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Article ; Online: Antibiotic Strategies for Severe Community-Acquired Pneumonia.

Bassetti, Matteo / Giacobbe, Daniele R / Magnasco, Laura / Fantin, Alberto / Vena, Antonio / Castaldo, Nadia

Seminars in respiratory and critical care medicine

2024 Volume 45, Issue 2, Page(s) 187–199

Abstract: Despite advancements in health systems and intensive care unit (ICU) care, along with the introduction of novel antibiotics and microbiologic techniques, mortality rates in severe community-acquired pneumonia (sCAP) patients have not shown significant ... ...

Abstract	Despite advancements in health systems and intensive care unit (ICU) care, along with the introduction of novel antibiotics and microbiologic techniques, mortality rates in severe community-acquired pneumonia (sCAP) patients have not shown significant improvement. Delayed admission to the ICU is a major risk factor for higher mortality. Apart from choosing the appropriate site of care, prompt and appropriate antibiotic therapy significantly affects the prognosis of sCAP. Treatment regimens involving ceftaroline or ceftobiprole are currently considered the best options for managing patients with sCAP. Additionally, several other molecules, such as delafloxacin, lefamulin, and omadacycline, hold promise as therapeutic strategies for sCAP. This review aims to provide a comprehensive summary of the key challenges in managing adults with severe CAP, focusing on essential aspects related to antibiotic treatment and investigating potential strategies to enhance clinical outcomes in sCAP patients.
MeSH term(s)	Adult ; Humans ; Anti-Bacterial Agents/therapeutic use ; Pneumonia/drug therapy ; Community-Acquired Infections/microbiology ; Prognosis ; Hospitalization ; Intensive Care Units
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1183617-9
ISSN	1098-9048 ; 1069-3424
ISSN (online)	1098-9048
ISSN	1069-3424
DOI	10.1055/s-0043-1778641
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Article ; Online: Controlled Molecular Diffusion in Fluorescent Polymer Films for Label‐Free Detection of Volatile Organic Compounds

Heba Megahd / Marco Carlotti / Martina Martusciello / Laura Magnasco / Andrea Pucci / Davide Comoretto / Paola Lova

Advanced Sensor Research, Vol 3, Iss 1, Pp n/a-n/a (2024)

2024

Abstract: Abstract Aggregation‐induced emission has eliminated the problem of fluorescence quenching in the solid state, making molecules with this property excellent candidates for vapor sensing due to their portability and ease of interpretation. Here, films of ... ...

Abstract	Abstract Aggregation‐induced emission has eliminated the problem of fluorescence quenching in the solid state, making molecules with this property excellent candidates for vapor sensing due to their portability and ease of interpretation. Here, films of polystyrene / 2‐[4‐vinyl(1,10‐biphenyl)‐40‐yl]‐cyanovinyljulolidine copolymers are reported that exhibit aggregation‐induced emission behavior for the detection of toluene, m‐xylene, dichloromethane, and chloroform. After exposure to the analytes, the emission of the copolymers shows significant changes in intensity and spectral shape corresponding to the reduced microviscosity of the molecular environment. However, these changes are similar for different analytes, resulting in low chemical selectivity. Therefore, label‐free selectivity is achieved by controlling the molecular diffusion of the four vapor analytes within the films using the Flory–Huggins solution theory with capping layers of cellulose acetate (CA) and poly(vinyl alcohol) (PVA) polymers.
Keywords	aggregation‐induced emission ; fluorescent sensors ; molecular diffusion ; polymer thin films ; volatile organic compounds ; Technology (General) ; T1-995 ; Science ; Q
Subject code	540
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Wiley-VCH
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Antibiotic Strategies for Severe Community-Acquired Pneumonia

Bassetti, Matteo / Giacobbe, Daniele R. / Magnasco, Laura / Fantin, Alberto / Vena, Antonio / Castaldo, Nadia

Seminars in Respiratory and Critical Care Medicine

(Severe community acquired pneumonia)

