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  1. Article: Superficial Venous Thrombosis: A Comprehensive Review.

    Mangiafico, Marco / Costanzo, Luca

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 4

    Abstract: Superficial venous thrombosis (SVT), an inflammatory-thrombotic process of a superficial vein, is a relatively common event that may have several different underlying causes. This phenomenon has been generally considered benign, and its prevalence has ... ...

    Abstract Superficial venous thrombosis (SVT), an inflammatory-thrombotic process of a superficial vein, is a relatively common event that may have several different underlying causes. This phenomenon has been generally considered benign, and its prevalence has been historically underestimated; the estimated incidence ranges from about 0.3 to 1.5 event per 1000 person-years, while the prevalence is approximately 3 to 11%, with different reports depending on the population studied. However, such pathology is not free of complications; indeed, it could extend to the deep circulation and embolize to pulmonary circulation. For this reason, an ultrasound examination is recommended to evaluate the extension of SVT and to exclude the involvement of deep circulation. Also, SVT may be costly, especially in the case of recurrence. Therefore, accurate management is necessary to prevent sequelae and costs related to the disease. This review aims to analyse the epidemiology of SVT, its complications, optimal medical treatment, and open questions with future perspectives.
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12040500
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  2. Article: Long-Term Efficacy and Safety of Direct Oral Anticoagulants at Reduced Doses in the Secondary Prevention of Venous Thromboembolism and Post-Thrombotic Syndrome.

    Costanzo, Luca / Di Paola, Federico / Pedi, Anastasia Maria / Failla, Giacomo / Mangiafico, Marco

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082394
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  3. Article: The Role of Heparin in COVID-19: An Update after Two Years of Pandemics.

    Mangiafico, Marco / Caff, Andrea / Costanzo, Luca

    Journal of clinical medicine

    2022  Volume 11, Issue 11

    Abstract: Coronavirus disease 2019 (COVID-19) is associated with an increased risk of venous thromboembolism (VTE) and coagulopathy, especially in critically ill patients. Endothelial damage induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is associated with an increased risk of venous thromboembolism (VTE) and coagulopathy, especially in critically ill patients. Endothelial damage induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is emerging as a crucial pathogenetic mechanism for the development of complications in an acute phase of the illness and for several postdischarge sequalae. Heparin has been shown to have a positive impact on COVID-19 due to its anticoagulant function. Moreover, several other biological actions of heparin were postulated: a potential anti-inflammatory and antiviral effect through the main protease (M
    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11113099
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  4. Article ; Online: The Role of Heparin in COVID-19

    Marco Mangiafico / Andrea Caff / Luca Costanzo

    Journal of Clinical Medicine, Vol 11, Iss 3099, p

    An Update after Two Years of Pandemics

    2022  Volume 3099

    Abstract: Coronavirus disease 2019 (COVID-19) is associated with an increased risk of venous thromboembolism (VTE) and coagulopathy, especially in critically ill patients. Endothelial damage induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is associated with an increased risk of venous thromboembolism (VTE) and coagulopathy, especially in critically ill patients. Endothelial damage induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is emerging as a crucial pathogenetic mechanism for the development of complications in an acute phase of the illness and for several postdischarge sequalae. Heparin has been shown to have a positive impact on COVID-19 due to its anticoagulant function. Moreover, several other biological actions of heparin were postulated: a potential anti-inflammatory and antiviral effect through the main protease (M pro ) and heparansulfate (HS) binding and a protection from the damage of vascular endothelial cells. In this paper, we reviewed available evidence on heparin treatment in COVID-19 acute illness and chronic sequalae, focusing on the difference between prophylactic and therapeutic dosage.
    Keywords COVID-19 ; heparin ; low molecular weight heparin ; coagulopathy ; thromboprophylaxis ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  5. Article ; Online: Medical treatment of critical limb ischemia: current state and future directions.

    Mangiafico, Roberto A / Mangiafico, Marco

    Current vascular pharmacology

    2011  Volume 9, Issue 6, Page(s) 658–676

    Abstract: Atherosclerotic critical limb ischemia (CLI) is manifested by ischemic rest pain, non-healing ulcers or gangrene. The incidence of CLI is estimated to be approximately 500-1000 new cases per year per million people and is expected to grow in developed ... ...

