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Book ; Online: Emerging Battery Technologies to Boost the Clean Energy Transition

Passerini, Stefano / Barelli, Linda / Baumann, Manuel / Peters, Jens / Weil, Marcel

Cost, Sustainability, and Performance Analysis

(The Materials Research Society Series)

2024

Author's details	edited by Stefano Passerini, Linda Barelli, Manuel Baumann, Jens Peters, Marcel Weil
Series title	The Materials Research Society Series
Keywords	Electric batteries ; Materials ; Chemistry ; Renewable energy sources
Language	English
Size	1 Online-Ressource (XVI, 337 p. 53 illus., 36 illus. in color)
Edition	1st ed. 2024
Publisher	Springer International Publishing ; Imprint: Springer
Publishing place	Cham
Document type	Book ; Online
HBZ-ID	HT030659163
ISBN	978-3-031-48359-2 ; 9783031483585 ; 9783031483608 ; 9783031483615 ; 3-031-48359-6 ; 3031483588 ; 303148360X ; 3031483618
DOI	10.1007/978-3-031-48359-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: The Role of Plasma Transfusion in Massive Bleeding: Protecting the Endothelial Glycocalyx?

Barelli, Stefano / Alberio, Lorenzo

Frontiers in medicine

2018 Volume 5, Page(s) 91

Abstract: Massive hemorrhage is a leading cause of death worldwide. During the last decade several retrospective and some prospective clinical studies have suggested a beneficial effect of early plasma-based resuscitation on survival in trauma patients. The ... ...

Abstract	Massive hemorrhage is a leading cause of death worldwide. During the last decade several retrospective and some prospective clinical studies have suggested a beneficial effect of early plasma-based resuscitation on survival in trauma patients. The underlying mechanisms are unknown but appear to involve the ability of plasma to preserve the endothelial glycocalyx. In this mini-review, we summarize current knowledge on glycocalyx structure and function, and present data describing the impact of hemorrhagic shock and resuscitation fluids on glycocalyx. Animal studies show that hemorrhagic shock leads to glycocalyx shedding, endothelial inflammatory changes, and vascular hyper-permeability. In these animal models, plasma administration preserves glycocalyx integrity and functions better than resuscitation with crystalloids or colloids. In addition, we briefly present data on the possible plasma components responsible for these effects. The endothelial glycocalyx is increasingly recognized as a critical component for the physiological vasculo-endothelial function, which is destroyed in hemorrhagic shock. Interventions for preserving an intact glycocalyx shall improve survival of trauma patients.
Language	English
Publishing date	2018-04-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2018.00091
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Article ; Online: The Role of Plasma Transfusion in Massive Bleeding

Stefano Barelli / Lorenzo Alberio

Frontiers in Medicine, Vol

Protecting the Endothelial Glycocalyx?

2018 Volume 5

Abstract	Massive hemorrhage is a leading cause of death worldwide. During the last decade several retrospective and some prospective clinical studies have suggested a beneficial effect of early plasma-based resuscitation on survival in trauma patients. The underlying mechanisms are unknown but appear to involve the ability of plasma to preserve the endothelial glycocalyx. In this mini-review, we summarize current knowledge on glycocalyx structure and function, and present data describing the impact of hemorrhagic shock and resuscitation fluids on glycocalyx. Animal studies show that hemorrhagic shock leads to glycocalyx shedding, endothelial inflammatory changes, and vascular hyper-permeability. In these animal models, plasma administration preserves glycocalyx integrity and functions better than resuscitation with crystalloids or colloids. In addition, we briefly present data on the possible plasma components responsible for these effects. The endothelial glycocalyx is increasingly recognized as a critical component for the physiological vasculo-endothelial function, which is destroyed in hemorrhagic shock. Interventions for preserving an intact glycocalyx shall improve survival of trauma patients.
Keywords	massive hemorrhage ; shock ; resuscitation ; fresh frozen plasma ; endothelium ; glycocalyx ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2018-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Managing argatroban in heparin-induced thrombocytopenia: A retrospective analysis of 729 treatment days in 32 patients with confirmed heparin-induced thrombocytopenia.

Marchetti, Matteo / Barelli, Stefano / Gleich, Tobias / Gomez, Francisco J / Goodyer, Matthew / Grandoni, Francesco / Alberio, Lorenzo

British journal of haematology

2022 Volume 197, Issue 6, Page(s) 766–790

MeSH term(s)	Anticoagulants/adverse effects ; Arginine/analogs & derivatives ; Heparin/adverse effects ; Humans ; Pipecolic Acids/therapeutic use ; Retrospective Studies ; Sulfonamides/adverse effects ; Thrombocytopenia/chemically induced ; Thrombocytopenia/drug therapy
Chemical Substances	Anticoagulants ; Pipecolic Acids ; Sulfonamides ; Heparin (9005-49-6) ; Arginine (94ZLA3W45F) ; argatroban (IY90U61Z3S)
Language	English
Publishing date	2022-03-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18120
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Article ; Online: A filter at the entrance of the Golgi that selects vesicles according to size and bulk lipid composition.