2024 Volume 45, Issue 02, Page(s) 187–199

Series title	Severe community acquired pneumonia
Abstract	Despite advancements in health systems and intensive care unit (ICU) care, along with the introduction of novel antibiotics and microbiologic techniques, mortality rates in severe community-acquired pneumonia (sCAP) patients have not shown significant improvement. Delayed admission to the ICU is a major risk factor for higher mortality. Apart from choosing the appropriate site of care, prompt and appropriate antibiotic therapy significantly affects the prognosis of sCAP. Treatment regimens involving ceftaroline or ceftobiprole are currently considered the best options for managing patients with sCAP. Additionally, several other molecules, such as delafloxacin, lefamulin, and omadacycline, hold promise as therapeutic strategies for sCAP. This review aims to provide a comprehensive summary of the key challenges in managing adults with severe CAP, focusing on essential aspects related to antibiotic treatment and investigating potential strategies to enhance clinical outcomes in sCAP patients.
Keywords	ceftobiprole ; ceftaroline ; sCAP ; community-acquired pneumonia ; ICU ; new antibiotics
Language	English
Publishing date	2024-02-01
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1183617-9
ISSN	1098-9048 ; 1069-3424
ISSN (online)	1098-9048
ISSN	1069-3424
DOI	10.1055/s-0043-1778641
Database	Thieme publisher's database

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Article ; Online: Predictors of Retention in Care Among a Cohort of Chronically HBV Infected Patients: What Are We Missing?

Magnasco, Laura / Di Nino, Livia / Nicolini, Laura Ambra

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2019 Volume 18, Issue 2, Page(s) 521–522

MeSH term(s)	Cohort Studies ; Hepatitis B virus ; Hepatitis B, Chronic ; Humans ; Infections ; Retention in Care
Language	English
Publishing date	2019-07-16
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2019.07.021
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Article ; Online: Challenges in the diagnosis and treatment of candidemia due to multidrug-resistant

Giacobbe, Daniele Roberto / Mikulska, Malgorzata / Vena, Antonio / Di Pilato, Vincenzo / Magnasco, Laura / Marchese, Anna / Bassetti, Matteo

Frontiers in fungal biology

2023 Volume 4, Page(s) 1061150

Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-6128
ISSN (online)	2673-6128
DOI	10.3389/ffunb.2023.1061150
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Article ; Online: Methicillin-resistant Staphylococcus aureus lung infection in coronavirus disease 2019: how common?

Bassetti, Matteo / Magnasco, Laura / Vena, Antonio / Portunato, Federica / Giacobbe, Daniele Roberto

Current opinion in infectious diseases

2022 Volume 35, Issue 2, Page(s) 149–162

Abstract: Purpose of review: Some patients with coronavirus disease 2019 (COVID-19) may develop pulmonary bacterial coinfection or superinfection, that could unfavorably impact their prognosis.: Recent findings: The exact burden of methicillin-resistant ... ...

Abstract	Purpose of review: Some patients with coronavirus disease 2019 (COVID-19) may develop pulmonary bacterial coinfection or superinfection, that could unfavorably impact their prognosis. Recent findings: The exact burden of methicillin-resistant Staphylococcus aureus (MRSA) lung infection in peculiar populations such as patients with COVID-19 remains somewhat elusive, possibly because of wide heterogeneity in methods and endpoints across studies. Summary: There was important heterogeneity in the retrieved literature on the epidemiology of MRSA lung infection in patients with COVID-19, both when considering all other bacteria as the denominator (relative prevalence ranging from 2% to 29%) and when considering only S. aureus as the denominator (relative prevalence ranging from 11% to 65%). Overall, MRSA is among the most frequent causative agents of pulmonary infection in patients with COVID-19. Improving our ability to rapidly reach etiological diagnosis of bacterial lung infection in COVID-19 patients remains fundamental if we are to improve the rates of appropriate antibiotic therapy in patients with COVID-19 and concomitant/superimposed MRSA infection, at the same time avoiding antibiotic overuse in line with antimicrobial stewardship principles.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; COVID-19/complications ; Humans ; Lung ; Methicillin-Resistant Staphylococcus aureus ; SARS-CoV-2 ; Staphylococcal Infections/complications ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Staphylococcus aureus
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-02-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645085-4
ISSN	1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
ISSN (online)	1473-6527 ; 1535-3877
ISSN	0951-7375 ; 1355-834X
DOI	10.1097/QCO.0000000000000813
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Zs.A 2462: Show issues

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Article ; Online: Current and emerging drug treatment strategies to tackle invasive community-associated methicillin-resistant

Vena, Antonio / Castaldo, Nadia / Magnasco, Laura / Bavastro, Martina / Limongelli, Alessandro / Giacobbe, Daniele Roberto / Bassetti, Matteo

Expert opinion on pharmacotherapy

2023 Volume 24, Issue 3, Page(s) 331–346

Abstract: Introduction: Community-acquired methicillin-resistant : Areas covered: In this review, the authors discuss the current and emerging drug treatment strategies to tackle invasive CA-MRSA infections. Articles reported in this review were selected from ... ...

