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Article ; Online: Development of ventilatory chemoreflexes in Coturnix quail chicks.

Song, Monata J / Pratt, Ashley E / Bavis, Ryan W

2020 Volume 276, Page(s) 103411

Abstract: Compared to mammals, little is known about the development of the respiratory control system in birds. In the present study, ventilation and metabolism were measured in Coturnix quail chicks exposed to room air, hypoxia (11 % ... ...

Abstract	Compared to mammals, little is known about the development of the respiratory control system in birds. In the present study, ventilation and metabolism were measured in Coturnix quail chicks exposed to room air, hypoxia (11 % O
MeSH term(s)	Animals ; Animals, Newborn ; Coturnix/growth & development ; Coturnix/physiology ; Hypercapnia/metabolism ; Hypoxia/metabolism ; Pulmonary Ventilation/physiology ; Reflex/physiology
Language	English
Publishing date	2020-02-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2020.103411
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Article ; Online: "I'm a security professional, a counselor, a leader, and sometimes a father figure": Transformative social emotional learning through the eyes of school security professionals.

Forber-Pratt, Anjali J / Espelage, Dorothy L / Robinson, Luz E / Woolweaver, Ashley B / Torgal, Cagil / El Sheikh, America J

American journal of community psychology

2023 Volume 71, Issue 3-4, Page(s) 317–331

Abstract: Schools are increasingly hiring full-time, unarmed school security professionals (SSPs), who are different from School Resource Officers (SROs), to help facilitate safe and supportive school climates. However, there is a paucity of literature about how ... ...

Abstract	Schools are increasingly hiring full-time, unarmed school security professionals (SSPs), who are different from School Resource Officers (SROs), to help facilitate safe and supportive school climates. However, there is a paucity of literature about how they describe and engage with social emotional learning (SEL), particularly equity-focused or transformative SEL. The current study is a secondary data analysis using qualitative responses to content embedded in two online professional development (PD) modules created for school security: SEL and cultural competence (CC). Forty-eight SSPs completed the SEL module and 18 of these SSPs also completed the CC module. Informed by the Collaborative for Academic, Social, and Emotional Learning's transformative SEL literature, researchers sought to understand how SSPs describe SEL and how they apply transformative SEL in their work. A qualitative transcript analysis was performed, and transformative SEL's five subthemes were identified through this iterative process: working collaboratively, equity and inclusion, cultural humility, ties to identity, and advocacy. Findings demonstrated that SSPs who completed the modules apply transformative SEL principles in various, overlapping ways, illustrating their capacity to support student SEL. However, some SSPs struggled to make ties to their own identity, highlighting the need for widespread training and additional emphasis on self-awareness in transformative SEL PD.
MeSH term(s)	Humans ; Male ; Counselors ; Social Learning ; Emotions ; Schools ; Fathers
Language	English
Publishing date	2023-01-03
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	222658-3
ISSN	1573-2770 ; 0091-0562
ISSN (online)	1573-2770
ISSN	0091-0562
DOI	10.1002/ajcp.12640
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Article ; Online: The relationship between trauma and weight status among adolescents in eating disorder treatment.

Hicks White, Ashley A / Pratt, Keeley J / Cottrill, Casey

Appetite

2018 Volume 129, Page(s) 62–69

Abstract: A relationship between trauma and eating disorders in adolescence is well established, though less is known about how different types of trauma, apart from childhood sexual abuse, associate with eating disorders. The purpose of this study is to describe ... ...

