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  1. Article ; Online: Adverse Food Reactions in Inflammatory Bowel Disease: State of the Art and Future Perspectives.

    Capobianco, Ivan / Di Vincenzo, Federica / Puca, Pierluigi / Becherucci, Guia / Mentella, Maria Chiara / Petito, Valentina / Scaldaferri, Franco

    Nutrients

    2024  Volume 16, Issue 3

    Abstract: Limited knowledge is available about the relationship between food allergies or intolerances and inflammatory bowel disease (IBD). Clinicians frequently encounter patients who report food allergies or intolerances, and gastroenterologists struggle ... ...

    Abstract Limited knowledge is available about the relationship between food allergies or intolerances and inflammatory bowel disease (IBD). Clinicians frequently encounter patients who report food allergies or intolerances, and gastroenterologists struggle distinguishing between patients with organic disorders and those with functional disorders, which the patients themselves may associate with specific dietary components. This task becomes even more arduous when managing patients with significant underlying organic conditions, like IBD. The aim of this review is to summarize and emphasize any actual associations between food allergies and intolerances and inflammatory diseases, such as ulcerative colitis and Crohn's disease. Through a narrative disceptation of the current literature, we highlight the increased prevalence of various food intolerances, including lactose, fructose, histamine, nickel, and non-celiac gluten sensitivity, in individuals with IBD. Additionally, we explore the association between increased epithelial barrier permeability in IBD and the development of food sensitization. By doing so, we aim to enhance clinicians' awareness of the nutritional management of patients with IBD when facing complaints or evidence of food allergies or intolerances.
    MeSH term(s) Humans ; Inflammatory Bowel Diseases ; Crohn Disease/epidemiology ; Colitis, Ulcerative/epidemiology ; Food Hypersensitivity/epidemiology ; Allergens
    Chemical Substances Allergens
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16030351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Role of Nutrition in the COVID-19 Pandemic.

    Mentella, Maria Chiara / Scaldaferri, Franco / Gasbarrini, Antonio / Miggiano, Giacinto Abele Donato

    Nutrients

    2021  Volume 13, Issue 4

    Abstract: SARS-CoV-2, the cause of the COVID-19 disease, is posing unprecedent challenges. In the literature, increasing evidence highlights how malnutrition negatively affects the immune system functionality, impairing protection from infections. The current ... ...

    Abstract SARS-CoV-2, the cause of the COVID-19 disease, is posing unprecedent challenges. In the literature, increasing evidence highlights how malnutrition negatively affects the immune system functionality, impairing protection from infections. The current review aims to summarize the complex relationship between SARS-CoV-2 infection and nutritional status and the effects of malnutrition in terms of disease severity, patients' recovery time, incidence of complications and mortality rate. Current studies evaluating the possibility of modulating nutrition and supplementation in combination with pharmacological treatments in the clinical setting to prevent, support, and overcome infection are also described. The discussion of the most recent pertinent literature aims to lay the foundations for making reasonable assumptions and evaluations for a nutritional "best practice" against COVID-19 pandemic and for the definition of sound cost-effective strategies to assist healthcare systems in managing patients and individuals in their recovery from COVID-19.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Humans ; Malnutrition/complications ; Nutritional Status ; Obesity/complications
    Language English
    Publishing date 2021-03-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13041093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nutrition, IBD and Gut Microbiota: A Review

    Mentella, Maria Chiara / Scaldaferri, Franco / Pizzoferrato, Marco / Gasbarrini, Antonio / Miggiano, Giacinto Abele Donato

    Nutrients. 2020 Mar. 29, v. 12, no. 4

    2020  

    Abstract: Inflammatory bowel disease (IBD) is a chronic relapsing–remitting systemic disease of the gastrointestinal tract, characterized by an inflammatory process that requires lifelong treatment. The underlying causes of IBD are still unclear, as this ... ...

    Abstract Inflammatory bowel disease (IBD) is a chronic relapsing–remitting systemic disease of the gastrointestinal tract, characterized by an inflammatory process that requires lifelong treatment. The underlying causes of IBD are still unclear, as this heterogeneous disorder results from a complex interplay between genetic variability, the host immune system and environmental factors. The current knowledge recognizes diet as a risk factor for the development of IBD and attributes a substantial pathogenic role to the intestinal dysbiosis inducing an aberrant mucosal immune response in genetically predisposed individuals. This review focused on the clinical evidence available that considers the impact of some nutrients on IBD onset and the role of different diets in the management of IBD and their effects on the gut microbiota composition. The effects of the Specific Carbohydrate Diet, low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet, gluten free diet, anti-inflammatory diet and Mediterranean diet are investigated with regard to their impact on microbiota and on the evolution of the disease. At present, no clear indications toward a specific diet are available but the assessment of dysbiosis prior to the recommendation of a specific diet should become a standard clinical approach in order to achieve a personalized therapy.
    Keywords Mediterranean diet ; administrative management ; disaccharides ; dysbiosis ; environmental factors ; evolution ; genetic variation ; gluten-free foods ; immune system ; inflammatory bowel disease ; intestinal microorganisms ; intestines ; knowledge ; monosaccharides ; mucosal immunity ; nutrients ; polyols ; risk factors ; therapeutics
    Language English
    Dates of publication 2020-0329
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12040944
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Nutrition, IBD and Gut Microbiota: A Review.