    Abstract Atherosclerotic critical limb ischemia (CLI) is manifested by ischemic rest pain, non-healing ulcers or gangrene. The incidence of CLI is estimated to be approximately 500-1000 new cases per year per million people and is expected to grow in developed countries as the population ages with an increasing prevalence of diabetes. Patients diagnosed with CLI are at very high risk of major amputation and cardiovascular morbidity and mortality and experience poor physical function and quality of life. The goals of treatment for CLI are relieving ischemic pain, healing ulcers, preventing limb loss, improving patient function and quality of life, and prolonging survival. Prompt surgical or endovascular revascularization is currently recommended for limb salvage in CLI. All patients with CLI should receive cardiovascular risk reduction therapies, focused on optimizing antiplatelet therapy and risk factor management, to reduce cardiovascular event rates. Adjunctive pharmacotherapy with antithrombotic drugs, statins, and beta-blockers is critical to decrease perioperative cardiovascular complications in patients undergoing surgical vascular reconstruction and enhance postrevascularization arterial and graft patency. In non-reconstructable patients with stable pain and tissue loss, evidence suggests that prostanoids, dedicated wound care programs, and several mechanical devices, such as spinal cord stimulation, intermittent pneumatic compression, and hyperbaric oxygen therapy, can alleviate ischemic symptoms and improve limb salvage. Current medical armamentarium used in treating ischemic wounds also includes ultrasound and negative pressure wound therapy. Therapeutic neovascularization, including gene- and cell-based approaches, is a novel promising tool in the management of CLI under ongoing investigation.
    MeSH term(s) Amputation ; Atherosclerosis/complications ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control ; Humans ; Ischemia/etiology ; Ischemia/physiopathology ; Ischemia/therapy ; Limb Salvage/methods ; Lower Extremity ; Peripheral Arterial Disease/etiology ; Peripheral Arterial Disease/physiopathology ; Peripheral Arterial Disease/therapy ; Quality of Life ; Risk Factors ; Survival
    Language English
    Publishing date 2011-05-13
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192362-0
    ISSN 1875-6212 ; 1570-1611
    ISSN (online) 1875-6212
    ISSN 1570-1611
    DOI 10.2174/157016111797484107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6282: Show issues Location:
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  6. Article: The Role of Bypass Surgery for the Management of Complex Intracranial Aneurysms in the Anterior Circulation in the Flow-Diverter Era: A Single-Center Series.

    Acerbi, Francesco / Mazzapicchi, Elio / Falco, Jacopo / Vetrano, Ignazio Gaspare / Restelli, Francesco / Faragò, Giuseppe / La Corte, Emanuele / Bonomo, Giulio / Bersano, Anna / Canavero, Isabella / Gemma, Marco / Broggi, Morgan / Schiariti, Marco / Ziliani, Vanessa / Raccuia, Gabriella / Mangiafico, Salvatore / Ganci, Giuseppe / Ciceri, Elisa / Ferroli, Paolo

    Brain sciences

    2022  Volume 12, Issue 10

    Abstract: Despite the increasing popularity of flow diverters (FDs) as an endovascular option for intracranial aneurysms, the treatment of complex aneurysms still represents a challenge. Combined strategies using a flow-preservation bypass could be considered in ... ...

    Abstract Despite the increasing popularity of flow diverters (FDs) as an endovascular option for intracranial aneurysms, the treatment of complex aneurysms still represents a challenge. Combined strategies using a flow-preservation bypass could be considered in selected cases. In this study, we retrospectively reviewed our series of patients with complex intracranial aneurysms submitted to bypass. From January 2015 to May 2022, 23 patients were selected. We identified 11 cases (47.8%) of MCA, 6 cases (26.1%) of ACA and 6 cases (26.1%) of ICA aneurysms. The mean maximal diameter was 22.73 ± 12.16 mm, 8 were considered as giant, 9 were fusiform, 8 presented intraluminal thrombosis, 10 presented wall calcification, and 18 involved major branches or perforating arteries. Twenty-five bypass procedures were performed in 23 patients (two EC-IC bypasses with radial artery graft, seventeen single- or double-barrel STA-MCA bypasses and six IC-IC bypasses in anterior cerebral arteries). The long-term bypass patency rate was 94.5%, and the total aneurysm exclusion was 95.6%, with a mean follow-up of 28 months. Median KPS values at last follow-up was 90, and a favorable outcome (KPS ≥ 70 and mRS ≤ 2) was obtained in 87% of the cases. The use of bypass techniques represents, in selected cases, a valid therapeutic option in the management of complex anterior circulation aneurysms when a simpler direct approach, including the use of FD, is considered not feasible.
    Language English
    Publishing date 2022-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci12101339
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  7. Article ; Online: Insights from Experiences on Antiplatelet Drugs in Stroke Prevention: A Review.

    Signorelli, Salvatore Santo / Platania, Ingrid / Tomasello, Salvatore Davide / Mangiafico, Marco / Barcellona, Giuliana / Di Raimondo, Domenico / Gaudio, Agostino

    International journal of environmental research and public health

    2020  Volume 17, Issue 16

    Abstract: Reduction of hazard risk of cerebral ischemic event (stroke, transient ischemic attack (TIA)) represents the hard point to be achieved from primary or secondary preventive strategy in the best clinical practice. However, results from clinical trials, ... ...

