Article ; Online: The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients.
2020 Volume 29, Issue 1, Page(s) 91–100
Abstract: Coronavirus disease 2019 (COVID-19) pandemic has affected health care systems worldwide. Severe presentations of COVID-19 such as severe pneumonia and acute respiratory distress syndrome (ARDS) have been associated with the post-viral activation and ... ...
| Abstract | Coronavirus disease 2019 (COVID-19) pandemic has affected health care systems worldwide. Severe presentations of COVID-19 such as severe pneumonia and acute respiratory distress syndrome (ARDS) have been associated with the post-viral activation and release of cytokine/chemokines which leads to a "cytokine storm" causing inflammatory response and destruction, mainly affecting the lungs. COVID-19 activation of transcription factor, NF-kappa B (NF-κB) in various cells such as macrophages of lung, liver, kidney, central nervous system, gastrointestinal system and cardiovascular system leads to production of IL-1, IL-2, IL-6, IL-12, TNF-α, LT-α, LT-β, GM-CSF, and various chemokines. The sensitised NF-κB in elderly and in patients with metabolic syndrome makes this set of population susceptible to COVID-19 and their worse complications, including higher mortality. Immunomodulation at the level of NF-κB activation and inhibitors of NF-κB (IκB) degradation along with TNF-α inhibition will potentially result in a reduction in the cytokine storm and alleviate the severity of COVID-19. Inhibition of NF-κB pathway has a potential therapeutic role in alleviating the severe form of COVID-19. |
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| MeSH term(s) | Aging/immunology ; COVID-19/complications ; COVID-19/immunology ; Cytokine Release Syndrome/prevention & control ; Glucocorticoids/therapeutic use ; Humans ; Metabolic Syndrome/immunology ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/immunology ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/immunology ; SARS-CoV-2 ; Severity of Illness Index ; Sex Characteristics ; Signal Transduction ; COVID-19 Drug Treatment |
| Chemical Substances | Glucocorticoids ; NF-kappa B |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-11-07 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 1080058-x |
| ISSN | 1568-5608 ; 0925-4692 |
| ISSN (online) | 1568-5608 |
| ISSN | 0925-4692 |
| DOI | 10.1007/s10787-020-00773-9 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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