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  1. Article: The Role of Vildagliptin in the Therapy of Type 2 Diabetic Patients with Renal Dysfunction.

    Trevisan, Roberto

    Diabetes therapy : research, treatment and education of diabetes and related disorders

    2017  Volume 8, Issue 6, Page(s) 1215–1226

    Abstract: Diabetes is the leading cause of chronic kidney disease, and even in the absence of albuminuria, decreased renal function in type 2 diabetes mellitus (T2DM) patients increases the risk for major adverse cardiovascular events and death. The evidence ... ...

    Abstract Diabetes is the leading cause of chronic kidney disease, and even in the absence of albuminuria, decreased renal function in type 2 diabetes mellitus (T2DM) patients increases the risk for major adverse cardiovascular events and death. The evidence derived from recent studies suggests that intensive glucose control not only reduces the risk for microalbuminuria and macroalbuminuria but may also decrease the rate of decline of glomerular filtration rate (GFR). Although insulin therapy is widely used in patients with T2DM and renal disease, metabolic control is particularly difficult to achieve and manage because of the limited therapeutic options and the frequent comorbidities seen in this population. Recent evidence suggests that dipeptidyl peptidase-4 (DPP-4) inhibitors may offer a better choice for improving glycemic control in T2DM patients with low GFR. This review will focus on vildagliptin, a DPP-4 inhibitor with a large body of evidence in patients with moderate to severe renal failure and a good clinical profile in terms of efficacy and safety. In particular, vildagliptin, with appropriate dose adjustment, provides clinically important reductions in glycated hemoglobin, without increasing weight and the risk of hypoglycemia even in patients with severe chronic kidney disease.
    Language English
    Publishing date 2017-10-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2566702-6
    ISSN 1869-6961 ; 1869-6953
    ISSN (online) 1869-6961
    ISSN 1869-6953
    DOI 10.1007/s13300-017-0302-3
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  2. Article ; Online: Sub-Gigahertz Path Loss Measurement Campaign in Marine Environment: A Case Study.

    De Piante, Marco / Midrio, Michele / Rinaldo, Roberto / Scagnetto, Ivan / Specogna, Ruben / Trevisan, Francesco

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 8

    Abstract: This paper focuses on the characterization of radio propagation, and data communication in a marine environment. More specifically, we consider signal propagation when three different sub-gigahertz industrial, scientific, and medical (ISM) bands, i.e., ... ...

    Abstract This paper focuses on the characterization of radio propagation, and data communication in a marine environment. More specifically, we consider signal propagation when three different sub-gigahertz industrial, scientific, and medical (ISM) bands, i.e., 169 MHz, 434 MHz, and 868 MHz, are used. The main focus of the paper is to evaluate the path loss (PL), i.e., the power loss that a propagation radio wave would experience when communication occurs between a sail boat and a buoy. We describe the measurement results obtained performing three different radio power measurement campaigns, at the three different aforementioned ISM sub-gigahertz bands. We also want to correlate the radio propagation quality with the weather conditions present in the measurement areas. The obtained results show that higher distances are achieved by transmitting at lower frequencies, i.e., 169 MHz, and, on average, the propagation is directly dependent from the dew point index.
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24082582
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  3. Article: Does denosumab exert a protective effect against COVID-19? Results of a large cohort study.

    Cassibba, Sara / Ippolito, Silvia / Pellegrini, Silvia / Trevisan, Roberto / Rossini, Alessandro

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1283101

    Abstract: Introduction: Denosumab is a monoclonal antibody blocking the receptor activator of nuclear factor kappa-B/receptor activator of nuclear factor kappa-B ligand (RANK/RANKL) pathway, thus inhibiting osteoclastogenesis. Since RANK and RANKL are also ... ...

