LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 75

Search options

  1. Article ; Online: Application of hybrid SFLA-ACO algorithm and CAM softwares for optimization of drilling tool path problems.

    Mehmood, Nasir / Umer, Muhammad / Asgher, Umer

    SN applied sciences

    2023  Volume 5, Issue 2, Page(s) 61

    Abstract: Abstract: In drilling process almost seventy percent time is spent in tool switching and moving the spindle from one hole to the other. This time travel is non productive as it does not take part in actual drilling process. Therefore, this non ... ...

    Abstract Abstract: In drilling process almost seventy percent time is spent in tool switching and moving the spindle from one hole to the other. This time travel is non productive as it does not take part in actual drilling process. Therefore, this non productive time needs to be optimized. Different metaheuristic algorithms have been applied to minimize this non productive tool travel time. In this study, two metaheuristic approaches, shuffled frog leaping algorithm (SFLA) and ant colony optimization (ACO) have been hybridized. In industry, the CAM softwares are employed for minimization of non productive tool travel time and it is considered that the path obtained by using the CAM softwares is the optimized path. However this is not the case in all problems. In order to show the contribution of the SFLA-ACO algorithm and to prove that results achieved through CAM softwares are not always optimized, hybrid SFLA-ACO algorithm has been applied to two drilling problems as case studies with the main objective of minimization of non productive tool travel time. The drilling problems which are taken from the manufacturing industry include ventilator manifold problem and lift axle mounting bracket problem. The results of hybrid SFLA-ACO algorithm have been compared with the results of commercially available computer aided manufacturing (CAM) software. For comparison purpose, the CAM softwares used are Creo 6.0, Pro E, Siemens NX and Solidworks. The comparison shows that the results of proposed hybrid SFLA-ACO algorithm are better than commercially available CAM softwares in both real world manufacturing problems.
    Article highlights: Different optimization techniques are being used for optimization of drilling tool path problems. In this paper two techniques SFLA and ACO has been combined to form a hybrid SFLA-ACO algorithm and has been applied to the real world industrial problems.Two real world problems have been taken from the local manufacturing industries. In both the problems the objective is to optimize the tool traveling time through hybrid SFLA-ACO and compare it with CAM software.Four CAM softwares have been used for comparison purpose. The problems undertaken are solved through these CAM software and compared with the results of hybrid SFLA-ACO results. As result of comparison it is found that in both the problems the performance of hybrid SFLA-ACO algorithm remains outclass. This signifies that results of CAM software in case of optimization of drilling tool path are not always optimal and these can be improved by using different optimization techniques.
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2947292-1
    ISSN 2523-3971 ; 2523-3963
    ISSN (online) 2523-3971
    ISSN 2523-3963
    DOI 10.1007/s42452-022-05271-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: Incidence of aflatoxin M

    Ullah, Inayat / Nasir, Amar / Kashif, Muhammad / Sikandar, Arbab / Sajid, Muhammad / Adil, Muhammad / Rehman, Aziz Ur / Iqbal, Muhammad Umer / Ullah, Habib

    Veterinarni medicina

    2023  Volume 68, Issue 6, Page(s) 238–245

    Abstract: The present study was aimed at measuring the concentration of aflatoxin ... ...

    Abstract The present study was aimed at measuring the concentration of aflatoxin M
    Language English
    Publishing date 2023-06-21
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 412227-6
    ISSN 0375-8427 ; 0590-5214
    ISSN 0375-8427 ; 0590-5214
    DOI 10.17221/18/2023-VETMED
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Primary mycetoma of the calcaneum: Case report on an unusual hazard of barefoot walking.

    Nasir, Muhammad Umar / Mukhtar, Muhammad Umer / Nasir, Zoha / Mehmood, Qasim / Raza, Muhammad Salar / Ali, Muhammad Nasir

    International journal of surgery case reports

    2023  Volume 108, Page(s) 108418

    Abstract: Introduction: Mycetoma is a rare tropical fungal infection characterized by a clinical triad of subcutaneous swelling, multiple discharging sinuses, and a purulent discharge containing granules. If left untreated, the disease can progress from cutaneous ...

