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Article ; Online: A Study of the Ping An Health App Based on User Reviews with Sentiment Analysis.

Fang, Fang / Zhou, Yin / Ying, Shi / Li, Zhijuan

International journal of environmental research and public health

2023 Volume 20, Issue 2

Abstract: By mining the dimensional sentiment and dimension weight of the Ping An Health App reviews ... suggestions for the Ping An Health App operators to improve user satisfaction. Firstly, the topic model is ... of the Ping An Health App in the Apple App Store, users' concerns about Ping An Health App can be summarized ...

Abstract	By mining the dimensional sentiment and dimension weight of the Ping An Health App reviews, this paper explores the changing trend of the influence of dimensions on user satisfaction and provides suggestions for the Ping An Health App operators to improve user satisfaction. Firstly, the topic model is used to identify the topic of user comments, and then the fine-grained sentiment analysis method is used to calculate the sentiment and weight of each dimension. Finally, the changing trend of the weight of each dimension and the changing trend of user satisfaction of each dimension are drawn. Based on the reviews of the Ping An Health App in the Apple App Store, users' concerns about Ping An Health App can be summarized into seven main dimensions: Usage, Bug report, Reliability, Feature information, Services, Other apps, and User Background. The "Feature information" dimension and "Reliability" dimension have a great impact on user satisfaction with the Ping An Health App, while the "Bug report" dimension has the lowest user satisfaction.
MeSH term(s)	Mobile Applications ; Sentiment Analysis ; Personal Satisfaction ; Attitude
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20021591
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ADAD2 interacts with RNF17 in P-bodies to repress the Ping-pong cycle in pachytene piRNA biogenesis.

Xiong, Mengneng / Yin, Lisha / Gui, Yiqian / Lv, Chunyu / Ma, Xixiang / Guo, Shuangshuang / Wu, Yanqing / Feng, Shenglei / Fan, Xv / Zhou, Shumin / Wang, Lingjuan / Wen, Yujiao / Wang, Xiaoli / Xie, Qingzhen / Namekawa, Satoshi H / Yuan, Shuiqiao

The Journal of cell biology

2023 Volume 222, Issue 5

Abstract: ... pachytene piRNA biogenesis with regard to the lack of a secondary amplification process known as the Ping ... pong cycle. However, the underlying molecular mechanism and the venue for the suppression of the Ping ... family member protein RNF17 and is associated with P-bodies. Importantly, ADAD2 directs RNF17 to repress Ping ...

Abstract	Pachytene piRNA biogenesis is a hallmark of the germline, distinct from another wave of pre-pachytene piRNA biogenesis with regard to the lack of a secondary amplification process known as the Ping-pong cycle. However, the underlying molecular mechanism and the venue for the suppression of the Ping-pong cycle remain elusive. Here, we showed that a testis-specific protein, ADAD2, interacts with a TDRD family member protein RNF17 and is associated with P-bodies. Importantly, ADAD2 directs RNF17 to repress Ping-pong activity in pachytene piRNA biogenesis. The P-body localization of RNF17 requires the intrinsically disordered domain of ADAD2. Deletion of Adad2 or Rnf17 causes the mislocalization of each other and subsequent Ping-pong activity derepression, secondary piRNAs overproduced, and disruption of P-body integrity at the meiotic stage, thereby leading to spermatogenesis arrested at the round spermatid stage. Collectively, by identifying the ADAD2-dependent mechanism, our study reveals a novel function of P-bodies in suppressing Ping-pong activity in pachytene piRNA biogenesis.
MeSH term(s)	Male ; Meiotic Prophase I ; Piwi-Interacting RNA ; Processing Bodies ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Spermatogenesis/genetics
Chemical Substances	Piwi-Interacting RNA ; RNA, Small Interfering
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.202206067
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Article: Anti-inflammatory effect of Yu-Ping-Feng-San

Yang, Zhong-Shan / Yan, Jin-Yuan / Han, Ni-Ping / Zhou, Wei / Cheng, Yu / Zhang, Xiao-Mei / Li, Ning / Yuan, Jia-Li

Iranian journal of basic medical sciences

2016 Volume 19, Issue 9, Page(s) 993–1002

Abstract: Objectives: Yu-Ping-Feng-San (YPFS) is a classical traditional Chinese medicine that is widely ...

