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Article ; Online: The Role of Na

Jafarova, S H / Adnaev, S A / Guliyeva, R T / Jafar, N H

Bulletin of experimental biology and medicine

2022 Volume 172, Issue 3, Page(s) 283–287

Abstract: We studied laboratory parameters of patients with COVID-19 against the background of chronic pathologies (cardiovascular pathologies, obesity, type 2 diabetes melitus, and cardiovascular pathologies with allergy to statins). A decrease in pH and a shift ... ...

Abstract	We studied laboratory parameters of patients with COVID-19 against the background of chronic pathologies (cardiovascular pathologies, obesity, type 2 diabetes melitus, and cardiovascular pathologies with allergy to statins). A decrease in pH and a shift in the electrolyte balance of blood plasma were revealed in all studied groups and were most pronounced in patients with cardiovascular pathologies with allergy to statin. It was found that low pH promotes destruction of lipid components of the erythrocyte membranes in patients with chronic pathologies, which was seen from a decrease in Na
MeSH term(s)	Aged ; COVID-19/complications ; COVID-19/metabolism ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/virology ; Case-Control Studies ; Chronic Disease ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/virology ; Drug Hypersensitivity/complications ; Drug Hypersensitivity/metabolism ; Drug Hypersensitivity/virology ; Erythrocyte Membrane/metabolism ; Erythrocytes/metabolism ; Female ; Fluid Shifts/physiology ; Humans ; Hydrogen-Ion Concentration ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hyponatremia/etiology ; Hyponatremia/metabolism ; Hyponatremia/virology ; Hypoxia/complications ; Hypoxia/metabolism ; Lipid Peroxidation/physiology ; Male ; Middle Aged ; Obesity/complications ; Obesity/metabolism ; Obesity/virology ; Oxidative Stress/physiology ; SARS-CoV-2/physiology ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/physiology ; Stress, Physiological/physiology
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Sodium (9NEZ333N27) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
Language	English
Publishing date	2022-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	390407-6
ISSN	1573-8221 ; 0007-4888 ; 0365-9615
ISSN (online)	1573-8221
ISSN	0007-4888 ; 0365-9615
DOI	10.1007/s10517-022-05377-7
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Article: Sodium Selenite As Potential Adjuvant Therapy for COVID-19.

Huseynov, T M / Guliyeva, R T / Jafarova, S H / Jafar, N H

Biophysics

2022 Volume 67, Issue 5, Page(s) 775–778

Abstract: The review considers the role that selenium plays in RNA virus infections and, in particular, COVID-19. Many RNA viruses are selenium dependent because antisense interactions arise between viral RNAs and host mRNA regions containing the selencysteine ... ...

Abstract	The review considers the role that selenium plays in RNA virus infections and, in particular, COVID-19. Many RNA viruses are selenium dependent because antisense interactions arise between viral RNAs and host mRNA regions containing the selencysteine insertion sequence to cause selenium deficiency, oxidative stress, immune response impairment, etc. Sodium selenite is a licensed selenium-containing product and is widely used in medicine, veterinary, and agriculture. Its advantages include the following. Sodium selenite rapidly penetrates through cell membranes in all tissues of the body; is intensely involved in metabolic processes accompanied by oxidation of sulfur-containing cell proteins; exerts an antiaggregation effect by reducing thromboxane activity; interrupts the contact of a virion (SARS-CoV-1 and SARS-CoV-2) with the membrane of a healthy cell; and suppresses NF-κB activity, which significantly increases in coronavirus infections. Arguments supporting the use of sodium selenite as adjuvant therapy in COVID-19 are discussed.
Language	English
Publishing date	2022-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	6617-5
ISSN	1555-6654 ; 0006-3509
ISSN (online)	1555-6654
ISSN	0006-3509
DOI	10.1134/S0006350922050074
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Article ; Online: The effect of acute topiramate administration on morphine withdrawal syndrome and brain-derived neurotrophic factor in central nervous system.

