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  1. Book: Target identification and validation in drug discovery

    Moll, Jürgen / Colombo, Riccardo

    methods and protocols

    (Methods in molecular biology ; 986 ; Springer protocols)

    2013  

    Author's details ed. by Jurgen Moll ; Riccardo Colombo
    Series title Methods in molecular biology ; 986
    Springer protocols
    Collection
    Keywords Drug targeting ; Drugs--Design ; Arzneimittel ; Zielstruktur
    Subject Target ; Drug Target ; Fertigarzneimittel ; Therapeutikum ; Medikament ; Medukamente ; Pharmakon ; Pharmaka ; Arzneistoff ; Arzneimittelwirkstoff ; Arznei ; Pharmazeutikum ; Pharmazeutika ; Pharmazeutischer Wirkstoff ; Arzneidroge
    Language English
    Size XV, 371 S. : Ill.,graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017568663
    ISBN 978-1-62703-310-7 ; 9781627033114 ; 1-62703-310-6 ; 1627033114
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 A 91 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Social Representations and Experiences of Sexual Transactions Among Swiss Youth.

    Colombo, Annamaria / Carbajal, Myrian / Milani, Riccardo

    Archives of sexual behavior

    2024  Volume 53, Issue 4, Page(s) 1431–1447

    Abstract: This article relies on quantitative data collected in Switzerland as part of a research study on sexual transactions among youth. Building on an analytical framework that defines sexual transactions in terms of negotiated exchanges rooted in social ... ...

    Abstract This article relies on quantitative data collected in Switzerland as part of a research study on sexual transactions among youth. Building on an analytical framework that defines sexual transactions in terms of negotiated exchanges rooted in social representations, we explored how they were perceived by the Swiss young people included in our sample at a cognitive, ethical, and political level. We found that research participants who reported having experienced sexual transactions viewed them much more positively than those who reported never having engaged in such exchanges. While this was especially true among young women, we also found that the tendency of respondents to perceive sexual transactions negatively increased with age. When analyzed in light of the qualitative results of our study, these quantitative findings suggest that negative representations of sexual transactions are less likely to be based on lived experience than on an ideal-type of sexual behavior. In other words, our research highlights how young people interpret sexuality according to norms developed within a heteronormative matrix.
    MeSH term(s) Humans ; Female ; Adolescent ; Switzerland ; Sexual Behavior/psychology ; Sexuality ; Ethnicity
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184221-3
    ISSN 1573-2800 ; 0004-0002
    ISSN (online) 1573-2800
    ISSN 0004-0002
    DOI 10.1007/s10508-024-02814-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Myocardial injury after non cardiac surgery: troponin assay is not enough… We need perioperative bearings.

    Colombo, Riccardo

    Minerva anestesiologica

    2018  Volume 84, Issue 10, Page(s) 1131–1133

    MeSH term(s) Humans ; Myocardial Ischemia ; Myocardium ; Troponin
    Chemical Substances Troponin
    Language English
    Publishing date 2018-09-13
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.18.13164-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 192: Show issues

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  4. Article ; Online: Cardiovascular imaging updates and future perspectives.

    Colombo, Giada / Cameli, Matteo / Metra, Marco / Inciardi, Riccardo M

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2023  Volume 24, Issue 8, Page(s) 488–491

    MeSH term(s) Humans ; Cardiovascular System/diagnostic imaging
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 559: Show issues

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  5. Article ; Online: An insight into REEs recovery from spent fluorescent lamps: Evaluation of the affinity of an NH

    Colombo, Francesco / Fantini, Riccardo / Di Renzo, Francesco / Malavasi, Gianluca / Malferrari, Daniele / Arletti, Rossella

    Waste management (New York, N.Y.)

    2024  Volume 175, Page(s) 339–347

    Abstract: The constantly increasing demand of Rare Earth Elements (REEs) made them to be part of the so-called "critical elements" indispensable for the energy transition. The monopoly of only a few countries, the so-called balance problem between demand and ... ...

    Abstract The constantly increasing demand of Rare Earth Elements (REEs) made them to be part of the so-called "critical elements" indispensable for the energy transition. The monopoly of only a few countries, the so-called balance problem between demand and natural abundance, and the need to limit the environmental costs of their mining, stress the necessity of a recycling policy of these elements. Different methods have been tested for REEs recovery. Despite the well-known ion-exchange properties of zeolites, just few preliminary works investigated their application for REEs separation and recycle. In this work we present a double ion exchange experiment on a NH
    MeSH term(s) Zeolites ; Metals, Rare Earth/analysis ; Household Articles ; Mining ; Recycling
    Chemical Substances Zeolites (1318-02-1) ; Metals, Rare Earth
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2001471-5
    ISSN 1879-2456 ; 0956-053X
    ISSN (online) 1879-2456
    ISSN 0956-053X
    DOI 10.1016/j.wasman.2024.01.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Unlocking endothelial barrier restoration: FX06 in systemic capillary leak syndrome and beyond.

    Wu, Maddalena Alessandra / Locatelli, Laura / Cogliati, Chiara / Colombo, Riccardo / Maier, Jeanette A

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 171, Page(s) 116147

    Abstract: Increased vascular permeability is a prevalent feature in a wide spectrum of clinical conditions, but no effective treatments to restore the endothelial barrier are available. Idiopathic systemic capillary leak syndrome (ISCLS) is a life-threatening ... ...