Abstract	Objectives: Yu-Ping-Feng-San (YPFS) is a classical traditional Chinese medicine that is widely used for treatment of the diseases in respiratory systems, including chronic obstructive pulmonary disease (COPD) recognized as chronic inflammatory disease. However, the molecular mechanism remains unclear. Here we detected the factors involved in transforming growth factor beta 1 (TGF-β1)/Smad2 signaling pathway and inflammatory cytokines, to clarify whether YPFS could attenuate inflammatory response dependent on TGF-β1/Smad2 signaling in COPD rats or cigarette smoke extract (CSE)-treated human bronchial epithelial (Beas-2B) cells. Materials and methods: The COPD rat model was established by exposure to cigarette smoke and intratracheal instillation of lipopolysaccharide, YPFS was administered to the animals. The efficacy of YPFS was evaluated by comparing the severity of pulmonary pathological damage, pro-inflammation cytokines, collagen related genes and the activation of TGF-β1/Smad2 signaling pathway. Furthermore, CSE-treated cells were employed to confirm whether the effect of YPFS was dependent on the TGF-β1/Smad2 signaling via knockdown Smad2 (Si-RNA), or pretreatment with the inhibitor of TGF-β1. Results: Administration of YPFS effectively alleviated injury of lung, suppressed releasing of pro-inflammatory cytokines and collagen deposition in COPD animals ( Conclusion: YPFS accomplished anti-inflammatory effects mainly by suppressing phosphorylation of Smad2, TGF-β1/Smad2 signaling pathway was required for YPFS-mediated anti-inflammation in COPD rats or CSE-treated Beas-2B cells.
Language	English
Publishing date	2016-10-17
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
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Article ; Online: Erratum: SHENGBO ZHOU (), LI HE (), SIYU MA (), SHUJUN XU (), QIANG ZHAI (), PING GUAN (), HUI WANG ()amp; JINGSONG SHI () (2022)Taxonomic status of Rana nigromaculata mongolia and the validity of Pelophylax tenggerensis (Anura, Ranidae) Zootaxa 5165 (4): 486500.

Zhou, Shengbo / He, L I / Ma, Siyu / Xu, Shujun / Zhai, Qiang / Guan, Ping / Wang, Hui / Shi, Jingsong

Zootaxa

2022 Volume 5174, Issue 5, Page(s) 600

Language	English
Publishing date	2022-08-12
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5174.5.8
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Article ; Online: Effects of Different LED Light Qualities on Plant Growth and Flower Traits of Chrysanthemum Ping Pong

Honghui LUO / Qing WU / Junxiao HOU / Zeyu LI / Jingwen LI / Fenglan WANG / Hougao ZHOU

Guangdong nongye kexue, Vol 49, Iss 12, Pp 44-

2022 Volume 54

Abstract: ... of 'Pink Ping Pong'and Purple Ping Pong, the LED white light treatment was used as the CK group, the total ... Ping Pong and 70-day-treatment Purple Ping Pong under RBFR treatment increased by 18.3% and 27.3 ... leaf dry weight of the 70-day-treatment Purple Ping Pong under RBFR treatment were 18.6%, 5.8%, 25.6 ...

