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  1. Article: The Rapid Coronavirus Antibody Test: Can We Improve Accuracy?

    Pavlova, Ina P / Nair, Sujit S / Kyprianou, Natasha / Tewari, Ash K

    Frontiers in medicine

    2020  Volume 7, Page(s) 569

    Keywords covid19
    Language English
    Publishing date 2020-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00569
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  2. Article: (

    Bulthuis, Nicholas E / McGowan, Josephine C / Ladner, Liliana R / LaGamma, Christina T / Lim, Sean C / Shubeck, Claire X / Brachman, Rebecca A / Sydnor, Ezra / Pavlova, Ina P / Seo, Dong-Oh / Drew, Michael R / Denny, Christine A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Standard antidepressant treatments often take weeks to reach efficacy and are ineffective for many patients. ( ...

    Abstract Standard antidepressant treatments often take weeks to reach efficacy and are ineffective for many patients. (
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.28.569043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Rapid Coronavirus Antibody Test

    Ina P. Pavlova / Sujit S. Nair / Natasha Kyprianou / Ash K. Tewari

    Frontiers in Medicine, Vol

    Can We Improve Accuracy?

    2020  Volume 7

    Keywords SARS-CoV-2 antibodies ; neutralizing antibodies ; rapid tests ; lateral flow assays ; paper based analytical devices ; Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Optimization of immunolabeling and clearing techniques for indelibly labeled memory traces.

    Pavlova, Ina P / Shipley, Shannon C / Lanio, Marcos / Hen, René / Denny, Christine A

    Hippocampus

    2018  Volume 28, Issue 7, Page(s) 523–535

    Abstract: Recent genetic tools have allowed researchers to visualize and manipulate memory traces (i.e., engrams) in small brain regions. However, the ultimate goal is to visualize memory traces across the entire brain in order to better understand how memories ... ...

    Abstract Recent genetic tools have allowed researchers to visualize and manipulate memory traces (i.e., engrams) in small brain regions. However, the ultimate goal is to visualize memory traces across the entire brain in order to better understand how memories are stored in neural networks and how multiple memories may coexist. Intact tissue clearing and imaging is a new and rapidly growing area of focus that could accomplish this task. Here, we utilized the leading protocols for whole-brain clearing and applied them to the ArcCreER
    MeSH term(s) AIDS-Related Complex/genetics ; AIDS-Related Complex/metabolism ; Animals ; Brain/anatomy & histology ; Brain/metabolism ; Channelrhodopsins/genetics ; Channelrhodopsins/metabolism ; Conditioning, Operant ; Estrogen Antagonists/pharmacology ; Fear ; Immunohistochemistry ; Indicators and Reagents/pharmacology ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Memory/physiology ; Mice ; Mice, Transgenic ; Microscopy, Confocal ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism ; Tamoxifen/analogs & derivatives ; Tamoxifen/pharmacology
    Chemical Substances Channelrhodopsins ; Estrogen Antagonists ; Indicators and Reagents ; Luminescent Proteins ; Receptors, Estrogen ; Tamoxifen (094ZI81Y45) ; afimoxifene (17197F0KYM)
    Language English
    Publishing date 2018-12-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1074352-2
    ISSN 1098-1063 ; 1050-9631
    ISSN (online) 1098-1063
    ISSN 1050-9631
    DOI 10.1002/hipo.22951
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  6. Article: Multiphoton Microscopy for Identifying Collagen Signatures Associated with Biochemical Recurrence in Prostate Cancer Patients.

    Pavlova, Ina P / Nair, Sujit S / Lundon, Dara / Sobotka, Stanislaw / Roshandel, Reza / Treacy, Patrick-Julien / Ratnani, Parita / Brody, Rachel / Epstein, Jonathan I / Ayala, Gustavo E / Kyprianou, Natasha / Tewari, Ashutosh K

    Journal of personalized medicine

    2021  Volume 11, Issue 11

    Abstract: Prostate cancer is a heterogeneous disease that remains dormant for long periods or acts aggressively with poor clinical outcomes. Identifying aggressive prostate tumor behavior using current glandular-focused histopathological criteria is challenging. ... ...