    Abstract Increased vascular permeability is a prevalent feature in a wide spectrum of clinical conditions, but no effective treatments to restore the endothelial barrier are available. Idiopathic systemic capillary leak syndrome (ISCLS) is a life-threatening Paroxysmal Permeability Disorder characterized by abrupt, massive plasma extravasation. This condition serves as a robust model for investigating therapeutic approaches targeting interendothelial junctions. We conducted a single-center, interventional in vitro study at the Referral Center for ISCLS in Italy, involving four diagnosed ISCLS patients, aiming at investigating the effects of FX06, a Bβ15-42 fibrin-derived peptide binding to VE-Cadherin, on endothelial barrier exposed to intercritical and acute ISCLS sera. The Transwell Permeability Assay was used to assess the permeability of human umbilical vein endothelial cells (HUVECs) exposed to ISCLS sera with or without FX06 (50 µg/ml). Acute ISCLS serum was also tested in a three-dimensional microfluidic device. Nitric oxide (NO), VE-Cadherin localization, and cytoskeletal organization were also assessed. In two and three-dimensional systems, ISCLS sera increased endothelial permeability, with a more pronounced effect for acute sera. Furthermore, acute sera altered VE-Cadherin localization and cytoskeletal organization. NO levels remained unchanged. FX06 restored the endothelial barrier function by influencing cellular localization rather than VE-Cadherin levels. In conclusion, FX06 prevents and reverts the hyperpermeability induced by ISCLS sera. These preliminary yet promising results provide initial evidence of the in vitro efficacy of a drug targeting the underlying pathophysiological mechanisms of ISCLS. Moreover, this approach may hold potential for addressing hyperpermeability in a spectrum of clinical conditions beyond ISCLS.
    MeSH term(s) Humans ; Capillary Leak Syndrome/metabolism ; Endothelial Cells ; Capillary Permeability ; Endothelium, Vascular ; Cadherins/metabolism ; Italy
    Chemical Substances Cadherins
    Language English
    Publishing date 2024-01-18
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Operando

    Negri, Chiara / Colombo, Riccardo / Bracconi, Mauro / Atzori, Cesare / Donazzi, Alessandro / Lucotti, Andrea / Tommasini, Matteo / Maestri, Matteo

    Catalysis science & technology

    2024  Volume 14, Issue 5, Page(s) 1318–1327

    Abstract: We propose the use of surface plasmon resonance (SPR) as a distinctive marker for real-time monitoring in reaction conditions of gold nanoparticles supported on α- ... ...

    Abstract We propose the use of surface plasmon resonance (SPR) as a distinctive marker for real-time monitoring in reaction conditions of gold nanoparticles supported on α-Al
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2595090-3
    ISSN 2044-4761 ; 2044-4753
    ISSN (online) 2044-4761
    ISSN 2044-4753
    DOI 10.1039/d3cy01392h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Autonomic Function and Baroreflex Control in COVID-19 Patients Admitted to the Intensive Care Unit.

    Gelpi, Francesca / Wu, Maddalena Alessandra / Bari, Vlasta / Cairo, Beatrice / De Maria, Beatrice / Fossali, Tommaso / Colombo, Riccardo / Porta, Alberto

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Computational Epitope Prediction and Design for Antibody Development and Detection.

    Capelli, Riccardo / Serapian, Stefano A / Colombo, Giorgio

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2552, Page(s) 255–266

    Abstract: The design of optimized protein antigens is a fundamental step in the development of new vaccine candidates and in the detection of therapeutic antibodies. A fundamental prerequisite is the identification of antigenic regions that are most prone to ... ...

    Abstract The design of optimized protein antigens is a fundamental step in the development of new vaccine candidates and in the detection of therapeutic antibodies. A fundamental prerequisite is the identification of antigenic regions that are most prone to interact with antibodies, namely, B-cell epitopes. Here, we describe an efficient structure-based computational method for epitope prediction, called MLCE. In this approach, all that is required is the 3D structure of the antigen of interest. MLCE can be applied to glycosylated proteins, facilitating the identification of immunoreactive versus immune-shielding carbohydrates.
    MeSH term(s) Computational Biology/methods ; Antibodies ; Epitopes, B-Lymphocyte ; Antigens ; Vaccines ; Epitope Mapping/methods
    Chemical Substances Antibodies ; Epitopes, B-Lymphocyte ; Antigens ; Vaccines
    Language English
    Publishing date 2022-11-13
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2609-2_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Model-based spectral causality of cardiovascular variability interactions during head-down tilt.

    Porta, Alberto / Cairo, Beatrice / Bari, Vlasta / Gelpi, Francesca / De Maria, Beatrice / Colombo, Riccardo

    Physiological measurement

    2023  Volume 44, Issue 5

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Male ; Humans ; Adult ; Middle Aged ; Aged ; Head-Down Tilt ; Heart Rate/physiology ; Heart/physiology ; Cardiovascular System ; Blood Pressure/physiology ; Baroreflex/physiology
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1149545-5
    ISSN 1361-6579 ; 0967-3334
    ISSN (online) 1361-6579
    ISSN 0967-3334
    DOI 10.1088/1361-6579/acce1f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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