Abstract	【Objective】Due to the instability of flower color and some other growth traits of chrysanthemums growing in high temperature environment in South China, effective LED light combinations were investigated to regulate the growth and flower color of chrysanthemums in order to provide theoretical references of LED light cultivation technology for the production of chrysanthemums.【Method】Different LED light combination treatments of RBFR (the photosynthetic photon flux density PPFD ratio of red ∶ blue ∶ far-red light ≈ 10 ∶ 7 ∶ 2.5), RBUV (red ∶ blue ∶ ultraviolet light ≈ 10 ∶ 6 ∶ 0.5) and WB (white ∶ blue ≈ 10 ∶ 4.8) were performed on 35-day-old potted seedlings of commercially popular chrysanthemum cultivars of 'Pink Ping Pong'and Purple Ping Pong, the LED white light treatment was used as the CK group, the total light intensity of each group was set to be about 240 μmol·m-2s-1, and all treatments lasted for 80 days. The changes of growth trait indicators of the chrysanthemums growing from seedling to mature flowering were observed and photographed.【Result】(1) Compared with CK group, the plant heights of 80-day-treatment Pink Ping Pong and 70-day-treatment Purple Ping Pong under RBFR treatment increased by 18.3% and 27.3% respectively, the stem thicknesses increased by 14.1% and 38.1% respectively, the petiole lengths increased by 0.4% and 34.8% respectively; and the mean values of leaf length, leaf width, leaf fresh weight and leaf dry weight of the 70-day-treatment Purple Ping Pong under RBFR treatment were 18.6%, 5.8%, 25.6% and 45.5% higher than those of CK group, respectively; values of the above growth trait indicators were the highest among all treatment groups. (2) In terms of flowering trait indicators of the 70-day-treatment Ping Pong, mean values of peduncle length, peduncle diameter, petal length and petal width of the top capitulum and diameter of side capitulum of 'Pink Ping Pong'under WB treatment were the highest among all treatment groups, which were 4.5%, 2.3%, 10.9%, 17.3%, and 19.1% higher than ...
Keywords	chrysanthemum 'ping pong' ; led light combination ; far-red to red-blue light ; plant growth ; white blue light ; flower color ; flower quality ; Agriculture ; S
Subject code	580
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Guangdong Academy of Agricultural Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Smart use of "ping-pong" energy transfer to improve the two-photon photodynamic activity of an Ir(iii) complex.

Jin, Zhihui / Qi, Shuang / Guo, Xusheng / Tian, Na / Hou, Yuanjun / Li, Chao / Wang, Xuesong / Zhou, Qianxiong

Chemical communications (Cambridge, England)

2020 Volume 56, Issue 19, Page(s) 2845–2848

Abstract: A two-photon excited "Ping-Pong" type energy transfer process is for the first time disclosed ...

Abstract	A two-photon excited "Ping-Pong" type energy transfer process is for the first time disclosed in a pyrene-modified Ir(iii) cyclometalated complex. The energy transfer, from the singlet excited state of the 4-(pyren-1-yl)-tpy (tpy-py) unit to the Ir(iii) moiety and then back again to the triplet excited state of the tpy-py unit, enhances both the two-photon absorption cross sections and singlet oxygen quantum yield of the complex, and dramatically boosts its two-photon photodynamic activity both in vitro and in 3D multicellular spheroids.
Language	English
Publishing date	2020-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c9cc09763e
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Article: Identifying potential therapeutic targets of Tang-Yi-Ping for the treatment of impaired glucose tolerance: a tandem mass tag-labeled quantitative proteomic analysis.

Li, Jie / Bu, Shuai / Zhou, Honglei / Bi, Siling / Xu, Yunsheng

Annals of translational medicine

2021 Volume 9, Issue 20, Page(s) 1532

Abstract: ... to identify potential therapeutic protein targets of a Chinese prescription called Tang-Yi-Ping (TYP ...