Abstract	A relationship between trauma and eating disorders in adolescence is well established, though less is known about how different types of trauma, apart from childhood sexual abuse, associate with eating disorders. The purpose of this study is to describe the prevalence of various trauma types in a clinical sample of adolescents presenting at an outpatient eating disorder treatment facility (N = 182). Thirty-five percent of the sample reported experiencing one or more traumatic events during their lifetime. Bullying was the most prevalent type of trauma (10%), followed by significant death/loss (9%), and sexual abuse (8%). Adolescents with any trauma exposure had higher body mass index (BMI), BMI percentile, and percent expected body weight (%EBW) compared to those without any trauma exposure. Specifically, patients who were exposed to bullying and domestic violence reported a significantly higher %EBW than those who were not exposed. On average, adolescents exposed to bullying had a %EBW that was 7 percentage points higher than their non-exposed peers. Patients with bulimia nervosa were more likely to report trauma exposure than those with other eating disorder diagnosis. Providers working with adolescents diagnosed with eating disorders of all weight statuses should consider assessing for past and current trauma, including bullying and exposure to domestic violence. Trauma informed approaches to eating disorder treatment are needed to avoid potentially activating or exacerbating trauma related distress for adolescents in eating disorder treatment.
MeSH term(s)	Adolescent ; Anorexia Nervosa ; Anxiety/complications ; Body Mass Index ; Body Weight ; Bulimia Nervosa ; Bullying ; Child Abuse, Sexual ; Comorbidity ; Depression/complications ; Domestic Violence ; Feeding and Eating Disorders/psychology ; Feeding and Eating Disorders/therapy ; Female ; Grief ; Humans ; Male ; Obsessive Behavior/complications ; Psychological Trauma/complications ; Stress Disorders, Post-Traumatic/complications
Language	English
Publishing date	2018-06-30
Publishing country	England
Document type	Journal Article
ISSN	1095-8304
ISSN (online)	1095-8304
DOI	10.1016/j.appet.2018.06.034
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Article ; Online: A Review of the Presentation of Overdiagnosis in Cancer Screening Patient Decision Aids.

Housten, Ashley J / Lowenstein, Lisa M / Hoffman, Aubri / Jacobs, Lianne E / Zirari, Zineb / Hoover, Diana S / Stacey, Dawn / Pratt, Greg / Bevers, Therese B / Volk, Robert J

MDM policy & practice

2019 Volume 4, Issue 2, Page(s) 2381468319881447

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2019-11-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2861432-X
ISSN	2381-4683 ; 2381-4683
ISSN (online)	2381-4683
ISSN	2381-4683
DOI	10.1177/2381468319881447
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Article ; Online: Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins.

Shin, David S / Pratt, Ashley J / Tainer, John A

Archaea (Vancouver, B.C.)

2014 Volume 2014, Page(s) 206735

Abstract: As the third domain of life, archaea, like the eukarya and bacteria, must have robust DNA replication and repair complexes to ensure genome fidelity. Archaea moreover display a breadth of unique habitats and characteristics, and structural biologists ... ...

Abstract	As the third domain of life, archaea, like the eukarya and bacteria, must have robust DNA replication and repair complexes to ensure genome fidelity. Archaea moreover display a breadth of unique habitats and characteristics, and structural biologists increasingly appreciate these features. As archaea include extremophiles that can withstand diverse environmental stresses, they provide fundamental systems for understanding enzymes and pathways critical to genome integrity and stress responses. Such archaeal extremophiles provide critical data on the periodic table for life as well as on the biochemical, geochemical, and physical limitations to adaptive strategies allowing organisms to thrive under environmental stress relevant to determining the boundaries for life as we know it. Specifically, archaeal enzyme structures have informed the architecture and mechanisms of key DNA repair proteins and complexes. With added abilities to temperature-trap flexible complexes and reveal core domains of transient and dynamic complexes, these structures provide insights into mechanisms of maintaining genome integrity despite extreme environmental stress. The DNA damage response protein structures noted in this review therefore inform the basis for genome integrity in the face of environmental stress, with implications for all domains of life as well as for biomanufacturing, astrobiology, and medicine.
MeSH term(s)	Archaea/genetics ; Bacteria ; DNA Repair Enzymes/genetics ; DNA Replication ; Eukaryota/genetics ; Evolution, Molecular ; Genome, Archaeal ; Genomic Instability
Chemical Substances	DNA Repair Enzymes (EC 6.5.1.-)
Language	English
Publishing date	2014-02-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2133011-6
ISSN	1472-3654 ; 1472-3646
ISSN (online)	1472-3654
ISSN	1472-3646
DOI	10.1155/2014/206735
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Amyotrophic lateral sclerosis: update and new developments.

Pratt, Ashley J / Getzoff, Elizabeth D / Perry, J Jefferson P

Degenerative neurological and neuromuscular disease

2012 Volume 2012, Issue 2, Page(s) 1–14

Abstract: Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease. It is typically characterized by adult-onset degeneration of the upper and lower motor neurons, and is usually fatal within a few years of onset. A subset of ALS ... ...