    Abstract Prostate cancer is a heterogeneous disease that remains dormant for long periods or acts aggressively with poor clinical outcomes. Identifying aggressive prostate tumor behavior using current glandular-focused histopathological criteria is challenging. Recent evidence has implicated the stroma in modulating prostate tumor behavior and in predicting post-surgical outcomes. However, the emergence of stromal signatures has been limited, due in part to the lack of adoption of imaging modalities for stromal-specific profiling. Herein, label-free multiphoton microscopy (MPM), with its ability to image tissue with stromal-specific contrast, is used to identify prostate stromal features associated with aggressive tumor behavior and clinical outcome. MPM was performed on unstained prostatectomy specimens from 59 patients and on biopsy specimens from 17 patients with known post-surgery recurrence status. MPM-identified collagen content, organization, and morphological tumor signatures were extracted for each patient and screened for association with recurrent disease. Compared to tumors from patients whose disease did not recur, tumors from patients with recurrent disease exhibited higher MPM-identified collagen amount and collagen fiber intensity signal and width. Our study shows an association between MPM-identified stromal collagen features of prostate tumors and post-surgical disease recurrence, suggesting their potential for prostate cancer risk assessment.
    Language English
    Publishing date 2021-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11111061
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  7. Article ; Online: Multiphoton Microscopy for Identifying Collagen Signatures Associated with Biochemical Recurrence in Prostate Cancer Patients

    Ina P. Pavlova / Sujit S. Nair / Dara Lundon / Stanislaw Sobotka / Reza Roshandel / Patrick-Julien Treacy / Parita Ratnani / Rachel Brody / Jonathan I. Epstein / Gustavo E. Ayala / Natasha Kyprianou / Ashutosh K. Tewari

    Journal of Personalized Medicine, Vol 11, Iss 1061, p

    2021  Volume 1061

    Abstract: Prostate cancer is a heterogeneous disease that remains dormant for long periods or acts aggressively with poor clinical outcomes. Identifying aggressive prostate tumor behavior using current glandular-focused histopathological criteria is challenging. ... ...

    Abstract Prostate cancer is a heterogeneous disease that remains dormant for long periods or acts aggressively with poor clinical outcomes. Identifying aggressive prostate tumor behavior using current glandular-focused histopathological criteria is challenging. Recent evidence has implicated the stroma in modulating prostate tumor behavior and in predicting post-surgical outcomes. However, the emergence of stromal signatures has been limited, due in part to the lack of adoption of imaging modalities for stromal-specific profiling. Herein, label-free multiphoton microscopy (MPM), with its ability to image tissue with stromal-specific contrast, is used to identify prostate stromal features associated with aggressive tumor behavior and clinical outcome. MPM was performed on unstained prostatectomy specimens from 59 patients and on biopsy specimens from 17 patients with known post-surgery recurrence status. MPM-identified collagen content, organization, and morphological tumor signatures were extracted for each patient and screened for association with recurrent disease. Compared to tumors from patients whose disease did not recur, tumors from patients with recurrent disease exhibited higher MPM-identified collagen amount and collagen fiber intensity signal and width. Our study shows an association between MPM-identified stromal collagen features of prostate tumors and post-surgical disease recurrence, suggesting their potential for prostate cancer risk assessment.
    Keywords optical microscopy ; prostate cancer ; reactive stroma ; collagen signatures ; prognosis ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Ventral CA3 Activation Mediates Prophylactic Ketamine Efficacy Against Stress-Induced Depressive-like Behavior.

    Mastrodonato, Alessia / Martinez, Randy / Pavlova, Ina P / LaGamma, Christina T / Brachman, Rebecca A / Robison, Alfred J / Denny, Christine A

    Biological psychiatry

    2018  Volume 84, Issue 11, Page(s) 846–856

    Abstract: Background: We previously reported that a single injection of ketamine prior to stress protects against the onset of depressive-like behavior and attenuates learned fear. However, the molecular pathways and brain circuits underlying ketamine-induced ... ...

