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  1. Article ; Online: Global-local least-squares support vector machine (GLocal-LS-SVM).

    Youssef Ali Amer, Ahmed

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0285131

    Abstract: This study introduces the global-local least-squares support vector machine (GLocal-LS-SVM), a novel machine learning algorithm that combines the strengths of localised and global learning. GLocal-LS-SVM addresses the challenges associated with ... ...

    Abstract This study introduces the global-local least-squares support vector machine (GLocal-LS-SVM), a novel machine learning algorithm that combines the strengths of localised and global learning. GLocal-LS-SVM addresses the challenges associated with decentralised data sources, large datasets, and input-space-related issues. The algorithm is a double-layer learning approach that employs multiple local LS-SVM models in the first layer and one global LS-SVM model in the second layer. The key idea behind GLocal-LS-SVM is to extract the most informative data points, known as support vectors, from each local region in the input space. Local LS-SVM models are developed for each region to identify the most contributing data points with the highest support values. The local support vectors are then merged at the final layer to form a reduced training set used to train the global model. We evaluated the performance of GLocal-LS-SVM using both synthetic and real-world datasets. Our results demonstrate that GLocal-LS-SVM achieves comparable or superior classification performance compared to standard LS-SVM and state-of-the-art models. In addition, our experiments show that GLocal-LS-SVM outperforms standard LS-SVM in terms of computational efficiency. For instance, on a training dataset of 9, 000 instances, the average training time for GLocal-LS-SVM was only 2% of the time required to train the LS-SVM model while maintaining classification performance. In summary, the GLocal-LS-SVM algorithm offers a promising solution to address the challenges associated with decentralised data sources and large datasets while maintaining high classification performance. Furthermore, its computational efficiency makes it a valuable tool for practical applications in various domains.
    MeSH term(s) Support Vector Machine ; Algorithms ; Machine Learning ; Least-Squares Analysis
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0285131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inverse ratio ventilation versus conventional ratio ventilation during one lung ventilation in neonatal open repair of esophageal atresia/tracheoesophageal fistula: A randomized clinical trial.

    Youssef, Azza M / El-Ozairy, Hala S / El-Hennawy, Ahmed M / Amer, Akram M

    Paediatric anaesthesia

    2024  Volume 34, Issue 4, Page(s) 332–339

    Abstract: Background: Maintaining oxygenation during neonatal open repair of esophageal atresia/tracheoesophageal fistula is difficult. Inverse ratio ventilation can be used during one lung ventilation to improve the oxygenation and lung mechanics.: Objective: ...

    Abstract Background: Maintaining oxygenation during neonatal open repair of esophageal atresia/tracheoesophageal fistula is difficult. Inverse ratio ventilation can be used during one lung ventilation to improve the oxygenation and lung mechanics.
    Objective: The aim of this study was to describe the impact of two different ventilatory strategies (inverse ratio ventilation vs. conventional ratio ventilation) during one lung ventilation in neonatal open repair of esophageal atresia/tracheoesophageal fistula on the incidence of oxygen desaturation episodes.
    Methods: We enrolled 40 term neonates undergoing open right thoracotomy for esophageal atresia/tracheoesophageal fistula repair and randomly assigned into two groups based on inspiratory to expiratory ratio of mechanical ventilation parameters (2:1 in inverse ratio ventilation "IRV" and 1:2 in conventional ratio ventilation "CRV"). The incidence of desaturation episodes that required stopping the procedure and reinflation of the lung were recorded as the primary outcome while hemodynamic parameters, incidence of complications, and length of surgical procedure were recorded as the secondary outcomes.
    Results: There was a trend toward a reduction in the incidence of severe desaturations (requiring stopping of surgery) with the use of inverse ratio ventilation (15% in IRV vs. 35% in CRV, RR [95% CI] 0.429 [0.129-1.426]). Incidence of all desaturations (including those requiring only an increase in ventilatory support or inspired oxygen saturation) was also reduced (40% in IRV vs. 75% in CRV, RR [95% CI] 0.533 [0.295-0.965]). This in turn affected the length of surgical procedure being significantly shorter in inverse ratio ventilation group (mean difference -16.3, 95% CI -31.64 to -0.958). The intraoperative fraction of inspired oxygen required to maintain adequate oxygen saturation was significantly lower in the inverse ratio ventilation group than in the conventional ratio ventilation group (mean difference -0.22, 95% CI -0.33 to -0.098), with no significant difference in hemodynamic stability or complications apart from higher blood loss in inverse ratio group.
    Conclusion: There may be a role for inverse ratio ventilation with appropriate positive end-expiratory pressure to reduce the incidence of hypoxemia during open repair of esophageal atresia/tracheoesophageal fistula in neonates, further studies are required to establish the safety and efficacy of this technique.
    MeSH term(s) Infant, Newborn ; Humans ; Tracheoesophageal Fistula/surgery ; Esophageal Atresia/surgery ; One-Lung Ventilation ; Respiration ; Oxygen ; Lung
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2024-01-08
    Publishing country France
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1086049-6
    ISSN 1460-9592 ; 1155-5645
    ISSN (online) 1460-9592
    ISSN 1155-5645
    DOI 10.1111/pan.14836
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  3. Article ; Online: Stability indicating potentiometric method for the determination of palonosetron HCl using two different sensors.