    Abstract Introduction: Denosumab is a monoclonal antibody blocking the receptor activator of nuclear factor kappa-B/receptor activator of nuclear factor kappa-B ligand (RANK/RANKL) pathway, thus inhibiting osteoclastogenesis. Since RANK and RANKL are also involved in the immune system activation, denosumab might interfere with the response against infections. Our study aimed to explore the relationship between denosumab treatment and coronavirus disease 2019 (COVID-19).
    Design and methods: The occurrence and severity of COVID-19 were recorded in consecutive patients referred to the Endocrinology Department of Papa Giovanni XXIII Hospital, Bergamo, from 1 January 2020 to 1 January 2021. Patients treated with denosumab were compared to outpatient controls. Patients' features were summarized by descriptive statistics. Multivariate logistic regression assessed the relationship between denosumab and COVID-19, adjusting for potential confounders. Subgroup analyses according to age, sex, body mass index (BMI), smoking status, and vitamin D levels were performed.
    Results: The final population included 331 patients treated with denosumab and 357 controls. COVID-19 incidence was lower in the denosumab group (7.6% vs. 14.6%, p = 0.004). COVID-19 severity was similar in both groups. Multiple logistic regression confirmed an association between denosumab and a reduced occurrence of symptomatic COVID-19 [odds ratio (OR) 0.46, 95% CI 0.21-0.98, p = 0.049]. Subgroup analyses suggested a potential protective effect of denosumab in patients over 75 years (OR 0.12, 95% CI 0.02-0.6, p = 0.011), with a significant interaction between denosumab and age categories (p = 0.047).
    Conclusion: Our study confirms that denosumab may be safely continued in COVID-19 patients. RANK/RANKL inhibition seems associated with a reduced incidence of symptomatic COVID-19, particularly among the elderly.
    MeSH term(s) Humans ; Aged ; Denosumab/therapeutic use ; Osteoporosis/metabolism ; Cohort Studies ; COVID-19/complications ; Bone Density Conservation Agents/therapeutic use ; Bone Density Conservation Agents/pharmacology
    Chemical Substances Denosumab (4EQZ6YO2HI) ; Bone Density Conservation Agents
    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1283101
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  4. Article ; Online: Liver Stiffness, Albuminuria and Chronic Kidney Disease in Patients with NAFLD: A Systematic Review and Meta-Analysis.

    Ciardullo, Stefano / Ballabeni, Cinzia / Trevisan, Roberto / Perseghin, Gianluca

    Biomolecules

    2022  Volume 12, Issue 1

    Abstract: An association between liver stiffness, a surrogate measure of liver fibrosis, and chronic kidney disease (CKD) in patients with nonalcoholic fatty liver disease (NAFLD) has been proposed. However, most studies were small and had low statistical power. ... ...

    Abstract An association between liver stiffness, a surrogate measure of liver fibrosis, and chronic kidney disease (CKD) in patients with nonalcoholic fatty liver disease (NAFLD) has been proposed. However, most studies were small and had low statistical power. We systematically searched PubMed-MEDLINE and Scopus from inception to August 2021 for cross-sectional or cohort studies reporting the association between liver stiffness diagnosed by vibration controlled transient elastography (VCTE) and renal dysfunction. The primary outcome was CKD, defined as a composite of urinary albumin to creatinine ratio (UACR) ≥ 30 mg/g and estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m
    MeSH term(s) Albuminuria ; Cross-Sectional Studies ; Humans ; Non-alcoholic Fatty Liver Disease/complications ; Renal Insufficiency, Chronic/complications
    Language English
    Publishing date 2022-01-08
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12010105
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  5. Article ; Online: Real-World Insulin Treatment in Pregnant Women with Type 1 Diabetes Using an Advanced Hybrid Closed-Loop System.

    Dodesini, Alessandro Roberto / Borella, Nicolò Diego / Lepore, Giuseppe / Bonfadini, Silvia / Corsi, Anna / Scaranna, Cristiana / Bellante, Rosalia / Trevisan, Roberto

    Diabetes technology & therapeutics

    2023  Volume 25, Issue 7, Page(s) 516–518

    MeSH term(s) Female ; Pregnancy ; Humans ; Diabetes Mellitus, Type 1/drug therapy ; Pregnant Women ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Blood Glucose ; Insulin Infusion Systems ; Blood Glucose Self-Monitoring
    Chemical Substances Hypoglycemic Agents ; Insulin ; Blood Glucose
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Letter
    ZDB-ID 1452816-2
    ISSN 1557-8593 ; 1520-9156
    ISSN (online) 1557-8593
    ISSN 1520-9156
    DOI 10.1089/dia.2023.0031
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  6. Article ; Online: Reply to "Liver fibrosis assessed by transient elastography and albuminuria".

    Ciardullo, Stefano / Ballabeni, Cinzia / Trevisan, Roberto / Perseghin, Gianluca

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2021  Volume 53, Issue 8, Page(s) 1056

    MeSH term(s) Albuminuria/pathology ; Elasticity Imaging Techniques ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/pathology
    Language English
    Publishing date 2021-05-11
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2021.04.003
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  7. Article ; Online: Resilience in pregnant women with pre-gestational diabetes during COVID-19 pandemic: the experience of the Papa Giovanni XXIII Hospital in Bergamo, Italy.

