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  1. Article: CD83 expression induced by CpG-DNA stimulation in a macrophage cell line RAW 264.7 Min Chul Park1, Dongbum Kim2, Younghee Lee3 & Hyung-Joo Kwon1,2,*

    Park, M.C., Hallym University, Chuncheon, Republic of Korea / Kim, D.B., Hallym University, Chuncheon, Republic of Korea / Lee, Y.H., Chungbuk National University, Cheongju, Republic of korea / Kwon, H.J., Hallym University, Chuncheon, Republic of Korea

    Biochemistry and Molecular Biology reports

    (Sep 2013)  Volume v. 46, Issue (9), Page(s) p. 448–453

    Abstract: CpG-DNA has various immunomodulatory effects in dendritic cells, B cells, and macrophages. While induction of cytokines by CpG-DNA has been well documented in macrophages, the expression of costimulatory molecules in CpG-DNA treated macrophages has not ... ...

    Abstract CpG-DNA has various immunomodulatory effects in dendritic cells, B cells, and macrophages. While induction of cytokines by CpG-DNA has been well documented in macrophages, the expression of costimulatory molecules in CpG-DNA treated macrophages has not yet been defined. Therefore, we investigated the effects of CpG-DNA on the expression of costimulatory molecules in RAW 264.7 cells. The surface expression of CD80 was slightly increased and CD83 expression was significantly increased in response to CpG-DNA. However, the expression of CD86 and MHC class II was not changed. As expression of CD83 mRNA was also increased by CpG-DNA, CD83 expression is regulated at a transcriptional level. To understand the contribution of signaling pathways to CD83 induction, we used pathway specific inhibitors. The NF-κB inhibitor significantly reduced surface expression of CD83 as well as phagocytic activity of RAW 264.7 cells. Therefore, CD83 expression may contribute to the immunostimulatory effects of CpG-DNA in macrophage cells
    Keywords MACROPHAGE ; MACROFAGOS ; MACROPHAGES
    Language English
    Document type Article
    ISSN 1976-6696
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  2. Article: CD83 expression induced by CpG-DNA stimulation in a macrophage cell line RAW 264.7 Min Chul Park1, Dongbum Kim2, Younghee Lee3 & Hyung-Joo Kwon1,2,*

    Park, M.C., Hallym University, Chuncheon, Republic of Korea / Kim, D.B., Hallym University, Chuncheon, Republic of Korea / Lee, Y.H., Chungbuk National University, Cheongju, Republic of korea / Kwon, H.J., Hallym University, Chuncheon, Republic of Korea

    Biochemistry and Molecular Biology reports

    (Sep 2013)  Volume v. 46, Issue (9), Page(s) p. 448–453

    Abstract: CpG-DNA has various immunomodulatory effects in dendritic cells, B cells, and macrophages. While induction of cytokines by CpG-DNA has been well documented in macrophages, the expression of costimulatory molecules in CpG-DNA treated macrophages has not ... ...

    Abstract CpG-DNA has various immunomodulatory effects in dendritic cells, B cells, and macrophages. While induction of cytokines by CpG-DNA has been well documented in macrophages, the expression of costimulatory molecules in CpG-DNA treated macrophages has not yet been defined. Therefore, we investigated the effects of CpG-DNA on the expression of costimulatory molecules in RAW 264.7 cells. The surface expression of CD80 was slightly increased and CD83 expression was significantly increased in response to CpG-DNA. However, the expression of CD86 and MHC class II was not changed. As expression of CD83 mRNA was also increased by CpG-DNA, CD83 expression is regulated at a transcriptional level. To understand the contribution of signaling pathways to CD83 induction, we used pathway specific inhibitors. The NF-κB inhibitor significantly reduced surface expression of CD83 as well as phagocytic activity of RAW 264.7 cells. Therefore, CD83 expression may contribute to the immunostimulatory effects of CpG-DNA in macrophage cells
    Keywords MACROPHAGE ; MACROFAGOS ; MACROPHAGES
    Language English
    Document type Article
    ISSN 1976-6696
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  3. Article: Response to letter to the editors "Re: Byung-Do Lee, Wan Lee, Kyung-Hwan Kwon, Moon-Ki Choi, Eun-Joo Choi and Jung-Hoon Yoon. Glandular odontogenic cyst mimicking ameloblastoma in a 78-year-old female: a case report. Imaging Science in Dentistry 2014; 44(3): 249-52.".

