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Article ; Online: How does Mei-yu precipitation respond to climate change?

Sun, Bo / Xue, Rufan / Li, Wanling / Zhou, Siyu / Li, Huixin / Zhou, Botao / Wang, Huijun

2023 Volume 10, Issue 12, Page(s) nwad246

Abstract: Mei-yu is an important weather phenomenon in the middle-lower Yangtze River valley (YRV) region ... This study investigates the changes in the characteristics of Mei-yu under global warming and the potential ... the frequency and intensity of extreme precipitation events (EPEs) in the YRV region during the Mei-yu period ...

Abstract	Mei-yu is an important weather phenomenon in the middle-lower Yangtze River valley (YRV) region. This study investigates the changes in the characteristics of Mei-yu under global warming and the potential reasons based on observation and reanalysis data during 1961-2022. Notable increasing long-term trends are detected in the number of days without rainfall (NDWOR), the intensity of rainfall events, and the frequency and intensity of extreme precipitation events (EPEs) in the YRV region during the Mei-yu period (15 June-10 July) over past decades. The increasing trend in NDWOR is attributed to decreased relative humidity over land surface and a longer time for the air to be replenished with moisture after rainfall events in a warming climate. The increasing trends in the intensity of rainfall events and frequency/intensity of EPEs are attributed to the strengthened transient water vapor convergence and convection in the atmosphere under global warming. Furthermore, the response of Mei-yu to 2°C of global warming with respect to the pre-industrial climate is analysed using CMIP6 models. The results suggest that the NDWOR, intensity of rainfall events and frequency of EPEs will increase in the YRV region during the Mei-yu period under the 2°C warming scenario, which implies a more challenging climate risk management in the future. Overall, the intensity of rainfall events during the Mei-yu period has the most significant response to climate change in observations and projections. The model results have a relatively large uncertainty.
Language	English
Publishing date	2023-09-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2745465-4
ISSN	2053-714X ; 2053-714X
ISSN (online)	2053-714X
ISSN	2053-714X
DOI	10.1093/nsr/nwad246
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Article ; Online: Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis.

Zhang, Peiguang / Cao, Jieqiong / Liang, Xujing / Su, Zijian / Zhang, Bihui / Wang, Zhenyu / Xie, Junye / Chen, Gengrui / Chen, Xue / Zhang, Jinting / Feng, Yanxian / Xu, Qin / Song, Jianping / Hong, An / Chen, Xiaojia / Zhang, Yibo

Acta biochimica et biophysica Sinica

2024 Volume 56, Issue 4, Page(s) 621–633

Abstract: ... therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with a global prevalence of 25%. Patients with NAFLD are more likely to suffer from advanced liver disease, cardiovascular disease, or type II diabetes. However, unfortunately, there is still a shortage of FDA-approved therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades to treat liver disorders. It has recently been applied to type II diabetes which is closely related to insulin resistance. Given that NAFLD is another disease involved in insulin resistance, we hypothesize that LMY might be a promising formula for NAFLD therapy. Herein, we verify that the LMY formula effectively reduces hepatic steatosis in diet-induced zebrafish and NAFLD model mice in a time- and dose-dependent manner. Mechanistically, LMY suppresses Yap1-mediated Foxm1 activation, which is crucial for the occurrence and development of NAFLD. Consequently, lipogenesis is ameliorated by LMY administration. In summary, the LMY formula alleviates diet-induced NAFLD in zebrafish and mice by inhibiting Yap1/Foxm1 signaling-mediated NAFLD pathology.
MeSH term(s)	Humans ; Mice ; Animals ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Lipogenesis ; Zebrafish ; Insulin Resistance ; Diabetes Mellitus, Type 2/metabolism ; Liver/metabolism ; Diet, High-Fat ; Transcription Factors/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Lipids ; Mice, Inbred C57BL ; Forkhead Box Protein M1/metabolism
Chemical Substances	Transcription Factors ; Adaptor Proteins, Signal Transducing ; Lipids ; FOXM1 protein, human ; Forkhead Box Protein M1
Language	English
Publishing date	2024-03-22
Publishing country	China
Document type	Journal Article
ZDB-ID	2175256-4
ISSN	1745-7270 ; 0582-9879 ; 1672-9145
ISSN (online)	1745-7270
ISSN	0582-9879 ; 1672-9145
DOI	10.3724/abbs.2024025
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Article ; Online: Treatment of ulcerative colitis with Wu-Mei-Wan by inhibiting intestinal inflammatory response and repairing damaged intestinal mucosa.