    Abstract Reduction of hazard risk of cerebral ischemic event (stroke, transient ischemic attack (TIA)) represents the hard point to be achieved from primary or secondary preventive strategy in the best clinical practice. However, results from clinical trials, recommendations, guidelines, systematic review, expert opinions, and meta-analysis debated on the optimal pharmacotherapy to achieve the objective. Aspirin and a number of antiplatelet agents, alone or in combination, have been considered from large trials focused on stroke prevention. The present review summarizes, discusses results from trials, and focuses on the benefits or disadvantages originating from antiplatelet drugs. Sections of the review were organized to show both benefits or consequences from antiplatelet pharmacotherapy. Conclusively, this review provides a potential synopsis on the most appropriate therapeutic approach for stroke prevention in clinical practice.
    MeSH term(s) Aged ; Diabetes Mellitus, Type 2/drug therapy ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Humans ; Ischemic Attack, Transient/drug therapy ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/therapeutic use ; Secondary Prevention ; Stroke/prevention & control
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2020-08-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph17165840
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  8. Article ; Online: The chance case history of an unusual disease: mesenteric panniculitis.

    Signorelli, Salvatore Santo / Fiore, Valerio / Mangiafico, Marco / Giuseppe, Caltabiano

    Internal and emergency medicine

    2015  Volume 10, Issue 7, Page(s) 883–884

    MeSH term(s) Aged, 80 and over ; Humans ; Leukemia/complications ; Male ; Panniculitis, Peritoneal/diagnosis ; Panniculitis, Peritoneal/diagnostic imaging
    Language English
    Publishing date 2015-10
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-015-1244-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6673: Show issues Location:
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  9. Article ; Online: Insights from Experiences on Antiplatelet Drugs in Stroke Prevention

    Salvatore Santo Signorelli / Ingrid Platania / Salvatore Davide Tomasello / Marco Mangiafico / Giuliana Barcellona / Domenico Di Raimondo / Agostino Gaudio

    International Journal of Environmental Research and Public Health, Vol 17, Iss 5840, p

    A Review

    2020  Volume 5840

    Abstract: Reduction of hazard risk of cerebral ischemic event (stroke, transient ischemic attack (TIA)) represents the hard point to be achieved from primary or secondary preventive strategy in the best clinical practice. However, results from clinical trials, ... ...

    Abstract Reduction of hazard risk of cerebral ischemic event (stroke, transient ischemic attack (TIA)) represents the hard point to be achieved from primary or secondary preventive strategy in the best clinical practice. However, results from clinical trials, recommendations, guidelines, systematic review, expert opinions, and meta-analysis debated on the optimal pharmacotherapy to achieve the objective. Aspirin and a number of antiplatelet agents, alone or in combination, have been considered from large trials focused on stroke prevention. The present review summarizes, discusses results from trials, and focuses on the benefits or disadvantages originating from antiplatelet drugs. Sections of the review were organized to show both benefits or consequences from antiplatelet pharmacotherapy. Conclusively, this review provides a potential synopsis on the most appropriate therapeutic approach for stroke prevention in clinical practice.
    Keywords prevention ; stroke ; aspirin ; clopidogrel ; cilostazol ; dipyridamole ; Medicine ; R
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Arterial Plaques in Peripheral Arteries Diagnosed by Ultrasound in a Cohort of Patients With Type 2 Diabetes Mellitus: A Single-Center Surveillance.

    Signorelli, Salvatore Santo / Fiore, Valerio / Mangiafico, Marco / Castrogiovanni, Davide

    Angiology

    2015  Volume 66, Issue 7, Page(s) 675–679

    Abstract: Macroangiopathy (eg, peripheral arterial disease) diagnosis in type 2 diabetes mellitus (T2DM) can be carried out by ultrasound. A surveillance study was performed in 366 consecutive patients (166 patients with T2DM and 200 non-T2DM) aiming to evaluate ... ...

    Abstract Macroangiopathy (eg, peripheral arterial disease) diagnosis in type 2 diabetes mellitus (T2DM) can be carried out by ultrasound. A surveillance study was performed in 366 consecutive patients (166 patients with T2DM and 200 non-T2DM) aiming to evaluate the frequency of single or multiple arterial plaques (Aplqs) in lower limbs and the relationship with different factors (age, duration of T2DM, glycemic balance, DM treatment, smoking habit, and microalbuminuria). Single and multiple Aplqs, respectively, were found in 10.2% and 38.6% among the patients with T2DM. Age, male gender (P < .0002), duration of T2DM (P < .009), insulin therapy (P < .03), and mediocalcinosis (P < .001) were risk factors in patients with T2DM. In conclusion, Aplqs of lower limbs are frequent in T2DM and several factors can play a determining role. Ultrasound is a helpful diagnostic tool.
    MeSH term(s) Aged ; Atherosclerosis/diagnostic imaging ; Diabetes Mellitus, Type 2/complications ; Diabetic Angiopathies/diagnostic imaging ; Female ; Humans ; Leg/blood supply ; Male ; Peripheral Arterial Disease/diagnostic imaging ; Population Surveillance ; Risk Factors ; Ultrasonography
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/0003319714548443
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    Ui IV Zs.61: Show issues Location:
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