    Lee, Byung-Do

    Imaging science in dentistry

    2015  Volume 45, Issue 2, Page(s) 139–140

    Language English
    Publishing date 2015-06-19
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2631801-5
    ISSN 2233-7830 ; 2233-7822
    ISSN (online) 2233-7830
    ISSN 2233-7822
    DOI 10.5624/isd.2015.45.2.139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Sediment and pore fluid chemistry for IODP Sites 311-U1325 and 311-U1329, supplementary data to: Kim, Ji-Hoon; Torres, Marta E; Haley, Brian A; Kastner, Miriam; Pohlman, John W; Riedel, Michael; Lee, Young-Joo (2012): The effect of diagenesis and fluid migration on rare earth element distribution in pore fluids of the northern Cascadia accretionary margin. Chemical Geology, 291, 152-165

    Kim, Ji-Hoon / Haley, Brian A / Kastner, Miriam / Lee, Young-Joo / Pohlman, John W / Riedel, Michael / Torres, Marta E

    2012  

    Abstract: Analytical challenges in obtaining high quality measurements of rare earth elements (REEs) from small pore fluid volumes have limited the application of REEs as deep fluid geochemical tracers. Using a recently developed analytical technique, we analyzed ... ...

    Abstract Analytical challenges in obtaining high quality measurements of rare earth elements (REEs) from small pore fluid volumes have limited the application of REEs as deep fluid geochemical tracers. Using a recently developed analytical technique, we analyzed REEs from pore fluids collected from Sites U1325 and U1329, drilled on the northern Cascadia margin during the Integrated Ocean Drilling Program (IODP) Expedition 311, to investigate the REE behavior during diagenesis and their utility as tracers of deep fluid migration. These sites were selected because they represent contrasting settings on an accretionary margin: a ponded basin at the toe of the margin, and the landward Tofino Basin near the shelf's edge. REE concentrations of pore fluid in the methanogenic zone at Sites U1325 and U1329 correlate positively with concentrations of dissolved organic carbon (DOC) and alkalinity. Fractionations across the REE series are driven by preferential complexation of the heavy REEs. Simultaneous enrichment of diagenetic indicators (DOC and alkalinity) and of REEs (in particular the heavy elements Ho to Lu), suggests that the heavy REEs are released during particulate organic carbon (POC) degradation and are subsequently chelated by DOC. REE concentrations are greater at Site U1325, a site where shorter residence times of POC in sulfate-bearing redox zones may enhance REE burial efficiency within sulfidic and methanogenic sediment zones where REE release ensues.
    Cross-plots of La concentrations versus Cl, Li and Sr delineate a distinct field for the deep fluids (z > 75 mbsf) at Site U1329, and indicate the presence of a fluid not observed at the other sites drilled on the Cascadia margin. Changes in REE patterns, the presence of a positive Eu anomaly, and other available geochemical data for this site suggest a complex hydrology and possible interaction with the igneous Crescent Terrane, located east of the drilled transect.
    Language English
    Dates of publication 2012-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1016/j.chemgeo.2011.10.010
    DOI 10.1594/PANGAEA.778552
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Book ; Online: Molecular and isotopic properties of gases from ODP Holes of ODP Leg 204, supplementary data to: Milkov, Alexei V; Claypool, George E; Lee, Young-Joo; Sassen, Roger (2005): Gas hydrate systems at Hydrate Ridge offshore Oregon inferred from molecular and isotopic properties of hydrate-bound and void gases. Geochimica et Cosmochimica Acta, 69(4), 1007-1026

    Milkov, Alexei V / Claypool, George E / Lee, Young-Joo / Sassen, Roger

    2005  

    Abstract: We report and discuss molecular and isotopic properties of hydrate-bound gases from 55 samples and void gases from 494 samples collected during Ocean Drilling Program (ODP) Leg 204 at Hydrate Ridge offshore Oregon. Gas hydrates appear to crystallize in ... ...