Yan, Shuguang / Wang, Ping / Wei, Hailiang / Jia, Rui / Zhen, Meijia / Li, Qian / Xue, Chang / Li, Jingtao

Phytomedicine : international journal of phytotherapy and phytopharmacology

2022 Volume 105, Page(s) 154362

Abstract: Background: Wu-Mei-Wan (WMW), a traditional Chinese medicine, has been applied in the treatment ...

Abstract	Background: Wu-Mei-Wan (WMW), a traditional Chinese medicine, has been applied in the treatment of gastrointestinal diseases with long-term diarrhea and mucopurulent bloody stool as the main symptoms since ancient times. Studies have shown that WMW inhibits intestinal inflammation, repairs damaged intestinal mucosa, resists colon necrosis, and resists intestinal fibrosis. However, the specific mechanism of action is not yet clear. Objective: Ulcerative colitis (UC), an intestinal disease with intestinal inflammation and injury as the main pathological manifestations, is one of the high-risk factors for colon cancer. Inhibiting the inflammatory response and promoting colonic epithelial repair are critical to the treatment of UC. However, there is still a lack of remedies with satisfactory curative effects. In this study, the role of WMW in dextran sulfate sodium (DSS)-induced colitis in mice and its related mechanisms are discussed from two aspects: intestinal inflammation and tissue repair. Methods: DSS was used to induce colitis in mice and the therapeutic effect of WMW was analyzed by disease activity score, histopathological score, colon length measurement, serum cytokine detection, and flow cytometry. Macrophage activation and colonic stem cell proliferation were observed by immunohistochemistry. The expression of critical molecules in macrophage activation and colonic stem cell proliferation signaling pathways in colon tissue was detected with immunohistochemistry, immunofluorescence staining, RT-qPCR, and Western blot. Results: WMW could significantly alleviate DSS-induced colitis. We showed that WMW could reduce disease activity, reduce pathological scores, limit weight loss, inhibit colon shortening, inhibit inflammatory factor secretion, attenuate inflammatory response, and promote the repair of damaged colonic epithelium. WMW inhibited the activation of colonic macrophages, and its mechanism might be inhibiting the Notch/NF-κB/NLRP3 pathway; WMW promoted the proliferation of colonic stem cells, and its mechanism was associated with the regulation of the Hippo/YAP signaling pathway. Conclusion: The results of this study suggested that WMW could treat UC via a mechanism that inhibited the intestinal inflammatory response and repaired damaged intestinal mucosa.
MeSH term(s)	Animals ; Colitis ; Colitis, Ulcerative ; Colon ; Dextran Sulfate ; Disease Models, Animal ; Inflammation ; Intestinal Mucosa ; Mice ; Mice, Inbred C57BL ; NF-kappa B
Chemical Substances	NF-kappa B ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2022-07-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154362
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Article: Treatment of ulcerative colitis with Wu-Mei-Wan by inhibiting intestinal inflammatory response and repairing damaged intestinal mucosa

Yan, Shuguang / Wang, Ping / Wei, Hailiang / Jia, Rui / Zhen, Meijia / Li, Qian / Xue, Chang / Li, Jingtao

Phytomedicine. 2022 Oct., v. 105

2022

Abstract: Wu-Mei-Wan (WMW), a traditional Chinese medicine, has been applied in the treatment ...