Ozkula, Songul / Jafarova Demirkapu, Mahluga / Yananli, Hasan Raci / Aydin, Banu / Nacar, Cevdet / Cabadak, Hulya

Neurological research

2023 Volume 45, Issue 8, Page(s) 730–737

Abstract: Objectives: Nucleus accumbens plays an important role in opioid addiction. Topiramate, increases postsynaptic gamma-aminobutyric acid receptor activity and antagonizes glutamatergic activity. Brain-derived neurotrophic factor (BDNF), which plays a key ... ...

Abstract	Objectives: Nucleus accumbens plays an important role in opioid addiction. Topiramate, increases postsynaptic gamma-aminobutyric acid receptor activity and antagonizes glutamatergic activity. Brain-derived neurotrophic factor (BDNF), which plays a key role in synaptic plasticity, is produced from proBDNF. The aim of this study is to investigate the effects of 100 µM topiramate applied into the lateral ventricle or nucleus accumbens on naloxone-induced morphine withdrawal and the BDNF/proBDNF ratio in the frontal cortex. Methods: In the study, 36 adult male Wistar rats weighing 250-350 g were used. Morphine dependence was created with morphine pellets following guide cannula implantations. Withdrawal findings were evaluated in naloxone-induced morphine withdrawal syndrome following topiramate administration, and locomotor activity measurements were performed simultaneously. The brains of sacrificed animals were removed for determination of BDNF/proBDNF ratio. Results: Topiramate administered by either route significantly suppressed the number of jumps in morphine withdrawal. Topiramate applied into the nucleus accumbens significantly reduced stereotypical behavior in morphine withdrawal, but did not cause any changes in other locomotor activity behaviors. Topiramate applied into the lateral ventricle significantly decreased the BDNF/proBDNF ratio, whereas administered into the nucleus accumbens significantly increased this ratio. Conclusion: The findings of this study indicate that topiramate administered into the lateral ventricle and nucleus accumbens reduces naloxone-induced morphine withdrawal symptoms, stereotypical locomotor activity, and changes the BDNF/proBDNF ratio.
MeSH term(s)	Rats ; Animals ; Male ; Morphine/adverse effects ; Brain-Derived Neurotrophic Factor/metabolism ; Topiramate/pharmacology ; Rats, Wistar ; Naloxone/pharmacology ; Nucleus Accumbens/metabolism ; Substance Withdrawal Syndrome/drug therapy
Chemical Substances	Morphine (76I7G6D29C) ; Brain-Derived Neurotrophic Factor ; Topiramate (0H73WJJ391) ; Naloxone (36B82AMQ7N)
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	424428-x
ISSN	1743-1328 ; 0161-6412
ISSN (online)	1743-1328
ISSN	0161-6412
DOI	10.1080/01616412.2023.2203611
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Article ; Online: The effects of etomidate on testicular ischemia reperfusion injury in ipsilateral and contralateral testes of rats.

Jafarova Demirkapu, M / Karabag, S / Akgul, H M / Mordeniz, C / Yananli, H R

European review for medical and pharmacological sciences

2022 Volume 26, Issue 1, Page(s) 211–217

Abstract: Objective: Testicular torsion is a condition that manifests with acute pain and can lead to infertility despite urgent surgical intervention. The aim of this study is to investigate the protective and preventive effects of etomidate, an imidazole ... ...

