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  1. Article ; Online: Editorial: Advances in cardiovascular medicine: debates and controversies.

    Pal, Nirvik / Kim, Christin

    Current opinion in anaesthesiology

    2022  Volume 36, Issue 1, Page(s) 1–4

    Language English
    Publishing date 2022-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000001216
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    Zs.A 2564: Show issues Location:
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  2. Article ; Online: Thrombotic Microangiopathic Anemia After Cardiac Surgery.

    Sweeney, Craig A / Quader, Mohammed / Kim, Christin

    Journal of cardiothoracic and vascular anesthesia

    2023  Volume 38, Issue 3, Page(s) 784–787

    MeSH term(s) Humans ; Anemia, Hemolytic ; Cardiac Surgical Procedures/adverse effects ; Thrombosis
    Language English
    Publishing date 2023-11-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.11.033
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    Zs.A 2203: Show issues Location:
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  3. Article ; Online: The Do Not Resuscitate (DNR) order in the perioperative setting: practical considerations.

    Kim, Christin / Keneally, Ryan

    Current opinion in anaesthesiology

    2021  Volume 34, Issue 2, Page(s) 141–144

    Abstract: Purpose of review: Addressing patients' Do Not Resuscitate (DNR) status in the perioperative setting is important for shared patient decision-making. Although the inherently resuscitative nature of anesthesia and surgery may pose an ethical quandary for ...

    Abstract Purpose of review: Addressing patients' Do Not Resuscitate (DNR) status in the perioperative setting is important for shared patient decision-making. Although the inherently resuscitative nature of anesthesia and surgery may pose an ethical quandary for clinicians tasked with caring for the patient, anesthesiologist-led efforts need to evaluate all aspects of the DNR order and operative procedures.
    Recent findings: Approximately 15% of patients undergoing surgical procedures have a preexisting DNR order (Margolis et al., 1995) [1]. American Society of Anesthesiologists (ASA) and the American College of Surgeons (ACS) do not support automatic reversal of the DNR order in the perioperative setting. Citing patient self-determination and autonomy, these societies advocate for a thoughtful discussion where a patient or legal designee may make an informed decision regarding resuscitation in the perioperative setting. Although studies have suggested increased perioperative mortality among patients with a preexisting DNR order, this data remains largely inconclusive.
    Summary: Efforts must be made to address the DNR order in the perioperative setting. The fundamental tenets of medical ethics, nonmaleficence, beneficence, and patient autonomy can help to guide this oftentimes challenging discussion.
    MeSH term(s) Anesthesia ; Anesthesiology ; Ethics, Medical ; Humans ; Resuscitation Orders
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000000974
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  4. Article ; Online: Extracorporeal cardiopulmonary resuscitation: is it futile?

    Kim, Christin / Vigneshwar, Mythili / Nicolato, Patricia

    Current opinion in anaesthesiology

    2022  Volume 35, Issue 2, Page(s) 190–194

    Abstract: Purpose of review: Extracorporeal cardiopulmonary resuscitation (ECPR) is a treatment modality used to restore end-organ perfusion in the setting of refractory cardiac arrest in patients receiving cardiopulmonary resuscitation (CPR). Despite advances in ...

    Abstract Purpose of review: Extracorporeal cardiopulmonary resuscitation (ECPR) is a treatment modality used to restore end-organ perfusion in the setting of refractory cardiac arrest in patients receiving cardiopulmonary resuscitation (CPR). Despite advances in medicine, survival from cardiac arrest remains low with conventional CPR. The body of literature relating to ECPR is limited to retrospective studies and case series, with data that are inconsistent. Routine use of ECPR is not currently endorsed by the American Heart Association.
    Recent findings: In several single-center retrospective studies, ECPR was associated with a higher level of return of spontaneous circulation and survival to hospital discharge, when compared with conventional CPR. However, data from larger population-based registry studies have not reproduced these findings. Implementation of ECPR is a complex endeavor that requires specialized, multidisciplinary expertise to be successful.
    Summary: ECPR may be considered as an adjunct to CPR in cases of refractory cardiac arrest. The success of ECPR relies on specialized expertise, thoughtful patient selection, and timely initiation.
    MeSH term(s) Cardiopulmonary Resuscitation ; Extracorporeal Membrane Oxygenation ; Humans ; Out-of-Hospital Cardiac Arrest/therapy ; Retrospective Studies
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000001097
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  5. Article ; Online: Plakophilin 1 deficiency in prostatic tumours is correlated with immune cell recruitment and controls the up‐regulation of cytokine expression post‐transcriptionally