Abstract	Wu-Mei-Wan (WMW), a traditional Chinese medicine, has been applied in the treatment of gastrointestinal diseases with long-term diarrhea and mucopurulent bloody stool as the main symptoms since ancient times. Studies have shown that WMW inhibits intestinal inflammation, repairs damaged intestinal mucosa, resists colon necrosis, and resists intestinal fibrosis. However, the specific mechanism of action is not yet clear. Ulcerative colitis (UC), an intestinal disease with intestinal inflammation and injury as the main pathological manifestations, is one of the high-risk factors for colon cancer. Inhibiting the inflammatory response and promoting colonic epithelial repair are critical to the treatment of UC. However, there is still a lack of remedies with satisfactory curative effects. In this study, the role of WMW in dextran sulfate sodium (DSS)-induced colitis in mice and its related mechanisms are discussed from two aspects: intestinal inflammation and tissue repair. DSS was used to induce colitis in mice and the therapeutic effect of WMW was analyzed by disease activity score, histopathological score, colon length measurement, serum cytokine detection, and flow cytometry. Macrophage activation and colonic stem cell proliferation were observed by immunohistochemistry. The expression of critical molecules in macrophage activation and colonic stem cell proliferation signaling pathways in colon tissue was detected with immunohistochemistry, immunofluorescence staining, RT-qPCR, and Western blot. WMW could significantly alleviate DSS-induced colitis. We showed that WMW could reduce disease activity, reduce pathological scores, limit weight loss, inhibit colon shortening, inhibit inflammatory factor secretion, attenuate inflammatory response, and promote the repair of damaged colonic epithelium. WMW inhibited the activation of colonic macrophages, and its mechanism might be inhibiting the Notch/NF-κB/NLRP3 pathway; WMW promoted the proliferation of colonic stem cells, and its mechanism was associated with the regulation of the Hippo/YAP signaling pathway. The results of this study suggested that WMW could treat UC via a mechanism that inhibited the intestinal inflammatory response and repaired damaged intestinal mucosa.
Keywords	Oriental traditional medicine ; Western blotting ; blood serum ; cell proliferation ; colon ; colorectal neoplasms ; cytokines ; dextran sulfate ; diarrhea ; fibrosis ; flow cytometry ; fluorescent antibody technique ; histopathology ; immunohistochemistry ; inflammation ; intestinal mucosa ; macrophage activation ; macrophages ; mechanism of action ; necrosis ; secretion ; stem cells ; therapeutics ; tissue repair ; ulcerative colitis ; weight loss
Language	English
Dates of publication	2022-10
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154362
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The water extract of "Jiao Mei Gu" attenuates the lipopolysaccharide-induced inflammatory response via inhibiting NF-κB activity in mice.

Luo, Li / Zhang, Wei / Zhang, Zaiqi / Zhu, Junyu / Li, Wei / Yi, Yuhao / Yang, Xue / Ma, Wei / Liang, Huaping

Journal of ethnopharmacology

2020 Volume 259, Page(s) 112882

Abstract: Ethnopharmacological relevance: Jiao Mei Gu (JMG), Cayratia albifolia C.L.Li, is a type of Dong ...