    Abstract We report and discuss molecular and isotopic properties of hydrate-bound gases from 55 samples and void gases from 494 samples collected during Ocean Drilling Program (ODP) Leg 204 at Hydrate Ridge offshore Oregon. Gas hydrates appear to crystallize in sediments from two end-member gas sources (deep allochthonous and in situ) as mixtures of different proportions. In an area of high gas flux at the Southern Summit of the ridge (Sites 1248-1250), shallow (0-40 m below the seafloor [mbsf]) gas hydrates are composed of mainly allochthonous mixed microbial and thermogenic methane and a small portion of thermogenic C2+ gases, which migrated vertically and laterally from as deep as 2- to 2.5-km depths. In contrast, deep (50-105 mbsf) gas hydrates at the Southern Summit (Sites 1248 and 1250) and on the flanks of the ridge (Sites 1244-1247) crystallize mainly from microbial methane and ethane generated dominantly in situ. A small contribution of allochthonous gas may also be present at sites where geologic and tectonic settings favor focused vertical gas migration from greater depth (e.g., Sites 1244 and 1245). Non-hydrocarbon gases such as CO2 and H2S are not abundant in sampled hydrates. The new gas geochemical data are inconsistent with earlier models suggesting that seafloor gas hydrates at Hydrate Ridge formed from gas derived from decomposition of deeper and older gas hydrates. Gas hydrate formation at the Southern Summit is explained by a model in which gas migrated from deep sediments, and perhaps was trapped by a gas hydrate seal at the base of the gas hydrate stability zone (GHSZ). Free gas migrated into the GHSZ when the overpressure in gas column exceeded sealing capacity of overlaying sediments, and precipitated as gas hydrate mainly within shallow sediments. The mushroom-like 3D shape of gas hydrate accumulation at the summit is possibly defined by the gas diffusion aureole surrounding the main migration conduit, the decrease of gas solubility in shallow sediment, and refocusing of gas by carbonate and gas hydrate seals near the seafloor to the crest of the local anticline structure.
    Language English
    Dates of publication 2005-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1016/j.gca.2004.08.021
    DOI 10.1594/PANGAEA.710774
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book: Radiology Illustrated: Chest Radiology

    Lee, Kyung Soo / Jeong, Yeon Joo / Chung, Man Pyo / Han, Joungho

    Pattern Approach for Lung Imaging

    (Radiology Illustrated)

    2024  

    Author's details Kyung Soo Lee, MD PhD Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine Joungho Han, MD PhD Department of Pathology, Samsung Medical Center Sungkyunkwan University School of Medicine Man Pyo Chung, MD PhD Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Yeon Joo Jeong, MD PhD Department of Radiology, Pusan National University Hospital Pusan National University School of Medicine and Medical Research Institute
    Series title Radiology Illustrated
    Keywords Differential diagnosis ; Imaging-Pathology Correlation ; Lung Diseases ; Computed Tomography ; Differential Diagnosis ; Pattern Approach
    Language English
    Size 392 p.
    Edition 2
    Publisher Springer Nature Singapore
    Document type Book
    Note PDA Manuell_25
    Format 215 x 285 x 26
    ISBN 9789819966325 ; 9819966329
    Database PDA

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  7. Book ; Online: Molecular properties of gases of ODP Leg 204 sites, supplementary data to: Milkov, Alexei V; Claypool, George E; Lee, Young-Joo; Torres, Marta E; Borowski, Walter S; Tomaru, Hitoshi; Sassen, Roger; Long, Philip E; ODP Leg 204 Shipboard Scientific Party (2004): Ethane enrichment and propane depletion in subsurface gases indicate gas hydrate occurrence in marine sediments at southern Hydrate Ridge offshore Oregon. Organic Geochemistry, 35(9), 1067-1080

    Milkov, Alexei V / Borowski, Walter S / Claypool, George E / Lee, Young-Joo / Long, Philip E / Sassen, Roger / Tomaru, Hitoshi / Torres, Marta E / ODP Leg 204 Shipboard Scientific Party

    2004  

    Abstract: The recognition of finely disseminated gas hydrate in deep marine sediments heavily depends on various indirect techniques because this mineral quickly decomposes upon recovery from in situ pressure and temperature conditions. Here, we discuss molecular ... ...