Abstract	Objective: Testicular torsion is a condition that manifests with acute pain and can lead to infertility despite urgent surgical intervention. The aim of this study is to investigate the protective and preventive effects of etomidate, an imidazole derivative, a non-barbiturate general anesthetic agent, without analgesic effect, on testicular ischemia-reperfusion injury. Materials and methods: Twenty-four adult male Wistar rats weighing 200-250 g were used in the study. Torsion was created in all rats by rotating left testes 720° clockwise on the day of the experiment. 30 minutes before detorsion, 4 mg/kg etomidate and 10 mg/kg propofol were administered intraperitoneally to the etomidate and propofol groups, respectively. After an hour of ischemia, the left testis was reinstated, and the tissues were repaired according to their physiology. Following 24 hours of reperfusion, the animals were euthanized after ipsilateral and contralateral testes were removed. Results: Etomidate applied before testicular detorsion significantly suppressed germ cell damage and Leydig cell loss in ipsilateral tissue. It did not cause any significant changes in the percentage of necrosis, histological score, and tubule rupture in ipsilateral tissue. Propofol administered before testicular detorsion significantly suppressed the percentage of necrosis only in the ipsilateral tissue. In addition, no signs of damage were observed in the contralateral testis. Conclusions: These findings show that etomidate administered before detortion creates a protective effect by preventing testicular ischemia-reperfusion injury.
MeSH term(s)	Animals ; Etomidate/pharmacology ; Male ; Malondialdehyde ; Rats ; Rats, Wistar ; Reperfusion Injury/drug therapy ; Reperfusion Injury/pathology ; Reperfusion Injury/prevention & control ; Testis
Chemical Substances	Malondialdehyde (4Y8F71G49Q) ; Etomidate (Z22628B598)
Language	English
Publishing date	2022-01-20
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202201_27770
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Article ; Online: Potential drug-drug interactions in University Hospital Medical Intensive Care Unit patients in Turkey.

Jafarova Demirkapu, M / Pinar Kara, S

European review for medical and pharmacological sciences

2021 Volume 25, Issue 22, Page(s) 7108–7114

Abstract: ... patients aged ≥18 years who stayed in the MICU for at least 24 h between January and December 2020 were ...

Abstract	Objective: Concomitant use of drugs not only enhances the therapeutic effect, but may also lead to undesirable interactions. Drug interactions are frequently seen in intensive care patients. In this study, we aimed to determine the frequency and clinical severity of drug interactions in Medical Intensive Care Unit (MICU) patients. Patients and methods: The ordered drugs and blood analysis results of 314 patients aged ≥18 years who stayed in the MICU for at least 24 h between January and December 2020 were evaluated. Using the Lexi-Interact online database, clinically significant types of drug interactions, frequently interacting drug/drug groups, and potential adverse reactions were identified. Results: The average number of drugs in 314 patients was 8.98±5.19. It was determined that polypharmacy was associated with comorbidity and the amount of drug used increased as the number of diagnoses increased. Potential drug-drug interactions were observed in 69.7% of the MICU patients, and it was determined that the amount of interactions increased as the amount of drug used increased. The most common X, D, and C type potential drug-drug interactions, were found between furosemide and salbutamol, enoxaparin and acetylsalicylic acid, ipratropium and potassium chloride, respectively. Conclusions: Use of frequently interacting drugs in the treatment of critically MICU patients may lead to potential drug-drug interactions and adverse reactions. Daily monitoring and updating of drug therapy can improve patient's quality of life by preventing or reducing potential drug-drug interactions.
MeSH term(s)	Aged ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Female ; Hospitals, University/statistics & numerical data ; Humans ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Retrospective Studies ; Turkey/epidemiology
Language	English
Publishing date	2021-12-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202111_27264
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Article ; Online: Etiological structure of bacterial meningitis in children

K.A. Jafarova

Саратовский научно-медицинский журнал, Vol 6, Iss 4, Pp 780-

2010 Volume 782

Abstract: ... diagnosed in 18 (30%) patients, H. influenzae meningitis - in 9 (15%), S. pneumoniae - in 8 (13,3 ...

Abstract	The microbiological investigation of 14 year old children with meningeal and infectious syndromes was held. Bacterial meningitis was diagnosed in 90,9% patients. The meningococcal meningitis was diagnosed in 18 (30%) patients, H. influenzae meningitis - in 9 (15%), S. pneumoniae - in 8 (13,3%). Meningitis as a monoinfection was revealed in 85% cases; mixed infection - in 15%. In 28 patients the etiologic agents of disease were gram-negative, in 16 children -gram-positive bacteria. Causative agents of bacterial meningitis were more resistant to penicillin, ampicillin and eritromycin
Keywords	bacterial meningitis ; causative agents ; Medicine (General) ; R5-920
Language	Russian
Publishing date	2010-12-01T00:00:00Z
Publisher	Saratov State Medical University
Document type	Article ; Online
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Article ; Online: A [4+2] mixed ligand approach to ruthenium DNA metallointercalators [Ru(tpa)(N-N)](PF(6))(2) using a tris(2-pyridylmethyl)amine (tpa) capping ligand.