Abstract	Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease. It is typically characterized by adult-onset degeneration of the upper and lower motor neurons, and is usually fatal within a few years of onset. A subset of ALS patients has an inherited form of the disease, and a few of the known mutant genes identified in familial cases have also been found in sporadic forms of ALS. Precisely how the diverse ALS-linked gene products dictate the course of the disease, resulting in compromised voluntary muscular ability, is not entirely known. This review addresses the major advances that are being made in our understanding of the molecular mechanisms giving rise to the disease, which may eventually translate into new treatment options.
Language	English
Publishing date	2012-08-28
Publishing country	New Zealand
Document type	Journal Article
ISSN	1179-9900
ISSN	1179-9900
DOI	10.2147/DNND.S19803
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Article: The relationship between trauma and weight status among adolescents in eating disorder treatment

Hicks White, Ashley A / Pratt, Keeley J / Cottrill, Casey

Appetite. 2018 Oct. 01, v. 129

2018

Abstract	A relationship between trauma and eating disorders in adolescence is well established, though less is known about how different types of trauma, apart from childhood sexual abuse, associate with eating disorders. The purpose of this study is to describe the prevalence of various trauma types in a clinical sample of adolescents presenting at an outpatient eating disorder treatment facility (N = 182). Thirty-five percent of the sample reported experiencing one or more traumatic events during their lifetime. Bullying was the most prevalent type of trauma (10%), followed by significant death/loss (9%), and sexual abuse (8%). Adolescents with any trauma exposure had higher body mass index (BMI), BMI percentile, and percent expected body weight (%EBW) compared to those without any trauma exposure. Specifically, patients who were exposed to bullying and domestic violence reported a significantly higher %EBW than those who were not exposed. On average, adolescents exposed to bullying had a %EBW that was 7 percentage points higher than their non-exposed peers. Patients with bulimia nervosa were more likely to report trauma exposure than those with other eating disorder diagnosis. Providers working with adolescents diagnosed with eating disorders of all weight statuses should consider assessing for past and current trauma, including bullying and exposure to domestic violence. Trauma informed approaches to eating disorder treatment are needed to avoid potentially activating or exacerbating trauma related distress for adolescents in eating disorder treatment.
Keywords	adolescence ; adolescents ; aggression ; body mass index ; body weight ; bulimia nervosa ; childhood ; death ; distress ; family violence ; life events ; patients ; peers ; sexual abuse
Language	English
Dates of publication	2018-1001
Size	p. 62-69.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	764440-1
ISSN	0195-6663
ISSN	0195-6663
DOI	10.1016/j.appet.2018.06.034
Database	NAL-Catalogue (AGRICOLA)

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Z 6097: Show issues

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Article ; Online: Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements.

Wirthlin, Morgan E / Schmid, Tobias A / Elie, Julie E / Zhang, Xiaomeng / Kowalczyk, Amanda / Redlich, Ruby / Shvareva, Varvara A / Rakuljic, Ashley / Ji, Maria B / Bhat, Ninad S / Kaplow, Irene M / Schäffer, Daniel E / Lawler, Alyssa J / Wang, Andrew Z / Phan, BaDoi N / Annaldasula, Siddharth / Brown, Ashley R / Lu, Tianyu / Lim, Byung Kook /

Azim, Eiman / Clark, Nathan L / Meyer, Wynn K / Pond, Sergei L Kosakovsky / Chikina, Maria / Yartsev, Michael M / Pfenning, Andreas R / Andrews, Gregory / Armstrong, Joel C / Bianchi, Matteo / Birren, Bruce W / Bredemeyer, Kevin R / Breit, Ana M / Christmas, Matthew J / Clawson, Hiram / Damas, Joana / Di Palma, Federica / Diekhans, Mark / Dong, Michael X / Eizirik, Eduardo / Fan, Kaili / Fanter, Cornelia / Foley, Nicole M / Forsberg-Nilsson, Karin / Garcia, Carlos J / Gatesy, John / Gazal, Steven / Genereux, Diane P / Goodman, Linda / Grimshaw, Jenna / Halsey, Michaela K / Harris, Andrew J / Hickey, Glenn / Hiller, Michael / Hindle, Allyson G / Hubley, Robert M / Hughes, Graham M / Johnson, Jeremy / Juan, David / Karlsson, Elinor K / Keough, Kathleen C / Kirilenko, Bogdan / Koepfli, Klaus-Peter / Korstian, Jennifer M / Kozyrev, Sergey V / Lawless, Colleen / Lehmann, Thomas / Levesque, Danielle L / Lewin, Harris A / Li, Xue / Lind, Abigail / Lindblad-Toh, Kerstin / Mackay-Smith, Ava / Marinescu, Voichita D / Marques-Bonet, Tomas / Mason, Victor C / Meadows, Jennifer R S / Moore, Jill E / Moreira, Lucas R / Moreno-Santillan, Diana D / Morrill, Kathleen M / Muntané, Gerard / Murphy, William J / Navarro, Arcadi / Nweeia, Martin / Ortmann, Sylvia / Osmanski, Austin / Paten, Benedict / Paulat, Nicole S / Pollard, Katherine S / Pratt, Henry E / Ray, David A / Reilly, Steven K / Rosen, Jeb R / Ruf, Irina / Ryan, Louise / Ryder, Oliver A / Sabeti, Pardis C / Serres, Aitor / Shapiro, Beth / Smit, Arian F A / Springer, Mark / Srinivasan, Chaitanya / Steiner, Cynthia / Storer, Jessica M / Sullivan, Kevin A M / Sullivan, Patrick F / Sundström, Elisabeth / Supple, Megan A / Swofford, Ross / Talbot, Joy-El / Teeling, Emma / Turner-Maier, Jason / Valenzuela, Alejandro / Wagner, Franziska / Wallerman, Ola / Wang, Chao / Wang, Juehan / Weng, Zhiping / Wilder, Aryn P / Xue, James R