    Tantawy, Mahmoud A / Elshabasy, Dalia A / Youssef, Nadia F / Amer, Sawsan M

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 12966

    Abstract: This paper presents a novel potentiometric approach for the determination of palonosetron HCl using two sensors; ionophore-free and ionophore-doped ones. The two sensors successfully determined the cited drug in the range of 1 × ... ...

    Abstract This paper presents a novel potentiometric approach for the determination of palonosetron HCl using two sensors; ionophore-free and ionophore-doped ones. The two sensors successfully determined the cited drug in the range of 1 × 10
    MeSH term(s) Ionophores ; Palonosetron ; Potentiometry/methods
    Chemical Substances Ionophores ; Palonosetron (5D06587D6R)
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-17349-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of low-level laser therapy on condylar growth in children treated with functional appliance: a preliminary study.

    Amer, Mohamed E / ElKadi, Abbadi / Nadim, Mohamed / Sedky, Youssef

    Lasers in dental science

    2022  Volume 6, Issue 3, Page(s) 177–187

    Abstract: Purpose: This study aimed to evaluate the skeletal and dentoalveolar changes achieved by combining low-level laser irradiation applied on the condyle area with twin-block therapy in growing class II malocclusion patients.: Methods: Fourteen patients ( ...

    Abstract Purpose: This study aimed to evaluate the skeletal and dentoalveolar changes achieved by combining low-level laser irradiation applied on the condyle area with twin-block therapy in growing class II malocclusion patients.
    Methods: Fourteen patients (9 males, 5 females; mean age, 11.4 ± 2 years) with skeletal class II mandibular deficiency were recruited. They were divided into two groups (G 1: twin-block + low-level laser therapy, G 2: twin-block only). A semiconductor diode laser with a wavelength of 940 nm was applied on the condyle area (100 mW, 2.5 J, 3.9 J/cm
    Results: Mandibular length (Co-Gn) was significantly increased by 3.6 mm in the experiment group (3.16 SD) and 4.3 mm (4.4 SD) in the control group, with no significant difference between groups at every time point (
    Conclusion: Based on the results of this preliminary study, low-level laser irradiation with the used parameters seems to have no synergetic impact on the skeletal and dental outcomes of twin-block therapy over 9 months. However, more studies are needed to investigate the effect of low-level laser therapy on condylar growth during functional orthodontic treatment.
    Supplementary information: The online version contains supplementary material available at 10.1007/s41547-022-00158-x.
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2367-2587
    ISSN (online) 2367-2587
    DOI 10.1007/s41547-022-00158-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Intensive Care Unit Admission After Spine Surgery: A Narrative Review.

    Assi, Ahmad / Daher, Mohammad / Zalaquett, Ziad / Aoun, Marven / Youssef, Bryan / Kreichati, Gaby / Kharrat, Khalil / Sebaaly, Amer

    International journal of spine surgery

    2024  

    Abstract: Introduction: Intensive care unit (ICU) admissions constitute a substantial financial challenge for health care systems and patients and are linked to various potentially life-altering complications. A wide range of patient-related, surgical, and ... ...