Abstract	Ethnopharmacological relevance: Jiao Mei Gu (JMG), Cayratia albifolia C.L.Li, is a type of Dong plant widely growing in Dong autonomous counties, Hunan province, China. As a type of traditional herbal medicine, the root of JMG plant has been used to treat inflammatory-related diseases such as arthritis because of its prominent anti-inflammatory effects in Dong medicine. Aim of the study: This work investigated the anti-inflammatory effects and mechanisms of the water extract from the root of JMG on lipopolysaccharide (LPS)-induced inflammatory models. Methods: Endotoxemia was induced in C57BL/6 mice by intraperitoneal injection of LPS (20 mg/kg), meanwhile intraperitoneal administration of safe doses of JMG. The survival curve of mice was determined. Serum inflammatory cytokines were detected by the Bio-Plex Mouse Cytokine 23-Plex Panel Kit and enzyme-linked immunosorbent assay (ELISA) at 6 h after drug treatment. Hematoxylin-eosin (HE) staining of important organs was completed at 24 h after treatment. The mechanism of inflammatory action was investigated in vitro on LPS-stimulated macrophages. Macrophage inflammation was then induced using 10 μg/mL LPS. The anti-inflammatory effect of JMG was investigated by the quantitative polymerase chain reaction (qPCR) and ELISA. The anti-inflammatory mechanism was determined using western blotting, the electrophoretic mobility shift assay, and immunocytochemistry. Finally, the antimicrobial activity of JMG was verified by survival experiments in vivo and by bacterial culture experiments in vitro. Results: A 200 mg/kg water extract of JMG was safe for mice and had a significant protective effect on LPS-induced sepsis. Organ damage of heart, liver, lung and kidney was also significantly reduced at 24 h in the JMG group, when compared with the LPS group. The serum MIP-1α (CCL-3), MIP-1β (CCL-4), IL-1β, and TNFα cytokines were significantly decreased at 6 h in the JMG group, when compared with the LPS group. In a similar manner, 0.2μg/ml JMG significantly reduced mRNA and protein levels of MIP-1α (CCL-3), MIP-1β (CCL-4), IL-1β, and TNFα in LPS-stimulated macrophage. JMG treatment inhibited the phosphorylation of NF-κB p65 and reduced nuclear transduction, thus reducing transcriptional activity. At the same time, we showed that JMG had no protective effect on Escherichia coli-induced sepsis, as well as no antimicrobial activity. Conclusions: Our results showed that a water-soluble extract of JMG inhibited LPS-induced inflammation via attenuating the NF-κB signaling pathway, which provides an important rationale for the treatment of inflammation-related diseases.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Cytokines/blood ; Cytokines/metabolism ; Drugs, Chinese Herbal/pharmacology ; Endotoxemia/chemically induced ; Endotoxemia/drug therapy ; Escherichia coli ; I-kappa B Proteins/metabolism ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Signal Transduction/drug effects ; Transcription Factor RelA/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; Drugs, Chinese Herbal ; I-kappa B Proteins ; Lipopolysaccharides ; NF-kappa B ; Transcription Factor RelA ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2020-04-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112882
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Article ; Online: Genome-wide identification, characterisation, and evolution of ABF/AREB subfamily in nine Rosaceae species and expression analysis in mei (Prunus mume)

Xue Yong / Tangchun Zheng / Xiaokang Zhuo / Sagheer Ahmad / Lulu Li / Ping Li / Jiayao Yu / Jia Wang / Tangren Cheng / Qixiang Zhang

PeerJ, Vol 9, p e

2021 Volume 10785

Abstract: Rosaceae is an important family containing some of the highly evolved fruit and ornamental plants. Abiotic stress responses play key roles in the seasonal growth and development of plants. However, the molecular basis of stress responses remains largely ... ...

Abstract	Rosaceae is an important family containing some of the highly evolved fruit and ornamental plants. Abiotic stress responses play key roles in the seasonal growth and development of plants. However, the molecular basis of stress responses remains largely unknown in Rosaceae. Abscisic acid (ABA) is a stress hormone involving abiotic stress response pathways. The ABRE-binding factor/ABA-responsive element-binding protein (ABF/AREB) is a subfamily of the basic domain/leucine zipper (bZIP) transcription factor family. It plays an important role in the ABA-mediated signaling pathway. Here, we analyzed the ABF/AREB subfamily genes in nine Rosaceae species. A total of 64 ABF/AREB genes were identified, including 18, 28, and 18 genes in the Rosoideae, Amygdaloideae, and Maloideae traditional subfamilies, respectively. The evolutionary relationship of the ABF/AREB subfamily genes was studied through the phylogenetic analysis, the gene structure and conserved motif composition, Ka/Ks values, and interspecies colinearity. These gene sets were clustered into four groups. In the Prunus ABF/AREB (PmABF) promoters, several cis-elements related to light, hormone, and abiotic stress response were predicted. PmABFs expressed in five different tissues, except PmABF5, which expressed only in buds. In the dormancy stages, PmABF1, 2, 5 and 7 showed differential expression. The expression of PmABF3, 4 and 6 was positively correlated with the ABA concentration. Except for PmABF5, all the PmABFs were sensitive to ABA. Several ABRE elements were contained in the promoters of PmABF1, 3, 6, 7. Based on the findings of our study, we speculate that PmABFs may play a role in flower bud dormancy in P. mume.
Keywords	Rosaceae ; ABF/AREB ; ABRE ; Evolution ; Expression ; Prunus mume ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	572
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
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Article: Case Report: Prenatal neurological injury in a neonate with pyruvate carboxylase deficiency type B.