    Abstract Introduction: Mycetoma is a rare tropical fungal infection characterized by a clinical triad of subcutaneous swelling, multiple discharging sinuses, and a purulent discharge containing granules. If left untreated, the disease can progress from cutaneous to intraosseous and can cause osteomyelitis. In very rare instances labeled "primary mycetoma", the fungus is insidiously inoculated directly into the bone and causes osteomyelitis without any preceding cutaneous involvement. This can make the diagnosis very difficult.
    Presentation of case: A twelve-year-old girl with a history of walking barefoot, presented with pain and inability to bear weight on her left foot. There was no overlying cutaneous involvement. X-ray showed an osteolytic lesion in the calcaneum. After the failure of antibiotic treatment, the diseased bone was excised. Black granules were discovered inside the lesion and their histopathology confirmed a diagnosis of primary eumycetoma. After some time, the disease relapsed, necessitating another debridement. This occurred many times with worsened severity in each successive episode. Because of worsening disease and failure of both antifungal and surgical treatment, foot amputation was done.
    Discussion: Primary mycetoma is an insidious fungal infection that causes osteomyelitis without any cutaneous findings. Timely diagnosis and treatment provide the best chance of preventing an amputation.
    Conclusion: A high index of suspicion must be maintained for patients presenting with symptoms of osteomyelitis without any skin involvement so that timely diagnosis and treatment can prevent the progression of the disease and the need for amputation.
    Language English
    Publishing date 2023-06-17
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2023.108418
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Colonic lipoma mimicking malignancy and presenting as an intussusception: A rare case report.

    Niazi, Shehryar Ahmed Khan / Raza, Muhammad Salar / Mukhtar, Muhammad Umer / Hassan, Rameez / Nasir, Muhammad Umar

    International journal of surgery case reports

    2023  Volume 109, Page(s) 108611

    Abstract: Introduction and importance: Lipomas of the gastrointestinal tract are a rare entity compared to the more common tumors of the gut, such as adenomatous polyps and carcinomas. They were first described by Bauer in 1757. Gastrointestinal lipomas can grow ... ...

    Abstract Introduction and importance: Lipomas of the gastrointestinal tract are a rare entity compared to the more common tumors of the gut, such as adenomatous polyps and carcinomas. They were first described by Bauer in 1757. Gastrointestinal lipomas can grow in all segments of the gut, with the highest frequency in the colon. In this case report, we present a rare case of gastrointestinal lipoma mimicking colonic malignancy and causing intussusception, necessitating emergent surgery. This paper highlights the potential diagnostic challenges and therapeutic interventions associated with GI lipomas.
    Case presentation: A 28-year-old female presented with symptoms of abdominal pain, weight loss, vomiting, and changes in bowel habits. Initially, she received a misdiagnosis of Irritable Bowel Syndrome. Subsequent investigations indicated the possibility of colonic malignancy. During the intra-operative biopsy, it was ultimately discovered that she had a colonic lipoma.
    Clinical discussion: CT revealed an abdominal mass and an intussusception, indicating the need for surgical intervention. A laparoscopic procedure was performed to remove the mass, which alleviated the symptoms. Subsequently, a histological examination confirmed the mass to be a lipoma.
    Conclusion: Differentiating a gastrointestinal lipoma from malignancy is crucial, and careful investigation is necessary to determine if a local excision can be performed instead of a wide excision.
    Language English
    Publishing date 2023-08-09
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2023.108611
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Deciphering the differential expression patterns of yield-related negative regulators in hexaploid wheat cultivars and hybrids at different growth stages.

    Awan, Muhammad Jawad Akbar / Farooq, Muhammad Awais / Naqvi, Rubab Zahra / Karamat, Umer / Bukhari, Sayyad Ali Raza / Waqas, Muhammad Abu Bakar / Mahmood, Muhammad Arslan / Buzdar, Muhammad Ismail / Rasheed, Awais / Amin, Imran / Saeed, Nasir A / Mansoor, Shahid

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 537

    Abstract: Background: Hexaploid bread wheat underwent a series of polyploidization events through interspecific hybridizations that conferred adaptive plasticity and resulted in duplication and neofunctionalization of major agronomic genes. The genetic ... ...