    Abstract Introduction: Intensive care unit (ICU) admissions constitute a substantial financial challenge for health care systems and patients and are linked to various potentially life-altering complications. A wide range of patient-related, surgical, and medical factors are associated with an increased risk of ICU admission following spine surgery.
    Discussion: The most notable examples include lung, heart, and kidney disease, as well as estimated blood loss and length of surgery. Various scores that include the most significant patient- and procedure-related factors have been described to assess the risk associated with surgery for individual patients. To date, the fusion risk score and the American Society of Anesthesiologists score have been the most useful in predicting postoperative complications and admission to the ICU. However, other risk factors have also been implicated in ICU admission and length of stay. The current scores must further adapt by using the available evidence to fulfill their intended purpose. Moreover, a handful of measures have shown efficacy in decreasing ICU admission and length of stay, with their benefits still to be demonstrated by future research.
    Conclusion: This review underscores the risk factors predictive of ICU admission following spine surgery and will help surgeons and clinicians in patient stratification. However, future studies are needed to validate the role of protective measures in preventing ICU admissions and the significance of certain risk factors.
    Language English
    Publishing date 2024-04-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-4599
    ISSN 2211-4599
    DOI 10.14444/8593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Iron/Copper/Phosphate nanocomposite as antimicrobial, antisnail, and wheat growth-promoting agent.

    Abdullah, Nashwa H / Elbialy, Nouran A / Amer, Mohamed Abdelnaser / Gabr, Mostafa Kh / Youssef, Amira Salah El-Din / Sharaf, Mohamed H / Shehata, M E / Kalaba, Mohamed H / Soliman, Elham R S

    BMC biotechnology

    2024  Volume 24, Issue 1, Page(s) 11

    Abstract: Background: One of the current challenges is to secure wheat crop production to meet the increasing global food demand and to face the increase in its purchasing power. Therefore, the current study aimed to exploit a new synthesized nanocomposite to ... ...

    Abstract Background: One of the current challenges is to secure wheat crop production to meet the increasing global food demand and to face the increase in its purchasing power. Therefore, the current study aimed to exploit a new synthesized nanocomposite to enhance wheat growth under both normal and drought regime. The effectiveness of this nanocomposite in improving the microbiological quality of irrigation water and inhibiting the snail's growth was also assessed.
    Results: Upon the employed one-step synthesis process, a spherical Fe/Cu/P nanocomposite was obtained with a mean particle size of 4.35 ± 1.524 nm. Cu
    Conclusion: The finding of the current study could be employed to mitigate the effect of drought stress on wheat growth and to enhance the microbiological quality of irrigation water. This is due to the increased efficacy of the newly synthesized Fe/Cu/P nanocomposite against bacteria, fungi, and snails. This methodology exhibits potential for promoting sustainable wheat growth and water resource conservation.
    MeSH term(s) Triticum ; Copper/pharmacology ; Anti-Infective Agents ; Escherichia coli ; Water ; Phosphates ; Iron
    Chemical Substances Copper (789U1901C5) ; Anti-Infective Agents ; Water (059QF0KO0R) ; Phosphates ; Iron (E1UOL152H7)
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2052746-9
    ISSN 1472-6750 ; 1472-6750
    ISSN (online) 1472-6750
    ISSN 1472-6750
    DOI 10.1186/s12896-024-00836-7
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  7. Article ; Online: Xbb subvariant of Omicron: Can the new wave sneak past your immune defense?

    Hefnawy, Mahmoud T / Shaheen, Nour / Abdelwahabd, Omar A / Desouki, Mariam Tarek / Attalla, Almoatazbellah / Khaity, Abdurthman / Rababah, Ala' A / Mohamed, Abdelrahman / Soliman, Youssef / Diab, Rehab A / Elganady, Asmaa / Amer, Samar A

    International journal of surgery (London, England)

    2023  Volume 109, Issue 2, Page(s) 85–87

    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000042
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  8. Article: Elective Thoracic Aortic Aneurysm Surgery: A Tertiary Center Experience.

    Badran, Abdul / Elghazouli, Youssef / Shirke, Manasi Mahesh / Al-Tawil, Mohammed / Harky, Amer / Ohri, Sunil K

    Cureus

    2023  Volume 15, Issue 5, Page(s) e39102

    Abstract: Background A thoracic aortic aneurysm (TAA) is a diseased expansion of the thoracic aorta. There is morbidity associated with a dilated aorta, as well as significant mortality. Open thoracic surgery is the fundamental management for proximal lesions, ... ...

