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  1. Article ; Online: Enabling inclusion and looking ahead.

    Dey, Mishtu

    Cell chemical biology

    2023  Volume 30, Issue 11, Page(s) 1323

    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Editorial
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2023.10.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Using chemical biology for targeting cancer.

    Dey, Mishtu

    Cell chemical biology

    2022  Volume 29, Issue 3, Page(s) 351–352

    MeSH term(s) Biology ; Humans ; Neoplasms/drug therapy
    Language English
    Publishing date 2022-03-18
    Publishing country United States
    Document type Editorial
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2022.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A collection of chemical biology strategies for visualization in live cells.

    Dey, Mishtu

    Cell chemical biology

    2022  Volume 29, Issue 1, Page(s) 1–2

    MeSH term(s) COVID-19/immunology ; COVID-19/therapy ; Humans ; Interleukin-23/chemistry ; Interleukin-23/immunology ; Protein Binding ; Receptors, Interleukin/chemistry ; Receptors, Interleukin/immunology ; SARS-CoV-2/immunology ; Viral Vaccines/immunology
    Chemical Substances IL23R protein, human ; Interleukin-23 ; Receptors, Interleukin ; Viral Vaccines
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2021.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cell Chemical Biology announces changes to the editorial team.

    Dey, Mishtu

    Cell chemical biology

    2021  Volume 28, Issue 10, Page(s) 1389

    MeSH term(s) Editorial Policies ; Publishing/organization & administration
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Editorial
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2021.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Chemical strategies to understand and manipulate host-pathogen interactions.

    Wagner, Bridget K / Dey, Mishtu

    Cell chemical biology

    2022  Volume 29, Issue 5, Page(s) 711–712

    MeSH term(s) Host-Pathogen Interactions
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Editorial
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2022.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Identification of residues involved in allosteric signal transmission from amino acid binding site of pyruvate kinase muscle isoform 2.

    Suparno Nandi / Mishtu Dey

    PLoS ONE, Vol 18, Iss 3, p e

    2023  Volume 0282508

    Abstract: PKM2 is a rate-limiting enzyme in the glycolytic process and is involved in regulating tumor proliferation. Several amino acids (AAs) such as Asn, Asp, Val, and Cys have been shown to bind to the AA binding pocket of PKM2 and modulate its oligomeric ... ...

    Abstract PKM2 is a rate-limiting enzyme in the glycolytic process and is involved in regulating tumor proliferation. Several amino acids (AAs) such as Asn, Asp, Val, and Cys have been shown to bind to the AA binding pocket of PKM2 and modulate its oligomeric state, substrate binding affinity, and activity. Although previous studies have attributed that the main chain and side chain of bound AAs are responsible for initiating signal to regulate PKM2, the signal transduction pathway remains elusive. To identify the residues involved in signal transfer process, N70 and N75 located at two ends of a β strand connecting the active site and AA binding pocket were altered. Biochemical studies of these variants with various AA ligands (Asn, Asp, Val, and Cys), illustrate that N70 and N75, along with β1 connecting these residues are part of the signal transduction pathway between the AA binding pocket and the active site. The results demonstrate that mutation of N70 to D prevents the transfer of the inhibitory signal mediated by Val and Cys, whereas N75 to L alteration blocks the activating signal initiated by Asn and Asp. Taken together, this study confirms that N70 is one of the residues responsible for transmitting the inhibitory signal and N75 is involved in the activation signal flow.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Identification of residues involved in allosteric signal transmission from amino acid binding site of pyruvate kinase muscle isoform 2.

    Nandi, Suparno / Dey, Mishtu

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0282508

    Abstract: PKM2 is a rate-limiting enzyme in the glycolytic process and is involved in regulating tumor proliferation. Several amino acids (AAs) such as Asn, Asp, Val, and Cys have been shown to bind to the AA binding pocket of PKM2 and modulate its oligomeric ... ...

    Abstract PKM2 is a rate-limiting enzyme in the glycolytic process and is involved in regulating tumor proliferation. Several amino acids (AAs) such as Asn, Asp, Val, and Cys have been shown to bind to the AA binding pocket of PKM2 and modulate its oligomeric state, substrate binding affinity, and activity. Although previous studies have attributed that the main chain and side chain of bound AAs are responsible for initiating signal to regulate PKM2, the signal transduction pathway remains elusive. To identify the residues involved in signal transfer process, N70 and N75 located at two ends of a β strand connecting the active site and AA binding pocket were altered. Biochemical studies of these variants with various AA ligands (Asn, Asp, Val, and Cys), illustrate that N70 and N75, along with β1 connecting these residues are part of the signal transduction pathway between the AA binding pocket and the active site. The results demonstrate that mutation of N70 to D prevents the transfer of the inhibitory signal mediated by Val and Cys, whereas N75 to L alteration blocks the activating signal initiated by Asn and Asp. Taken together, this study confirms that N70 is one of the residues responsible for transmitting the inhibitory signal and N75 is involved in the activation signal flow.
    MeSH term(s) Amino Acids/metabolism ; Catalytic Domain ; Protein Isoforms/metabolism ; Pyruvate Kinase/chemistry ; Pyruvate Kinase/metabolism ; Humans ; Signal Transduction ; Thyroid Hormone-Binding Proteins
    Chemical Substances Amino Acids ; Protein Isoforms ; Pyruvate Kinase (EC 2.7.1.40)
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0282508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Advances and opportunities in targeted protein degradation.

    Nomura, Daniel K / Dey, Mishtu

    Cell chemical biology

    2021  Volume 28, Issue 7, Page(s) 887–888

    MeSH term(s) Humans ; Proteolysis ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2021.06.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Phenotypic approaches to small-molecule discovery in chemical biology.

    Wagner, Bridget K / Dey, Mishtu

    Cell chemical biology

    2021  Volume 28, Issue 3, Page(s) 245

    MeSH term(s) Drug Discovery ; High-Throughput Screening Assays ; Humans ; Pharmaceutical Preparations/chemistry ; Phenotype ; Small Molecule Libraries/chemistry
    Chemical Substances Pharmaceutical Preparations ; Small Molecule Libraries
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2021.02.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Chemical Tools in Biological Discovery.

    Dey, Mishtu / Weerapana, Eranthie

    Cell chemical biology

    2020  Volume 27, Issue 8, Page(s) 889–890

    MeSH term(s) Drug Discovery ; Molecular Probes/chemistry ; Small Molecule Libraries/chemistry
    Chemical Substances Molecular Probes ; Small Molecule Libraries
    Keywords covid19
    Language English
    Publishing date 2020-08-21
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2020.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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