Kraft, Sabine Seeberg née / Bischof, Caroline / Loos, Annette / Braun, Sebastian / Jafarova, Nigar / Schatzschneider, Ulrich

Journal of inorganic biochemistry

2009 Volume 103, Issue 8, Page(s) 1126–1134

Abstract: ... show C(1) symmetry while in solution, the (1)H and (13)C NMR spectra are in accordance with an average ... C(s) symmetry. This is thought to be due to a low energy barrier for flipping of the equatorial ...

Abstract	A series of five tris(2-pyridylmethyl)amine (tpa) ruthenium complexes [Ru(tpa)(N-N)](PF(6))(2) with N-N=bpy (2,2'-bipyridine), phen (1,10-phenanthroline), dpq (dipyrido[3,2-d:2',3'-f]quinoxaline), dppz (dipyrido[3,2-a;2',3'-c]phenazine), and dppn (4,5,9,16-tetraazadibenzo[a,c]naphthacene) was prepared and characterized by NMR, UV-Visible (UV/Vis), and fluorescence spectroscopy as well as cyclic voltammetry. Structures optimized with density functional theory methods (DFT, BP86, TZVP) without constraints show C(1) symmetry while in solution, the (1)H and (13)C NMR spectra are in accordance with an average C(s) symmetry. This is thought to be due to a low energy barrier for flipping of the equatorial pyridine ring from one side of the N-N plane to the other. The electronic structure of the compounds was studied with DFT and a change in the highest occupied molecular orbital (HOMO) character from Ru t(2g) for the bpy, phen, and dpq to N-N ligand-based for the dppz and dppn complexes was found. TDDFT calculations showed dominant N-N-based intra-ligand charge transfer (ILCT) transitions in the latter two complexes mixed with metal-to-ligand charge transfer (MLCT) bands found for all five compounds. DNA binding of the complexes was studied with UV/Vis titrations, the fluorescent ethidium bromide displacement assay, and CD spectroscopy. The affinity increases with the aromatic surface area of of the bidentate N-N ligand in the order bpy<<phen<dpq<dppz approximately dppn. Viscosity measurements support an intercalative binding mode for the latter three compounds, while the others did not show a pronounced effect of the hydrodynamic properties of calf thymus (CT) DNA.<br />
MeSH term(s)	Circular Dichroism ; DNA/chemistry ; Electrochemical Techniques ; Ethidium ; Ligands ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Organometallic Compounds/chemical synthesis ; Organometallic Compounds/chemistry ; Pyridines/chemistry ; Ruthenium Compounds/chemical synthesis ; Ruthenium Compounds/chemistry ; Spectrophotometry ; Viscosity
Chemical Substances	Ligands ; Organometallic Compounds ; Pyridines ; Ruthenium Compounds ; tris(2-pyridylmethyl)amine ; DNA (9007-49-2) ; Ethidium (EN464416SI)
Language	English
Publishing date	2009-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2009.05.013
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Article: Lectin from Phaseolus acutifolius var. escumite: chemical characterization, sugar specificity, and effect on human T-lymphocytes.

Castillo-Villanueva, Adriana / Caballero-Ortega, Heriberto / Abdullaev-Jafarova, Fikrat / Garfias, Yonathan / del Carmen Jiménez-Martínez, Maria / Bouquelet, Stéphane / Martínez, Gisela / Mendoza-Hernández, Guillermo / Zenteno, Edgar

Journal of agricultural and food chemistry

2007 Volume 55, Issue 14, Page(s) 5781–5787

Abstract: ... by ion-exchange chromatography on a mono-S column. The lectin and its isolectins showed identical NH2 terminal residues ...