Abstract	Background: This study uses the tandem mass tag (TMT)-labeled quantitative proteomic analysis to identify potential therapeutic protein targets of a Chinese prescription called Tang-Yi-Ping (TYP) for the treatment of impaired glucose tolerance (IGT) in rats. Methods: A total of 31 specific-pathogen free (SPF) male Wistar rats were used in our study. Ten were randomly selected as a control group, while 21 received a high-sugar and high-fat diet combined with an intraperitoneal injection of streptozotocin to establish IGT subjects. After eliminating 2 rats without successful modeling, 19 were randomly divided into a TYP group (n=9) and IGT model group (n=10). The TYP group was given a TYP decoction of 6.36 mg/kg-1/d-1. After 8 weeks of intervention, blood glucose-related indicators were measured, and cell morphology was observed by hematoxylin and eosin (HE) staining. TMT-labeled proteomic analysis was applied to detect the differentially expressed proteins (DEPs) in the pancreases of the three groups. The intersection of the DEPs in both the TYP group and IGT model group underwent Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses to identify the related biological functions and signal transduction pathways. Finally, western blot (WB) was used to verify the TMT proteomics results. Results: TYP can effectively reduce blood glucose and improve islet morphology in IGT rats. We identified a total of 16 potential therapeutic protein targets of TYP, 4 of which were upregulated, while 12 were downregulated, including Rbp4, Fam3b, Flot2, etc. [fold change (FC) >1.1, P<0.05]. The significant signal transduction pathways included arginine and proline metabolism, glyceride metabolism, glycerophospholipid metabolism, mTOR, Wnt, and insulin signaling pathways. Conclusions: For anti-IGT therapy, we found TYP regulates 16 protein targets, multiple biological functions, and multiple signal transduction pathways. This study thus makes a significant contribution to identifying new potential therapeutic targets for treating IGT.
Language	English
Publishing date	2021-08-29
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-21-4257
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Article: Yu Ping Feng San Exert Anti-Angiogenesis Effects through the Inhibition of TSLP-STAT3 Signaling Pathways in Hepatocellular Carcinoma.

Yuan, Qin / Yao, Fei / Zhou, Liang / Liang, Guoqiang / Song, Xiudao / Jiang, Guorong / Zhou, Man / Zhang, Lurong

Evidence-based complementary and alternative medicine : eCAM

2019 Volume 2019, Page(s) 1947156

Abstract: Background: Clinically, Yu ping feng san (YPFS) has been extensively used as a medication ...

Abstract	Background: Clinically, Yu ping feng san (YPFS) has been extensively used as a medication for treating immune deficiency, and YPFS is combined with chemotherapy drugs to treat cancer, including hepatocellular carcinoma (HCC), lung cancer, and pancreatic cancer. Previous research has shown that YPFS has a therapeutic effect on HCC by improving the immunosuppressive state of the liver cancer microenvironment. The present study aimed to investigate the effect of YPFS on angiogenesis of HCC. Methods: High-performance liquid chromatography (HPLC) was used to certify the composition of YPFS. An orthotopic transplanted model of murine HCC was entrenched. Immunohistochemistry was used to observe the changes of the microvessel density (MVD). The MTT assay was used to detect the cell viability. ELISA was performed to analyze the expression of related factors. Western blot was used to analyze the protein expression. Tube formation assay was used to analyze the anti-angiogenic efficiency. Results: YPFS significantly reduced the tumor volume and weight, thus exerted the growth inhibitory effect. The level of MVD and VEGF was obviously decreased in YPFS-treated HCC-bearing mice, and the YPFS treatment also reduced the VEGF level in Hepa1-6 cells. Further study revealed that the expression of TSLP/TSLPR and p-STAT3/STAT3 was decreased by YPFS. The level of MVD and VEGF and the expression of TSLP/TSLPR and p-STAT3/STAT3 in tumor tissue and Hepa1-6 cells were suppressed by incubation with the anti-TSLP antibody, whereas treatment with the anti-TSLP antibody in YPFS-treated cells did not cause further significant inhibition compared with the cells treated only with YPFS. More importantly, YPFS inhibited proliferation, expression of p-STAT3/STAT3, and tube formation of HUVECs induced by TSLP. Conclusions: These results indicated that YPFS attenuated the activation of the TSLP-STAT3 signaling pathway by inhibiting the immune-related factor-TSLP, thereby inhibiting the formation of hepatic microvessels and exerting an anti-HCC effect.
Language	English
Publishing date	2019-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2019/1947156
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Article: A Chinese Prescription Yu-Ping-Feng-San Administered in Remission Restores Bronchial Epithelial Barrier to Inhibit House Dust Mite-Induced Asthma Recurrence.