    Abstract The recognition of finely disseminated gas hydrate in deep marine sediments heavily depends on various indirect techniques because this mineral quickly decomposes upon recovery from in situ pressure and temperature conditions. Here, we discuss molecular properties of closely spaced gas voids (formed as a result of core recovery) and gas hydrates from an area of relatively low gas flux at the flanks of the southern Hydrate Ridge offshore Oregon (ODP Sites 1244, 1245 and 1247). Within the gas hydrate occurrence zone (GHOZ), the concentration of ethane (C2) and propane (C3) in adjacent gas voids shows large variability. Sampled gas hydrates are enriched in C2 relative to void gases but do not contain C3. We suggest that the observed variations in the composition of void gases is a result of molecular fractionation during crystallization of structure I gas hydrate that contains C2 but excludes C3 from its crystal lattice. This hypothesis is used to identify discrete intervals of finely disseminated gas hydrate in cored sediments. Variations in gas composition help better constrain gas hydrate distribution near the top of the GHOZ along with variations in pore water chemistry and core temperature. Sediments near the base of the gas hydrate stability zone are relatively enriched in C2+ hydrocarbon gases. Complex and poorly understood geological and geochemical processes in these deeper sediments make the identification of gas hydrate based on molecular properties of void gases more ambiguous. The proposed technique appears to be a useful tool to better understand the distribution of gas hydrate in marine sediments and ultimately the role of gas hydrate in the global carbon cycle.
    Language English
    Dates of publication 2004-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1016/j.orggeochem.2004.04.003
    DOI 10.1594/PANGAEA.763253
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Conference proceedings ; Online: Carbon and deuterium isotopes and C ratios in gas hydrates of ODP Leg 204 sites, supplementary data to: Claypool, George E; Milkov, Alexei V; Lee, Young-Joo; Torres, Marta E; Borowski, Walter S; Tomaru, Hitoshi (2006): Microbial methane generation and gas transport in shallow sediments of an accretionary complex, southern Hydrate Ridge (ODP Leg 204), offshore Oregon, USA. In: Tr?hu, AM; Bohrmann, G; Torres, ME; Colwell, FS (eds.), Proceedings of the Ocean Drilling Program, Scientific Results, College Station, TX (Ocean Drilling Program), 204, 1-52

    Claypool, George E / Borowski, Walter S / Lee, Young-Joo / Milkov, Alexei V / Tomaru, Hitoshi / Torres, Marta E

    2006  

    Abstract: Sediments at the southern summit of Hydrate Ridge display two distinct modes of gas hydrate occurrence. The dominant mode is associated with active venting of gas exsolved from the accretionary prism and leads to high concentrations (15%-40% of pore ... ...