    Kim, Martin / Reidenbach, Sonja / Schlechter, Tanja / Rothmann, Ann Christin / Will, Rainer / Hofmann, Ilse

    The FEBS Journal. 2023 Apr., v. 290, no. 7 p.1907-1919

    2023  

    Abstract: Plakophilin (PKP1) 1 is a member of the arm‐repeat family of catenins and acts as a structural component of desmosomes, which are important stabilizers of cell–cell adhesion. Besides this, PKP1 also occurs in a non‐junctional, cytoplasmic form ... ...

    Abstract Plakophilin (PKP1) 1 is a member of the arm‐repeat family of catenins and acts as a structural component of desmosomes, which are important stabilizers of cell–cell adhesion. Besides this, PKP1 also occurs in a non‐junctional, cytoplasmic form contributing to post‐transcriptional regulation of gene expression. Moreover, PKP1 is expressed in the prostate epithelium but its expression is frequently downregulated in prostate cancers with a more aggressive phenotype. This observation may imply a tumour‐suppressive role of PKP1. We found that, in prostatic adenocarcinomas with PKP1 deficiency, the occurrence of T‐cells, B‐cells, macrophages and neutrophils were significantly increased. In a PKP1‐deficient prostatic cancer cell line expressing IL8, these levels were statistically meaningfully reduced upon PKP1 re‐expression. When analysing prostatic PKP1 knockdown cell lines, the mRNA and protein levels of additional cytokines, namely CXCL1 and IL6, were upregulated. The effect was rescued upon re‐expression of a PKP1 RNAi‐resistant form. The corresponding mRNAs were co‐precipitated with cytoplasmic PKP1, indicating that they are components of PKP1‐containing mRNA ribonucleoprotein particles. Moreover, the mRNA half‐lives of CXCL1, IL8 and IL6 were significantly increased in PKP1‐deficient cells, showing that these mRNAs were stabilized by PKP1. In an in vitro migration assay, the higher cytokine concentrations led to higher migration rates of THP1 and PBMC cells. This finding implies that PKP1 loss of expression in vivo correlates with the recruitment of immune cells into the tumour area to set up a tumour‐specific environment. One may speculate that this newly established tumour environment has tumour‐suppressive characteristics and thereby accelerates tumour progression and metastasis.
    Keywords T-lymphocytes ; adenocarcinoma ; catenins ; cell adhesion ; cell lines ; coprecipitation ; desmosomes ; epithelium ; gene expression regulation ; half life ; interleukin-6 ; interleukin-8 ; macrophages ; metastasis ; neoplasm cells ; neoplasm progression ; neutrophils ; phenotype ; prostatic neoplasms ; ribonucleoproteins
    Language English
    Dates of publication 2023-04
    Size p. 1907-1919.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16680
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Zellkulturbasierte Influenzaimpfstoffe: eine effektive Impfstoffoption für unter 60-Jährige.

    Gärtner, Barbara C / Beier, Dietmar / Gosch, Gunther / Wahle, Klaus / Wendt, Luise / Förster, Laura-Christin / Schmidt, Kim J / Schwarz, Tino F

    Wiener klinische Wochenschrift

    2024  Volume 136, Issue Suppl 2, Page(s) 35–42

    Abstract: The population < 60 years of age is also affected by a significant disease burden from seasonal influenza. It carries a high economic burden, mainly driven by influenza-associated productivity losses in the working population. Conventional egg-based ... ...

    Title translation Cell-based influenza vaccines: an effective vaccine option for under 60-year-olds.
    Abstract The population < 60 years of age is also affected by a significant disease burden from seasonal influenza. It carries a high economic burden, mainly driven by influenza-associated productivity losses in the working population. Conventional egg-based influenza vaccines may experience reduced effectiveness due to antigen adaptation in eggs. In contrast, cell-based influenza vaccines are less likely to be affected by antigenic adaptations to the host system and showed better effectiveness in individuals 4-64 years old over several seasons compared to conventional egg-based influenza vaccines under real-world conditions. Preferential use of cell-based influenza vaccines, as opposed to conventional egg-based vaccines, could reduce the burden of influenza-related symptoms on individuals and alleviate the economic impact on the German population < 60 years of age.
    MeSH term(s) Humans ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Influenza Vaccines ; Influenza, Human/prevention & control ; Influenza, Human/epidemiology ; Vaccination ; Seasons ; Cost of Illness
    Chemical Substances Influenza Vaccines
    Language German
    Publishing date 2024-02-23
    Publishing country Austria
    Document type English Abstract ; Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-024-02327-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 902: Show issues Location:
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  7. Book ; Online ; Thesis: Komplikationen im Rahmen von Transkatheter-Aortenklappen-Implantationen