Science (New York, N.Y.)

2024 Volume 383, Issue 6690, Page(s) eabn3263

Abstract: Vocal production learning ("vocal learning") is a convergently evolved trait in vertebrates. To identify brain genomic elements associated with mammalian vocal learning, we integrated genomic, anatomical, and neurophysiological data from the Egyptian ... ...

Abstract	Vocal production learning ("vocal learning") is a convergently evolved trait in vertebrates. To identify brain genomic elements associated with mammalian vocal learning, we integrated genomic, anatomical, and neurophysiological data from the Egyptian fruit bat (
MeSH term(s)	Animals ; Chiroptera/genetics ; Chiroptera/physiology ; Vocalization, Animal/physiology ; Motor Cortex/cytology ; Motor Cortex/physiology ; Chromatin/metabolism ; Enhancer Elements, Genetic ; Motor Neurons/physiology ; Larynx/physiology ; Epigenesis, Genetic ; Genome ; Gene Expression Regulation ; Evolution, Molecular ; Proteins/genetics ; Proteins/metabolism ; Amino Acid Sequence ; Eutheria/genetics ; Eutheria/physiology ; Machine Learning
Chemical Substances	Chromatin ; Proteins
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abn3263
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

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Article ; Online: The RNA-induced silencing complex: a versatile gene-silencing machine.

Pratt, Ashley J / MacRae, Ian J

The Journal of biological chemistry

2009 Volume 284, Issue 27, Page(s) 17897–17901

Abstract: RNA interference is a powerful mechanism of gene silencing that underlies many aspects of eukaryotic biology. On the molecular level, RNA interference is mediated by a family of ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs), ... ...

Abstract	RNA interference is a powerful mechanism of gene silencing that underlies many aspects of eukaryotic biology. On the molecular level, RNA interference is mediated by a family of ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs), which can be programmed to target virtually any nucleic acid sequence for silencing. The ability of RISC to locate target RNAs has been co-opted by evolution many times to generate a broad spectrum of gene-silencing pathways. Here, we review the fundamental biochemical and biophysical properties of RISC that facilitate gene targeting and describe the various mechanisms of gene silencing known to exploit RISC activity.
MeSH term(s)	Animals ; Humans ; Multiprotein Complexes/chemistry ; Multiprotein Complexes/genetics ; Protein Structure, Tertiary ; RNA Interference/physiology
Chemical Substances	Multiprotein Complexes
Language	English
Publishing date	2009-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.R900012200
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Article: The RNA-induced Silencing Complex: A Versatile Gene-silencing Machine

Pratt, Ashley J / MacRae, Ian J

Journal of biological chemistry. 2009 July 3, v. 284, no. 27

2009

Abstract	RNA interference is a powerful mechanism of gene silencing that underlies many aspects of eukaryotic biology. On the molecular level, RNA interference is mediated by a family of ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs), which can be programmed to target virtually any nucleic acid sequence for silencing. The ability of RISC to locate target RNAs has been co-opted by evolution many times to generate a broad spectrum of gene-silencing pathways. Here, we review the fundamental biochemical and biophysical properties of RISC that facilitate gene targeting and describe the various mechanisms of gene silencing known to exploit RISC activity.
Language	English
Dates of publication	2009-0703
Size	p. 17897-17901.
Publishing place	American Society for Biochemistry and Molecular Biology
Document type	Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
Database	NAL-Catalogue (AGRICOLA)

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