    Abstract Sediments at the southern summit of Hydrate Ridge display two distinct modes of gas hydrate occurrence. The dominant mode is associated with active venting of gas exsolved from the accretionary prism and leads to high concentrations (15%-40% of pore space) of gas hydrate in seafloor or near-surface sediments at and around the topographic summit of southern Hydrate Ridge. These near-surface gas hydrates are mainly composed of previously buried microbial methane but also contain a significant (10%-15%) component of thermogenic hydrocarbons and are overprinted with microbial methane currently being generated in shallow sediments. Focused migration pathways with high gas saturation (>65%) abutting the base of gas hydrate stability create phase equilibrium conditions that permit the flow of a gas phase through the gas hydrate stability zone. Gas seepage at the summit supports rapid growth of gas hydrates and vigorous anaerobic methane oxidation.
    The other mode of gas hydrate occurs in slope basins and on the saddle north of the southern summit and consists of lower average concentrations (0.5%-5%) at greater depths (30-200 meters below seafloor [mbsf]) resulting from the buildup of in situ-generated dissolved microbial methane that reaches saturation levels with respect to gas hydrate stability at 30-50 mbsf. Net rates of sulfate reduction in the slope basin and ridge saddle sites estimated from curve fitting of concentration gradients are 2-4 mmol/m**3/yr, and integrated net rates are 20-50 mmol/m**2/yr. Modeled microbial methane production rates are initially 1.5 mmol/m**3/yr in sediments just beneath the sulfate reduction zone but rapidly decrease to rates of <0.1 mmol/m**3/yr at depths >100 mbsf. Integrated net rates of methane production in sediments away from the southern summit of Hydrate Ridge are 25-80 mmol/m**2/yr. Anaerobic methane oxidation is minor or absent in cored sediments away from the summit of southern Hydrate Ridge.
    Ethane-enriched Structure I gas hydrate solids are buried more rapidly than ethane-depleted dissolved gas in the pore water because of advection from compaction. With subsidence beneath the gas hydrate stability zone, the ethane (mainly of low-temperature thermogenic origin) is released back to the dissolved gas-free gas phases and produces a discontinuous decrease in the C1/C2 vs. depth trend. These ethane fractionation effects may be useful to recognize and estimate levels of gas hydrate occurrence in marine sediments.
    Language English
    Dates of publication 2006-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Conference proceedings ; Online
    Note This dataset is supplement to doi:10.2973/odp.proc.sr.204.113.2006
    DOI 10.1594/PANGAEA.774729
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book ; Online: Environmental Disasters and Individuals' Emergency Preparedness

    Hong, Yuxiang / Han, Ziqiang / Kim, Jong-Suk / Lee, Joo-Heon

    In the Perspective of Psychology and Behavior

    2022  

    Keywords Psychology ; social networks ; trust ; risk perception ; multiple disasters ; China ; volunteering ; disaster preparedness ; accidental life insurance ; training ; organizational identification ; pandemic ; public sentiment ; system dynamics ; cross-validation ; simulation and control ; place attachment ; self-efficacy ; disaster experience ; water resources carrying risk ; vulnerability of disaster-bearers ; hazard of disaster-causing factors ; coping behaviors ; psychological capital ; theory of planned behavior ; structural equation model ; MHO staff ; emergency preparedness behavior ; COVID-19 ; campus signal ; disaster awareness ; structural regression model
    Language 0|e
    Size 1 electronic resource (138 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021611600
    ISBN 9783036532349 ; 303653234X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: Inhibition of the RPS6KA1/FoxO1 signaling axis by hydroxycitric acid attenuates HFD-induced obesity through MCE suppression.

    Lee, Hyung-Won / Karki, Rajendra / Han, Joo-Hui

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2024  Volume 128, Page(s) 155551

    Abstract: Background: Because obesity is associated with a hyperplasia-mediated increase in adipose tissue, inhibiting cell proliferation during mitotic clonal expansion (MCE) is a leading strategy for preventing obesity. Although (-)-hydroxycitric acid (HCA) is ... ...

    Abstract Background: Because obesity is associated with a hyperplasia-mediated increase in adipose tissue, inhibiting cell proliferation during mitotic clonal expansion (MCE) is a leading strategy for preventing obesity. Although (-)-hydroxycitric acid (HCA) is used to control obesity, the molecular mechanisms underlying its effects on MCE are poorly understood.
    Purpose: This study aimed to investigate the potential effects of HCA on MCE and underlying molecular mechanisms affecting adipogenesis and obesity improvements.
    Methods: Preadipocyte cell line, 3T3-L1, were treated with HCA; oil red O, cell proliferation, cell cycle, and related alterations in signaling pathways were examined. High-fat diet (HFD)-fed mice were administered HCA for 12 weeks; body and adipose tissues weights were evaluated, and the regulation of signaling pathways in epidydimal white adipose tissue were examined in vivo.
    Results: Here, we report that during MCE, HCA attenuates the proliferation of the preadipocyte cell line, 3T3-L1, by arresting the cell cycle at the G
    Conclusions: These findings provide novel insights into the mechanism by which HCA regulates adipogenesis and highlight the RPS6KA1/FoxO1 signaling axis as a therapeutic target for obesity.
    Language English
    Publishing date 2024-03-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2024.155551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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