    Dodesini, Alessandro Roberto / Caffi, Anna / Spada, Maria Simonetta / Trevisan, Roberto

    Acta diabetologica

    2020  Volume 58, Issue 3, Page(s) 397–399

    Language English
    Publishing date 2020-11-25
    Publishing country Germany
    Document type Letter
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-020-01640-3
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    Zs.A 611: Show issues Location:
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  8. Book: Impact of substitution among generic drugs on persistence and adherence

    Colombo, Giorgio L. / Agabiti-Rosei, Enrico / Margonato, Alberto / Mencacci, Claudio / Montecucco, Carlomaurizio / Trevisan, Roberto / Catapano, Alberico L.

    a retrospective claims data study from 2 local healthcare units in the Lombardy region of Italy : the supplement is from the Annual National Meeting of the SITeCS

    (Atherosclerosis. Supplements ; volume 21 (June 2016))

    2016  

    Author's details Giorgio L. Colombo, Enrico Agabiti-Rosei, Alberto Margonato, Claudio Mencacci, Carlo Maurizio Montecucco, Roberto Trevisan, Alberico L. Catapano
    Series title Atherosclerosis. Supplements ; volume 21 (June 2016)
    Atherosclerosis
    Collection Atherosclerosis
    Language English
    Size 8 Seiten
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT019628660
    Database Catalogue ZB MED Medicine, Health

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    Zs A 226 -Suppl.21- not available for loan Zeitschriften-Lesesaal

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  9. Article ; Online: The Hyperfiltering Kidney in Diabetes.

    Trevisan, Roberto / Dodesini, Alessandro Roberto

    Nephron

    2017  Volume 136, Issue 4, Page(s) 277–280

    Abstract: Hyperfiltering kidney is a typical feature of diabetes. Improvement observed with regard to glucose control and blood pressure control reduces the high glomerular filtration rate and may contribute to retard the appearance and the progression of diabetic ...

    Abstract Hyperfiltering kidney is a typical feature of diabetes. Improvement observed with regard to glucose control and blood pressure control reduces the high glomerular filtration rate and may contribute to retard the appearance and the progression of diabetic renal disease. Although the mechanism of hyperfiltration is still unclear, there is mounting evidence that the increased reabsorption of glucose and sodium by sodium glucose transporter-2 (SGLT-2) is involved in this altered renal function. There is a possibility that SGLT-2 inhibition may correct hyperfiltration in diabetes, adding a new therapeutic approach to halt renal disease in patients with diabetes.
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000448183
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  10. Article ; Online: Development of a New Model of Insulin Sensitivity in Patients With Type 2 Diabetes and Association With Mortality.

    Ciardullo, Stefano / Dodesini, Alessandro Roberto / Lepore, Giuseppe / Corsi, Anna / Scaranna, Cristiana / Perseghin, Gianluca / Trevisan, Roberto

    The Journal of clinical endocrinology and metabolism

    2023  Volume 109, Issue 5, Page(s) 1308–1317

    Abstract: Context: Despite being one of the major drivers of diabetes incidence, the degree of insulin resistance in patients with type 2 diabetes (T2D) is not usually evaluated in clinical practice or in large epidemiologic studies.: Objective: To identify a ... ...

    Abstract Context: Despite being one of the major drivers of diabetes incidence, the degree of insulin resistance in patients with type 2 diabetes (T2D) is not usually evaluated in clinical practice or in large epidemiologic studies.
    Objective: To identify a model of insulin sensitivity using widely available clinical and laboratory parameters in patients with T2D and evaluate its association with all-cause and cardiovascular mortality.
    Methods: One hundred forty patients with T2D underwent a euglycemic hyperinsulinemic clamp to measure total body glucose disposal rate (mg kg-1 minute-1). We used demographic, clinical, and common laboratory parameters to estimate insulin sensitivity (IS) via stepwise linear regression on 85 patients (training cohort) and validated it in the remaining 55 (validation cohort). The identified equation was then applied to 3553 patients with T2D from the 1999-2010 cycles of the National Health and Nutrition Examination Survey (NHANES) to evaluate its association with all-cause and cardiovascular mortality up to December 2015.
    Results: The best model included triglycerides, gamma glutamyl transpeptidase, albumin excretion rate, and body mass index. The identified IS score correlated well with the clamp-derived glucose disposal rate in both the training (r = 0.77, P < .001) and the validation (r = 0.74, P < .001) cohorts. In the NHANES cohort, after a median follow-up of 8.3 years, 1054 patients died, 265 of cardiovascular causes. In a multivariable Cox proportional hazard model adjusted for age, sex, race-ethnicity, education, cigarette smoke, total cholesterol, chronic kidney disease, blood pressure, prevalent cardiovascular disease, and alcohol consumption, a higher estimated IS was associated with a lower risk of both all-cause and cardiovascular mortality.
    Conclusion: We propose a new model of IS in patients with T2D based on readily available clinical and laboratory data. Its potential applications are in both diagnosis as well as prognostication.
    MeSH term(s) Humans ; Insulin Resistance/physiology ; Diabetes Mellitus, Type 2 ; Nutrition Surveys ; Blood Glucose ; Glucose ; Cardiovascular Diseases/complications ; Insulin
    Chemical Substances Blood Glucose ; Glucose (IY9XDZ35W2) ; Insulin
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad682
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