Abstract	Purification of the lectin from Phaseolus acutifolius var. escumite was achieved by affinity chromatography on a column containing glutaraldehyzed membranes from blood group O erythrocytes. The lectin is a tetrameric glycoprotein of 121 kDa with 10% of sugar by weight composed by four subunits of 30 kDa as determined by SDS-PAGE. The lectin is composed of four isolectins as determined by ion-exchange chromatography on a mono-S column. The lectin and its isolectins showed identical NH2 terminal residues (ANDLSFNFQR FNETN) with homology to the PHA leucoagglutinin-precursor. Peptide mass fingerprint from each lectin isoform determined from tryptic peptides by MALDI-TOF (matrix assisted laser desorption ionization-time-of-flight) showed differences among subunits, thus suggesting microheterogeneity in their amino acid sequences or different glycosylation patterns. The lectin and its four isolectins agglutinated erythrocytes without serological specificity and showed mitogenic activity on human leukocytes; moreover, the main effect was rather toward CD8+ than to CD4+ human peripheral lymphocytes. The lectin from escumite was not inhibitable by simple sugars; however, the specificity of the lectin and its isoforms was mainly addressed toward galactose residues present in bi- or triantennary N-acetyllactosamine-type glycans.
MeSH term(s)	Amino Acid Sequence ; Carbohydrates/analysis ; Carbohydrates/chemistry ; Cell Division/drug effects ; Galactose/chemistry ; Humans ; Molecular Sequence Data ; Phaseolus/chemistry ; Plant Lectins/chemistry ; Plant Lectins/metabolism ; Plant Lectins/pharmacology ; Sequence Homology ; T-Lymphocytes/drug effects
Chemical Substances	Carbohydrates ; Plant Lectins ; Galactose (X2RN3Q8DNE)
Language	English
Publishing date	2007-07-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/jf063644k
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Article ; Audio / Video: Lectin from Phaseolus acutifolius var. escumite: Chemical Characterization, Sugar Specificity, and Effect on Human T-Lymphocytes

Castillo-Villanueva, A / Caballero-Ortega, H / Abdullaev-Jafarova, F / Garfias, Y / Jimenez-Martinez, M. del C / Bouquelet, S / Martinez, G / Mendoza-Hernandez, G / Zenteno, E

Journal of agricultural and food chemistry. 2007 July 11, v. 55, no. 14

2007

Abstract: ... by ion-exchange chromatography on a mono-S column. The lectin and its isolectins showed identical NH2 terminal residues ...

Abstract	Purification of the lectin from Phaseolus acutifolius var. escumite was achieved by affinity chromatography on a column containing glutaraldehyzed membranes from blood group O erythrocytes. The lectin is a tetrameric glycoprotein of 121 kDa with 10% of sugar by weight composed by four subunits of 30 kDa as determined by SDS-PAGE. The lectin is composed of four isolectins as determined by ion-exchange chromatography on a mono-S column. The lectin and its isolectins showed identical NH2 terminal residues (ANDLSFNFQR FNETN) with homology to the PHA leucoagglutinin-precursor. Peptide mass fingerprint from each lectin isoform determined from tryptic peptides by MALDI-TOF (matrix assisted laser desorption ionization-time-of-flight) showed differences among subunits, thus suggesting microheterogeneity in their amino acid sequences or different glycosylation patterns. The lectin and its four isolectins agglutinated erythrocytes without serological specificity and showed mitogenic activity on human leukocytes; moreover, the main effect was rather toward CD8+ than to CD4+ human peripheral lymphocytes. The lectin from escumite was not inhibitable by simple sugars; however, the specificity of the lectin and its isoforms was mainly addressed toward galactose residues present in bi- or triantennary N-acetyllactosamine-type glycans.
Keywords	Phaseolus acutifolius ; antinutritional factors ; seeds ; beans ; lectins ; glycoproteins ; amino acid sequences ; protein subunits ; molecular weight ; hemagglutination tests ; hemagglutination ; erythrocytes ; humans ; lymphocyte proliferation ; CD8-positive T-lymphocytes ; CD4-positive T-lymphocytes
Language	English
Dates of publication	2007-0711
Size	p. 5781-5787.
Document type	Article ; Audio / Video
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/jf063644k
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

Nepogodiev D. / Bhangu A. / Glasbey J.C. / Li E. / Omar O.M. / Simoes J.F. / Abbott T.E. / Alser O. / Arnaud A.P. / Bankhead-Kendall B.K. / Breen K.A. / Cunha M.F. / Davidson G.H. / Di Saverio S. / Gallo G. / Griffiths E.A. / Gujjuri R.R. / Hutchinson P.J. / Kaafarani H.M. /