Xue, Mei

Frontiers in endocrinology

2023 Volume 14, Page(s) 1199590

Abstract: Background: Pyruvate carboxylase (PC) is a key enzyme for gluconeogenesis. PC deficiency (PCD) is an extremely rare autosomal recessive metabolic disease and is divided into three types. Type B PCD is clinically featured by lactic acidosis, ... ...

Abstract	Background: Pyruvate carboxylase (PC) is a key enzyme for gluconeogenesis. PC deficiency (PCD) is an extremely rare autosomal recessive metabolic disease and is divided into three types. Type B PCD is clinically featured by lactic acidosis, hyperammonemia, hypercitrullinemia, hypotonia, abnormal movement, and seizures. Case presentation: Here, we report the first case of type B PCD in China, presenting with intractable lactic acidosis shortly after birth. A compound heterozygous mutation in the PC gene was identified by whole-exome sequencing, NM_001040716.2: c.1154_1155del and c.152G>A, which were inherited from her asymptomatic parents, respectively. Furthermore, prenatal neuroradiological presentations including widened posterior horns of lateral ventricles, huge subependymal cysts, and increased biparietal diameter and head circumference were concerned. Symptomatic treatment was taken and the infant died at 26 days. Conclusion: To our knowledge, this is the minimum gestational age (22w5d) that's when the prenatal onset of the neuroradiologic phenotype of PCD was observed. PCD has a poor prognosis and lacks an effective treatment, so this paper is shared to highlight the importance of PCD prenatal diagnosis in the absence of family history.
MeSH term(s)	Pregnancy ; Female ; Humans ; Pyruvate Carboxylase Deficiency Disease/diagnosis ; Pyruvate Carboxylase Deficiency Disease/genetics ; Acidosis, Lactic ; Pyruvate Carboxylase/genetics ; Seizures ; Muscle Hypotonia
Chemical Substances	Pyruvate Carboxylase (EC 6.4.1.1)
Language	English
Publishing date	2023-07-07
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1199590
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Article: Circulating micronutrient levels and their association with sepsis susceptibility and severity: a Mendelian randomization study.

Wei, Zhengxiao / Liu, Yingfen / Mei, Xue / Zhong, Jing / Huang, Fuhong

Frontiers in genetics

2024 Volume 15, Page(s) 1353118

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2024.1353118
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Article ; Online: Expression level of serum miR-374a-5p in patients with acute pancreatitis and its effect on viability, apoptosis, and inflammatory factors of pancreatic acinar cells induced by cerulein.

Wang, Fu-Jun / Mei, Xue

The Kaohsiung journal of medical sciences

2023 Volume 39, Issue 6, Page(s) 616–623

Abstract: Acute pancreatitis (AP) is one of the life-threatening diseases of the digestive system. MicroRNA has been asserted to be a regulator of AP. This paper explored the miR-374a-5p expression in AP patients and investigated the efficacy of AR42J cells. In ... ...