Bao, Kaifan / Yuan, Weiyuan / Zhou, Yijing / Chen, Yanyan / Yu, Xuerui / Wang, Xiaoyu / Jia, Zhirong / Yu, Xi / Wang, Xiaotong / Yao, Lu / Wang, Siqi / Xu, Yifan / Zhang, Yuheng / Zheng, Jie / Hong, Min

Frontiers in pharmacology

2020 Volume 10, Page(s) 1698

Abstract: Clinically, the treatments against asthma like ... ...

Abstract	Clinically, the treatments against asthma like β
Language	English
Publishing date	2020-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2019.01698
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Article ; Online: Xiao-ai-ping injection adjunct with platinum-based chemotherapy for advanced non-small-cell lung cancer: a systematic review and meta-analysis.

Feng, Fanchao / Huang, Jingyi / Wang, Zhichao / Zhang, Jiarui / Han, Di / Wu, Qi / He, Hailang / Zhou, Xianmei

BMC complementary medicine and therapies

2020 Volume 20, Issue 1, Page(s) 3

Abstract: Background: Xiao-ai-ping injection (XAPI), as patented Chinese medicine, has shown promising ...

Abstract	Background: Xiao-ai-ping injection (XAPI), as patented Chinese medicine, has shown promising outcomes in non-small-cell lung cancer (NSCLC) patients. This meta-analysis investigated the efficacy and safety of XAPI in combination with platinum-based chemotherapy. Methods: A comprehensive literature search was conducted to identify relevant studies in Pubmed, EMBASE, the Cochrane Library, Chinese National Knowledge Infrastructure, Wangfang Database, VIP Database, and Chinese Biology Medical Database from the date of their inception to September 2018. The RevMan 5.3 software was applied to calculate the risk ratio (RR) and mean difference (MD) with 95% confidence interval (CI). Results: We included and analyzed 24 randomized controlled trials. The meta-analysis showed that XAPI adjunctive to platinum-based chemotherapy had better outcomes in objective tumor response rate (ORR) (RR: 1.27, 95% CI, 1.14-1.40); improved Karnofsky performance scores (KPS) (RR: 1.70, 95% CI, 1.48-1.95); reduction in occurrence of grade 3/4 leukopenia (RR: 0.49, 95% CI, 0.38-0.64), anemia (RR: 0.63, 95% CI, 0.46-0.87) and thrombocytopenia (RR: 0.53, 95% CI, 0.38-0.73), nausea and vomiting (RR: 0.57, 95% CI, 0.36-0.90); and enhanced immune function (CD8 Conclusions: Our meta-analyses demonstrated that XAPI in combination with platinum-based chemotherapy had a better tumor response, improved the quality of life, attenuated adverse side effects, and enhanced immune function, which suggests that it might be used for advanced NSCLC. Moreover, low dosage (< 60 ml/d) and long-term treatment of XAPI might be a choice for advanced NSCLC patients.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Injections ; Karnofsky Performance Status ; Lung Neoplasms/drug therapy ; Medicine, Chinese Traditional ; Platinum Compounds/therapeutic use ; Randomized Controlled Trials as Topic
Chemical Substances	Drugs, Chinese Herbal ; Marsdeniae tenacissimae extract ; Platinum Compounds
Language	English
Publishing date	2020-01-13
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-019-2795-y
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