    Abstract Background: We previously reported that a single injection of ketamine prior to stress protects against the onset of depressive-like behavior and attenuates learned fear. However, the molecular pathways and brain circuits underlying ketamine-induced stress resilience are still largely unknown.
    Methods: Here, we tested whether prophylactic ketamine administration altered neural activity in the prefrontal cortex and/or hippocampus. Mice were injected with saline or ketamine (30 mg/kg) 1 week before social defeat. Following behavioral tests assessing depressive-like behavior, mice were sacrificed and brains were processed to quantify ΔFosB expression. In a second set of experiments, mice were stereotaxically injected with viral vectors into ventral CA3 (vCA3) in order to silence or overexpress ΔFosB prior to prophylactic ketamine administration. In a third set of experiments, ArcCreER
    Results: Prophylactic ketamine administration increased ΔFosB expression in the ventral dentate gyrus and vCA3 of social defeat mice but not of control mice. Transcriptional silencing of ΔFosB activity in vCA3 inhibited prophylactic ketamine efficacy, while overexpression of ΔFosB mimicked and occluded ketamine's prophylactic effects. In ArcCreER
    Conclusions: Our data indicate that prophylactic ketamine may be protective against a stressor by altering neural activity, specifically the neural ensembles representing an individual stressor in vCA3.
    MeSH term(s) Animals ; Behavior Rating Scale ; CA3 Region, Hippocampal/drug effects ; CA3 Region, Hippocampal/physiology ; Conditioning, Classical/drug effects ; Depression/drug therapy ; Fear ; Female ; Ketamine/pharmacology ; Male ; Mice ; Proto-Oncogene Proteins c-fos/metabolism ; Stress, Psychological/drug therapy
    Chemical Substances Fosb protein, mouse ; Proto-Oncogene Proteins c-fos ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2018-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2018.02.011
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    Zs.A 720: Show issues Location:
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  9. Article ; Online: Optogenetic stimulation of dentate gyrus engrams restores memory in Alzheimer's disease mice.

    Perusini, Jennifer N / Cajigas, Stephanie A / Cohensedgh, Omid / Lim, Sean C / Pavlova, Ina P / Donaldson, Zoe R / Denny, Christine A

    Hippocampus

    2017  Volume 27, Issue 10, Page(s) 1110–1122

    Abstract: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques and tau neurofibrillary tangles. APPswe/PS1dE9 (APP/PS1) mice have been developed as an AD model and are characterized by plaque formation at 4- ... ...

    Abstract Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques and tau neurofibrillary tangles. APPswe/PS1dE9 (APP/PS1) mice have been developed as an AD model and are characterized by plaque formation at 4-6 months of age. Here, we sought to better understand AD-related cognitive decline by characterizing various types of memory. In order to better understand how memory declines with AD, APP/PS1 mice were bred with ArcCreER
    MeSH term(s) Aging/pathology ; Aging/physiology ; Aging/psychology ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Alzheimer Disease/psychology ; Alzheimer Disease/therapy ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Cognition/physiology ; Dentate Gyrus/pathology ; Dentate Gyrus/physiopathology ; Disease Models, Animal ; Disease Progression ; Humans ; Male ; Memory/physiology ; Memory Disorders/pathology ; Memory Disorders/physiopathology ; Memory Disorders/therapy ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Transgenic ; Neuropsychological Tests ; Optogenetics ; Presenilin-1/genetics ; Presenilin-1/metabolism ; Social Behavior ; Spatial Behavior/physiology
    Chemical Substances APP protein, human ; Amyloid beta-Protein Precursor ; PSEN1 protein, human ; Presenilin-1
    Language English
    Publishing date 2017-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1074352-2
    ISSN 1098-1063 ; 1050-9631
    ISSN (online) 1098-1063
    ISSN 1050-9631
    DOI 10.1002/hipo.22756
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  10. Article: Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents

    Pavlova, A. V / D. V. Korchagina / E. A. Morozova / E. V. Nazimova / I. V. Il’ina / K. P. Volcho / N. F. Salakhutdinov / O. S. Mikhal’chenko / O. V. Ardashov / T. G. Tolstikova

    Chemistry of natural compounds. 2016 Sept., v. 52, no. 5

    2016  

    Abstract: Hexahydro-2H-chromenes with thiophene fragments were synthesized via reactions of a p-menthane ...

    Abstract Hexahydro-2H-chromenes with thiophene fragments were synthesized via reactions of a p-menthane monoterpenoid diol with several thiophenecarboxaldehydes. Most of the synthesized compounds with an additional thiophene fragment displayed analgesic activity in vivo tests at a dose of 10 mg/kg. It was found that the activity in either an acetate-writhing test or a hot-plate test depended on the type and location of substituent in the heteroaromatic ring.
    Keywords analgesic effect ; chemistry ; hot plate test ; in vivo studies ; monoterpenoids ; thiophene
    Language English
    Dates of publication 2016-09
    Size p. 813-820.
    Publishing place Springer US
    Document type Article
    ZDB-ID 213866-9
    ISSN 0009-3130
    ISSN 0009-3130
    DOI 10.1007/s10600-016-1785-2
    Database NAL-Catalogue (AGRICOLA)

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