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  1. Article: Abnormal Phenylalanine Metabolism of

    Ren, Hong / Zhou, Ping / Shen, Xiaoyun

    Metabolites

    2023  Volume 13, Issue 9

    Abstract: Selenium (Se)-enriched habitats have led to chronic selenosis, seriously affecting the health and survival of Procapra przewalskii ( ...

    Abstract Selenium (Se)-enriched habitats have led to chronic selenosis, seriously affecting the health and survival of Procapra przewalskii (
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13090982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Macroamylasemia or Cholecystitis: What is the Culprit of Abdominal Pain?

    Xie, Runxiang / Zhou, Bingqian / Ding, Xiaoyun

    Gastroenterology

    2023  Volume 166, Issue 3, Page(s) 379–381

    MeSH term(s) Humans ; Hyperamylasemia ; Amylases ; Cholecystitis/complications ; Cholecystitis/diagnosis ; Abdominal Pain/diagnosis ; Abdominal Pain/etiology
    Chemical Substances Amylases (EC 3.2.1.-)
    Language English
    Publishing date 2023-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.10.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical application of metagenomic next-generation sequencing in patients with different organ system infection: A retrospective observational study.

    Zhang, Haiyan / Zhou, Fengli / Liu, Xiaoyun / Huang, Jiabao

    Medicine

    2024  Volume 103, Issue 4, Page(s) e36745

    Abstract: Microbiological identification is essential for appropriate treatment, but conventional methods are time-consuming and have a low sensitivity. In contrast, metagenomic next-generation sequencing (mNGS) is a culture-free and hypothesis-free technique that ...

    Abstract Microbiological identification is essential for appropriate treatment, but conventional methods are time-consuming and have a low sensitivity. In contrast, metagenomic next-generation sequencing (mNGS) is a culture-free and hypothesis-free technique that can detect a wide array of potential pathogens. This study aimed to reveal the overall diagnostic value of mNGS for infectious diseases of different organ systems and compare the sensitivity and specificity of mNGS with conventional methods. In a retrospective cohort study, 94 patients with mNGS results were enrolled, and clinical data were recorded and analyzed to compare the positive rate of mNGS with traditional methods including as smears, serological tests, and traditional PCR, etc. In this study, mNGS and culture were both positive in 12.77% cases and were both negative in 23.4% cases. There were positive results in 56 cases (54.26%) only by mNGS and 4 cases (4.26%) were positive only by culture. There were significant differences in sensitivity of pathogen detection between of ID and NID group for mNGS (χ2 = 10.461, P = .001)and conventional methods(χ2 = 7.963, P = .005). The positive predictive values and negative predictive values of diagnosing infectious disease by mNGS were 94.12% and 30.77%, respectively. mNGS increased the sensitivity rate by approximately 53.66% compared with that of culture (78.05% vs24.39%; χ2 = 47.248, P < .001) and decreased the specificity rate by 12.5% compared with that of culture (66.67% vs 100.0%; χ2 = 4.8, P = .028). mNGS can identify emerging or rare pathogen and further guide treatment regimens. mNGS has advantages in identifying overall pathogens and bacteria, however, there was no obvious advantage in identifying fungi, virus and tuberculosis. mNGS has higher specificity than conventional methods in identifying pathogens and advantages in detecting emerging or rare pathogens.
    MeSH term(s) Humans ; Retrospective Studies ; High-Throughput Nucleotide Sequencing ; Metagenome ; Metagenomics ; Sensitivity and Specificity
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000036745
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  4. Article ; Online: Radiosynthesis of

    Deng, Xiaoyun / Wang, Ziqiang / Zhou, Huimin / Liu, Junyi / Yu, Bo / Zhu, Xiaohua

    Organic letters

    2023  Volume 25, Issue 11, Page(s) 1969–1973

    Abstract: ... A ... ...

    Abstract A novel
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c00516
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  5. Article ; Online: 3-

    Wang, Xiaoyun / Sun, Zhendong / Pei, Yao / Liu, Qian S / Zhou, Qunfang / Jiang, Guibin

    Environmental science & technology

    2023  Volume 57, Issue 30, Page(s) 10998–11008

    Abstract: 3- ...

    Abstract 3-
    Language English
    Publishing date 2023-07-23
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c02346
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  6. Article: Prognostic value and therapeutic potential of NEK family in stomach adenocarcinoma.

    Zhou, Xunjian / Nie, Hui / Wang, Chunrong / Yu, Xiaoqian / Yang, Xuejie / He, Xiaoyun / Ou, Chunlin

    Journal of Cancer

    2024  Volume 15, Issue 10, Page(s) 3154–3172

    Abstract: Never in mitosis gene A-related kinase (NEK) is an 11-membered family of serine/threonine kinases (NEK1-NEK11), which are known to play important roles in the formation and development of cancer. However, few studies have examined the roles of these ... ...