    Abstract Background: Hexaploid bread wheat underwent a series of polyploidization events through interspecific hybridizations that conferred adaptive plasticity and resulted in duplication and neofunctionalization of major agronomic genes. The genetic architecture of polyploid wheat not only confers adaptive plasticity but also offers huge genetic diversity. However, the contribution of different gene copies (homeologs) encoded from different subgenomes (A, B, D) at different growth stages remained unexplored.
    Methods: In this study, hybrid of elite cultivars of wheat were developed via reciprocal crosses (cytoplasm swapping) and phenotypically evaluated. We assessed differential expression profiles of yield-related negative regulators in these cultivars and their F1 hybrids and identified various cis-regulatory signatures by employing bioinformatics tools. Furthermore, the preferential expression patterns of the syntenic triads encoded from A, B, and D subgenomes were assessed to decipher their functional redundancy at six different growth stages.
    Results: Hybrid progenies showed better heterosis such as up to 17% increase in the average number of grains and up to 50% increase in average thousand grains weight as compared to mid-parents. Based on the expression profiling, our results indicated significant dynamic transcriptional expression patterns, portraying the different homeolog-dominance at the same stage in the different cultivars and their hybrids. Albeit belonging to same syntenic triads, a dynamic trend was observed in the regulatory signatures of these genes that might be influencing their expression profiles.
    Conclusion: These findings can substantially contribute and provide insights for the selective introduction of better cultivars into traditional and hybrid breeding programs which can be harnessed for the improvement of future wheat.
    MeSH term(s) Triticum/genetics ; Plant Breeding ; Hybridization, Genetic ; Hybrid Vigor/genetics
    Language English
    Publishing date 2024-04-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09454-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: A Cross-Sectional Study of Potential Antimicrobial Resistance and Ecology in Gastrointestinal and Oral Microbial Communities of Young Normoweight Pakistani Individuals.

    Batool, Maria / Keating, Ciara / Javed, Sundus / Nasir, Arshan / Muddassar, Muhammad / Ijaz, Umer Zeeshan

    Microorganisms

    2023  Volume 11, Issue 2

    Abstract: Antimicrobial resistance (AMR) is a major global public health concern mainly affecting low- and middle-income countries (LMICs) due to lack of awareness, inadequate healthcare and sanitation infrastructure, and other environmental factors. In this study, ...

    Abstract Antimicrobial resistance (AMR) is a major global public health concern mainly affecting low- and middle-income countries (LMICs) due to lack of awareness, inadequate healthcare and sanitation infrastructure, and other environmental factors. In this study, we aimed to link microbial assembly and covariates (body mass index, smoking, and use of antibiotics) to gut microbiome structure and correlate the predictive antimicrobial gene prevalence (piARG) using PICRUSt2. We examined the gastrointestinal and oral microbial profiles of healthy adults in Pakistan through 16S rRNA gene sequencing with a focus on different ethnicities, antibiotic usage, drinking water type, smoking, and other demographic measures. We then utilised a suite of innovative statistical tools, driven by numerical ecology and machine learning, to address the above aims. We observed that drinking tap water was the main contributor to increased potential AMR signatures in the Pakistani cohort compared to other factors considered. Microbial niche breadth analysis highlighted an aberrant gut microbial signature of smokers with increased age. Moreover, covariates such as smoking and age impact the human microbial community structure in this Pakistani cohort.
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11020279
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Our experience of treating adult bone lymphoma, A retrospective cross-sectional study in a tertiary care center, Aga Khan University Hospital, Karachi.

    Umer, Masood / Khan Durrani, Muhammad Younus / Saeed, Javeria / Uddin, Nasir

    JPMA. The Journal of the Pakistan Medical Association

    2021  Volume 71Suppl 5, Issue 8, Page(s) S83–S86

    Abstract: Objective: To determine the experience at the Aga Khan University Hospital in diagnosing and treating adult patients with primary lymphoma of bone.: Methodology: All patients with Primary lymphoma of bone (PLB) that were diagnosed and/or treated at ... ...

    Abstract Objective: To determine the experience at the Aga Khan University Hospital in diagnosing and treating adult patients with primary lymphoma of bone.
    Methodology: All patients with Primary lymphoma of bone (PLB) that were diagnosed and/or treated at Aga Khan University Hospital, Karachi from 2005 to 2019 were included as part of this study.
    Results: There were 17 patients with PLB including 13 (76.5%) males and 4 (23.5%) females with a mean age of 44 ± 16.5 years. Nine patients were between 30-59 years of age at diagnosis. The mean follow-up time of patients was 80±46.7 months. Six patients had tumours of pelvic bone followed by tibia (5) and femur (4). Four patients had a pathological fracture at the time of presentation whereas 2 (11.8%) required surgical fixation of the pathological fracture. The stage of the tumour was based on Ann Arbor classification. Nine (52.9%) cases had Stage 1 disease, 7 (41.2%) had stage IV disease with metastasis in extra nodal tissues. As for treatment, every patient received chemotherapy whereas 5 (29.4%) received adjuvant radiotherapy. Complete remission in the size of the tumour was seen in 11 (64.7%) patients while 6 (35.3%) had partial remission. Post-treatment, 4 (23.5%) patients expired. The mean Overall Survival (OS) time was 80.18 ± 46.71months with a survival rate of 76.5.
    Conclusions: Primary lymphoma of the bone can be treated with medical regime and good prophylactic surgeries to avoid pathological fracture such as intramedullary nailing.
    MeSH term(s) Adult ; Cross-Sectional Studies ; Female ; Hospitals, University ; Humans ; Lymphoma/epidemiology ; Lymphoma/therapy ; Male ; Middle Aged ; Retrospective Studies ; Tertiary Care Centers
    Language English
    Publishing date 2021-10-11
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Nutritional probing and storage stability of papaya jam supplemented with date pit powder.