    Mentella, Maria Chiara / Scaldaferri, Franco / Pizzoferrato, Marco / Gasbarrini, Antonio / Miggiano, Giacinto Abele Donato

    Nutrients

    2020  Volume 12, Issue 4

    Abstract: Inflammatory bowel disease (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract, characterized by an inflammatory process that requires lifelong treatment. The underlying causes of IBD are still unclear, as this ... ...

    Abstract Inflammatory bowel disease (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract, characterized by an inflammatory process that requires lifelong treatment. The underlying causes of IBD are still unclear, as this heterogeneous disorder results from a complex interplay between genetic variability, the host immune system and environmental factors. The current knowledge recognizes diet as a risk factor for the development of IBD and attributes a substantial pathogenic role to the intestinal dysbiosis inducing an aberrant mucosal immune response in genetically predisposed individuals. This review focused on the clinical evidence available that considers the impact of some nutrients on IBD onset and the role of different diets in the management of IBD and their effects on the gut microbiota composition. The effects of the Specific Carbohydrate Diet, low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet, gluten free diet, anti-inflammatory diet and Mediterranean diet are investigated with regard to their impact on microbiota and on the evolution of the disease. At present, no clear indications toward a specific diet are available but the assessment of dysbiosis prior to the recommendation of a specific diet should become a standard clinical approach in order to achieve a personalized therapy.
    MeSH term(s) Diet ; Dysbiosis ; Environment ; Female ; Gastrointestinal Microbiome ; Humans ; Inflammatory Bowel Diseases/etiology ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/microbiology ; Inflammatory Bowel Diseases/therapy ; Male ; Nutritional Physiological Phenomena/physiology ; Risk Factors
    Language English
    Publishing date 2020-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12040944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cancer and Mediterranean Diet: A Review

    Mentella, Maria Chiara / Scaldaferri, Franco / Ricci, Caterina / Gasbarrini, Antonio / Miggiano, Giacinto Abele Donato

    Nutrients. 2019 Sept. 02, v. 11, no. 9

    2019  

    Abstract: The Mediterranean diet is considered one of the most worldwide healthy dietary patterns thanks to a combination of foods rich mainly in antioxidants and anti-inflammatory nutrients. Many studies have demonstrated a strong and inverse relationship between ...

    Abstract The Mediterranean diet is considered one of the most worldwide healthy dietary patterns thanks to a combination of foods rich mainly in antioxidants and anti-inflammatory nutrients. Many studies have demonstrated a strong and inverse relationship between a high level of Mediterranean diet adherence and some chronic diseases (such as cardiovascular diseases, diabetes, etc.) and cancer. Given its protective effects in reducing oxidative and inflammatory processes of cells and avoiding DNA damages, cell proliferation, and their survival, angiogenesis, inflammations and metastasis, the Mediterranean diet is considered a powerful and manageable method to fight cancer incidence. The aim of this narrative review was to determine the magnitude of interaction between the Mediterranean diet and more widespread types of cancer so as to give a first and useful overview on this relationship identifying, with a nutritional approach, those nutrients of Mediterranean diet able to reduce cancer incidence.
    Keywords DNA damage ; Mediterranean diet ; angiogenesis ; antioxidants ; cardiovascular diseases ; cell proliferation ; chronic diseases ; diabetes ; eating habits ; foods ; metastasis ; neoplasms ; nutrients ; protective effect
    Language English
    Dates of publication 2019-0902
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11092059
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD

    Mentella, Maria Chiara / Scaldaferri, Franco / Pizzoferrato, Marco / Gasbarrini, Antonio / Miggiano, Giacinto Abele Donato

    Nutrients. 2019 Oct. 26, v. 11, no. 11

    2019  

    Abstract: Hypovitaminosis D is frequently present in inflammatory bowel disease (IBD) with a higher incidence in Crohn’s disease (CD) than in Ulcerative Colitis (UC). Given the involvement of the alimentary tract, many factors can contribute to hypovitaminosis D. ... ...