    Abstract Background A thoracic aortic aneurysm (TAA) is a diseased expansion of the thoracic aorta. There is morbidity associated with a dilated aorta, as well as significant mortality. Open thoracic surgery is the fundamental management for proximal lesions, offering definitive treatment with excellent results. This study aimed to summarize preoperative data and operative outcomes of patients who underwent TAA repair at our institution. Methods Data were retrospectively collected from 234 patients that underwent elective open thoracic surgery at University Hospital Southampton for TAA disease, between 2015 and 2019. Demographics, clinical factors, surgical details, as well as outcome measures, were gathered. Results There were 166 males and 68 females, with an overall mean age of 66 years. The breakdown of operations comprised 105 aortic roots, 171 ascending aorta, 20 aortic arch, and 12 descending aorta cases. The mean follow-up was 370 days. 30-day mortality was 5.13%. Mortality was associated with female gender, aortic root surgery, and prosthetic valves. Mean aortic diameters at the time of surgery for the non-genetic aortopathy and genetic aortopathy groups were respectively 4.93cm and 4.63cm in the aortic root, 5.56cm and 4.88cm in the ascending aorta, 5.08cm and 3.87cm in the aortic arch, and 6.63cm and 5.50cm in the descending aorta. Conclusion Several factors are associated with complications and morbidity, which should be considered when discussing the risks of intervention with patients. There were no neuroprotective strategies that altered post-operative neurological function. Current practice in our unit fits in with current international guidance.
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.39102
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  9. Article ; Online: Nematicidal activity of sweet annie and garden cress nano-formulations and their impact on the vegetative growth and fruit quality of tomato plants.

    Mohammad, Ayman A / Amer, Heba M / El-Sawy, Sameh M / Youssef, Dalia A / Nour, Shaimaa A / Soliman, Gaziea M

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 22302

    Abstract: Root-knot nematode is one of the major problems that face the agricultural production of several vegetable crops. Chemical nematicides have been banned because of their healthy and environmental undesirable attributes. So, this study aimed to evaluate ... ...

    Abstract Root-knot nematode is one of the major problems that face the agricultural production of several vegetable crops. Chemical nematicides have been banned because of their healthy and environmental undesirable attributes. So, this study aimed to evaluate the potential use of sweet annie (Artimisia annua) and garden cress (Lepidium sativum) as green routes for the development of effective and eco-friendly alternative nematicides. Nematicidal activity of sweet annie and garden cress aqueous extracts (500 g/L) in the original and nano-forms were evaluated against Meloidogyne incognita in tomato planted in infected soil under greenhouse conditions. Nineteen phenolic compounds were identified in A. annua extract, which was dominated by chlorogenic acid (5059 µg/100 mL), while 11 compounds were identified in L. sativum extract, that dominated by p-hydroxybenzoic acid (3206 μg/100 mL). Nano-particles were characterized with smooth surface, spherical shape and small size (50-100 nm). Under laboratory, the nano-formulations showed mortality percentage of M. incognita J
    MeSH term(s) Animals ; Lepidium sativum ; Fruit ; Solanum lycopersicum ; Artemisia annua ; Antinematodal Agents/pharmacology ; Tylenchoidea
    Chemical Substances Antinematodal Agents
    Language English
    Publishing date 2022-12-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-26819-2
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  10. Article: Regulation of Osteogenic Differentiation of Placental-Derived Mesenchymal Stem Cells by Insulin-Like Growth Factors and Low Oxygen Tension.

    Youssef, Amer / Han, Victor K M

    Stem cells international

    2017  Volume 2017, Page(s) 4576327

    Abstract: Placental mesenchymal stem cells (PMSCs) are multipotent cells that can ... ...

    Abstract Placental mesenchymal stem cells (PMSCs) are multipotent cells that can differentiate
    Language English
    Publishing date 2017-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573856-2
    ISSN 1687-9678 ; 1687-966X
    ISSN (online) 1687-9678
    ISSN 1687-966X
    DOI 10.1155/2017/4576327
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