    Anwar, Shafaq / Saleem, Anam / Razzaq, Ayesha / Nasir, Muhammad Adnan / Hussain, Abrar / Tariq, Muhammad Rizwan / Ali, Shinawar Waseem / Intisar, Azeem / Safdar, Waseem / Umer, Zujaja / Basharat, Zunaira / Ali, Umair / Mehmood, Huzaifa / Masood, Shahid

    Heliyon

    2023  Volume 9, Issue 5, Page(s) e15912

    Abstract: Jam Quality is a factor robustly influenced by storage conditions. The current research aimed to develop papaya jam with improved nutritional attributes, rheological profile, and shelf-life utilizing date pit powder as a functional ingredient. The effect ...

    Abstract Jam Quality is a factor robustly influenced by storage conditions. The current research aimed to develop papaya jam with improved nutritional attributes, rheological profile, and shelf-life utilizing date pit powder as a functional ingredient. The effect of date pit powder on the formulated product's physicochemical, microbial, and organoleptic properties was analyzed. Results revealed that overall mineral profile (0.35-1.11%), crude fiber (0.56-2.01%), pH (3.51-3.70%), and antioxidant properties (22.97-30.67%) were significantly increased while water activity reduced (0.77-0.73). Moreover, date pit powder improved the color scores like a*(10.10-10.67), b* (8.13-8.78), L* (25.56-28.09), and textural attributes (Cohesiveness: 0.83-0.90; Firmness: 6.82-6.93) of functional papaya jam. Microbial count reduced from 3.60 × 10
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15912
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Advances in nanotechnology-assisted photodynamic therapy for neurological disorders: a comprehensive review.

    Nasir, Abdul / Rehman, Mujeeb Ur / Khan, Tamreez / Husn, Mansoor / Khan, Manzar / Khan, Ahmad / Nuh, Abdifatah Mohamed / Jiang, Wei / Farooqi, Hafiz Muhammad Umer / Bai, Qain

    Artificial cells, nanomedicine, and biotechnology

    2024  Volume 52, Issue 1, Page(s) 84–103

    Abstract: Neurological disorders such as neurodegenerative diseases and nervous system tumours affect more than one billion people throughout the globe. The physiological sensitivity of the nervous tissue limits the application of invasive therapies and leads to ... ...

    Abstract Neurological disorders such as neurodegenerative diseases and nervous system tumours affect more than one billion people throughout the globe. The physiological sensitivity of the nervous tissue limits the application of invasive therapies and leads to poor treatment and prognosis. One promising solution that has generated attention is Photodynamic therapy (PDT), which can potentially revolutionise the treatment landscape for neurological disorders. PDT attracted substantial recognition for anticancer efficacy and drug conjugation for targeted drug delivery. This review thoroughly explained the basic principles of PDT, scientific interventions and advances in PDT, and their complicated mechanism in treating brain-related pathologies. Furthermore, the merits and demerits of PDT in the context of neurological disorders offer a well-rounded perspective on its feasibility and challenges. In conclusion, this review encapsulates the significant potential of PDT in transforming the treatment landscape for neurological disorders, emphasising its role as a non-invasive, targeted therapeutic approach with multifaceted applications.
    MeSH term(s) Humans ; Photochemotherapy ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Nanotechnology ; Drug Delivery Systems ; Nervous System Diseases/drug therapy
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2723095-8
    ISSN 2169-141X ; 2169-1401
    ISSN (online) 2169-141X
    ISSN 2169-1401
    DOI 10.1080/21691401.2024.2304814
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: A Personalized Therapeutics Approach Using an

    Gondal, Mahnoor Naseer / Butt, Rida Nasir / Shah, Osama Shiraz / Sultan, Muhammad Umer / Mustafa, Ghulam / Nasir, Zainab / Hussain, Risham / Khawar, Huma / Qazi, Romena / Tariq, Muhammad / Faisal, Amir / Chaudhary, Safee Ullah

    Frontiers in oncology

    2021  Volume 11, Page(s) 692592

    Abstract: ... In ... ...

    Abstract In silico
    Language English
    Publishing date 2021-07-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.692592
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top