Magdeleine, Maud / Gautier, Romain / Gounon, Pierre / Barelli, Hélène / Vanni, Stefano / Antonny, Bruno

eLife

2016 Volume 5

Abstract: When small phosphatidylcholine liposomes are added to perforated cells, they bind preferentially to the Golgi suggesting an exceptional avidity of this organelle for curved membranes without stereospecific interactions. We show that the cis golgin GMAP- ... ...

Abstract	When small phosphatidylcholine liposomes are added to perforated cells, they bind preferentially to the Golgi suggesting an exceptional avidity of this organelle for curved membranes without stereospecific interactions. We show that the cis golgin GMAP-210 accounts for this property. First, the liposome tethering properties of the Golgi resembles that of the amphipathic lipid-packing sensor (ALPS) motif of GMAP-210: both preferred small (radius < 40 nm) liposomes made of monounsaturated but not saturated lipids. Second, reducing GMAP-210 levels or redirecting its ALPS motif to mitochondria decreased liposome capture by the Golgi. Extensive mutagenesis analysis suggests that GMAP-210 tethers authentic transport vesicles via the same mechanism whereby the ALPS motif senses lipid-packing defects at the vesicle surface through its regularly spaced hydrophobic residues. We conclude that the Golgi uses GMAP-210 as a filter to select transport vesicles according to their size and bulk lipid composition.
Language	English
Publishing date	2016-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.16988
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Article ; Online: A sub-nanometre view of how membrane curvature and composition modulate lipid packing and protein recruitment.

Vanni, Stefano / Hirose, Hisaaki / Barelli, Hélène / Antonny, Bruno / Gautier, Romain

Nature communications

2014 Volume 5, Page(s) 4916

Abstract: Two parameters of biological membranes, curvature and lipid composition, direct the recruitment of many peripheral proteins to cellular organelles. Although these traits are often studied independently, it is their combination that generates the unique ... ...

Abstract	Two parameters of biological membranes, curvature and lipid composition, direct the recruitment of many peripheral proteins to cellular organelles. Although these traits are often studied independently, it is their combination that generates the unique interfacial properties of cellular membranes. Here, we use a combination of in vivo, in vitro and in silico approaches to provide a comprehensive map of how these parameters modulate membrane adhesive properties. The correlation between the membrane partitioning of model amphipathic helices and the distribution of lipid-packing defects in membranes of different shape and composition explains how macroscopic membrane properties modulate protein recruitment by changing the molecular topography of the membrane interfacial region. Furthermore, our results suggest that the range of conditions that can be obtained in a cellular context is remarkably large because lipid composition and curvature have, under most circumstances, cumulative effects.
MeSH term(s)	Cell Adhesion ; Cell Line, Transformed ; Cell Membrane/chemistry ; Cell Membrane/metabolism ; Cell Membrane/ultrastructure ; Cell Shape ; Dimyristoylphosphatidylcholine/chemistry ; Epithelial Cells/metabolism ; Epithelial Cells/ultrastructure ; Fatty Acids/chemistry ; GTPase-Activating Proteins/chemistry ; GTPase-Activating Proteins/genetics ; GTPase-Activating Proteins/metabolism ; Gene Expression ; Green Fluorescent Proteins/chemistry ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Lipid Bilayers/chemistry ; Lipid Bilayers/metabolism ; Molecular Dynamics Simulation ; Phosphatidylcholines/chemistry ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Retinal Pigment Epithelium/metabolism ; Retinal Pigment Epithelium/ultrastructure
Chemical Substances	ARFGAP1 protein, human ; Fatty Acids ; GTPase-Activating Proteins ; Lipid Bilayers ; Phosphatidylcholines ; Recombinant Fusion Proteins ; enhanced green fluorescent protein ; Green Fluorescent Proteins (147336-22-9) ; 1,2-oleoylphosphatidylcholine (EDS2L3ODLV) ; 1-palmitoyl-2-oleoylphosphatidylcholine (TE895536Y5) ; Dimyristoylphosphatidylcholine (U86ZGC74V5)
Language	English
Publishing date	2014-09-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/ncomms5916
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Article ; Online: High-dose therapy and autologous hematopoietic stem cell transplant in T-cell lymphoma: a single center experience.