Lederhuber H. / Loffler M.W. / Mashbari H.N. / Minaya-Bravo A. / Morton D.G. / Moszkowicz D. / Pata F. / Tsoulfas G. / Venn M.L. / Cox D. / Roslani A.C. / Alakaloko F. / de Vries J.-P.P. / Aaraj M.A. / Abbott S.J. / Abdalla M.O. / Abdelaal A.S. / Ademuyiwa A.O. / Aherne T.M. / Ali O.M. / Alkadeeki G.Z. / Almeida A.C. / Alrahawy M.M. / Ambler G.K. / Alameer E. / Andreani S.M. / De Andres-Asenjo B. / Antonanzas L.L. / Aoun S.G. / Ashoush F.M. / Augestad K.M. / Avellana R.B. / Ayeni F.A. / Ayorinde J.O. / Babu B.H. / Baig M.M. / Bajomo O.M. / Baker O.J. / Baker M.P. / Baldwin A.J. / Ban V.S. / Baron R.D. / Barranquero A.G. / Barry C.P. / DI Bartolomeo A. / Bass G.A. / Bath M.F. / Batjer H.H. / Beamish A.J. / Belgaumkar A.P. / Bence M.N. / Benson R.A. / Bernal-Sprekelsen J.C. / Bhama A.R. / Bhavaraju A.V. / Biffl W.L. / Blundell C.M. / Boddy A.P. / Borgstein A.B. / Bosanquet D.C. / Bosch K.D. / Bouhuwaish A.E. / Bozkurt M.A. / Brathwaite C.E. / Brown B.C. / Brown O.D. / Brown A.K. / Buarque I.L. / Bueno-Canones A.D. / Bulugma M.R. / Burke J.R. / Byrne M.H. / Cagigal-Ortega E.P. / Callcut R.A. / DI Candido F. / Canova M.E. / Carlos W.J. / Caruana E.J. / Cato L.D. / Catton A.B. / Ceretti A.P. / Chase T.J. / Chiara F.D. / Chowdhury A.H. / Chung E.A. / Cicerchia P.M. / Clough E.C. / Coleman N.L. / Collins C.G. / Collins M.L. / Colonna E.T. / Comini L.V. / Coughlin P.A. / Cruzado L.F.-G. / Davidson B.R. / Davies R.J. / Davies E.J. / Davis N.F. / Dawson B.E. / Dean B.J. / Delgado M.G.-C. / Diaz J.J. / Dickson K.E. / Diez-Alonso M.M. / Dixon J.R. / Doe M.J. / Drake T.D. / Drake F.T. / Duffy J.P. / Dunne D.F. / Dunne N.J. / Duran-Munoz-Cruzado V.M. / Durst A.Z. / Eardley N.J. / Edwards J.G. / Elfallal A.H. / Elfiky M.M. / Elliott J.A. / Emile S.H. / Emslie K.M. / Endorf F.W. / Engel J.L. / Enjuto D.T. / Etchill E.W. / Evans J.P. / Fahey B.A. / Faria C.S. / Feo C.V. / Ferguson H.J. / Fernandez B.D. / Fernandez A.G. / Fernandez A.J. / Fernandez-Pacheco B.C. / Fitzgerald 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G.S. / Mateo-Sierra O. / Martinez-Perez C. / Serrano Gonzalez J. / Hernandez Bartolome M.A. / Diaz Perez D. / Gutierrez Samaniego M. / Galindo Jara P. / Sharma N. / Smart N.J. / Keller D.S.

an international cohort study

2020

Abstract: Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and ... ...

Abstract	Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p<0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p<0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p<0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
Keywords	Adult ; Aged ; Betacoronavirus ; Coronavirus Infections ; Elective Surgical Procedures ; Emergency Medical Services ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia ; Viral ; Postoperative Complications ; Respiratory Tract Diseases ; Retrospective Studies ; Surgical Procedures ; Operative ; Young Adult ; covid19
Subject code	610 ; 616
Language	English
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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