    Abstract Hypovitaminosis D is frequently present in inflammatory bowel disease (IBD) with a higher incidence in Crohn’s disease (CD) than in Ulcerative Colitis (UC). Given the involvement of the alimentary tract, many factors can contribute to hypovitaminosis D. The aim of the study was to investigate the association of disease activity, body mass index (BMI) and phase angle with vitamin D deficiency in patients with IBD. A cross-sectional study was conducted on a cohort of 206 IBD patients (October 2016–September 2018). Of these patients, 32.6% were affected by hypovitaminosis D (CD: 38.6%; UC: 25.6%; p < 0.01). Negative and significant associations (p < 0.01) were found between BMI and vitamin D serum levels both in CD and UC patients. BMI represented a determinant of hypovitaminosis D (Odds Ratio (OR) = 1.12, p < 0.01) only in UC patients; phase angle was associated to hypovitaminosis D in both groups (CD: OR = 0.64, p < 0.05; UC: OR = 0.49, p < 0.01). Results of the present study confirm a higher incidence of hypovitaminosis D in patients with CD than in those with UC, and show that nutritional status plays a crucial role in the incidence of vitamin D deficiency in patients with IBD.
    Keywords blood serum ; body mass index ; cross-sectional studies ; nutritional status ; odds ratio ; patients ; ulcerative colitis ; vitamin D ; vitamin D deficiency
    Language English
    Dates of publication 2019-1026
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11112583
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Cancer and Mediterranean Diet: A Review.

    Mentella, Maria Chiara / Scaldaferri, Franco / Ricci, Caterina / Gasbarrini, Antonio / Miggiano, Giacinto Abele Donato

    Nutrients

    2019  Volume 11, Issue 9

    Abstract: The Mediterranean diet is considered one of the most worldwide healthy dietary patterns thanks to a combination of foods rich mainly in antioxidants and anti-inflammatory nutrients. Many studies have demonstrated a strong and inverse relationship between ...

    Abstract The Mediterranean diet is considered one of the most worldwide healthy dietary patterns thanks to a combination of foods rich mainly in antioxidants and anti-inflammatory nutrients. Many studies have demonstrated a strong and inverse relationship between a high level of Mediterranean diet adherence and some chronic diseases (such as cardiovascular diseases, diabetes, etc.) and cancer. Given its protective effects in reducing oxidative and inflammatory processes of cells and avoiding DNA damages, cell proliferation, and their survival, angiogenesis, inflammations and metastasis, the Mediterranean diet is considered a powerful and manageable method to fight cancer incidence. The aim of this narrative review was to determine the magnitude of interaction between the Mediterranean diet and more widespread types of cancer so as to give a first and useful overview on this relationship identifying, with a nutritional approach, those nutrients of Mediterranean diet able to reduce cancer incidence.
    MeSH term(s) Diet, Mediterranean ; Humans ; Neoplasms/diet therapy ; Neoplasms/prevention & control
    Language English
    Publishing date 2019-09-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11092059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD.

    Mentella, Maria Chiara / Scaldaferri, Franco / Pizzoferrato, Marco / Gasbarrini, Antonio / Miggiano, Giacinto Abele Donato

    Nutrients

    2019  Volume 11, Issue 11

    Abstract: Hypovitaminosis D is frequently present in inflammatory bowel disease (IBD) with a higher incidence in Crohn's disease (CD) than in Ulcerative Colitis (UC). Given the involvement of the alimentary tract, many factors can contribute to hypovitaminosis D. ... ...

    Abstract Hypovitaminosis D is frequently present in inflammatory bowel disease (IBD) with a higher incidence in Crohn's disease (CD) than in Ulcerative Colitis (UC). Given the involvement of the alimentary tract, many factors can contribute to hypovitaminosis D. The aim of the study was to investigate the association of disease activity, body mass index (BMI) and phase angle with vitamin D deficiency in patients with IBD. A cross-sectional study was conducted on a cohort of 206 IBD patients (October 2016-September 2018). Of these patients, 32.6% were affected by hypovitaminosis D (CD: 38.6%; UC: 25.6%;
    MeSH term(s) Adult ; Body Mass Index ; Cross-Sectional Studies ; Electric Impedance ; Female ; Humans ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/physiopathology ; Male ; Middle Aged ; Vitamin D/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/physiopathology ; Young Adult
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2019-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11112583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Use of Faecal Transplantation with a Novel Diet for Mild to Moderate Active Ulcerative Colitis: The CRAFT UC Randomised Controlled Trial.

    Sarbagili Shabat, Chen / Scaldaferri, Franco / Zittan, Eran / Hirsch, Ayal / Mentella, Maria Chiara / Musca, Tania / Cohen, Nathaniel Aviv / Ron, Yulia / Fliss Isakov, Naomi / Pfeffer, Jorge / Yaakov, Michal / Fanali, Caterina / Turchini, Laura / Masucci, Luca / Quaranta, Gianluca / Kolonimos, Nitzan / Godneva, Anastasia / Weinberger, Adina / Kopylov, Uri /
    Levine, Arie / Maharshak, Nitsan

    Journal of Crohn's & colitis

    2021  Volume 16, Issue 3, Page(s) 369–378

    Abstract: Background: We evaluated whether integration of novel diets for donors and patients, in addition to faecal transplantation [FT], could increase FT remission rate in refractory ulcerative colitis [UC].: Methods: This was a blinded, randomised, ... ...