Cairoli, Anne / Ketterer, Nicolas / Barelli, Stefano / Duchosal, Michel A

Leukemia & lymphoma

2014 Volume 55, Issue 8, Page(s) 1827–1831

Abstract: We report here the long-term outcome of autologous stem cell transplant in peripheral T-cell lymphoma (PTCL). Forty-three consecutive patients with PTCL diagnosed between 2000 and 2011 were treated with high-dose chemotherapy (HDCT) and autologous stem ... ...

Abstract	We report here the long-term outcome of autologous stem cell transplant in peripheral T-cell lymphoma (PTCL). Forty-three consecutive patients with PTCL diagnosed between 2000 and 2011 were treated with high-dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) in our center. Diagnoses included PTCL-not otherwise specified (n = 19), anaplastic large cell lymphoma (n = 11), angioimmunoblastic T-cell lymphoma (n = 5), enteropathy-associated T-cell lymphoma (n = 5) and other rare subtypes (n = 3). Thirty-six patients with a median age of 50 years (range 22-65) were transplanted in first response and seven after relapse. After a median follow-up of 63 months, estimated overall survival at 12 years was 40%, progression-free survival at 12 years was 34% and event-free survival at 12 years was 30%. On univariate analysis, age less than 50 years and no B symptoms at diagnosis were significantly associated with prolonged overall and progression-free-survival. HDCT/ASCT for peripheral T-cell lymphoma can lead to long-term survival for patients responding to induction chemotherapy.
MeSH term(s)	Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Disease Progression ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Lymphoma, T-Cell/diagnosis ; Lymphoma, T-Cell/mortality ; Lymphoma, T-Cell/therapy ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Recurrence ; Remission Induction ; Transplantation, Autologous ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2014-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.3109/10428194.2013.852666
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Article ; Online: Generation of procoagulant collagen- and thrombin-activated platelets in platelet concentrates derived from buffy coat: the role of processing, pathogen inactivation, and storage.

Bertaggia Calderara, Debora / Crettaz, David / Aliotta, Alessandro / Barelli, Stefano / Tissot, Jean-Daniel / Prudent, Michel / Alberio, Lorenzo

Transfusion

2018 Volume 58, Issue 10, Page(s) 2395–2406

Abstract: Background: Collagen- and thrombin-activated (COAT) platelets (PLTs), generated by dual-agonist stimulation with collagen and thrombin (THR), enhance THR generation at the site of vessel wall injury. There is evidence that higher amounts of procoagulant ...

Abstract	Background: Collagen- and thrombin-activated (COAT) platelets (PLTs), generated by dual-agonist stimulation with collagen and thrombin (THR), enhance THR generation at the site of vessel wall injury. There is evidence that higher amounts of procoagulant COAT PLTs are associated with stroke, while a decreased ability to generate them is associated with bleeding diathesis. Our aim was to study PLT functions, particularly the ability to generate COAT PLTs, in PLT concentrates (PCs) from buffy coat. Thus, we investigated the effect of processing, pathogen inactivation treatment (amotosalen-UVA), and PC storage. Study design and methods: Two PCs from five donors each were pooled and split in two bags; one of them was pathogen inactivated and the other one was left untreated (n = 5). Flow cytometric analyses were performed immediately after PC preparation (Day 1) and thereafter on Days 2, 5, 7, and 9 in treated and untreated PCs to measure the reactivity of PLTs (CD62P and PAC-1), the content and secretion of dense granule after stimulation with different agonists, and the percentage of COAT PLTs after dual stimulation with convulxin (agonist of the collagen receptor GPVI) and THR. Results: Preparation of PCs resulted in a significant decrease of COAT PLTs and in an impaired response to adenosine 5'-diphosphate sodium (ADP). Storage further decreased ADP response. Minor differences were observed between untreated or amotosalen-UVA-treated PCs. Conclusion: Preparation of PCs from buffy coats decreased the ability to generate COAT PLTs and impaired PLT response to ADP.
MeSH term(s)	Adenosine Diphosphate/pharmacology ; Blood Buffy Coat/cytology ; Blood Platelets/cytology ; Blood Preservation/methods ; Collagen/pharmacology ; Furocoumarins ; Humans ; Platelet Activation/drug effects ; Sterilization/methods ; Thrombin/pharmacology ; Ultraviolet Rays
Chemical Substances	Furocoumarins ; Adenosine Diphosphate (61D2G4IYVH) ; Collagen (9007-34-5) ; Thrombin (EC 3.4.21.5) ; amotosalen (K1LDZ0VBC0)
Language	English
Publishing date	2018-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.14883
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Article ; Online: Rapid and accurate Bayesian diagnosis of heparin-induced thrombocytopenia.