Abstract	Acute pancreatitis (AP) is one of the life-threatening diseases of the digestive system. MicroRNA has been asserted to be a regulator of AP. This paper explored the miR-374a-5p expression in AP patients and investigated the efficacy of AR42J cells. In this study, 60 healthy people, 58 MAP patients and 58 SAP patients were included, and the serum miR-374a-5p levels of the subjects were detected by RT-qPCR technology. The pancreatitis cell model was structured by stimulating AR42J cells with cerulein. Next, cell viability and apoptosis were detected by CCK-8 assay and flow cytometry. ELISA was used to measure the concentration of cytokines, such as TNF-α, IL-6, and IL-1β. The data showed that miR-374a-5p was downregulated in samples from AP patients, while showing discriminative power for AP populations. Attenuated miR-374a-5p were negatively bound up with patients' Ranson score and APACHE II score. Besides, miR-374a-5p was declined in cerulein-treated AR42J cells and forced elevation of miR-374a-5p was beneficial to increase cell viability, and inhibit cell apoptosis and inflammation. The present study found that miR-374a-5p was reduced in AP serum samples, and up-regulated expression level of miR-374a-5p in cell models had a protective effect on cerulein-induced inhibition of cell function and inflammatory response.
MeSH term(s)	Humans ; Pancreatitis/genetics ; Ceruletide/adverse effects ; Ceruletide/metabolism ; Acinar Cells/metabolism ; Acute Disease ; MicroRNAs/metabolism ; Apoptosis/genetics
Chemical Substances	Ceruletide (888Y08971B) ; MicroRNAs
Language	English
Publishing date	2023-03-13
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12666
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Article ; Online: Effect of CASC15 on apoptosis and oxidative stress of cardiomyocytes after hypoxia/reperfusion injury.

Sun, Shuai / Mei, Xue

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

2023 Volume 43, Issue 2, Page(s) 77–84

Abstract: Introduction and objectives: The increasing incidence of ischemic heart disease is a serious threat to human health. Increased CASC15, a long non-coding RNA, has been shown to adversely affect cardiac muscle. The objective of this paper was to explore ... ...

Abstract	Introduction and objectives: The increasing incidence of ischemic heart disease is a serious threat to human health. Increased CASC15, a long non-coding RNA, has been shown to adversely affect cardiac muscle. The objective of this paper was to explore the effect of CASC15 on a cell model of myocardial infarction and its possible mechanism. Methods: H9c2 cells were selected to establish the myocardial infarction model through hypoxia/reoxygenation (H/R) treatment. The expression of CASC15 was attenuated by cell transfection in vitro. The level of CASC15 was detected by RT-qPCR. Cell viability was detected by CCK-8 assay, and cell apoptosis was assessed by flow cytometry. The content of MDA and the activity of SOD and GSH-Px were measured by ELISA. Luciferase reporter gene assay was used to determine the relationship between CASC15 and miRNA. Results: CASC15 expression was increased in H/R-treated H9c2 cells. Overexpression of CASC15 adversely affected cell viability and promoted H/R-induced oxidative stress. Inhibition of CASC15 promoted cell viability and suppressed cell apoptosis and oxidative stress damage. Additionally, luciferase reporter gene assay confirmed the targeting relationship between CASC15 and miR-542-3p, and attenuating CASC15 expression enhanced the level of miR-542-3p. Reduction of miR-542-3p weakened the viability of the H/R cell model, increased apoptosis, and enhanced oxidative stress damage. Conclusion: This study suggests that overexpression of CASC15 may inhibit the viability of H9c2 cells, promote apoptosis and induce oxidative stress through targeted regulation of miR-542-3p expression.
MeSH term(s)	Humans ; Apoptosis/genetics ; Hypoxia/metabolism ; Luciferases/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Myocardial Infarction ; Myocytes, Cardiac/metabolism ; Oxidative Stress ; Reperfusion Injury/metabolism ; Animals ; Rats
Chemical Substances	Luciferases (EC 1.13.12.-) ; MicroRNAs
Language	Portuguese
Publishing date	2023-08-29
Publishing country	Portugal
Document type	Journal Article
ZDB-ID	632718-7
ISSN	2174-2030 ; 0870-2551 ; 0304-4750
ISSN (online)	2174-2030
ISSN	0870-2551 ; 0304-4750
DOI	10.1016/j.repc.2023.04.017
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