Abstract	Introduction: Community-acquired methicillin-resistant Areas covered: In this review, the authors discuss the current and emerging drug treatment strategies to tackle invasive CA-MRSA infections. Articles reported in this review were selected from through literature searches using the PubMed database. Expert opinion: The availability of new drugs showing a potent in vitro activity against CA-MRSA represents a unique opportunity to face the threat of resistance while potentially reducing toxicity. All these compounds represent promising options to enhance our antibiotic armamentarium. However, data regarding the use of these new drugs in real-life studies are limited and their best placement in therapy and in terms of optimization of medical resources and balance of cost-effectiveness requires further investigation.
MeSH term(s)	Humans ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcal Infections/drug therapy ; Community-Acquired Infections/drug therapy ; Anti-Bacterial Agents/adverse effects ; Clindamycin/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Clindamycin (3U02EL437C)
Language	English
Publishing date	2023-01-03
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2001535-5
ISSN	1744-7666 ; 1465-6566
ISSN (online)	1744-7666
ISSN	1465-6566
DOI	10.1080/14656566.2022.2161885
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Zs.A 5130: Show issues

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Article: Barriers to HCV micro-elimination in a cohort of people living with HIV (PLWH).

Bartalucci, Claudia / Taramasso, Lucia / Nicolini, Laura Ambra / Magnasco, Laura / Labate, Laura / Vena, Antonio / Mora, Sara / Giacomini, Mauro / Bassetti, Matteo / Di Biagio, Antonio

The new microbiologica

2023 Volume 46, Issue 3, Page(s) 246–251

Abstract: To achieve the World Health Organization goal of hepatitis C virus (HCV) eradication, barriers to treatment should be investigated and overcome. The aim of this study was to identify those barriers and describe the strategies adopted to achieve HCV micro- ...

Abstract	To achieve the World Health Organization goal of hepatitis C virus (HCV) eradication, barriers to treatment should be investigated and overcome. The aim of this study was to identify those barriers and describe the strategies adopted to achieve HCV micro-elimination in a cohort of coinfected people living with HIV (PLWH-HCV). Adult PLWH-HCV followed at our hospital with detectable serum HCV-RNA in 2018 were enrolled. After a three-year follow-up, barriers to HCV treatment were investigated and strategies to overcome them were described. Of 492 PLWH-HCV seen in 2018, 29 (5.9%) had detectable serum HCV-RNA. Eight out of 29 (27.6%) were excluded because they were already under treatment, while 2 others were excluded because they moved to other outpatient clinics. Among the remaining 19 study participants, the most common barriers to treatment were poor adherence to therapies and follow-up visits (n=9, 47%), recent HCV diagnosis awaiting proper staging (n=3, 16%) and treatment hesitancy (n=2, 10%). During the following three years, direct-acting antivirals (DAAs) treatment was completed in 11/19 (58%) cases, with achievement of sustained virological response in 100% of cases. For the remaining cases, 2/19 (10.5%) were lost to follow-up, 2/19 (10.5%) died before treatment initiation and 4/19 (21.0%) are still awaiting treatment. Despite 3 years of effort, HCV micro-elimination has not been achieved at our center. We observed that poor adherence and treatment hesitancy were the main barriers to treatment. Strategies addressing these issues need to be implemented.
MeSH term(s)	Adult ; Humans ; Hepacivirus ; Antiviral Agents/therapeutic use ; Hepatitis C, Chronic ; Hepatitis C/drug therapy ; RNA
Chemical Substances	Antiviral Agents ; RNA (63231-63-0)
Language	English
Publishing date	2023-09-25
Publishing country	Italy
Document type	Journal Article
ZDB-ID	756168-4
ISSN	1121-7138 ; 0391-5352
ISSN	1121-7138 ; 0391-5352
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Article ; Online: Lower (1,3)-beta-d-glucan sensitivity and in vitro levels in Candida auris and Candida parapsilosis strains.