    Abstract Never in mitosis gene A-related kinase (NEK) is an 11-membered family of serine/threonine kinases (NEK1-NEK11), which are known to play important roles in the formation and development of cancer. However, few studies have examined the roles of these kinases in the development of stomach adenocarcinoma (STAD). In this study, we conducted a comprehensive analysis of the relationships between the NEKs family members and STAD. The differential expression of the
    Language English
    Publishing date 2024-04-15
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.90197
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  7. Article ; Online: (±)-Involucrasin D, a pair of enantiomeric bisflavonoid from the roots of

    Zhou, Xiaoying / Jin, Qiong / Zhang, Bingruo / Wei, Lisha / Bao, Lue / Jiang, Xiaoyun / Duan, Rong / Liu, Lu / Yang, Zhuya

    Natural product research

    2024  , Page(s) 1–9

    Abstract: An undescribed bisflavonoid, named involucrasin D ( ...

    Abstract An undescribed bisflavonoid, named involucrasin D (
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2332486
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  8. Article ; Online: Primary Surgical Management of Laryngeal Neuroendocrine Neoplasms: A Single Institution Case Series.

    Gu, Yajun / Liu, Dingding / Gao, Xinyu / Zhou, Han / Song, Panpan / Qian, Xiaoyun

    Ear, nose, & throat journal

    2023  , Page(s) 1455613231183882

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613231183882
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 107: Show issues Location:
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  9. Article ; Online: The value of platelet-rich plasma-derived extracellular vesicles in modern medicine.

    Hou, Ya / Wen, Xiaoyun / Zhou, Liang / Fang, Xiansong

    Annals of medicine

    2023  Volume 55, Issue 2, Page(s) 2287705

    Abstract: Platelet-rich plasma (PRP) has been widely used in clinical practice. The mechanism by which PRP promotes tissue repair lies in the release of multiple growth factors upon platelet activation, which accelerates the proliferation and differentiation of ... ...

    Abstract Platelet-rich plasma (PRP) has been widely used in clinical practice. The mechanism by which PRP promotes tissue repair lies in the release of multiple growth factors upon platelet activation, which accelerates the proliferation and differentiation of repair cells and the synthesis of extracellular matrix. In recent years, as extracellular vesicles (EVs) research has increased and intensified, it has been found that EVs also play an important role in tissue repair. This article provides a comprehensive review of the role of PRP and PRP-derived extracellular vesicles (PRP-EVs) in tissue repair. It discusses the biological characteristics, extraction, identification, activation, and preservation of PRP-EVs. It also reviews their applications in orthopedics and wound repair. The article highlights the importance of PRP-EVs in modern medicine and suggests that they could be a promising natural nanocarrier.
    MeSH term(s) Humans ; Platelet-Rich Plasma ; Extracellular Vesicles ; Blood Platelets/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism
    Chemical Substances Intercellular Signaling Peptides and Proteins
    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2287705
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    Zs.A 680: Show issues Location:
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  10. Article ; Online: Advances in protein kinase drug discovery through targeting gatekeeper mutations.

    Guo, Jing / Zhou, Yang / Lu, Xiaoyun

    Expert opinion on drug discovery

    2023  Volume 18, Issue 12, Page(s) 1349–1366

    Abstract: Introduction: Acquired resistance caused by gatekeeper mutations has become a major challenge for approved kinase inhibitors used in the clinic. Consequently, the development of new-generation inhibitors or degraders to overcome clinical resistance has ... ...

    Abstract Introduction: Acquired resistance caused by gatekeeper mutations has become a major challenge for approved kinase inhibitors used in the clinic. Consequently, the development of new-generation inhibitors or degraders to overcome clinical resistance has become an important research focus for the field.
    Areas covered: This review summarizes the common gatekeeper mutations in druggable kinases and the constantly evolving inhibitors or degraders designed to overcome single or double mutations of gatekeeper residues. Furthermore, the authors provide their perspectives on the medicinal chemistry strategies for addressing clinical resistance with gatekeeper mutations.
    Expert opinion: The authors suggest optimizing kinase inhibitors to interact effectively with gatekeeper residues, altering the binding mode or binding pocket to avoid steric clashes, improving binding affinity with the target, utilizing protein degraders, and developing combination therapy. These approaches have the potential to be effective in overcoming resistance due to gatekeeper residues.
    MeSH term(s) Humans ; Protein Kinases ; Mutation ; Drug Discovery ; Protein Kinase Inhibitors/chemistry ; Drug Resistance, Neoplasm/genetics
    Chemical Substances Protein Kinases (EC 2.7.-) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2259618-5
    ISSN 1746-045X ; 1746-0441
    ISSN (online) 1746-045X
    ISSN 1746-0441
    DOI 10.1080/17460441.2023.2265303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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