans ; Malaria ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-01882-9
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  6. Article ; Online: A dual paper-based nucleic acid extraction method from blood in under ten minutes for point-of-care diagnostics.

    Malpartida-Cardenas, Kenny / Baum, Jake / Cunnington, Aubrey / Georgiou, Pantelis / Rodriguez-Manzano, Jesus

    The Analyst

    2023  Volume 148, Issue 13, Page(s) 3036–3044

    Abstract: Nucleic acid extraction (NAE) plays a crucial role for diagnostic testing procedures. For decades, dried blood spots (DBS) have been used for serology, drug monitoring, and molecular studies. However, extracting nucleic acids from DBS remains a ... ...

    Abstract Nucleic acid extraction (NAE) plays a crucial role for diagnostic testing procedures. For decades, dried blood spots (DBS) have been used for serology, drug monitoring, and molecular studies. However, extracting nucleic acids from DBS remains a significant challenge, especially when attempting to implement these applications to the point-of-care (POC). To address this issue, we have developed a paper-based NAE method using cellulose filter papers (DBSFP) that operates without the need for electricity (at room temperature). Our method allows for NAE in less than 7 min, and it involves grade 3 filter paper pre-treated with 8% (v/v) igepal surfactant, 1 min washing step with 1× PBS, and 5 min incubation at room temperature in 1× TE buffer. The performance of the methodology was assessed with loop-mediated isothermal amplification (LAMP), targeting the human reference gene beta-actin and the
    MeSH term(s) Point-of-Care Systems ; Nucleic Acids/isolation & purification ; Hematologic Tests/methods ; Humans ; Actins/genetics ; Nucleic Acid Amplification Techniques/methods ; Malaria, Falciparum/diagnosis ; Colorimetry ; Plasmodium falciparum/genetics ; Plasmodium falciparum/isolation & purification
    Chemical Substances Nucleic Acids ; Actins
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d3an00296a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A complete molecular understanding of malaria parasite invasion of the human erythrocyte: are we there yet?

    Baum, Jake

    Pathogens and global health

    2013  Volume 107, Issue 3, Page(s) 107

    MeSH term(s) Erythrocytes/parasitology ; Host-Pathogen Interactions ; Humans ; Malaria/parasitology ; Malaria/pathology ; Plasmodium/physiology
    Language English
    Publishing date 2013-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2625162-0
    ISSN 2047-7732 ; 2047-7724
    ISSN (online) 2047-7732
    ISSN 2047-7724
    DOI 10.1179/2047772413Z.000000000121
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  8. Article ; Online: A novel computational pipeline for

    Andradi-Brown, Clare / Wichers-Misterek, Jan Stephan / von Thien, Heidrun / Höppner, Yannick D / Scholz, Judith A M / Hansson, Helle / Filtenborg Hocke, Emma / Gilberger, Tim Wolf / Duffy, Michael F / Lavstsen, Thomas / Baum, Jake / Otto, Thomas D / Cunnington, Aubrey J / Bachmann, Anna

    eLife

    2024  Volume 12

    Abstract: The pathogenesis of ... ...

    Abstract The pathogenesis of severe
    MeSH term(s) Humans ; Plasmodium falciparum/genetics ; Transcriptome ; Malaria, Falciparum ; Benchmarking ; Emotions
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.87726
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