Marchetti, Matteo / Barelli, Stefano / Zermatten, Maxime G / Monnin-Respen, Fanny / Matthey-Guirao, Elena / Nicolas, Nicole / Gomez, Francisco / Goodyer, Matthew / Gerschheimer, Christiane / Alberio, Lorenzo

Blood

2020 Volume 135, Issue 14, Page(s) 1171–1184

Abstract: Prompt diagnostic evaluation of suspected heparin-induced thrombocytopenia (HIT) is critical for guiding initial patient management. We assessed the performance of 3 immunoassays detecting anti-platelet factor 4 (PF4)/heparin antibodies, derived a ... ...

Abstract	Prompt diagnostic evaluation of suspected heparin-induced thrombocytopenia (HIT) is critical for guiding initial patient management. We assessed the performance of 3 immunoassays detecting anti-platelet factor 4 (PF4)/heparin antibodies, derived a diagnostic algorithm with a short analytical turnaround time (TAT), and prospectively validated the algorithm. Plasma samples were analyzed by Zymutest-HIA-IgG, HemosIL-AcuStar-HIT-IgG, and ID-H/PF4-PaGIA in retrospective (n = 221) and prospective (n = 305) derivation cohorts. We calculated likelihood ratios of result intervals and cutoff values with 100% negative (NPV) and positive (PPV) predictive values for a positive gold standard functional assay (heparin-induced platelet activation [HIPA]). A diagnostic algorithm was established based on the Bayesian combination of pretest probability and likelihood ratios of first- and second-line immunoassays. Cutoffs with 100% PPV for positive HIPA were >3.0 U/mL (HemosIL-AcuStar-HIT-IgG) and titer ≥16 (ID-H/PF4-PaGIA); cutoffs with 100% NPV were <0.13 U/mL and ≤1, respectively. During the prospective validation of the derived algorithm (n = 687), HemosIL-AcuStar-HIT-IgG was used as unique testing in 566 (82.4%) of 687 cases (analytical TAT, 30 minutes). In 121 (17.6%) of 687 unresolved cases, ID-H/PF4-PaGIA was used as second-line testing (additional TAT, 30 minutes). The algorithm accurately predicted HIT in 51 (7.4%) of 687 patients and excluded it in 604 (87.9%) of 687 patients, leaving only 20 (2.9%) cases unresolved. We also identified 12 (1.7%) of 687 positive predictions not confirmed by HIPA: 10 patients with probable HIT despite negative HIPA and 2 possible false-positive algorithm predictions. The combination of pretest probability with first- and second-line immunoassays for anti-PF4/heparin antibodies is accurate for ruling in or out HIT in ≥95% of cases within 60 minutes. This diagnostic approach improves initial management of patients with suspected HIT.
MeSH term(s)	Aged ; Antibodies/blood ; Antibodies/immunology ; Anticoagulants/adverse effects ; Anticoagulants/immunology ; Bayes Theorem ; Enzyme-Linked Immunosorbent Assay/economics ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Heparin/adverse effects ; Heparin/immunology ; Humans ; Immunoassay/economics ; Immunoassay/methods ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Male ; Platelet Factor 4/immunology ; Prospective Studies ; Retrospective Studies ; Sensitivity and Specificity ; Thrombocytopenia/blood ; Thrombocytopenia/chemically induced ; Thrombocytopenia/diagnosis ; Time Factors
Chemical Substances	Antibodies ; Anticoagulants ; Immunoglobulin G ; Platelet Factor 4 (37270-94-3) ; Heparin (9005-49-6)
Language	English
Publishing date	2020-10-29
Publishing country	United States
Document type	Journal Article ; Validation Study
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2019002845
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Article ; Online: A filter at the entrance of the Golgi that selects vesicles according to size and bulk lipid composition

Maud Magdeleine / Romain Gautier / Pierre Gounon / Hélène Barelli / Stefano Vanni / Bruno Antonny

eLife, Vol

2016 Volume 5

Abstract	When small phosphatidylcholine liposomes are added to perforated cells, they bind preferentially to the Golgi suggesting an exceptional avidity of this organelle for curved membranes without stereospecific interactions. We show that the cis golgin GMAP-210 accounts for this property. First, the liposome tethering properties of the Golgi resembles that of the amphipathic lipid-packing sensor (ALPS) motif of GMAP-210: both preferred small (radius < 40 nm) liposomes made of monounsaturated but not saturated lipids. Second, reducing GMAP-210 levels or redirecting its ALPS motif to mitochondria decreased liposome capture by the Golgi. Extensive mutagenesis analysis suggests that GMAP-210 tethers authentic transport vesicles via the same mechanism whereby the ALPS motif senses lipid-packing defects at the vesicle surface through its regularly spaced hydrophobic residues. We conclude that the Golgi uses GMAP-210 as a filter to select transport vesicles according to their size and bulk lipid composition.
Keywords	ALPS motif ; membrane curvature ; golgin ; Golgi ; transport vesicle ; perforated cell ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2016-07-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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