    Abstract Background: We evaluated whether integration of novel diets for donors and patients, in addition to faecal transplantation [FT], could increase FT remission rate in refractory ulcerative colitis [UC].
    Methods: This was a blinded, randomised, controlled trial in adults with active UC, defined by a simple clinical colitis activity index [SCCAI] of ≥5 and ≤11 and endoscopic Mayo score 2-3, refractory to medication. Group 1 received free diet and single donor standard FT by colonoscopy on Day 1and rectal enemas on Days 2 and 14 without dietary conditioning of the donor. Group 2 received FT as above but with dietary pre-conditioning of the donor for 14 days and a UC Exclusion Diet [UCED] for the patients. Group 3 received the UCED alone. The primary endpoint was Week 8 clinical steroid-free remission, defined as SCCAI <3.
    Results: Of 96 planned patients, 62 were enrolled. Remission Week 8 Group 1 was 2/17 [11.8%], Group 2 was 4/19 [21.1%], Group 3 was 6/15 [40%] [non-significant]. Endoscopic remission Group 1 was 2/17 [12%], Group 2 was 3/19 [16%], Group 3 was 4/15 [27%] [Group 1 vs 3 p = 0.38]. Mucosal healing [Mayo 0] was achieved only in Group 3 [3/15, 20%] vs 0/36 FT patients [p = 0.022]. Exacerbation of disease occurred in 3/17 [17.6%] of Group 1, 4/19 [21.1%] of Group 2, and 1/15 [6.7%] of Group 3 [Group 2 vs 3, p = 0.35].
    Conclusions: UCED alone appeared to achieve higher clinical remission and mucosal healing than single donor FT with or without diet. The study was stopped for futility by a safety monitoring board.
    MeSH term(s) Adult ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/surgery ; Colonoscopy ; Diet ; Fecal Microbiota Transplantation/adverse effects ; Humans ; Remission Induction
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjab165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Skeletal muscle-gut axis: emerging mechanisms of sarcopenia for intestinal and extra intestinal diseases.

    de Sire, Roberto / Rizzatti, Gianenrico / Ingravalle, Fabio / Pizzoferrato, Marco / Petito, Valentina / Lopetuso, Loris / Graziani, Cristina / de Sire, Alessandro / Mentella, Maria Chiara / Mele, Maria Cristina / Gasbarrini, Antonio / Scaldaferri, Franco

    Minerva gastroenterologica e dietologica

    2018  Volume 64, Issue 4, Page(s) 351–362

    Abstract: In recent years, there has been an increasing interest on muscle wasting, considering the reduction of quality of life and the increase of morbidity and mortality associated. Sarcopenia and cachexia represent two conditions of reduction of muscle mass, ... ...

    Abstract In recent years, there has been an increasing interest on muscle wasting, considering the reduction of quality of life and the increase of morbidity and mortality associated. Sarcopenia and cachexia represent two conditions of reduction of muscle mass, sharing several elements involved in their pathogenesis, such as systemic inflammation, impaired muscle protein synthesis, increased muscle apoptosis, mitochondrial dysfunction in skeletal muscle tissue and insulin resistance. These features often characterize cancer, inactivity or denervation, but also inflammatory diseases, such as chronic obstructive pulmonary disease, renal failure, cardiac failure, rheumatoid arthritis, inflammatory bowel disease and aging in general. The gastrointestinal tract and gut microbiota are thought to be deeply associated with muscle function and metabolism, although the exact mechanisms that link gut with skeletal muscle are still not well known. This review summarized the potential pathways linking gut with muscle, in particular in conditions as sarcopenia and cachexia. The main emerging pathways implicated in the skeletal muscle-gut axis are: the myostatin/activin signaling pathway, the IGF1/PI3K/AKT/mTOR signaling pathway, which results suppressed, the NF-kB signaling pathway and the FOXO signaling pathway. Further researches in this field are necessary to better explain the linkage between gut microbiota and muscle wasting and the possible emerging therapies associated.
    MeSH term(s) Cachexia/etiology ; Gastrointestinal Microbiome ; Gastrointestinal Tract/physiology ; Humans ; Inflammation/complications ; Intestinal Diseases/complications ; Muscle, Skeletal/physiology ; Sarcopenia/etiology
    Language English
    Publishing date 2018-07-18
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 1077354-x
    ISSN 1827-1642 ; 1121-421X ; 0026-4776
    ISSN (online) 1827-1642
    ISSN 1121-421X ; 0026-4776
    DOI 10.23736/S1121-421X.18.02511-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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