Mikulska, Malgorzata / Ullah, Nadir / Magnasco, Laura / Codda, Giulia / Bartalucci, Claudia / Miletich, Franca / Sepulcri, Chiara / Willison, Edward / Vena, Antonio / Giacobbe, Daniele R / di Pilato, Vincenzo / Robba, Chiara / Ball, Lorenzo / Marchese, Anna / Bassetti, Matteo

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2024

Abstract: Objectives: The serum (1,3)-beta-d-glucan (BDG) assay gives quicker results and has higher sensitivity than blood cultures, therefore it is advised for early diagnosis of invasive candidemia and/or discontinuation of empirical therapy. Its sensitivity ... ...

Abstract	Objectives: The serum (1,3)-beta-d-glucan (BDG) assay gives quicker results and has higher sensitivity than blood cultures, therefore it is advised for early diagnosis of invasive candidemia and/or discontinuation of empirical therapy. Its sensitivity may depend on different factors. The aim of our study was to analyse the in vitro and in vivo BDG levels in clinical isolates of three species of Candida responsible for candidemia. Methods: C. albicans, C. parapsilosis, and C. auris strains were collected from blood cultures of patients who had a concurrent (-1 to +3 days) serum BDG test (Fungitell assay). Supernatants of all strains were tested in quadruplicate for BDG levels. Results: Twenty-two C. auris, 14 C. albicans, and ten C. parapsilosis strains were included. The median BDG levels in supernatants were 463 pg/mL (interquartile range [IQR] 379-648) for C. auris, 1080 pg/mL (IQR 830-1276) for C. albicans, and 755 pg/mL (IQR 511-930) for C. parapsilosis, with the significant difference among the species (p < 0.0001). Median serum BDG levels (IQR) were significantly lower in case C. auris and C. parapsilosis vs. C. albicans (p < 0.0001), respectively, 50 pg/mL (IQR 15-161) and 57 pg/mL (IQR 18-332), vs. 372 pg/mL (IQR 102-520). Sensitivity of serum BDG was 39% (95% confidence interval [CI], 18-64) in case of C. auris, 30% (95% CI, 8-65) C. parapsilosis and 78% (95% CI, 49-94) C. albicans candidemia. Discussion: In our centre C. auris and C. parapsilosis strains have lower BDG content as compared with C. albicans, with a potential impact on serum BDG performance for the diagnosis of candidemia.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2024.02.012
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Innovative therapies for acute bacterial skin and skin-structure infections (ABSSSI) caused by methicillin-resistant

Bassetti, Matteo / Del Puente, Filippo / Magnasco, Laura / Giacobbe, Daniele Roberto

Expert opinion on investigational drugs

2020 Volume 29, Issue 5, Page(s) 495–506

Abstract: Introduction: Methicillin-resistant : Areas covered: In this review, we focus on those novel anti-MRSA agents currently in phase I or II of clinical development that may enrich the armamentarium against ABSSSI caused by MRSA in the future.: Expert ... ...

Abstract	Introduction: Methicillin-resistant Areas covered: In this review, we focus on those novel anti-MRSA agents currently in phase I or II of clinical development that may enrich the armamentarium against ABSSSI caused by MRSA in the future. Expert opinion: Promising agents belonging to either old or novel antibiotic classes are currently in early phases of clinical development and may become available in the future for the effective treatment of ABSSSI caused by MRSA. In particular, the future availability of agents belonging to novel classes will be important for guaranteeing an effective treatment and for allowing outpatient treatment/early discharge, with a consequent reduced impact on healthcare resources. However, this does not mean that we can relax our efforts directed toward improving the responsible use of already available agents. Indeed, preserving their activity in the long term is crucial for optimizing the use of healthcare resources.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Drug Development ; Humans ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Skin Diseases, Bacterial/drug therapy ; Skin Diseases, Bacterial/microbiology ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-04-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1182884-5
ISSN	1744-7658 ; 0967-8298 ; 1354-3784
ISSN (online)	1744-7658
ISSN	0967-8298 ; 1354-3784
DOI	10.1080/13543784.2020.1750595
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