    Meertens, Max Maria [Verfasser] / Schmidt, Tobias [Akademischer Betreuer] / Honselmann genannt Humme, Kim Christin [Akademischer Betreuer]

    2023  

    Author's details Max Maria Meertens ; Akademische Betreuer: Tobias Schmidt, Kim Christin Honselmann genannt Humme
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Zentrale Hochschulbibliothek Lübeck
    Publishing place Lübeck
    Document type Book ; Online ; Thesis
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  8. Conference proceedings: Interprofessionelle Zusammenarbeit mittels digital-unterstützter Kommunikation: Ergebnisse eines Scoping Reviews

    Nordmann, Kim / Sauter, Stefanie / Möbius-Lerch, Patricia / Redlich, Marie-Christin / Schaller, Michael / Fischer, Florian

    2023  , Page(s) 23dkvf350

    Event/congress 22. Deutscher Kongress für Versorgungsforschung (DKVF); Berlin; Deutsches Netzwerk Versorgungsforschung; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-10-02
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkvf350
    Database German Medical Science

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  9. Book ; Online ; Thesis: Die Modulation der kutanen Durchblutung unter blauem LED-Licht der Wellenlänge 453 nm und dessen Auswirkung auf die Zellvitalität

    Kotte, Kim Christin [Verfasser]

    2019  

    Author's details Kim Christin Kotte
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
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  10. Article: Spectroscopic-Based Prediction of Milk Foam Properties for Barista Applications [Erratum: August 2022, v.15(8); pp.1758-1759]

    Christin Brettschneider, Kim / Zettel, Viktoria / Sadeghi Vasafi, Pegah / Hummel, Darius / Hinrichs, Jörg / Hitzmann, Bernd

    Food and bioprocess technology. 2022 Aug., v. 15, no. 8

    2022  

    Abstract: The important quality parameters of cow’s milk for barista applications are frothability and foam stability. In the past, quality assessment was very time-consuming and could only be carried out after milk treatment had been completed. Since spectroscopy ...

    Abstract The important quality parameters of cow’s milk for barista applications are frothability and foam stability. In the past, quality assessment was very time-consuming and could only be carried out after milk treatment had been completed. Since spectroscopy is already established in dairies, it could be advantageous to develop a spectrometer-based measurement method for quality control for barista applications. By integrating online spectroscopy to the processing of UHT (ultra-high temperature processing) milk before filling, it can be checked whether the currently processed product is suitable for barista applications. To test this hypothesis, a feasibility study was conducted. For this purpose, seasonal UHT whole milk samples were measured every 2 months over a period of more than 1 year, resulting in a total of 269 milk samples that were foamed. Samples were frothed using a self-designed laboratory frother. Frothability at the beginning and foam loss after 15 min describe the frothing characteristics of the milk and are predicted from the spectra. Near-infrared, Raman, and fluorescence spectra were recorded from each milk sample. These spectra were preprocessed using 15 different mathematical methods. For each spectrometer, 85% of the resulting spectral dataset was analyzed using partial least squares (PLS) regression and nine different variable selection (VS) algorithms. Using the remaining 15% of the spectral dataset, a prediction error was determined for each model and used to compare the models. Using spectroscopy and PLS modeling, the best results show a prediction error for milk frothability of 3% and foam stability of 2%.
    Keywords UHT milk ; UHT treatment ; bioprocessing ; cows ; data collection ; feasibility studies ; fluorescence ; foams ; milk ; models ; prediction ; quality control ; spectrometers
    Language English
    Dates of publication 2022-08
    Size p. 1748-1757.
    Publishing place Springer US
    Document type Article
    ZDB-ID 2425455-1
    ISSN 1935-5149 ; 1935-5130
    ISSN (online) 1935-5149
    ISSN 1935-5130
    DOI 10.1007/s11947-022-02822-3
    Database NAL-Catalogue (AGRICOLA)

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