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  1. Article ; Online: Reproducible 2D Ti

    Shen, Qingchao / Chen, Chaoran / Long, Jiao / Wang, Saili

    RSC advances

    2023  Volume 13, Issue 14, Page(s) 9555–9562

    Abstract: ... ...

    Abstract Ti
    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra08088e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: IRGD-modified erythrocyte membrane biomimetic temozolomide nanodots for the treatment of glioblastoma.

    Luo, Dong / Chen, Zhichao / Peng, Yaonan / Liu, Chaoran

    Nanotechnology

    2024  Volume 35, Issue 24

    Abstract: The crossing of the blood-brain barrier (BBB) for conventional anticancer drugs is still a big challenge in treating glioma. The biomimetic nanoparticle delivery system has attracted increasing attention and has a promising future for crossing the BBB. ... ...

    Abstract The crossing of the blood-brain barrier (BBB) for conventional anticancer drugs is still a big challenge in treating glioma. The biomimetic nanoparticle delivery system has attracted increasing attention and has a promising future for crossing the BBB. Herein, we construct a multifunctional biomimetic nanoplatform using the erythrocyte membrane (EM) with the tumor-penetrating peptide iRGD (CRGDK/RGPD/EC) as a delivery, and the inner core loaded with the chemotherapeutic drug temozolomide (TMZ). The resulting biomimetic nanoparticle has perfect biocompatibility and stealth ability, which will provide more chances to escape the reticuloendothelial system (RES) entrapment, and increase the opportunity to enter the tumor site. Moreover, the decorated iRGD has been extensively used to actively targeting and deliver therapeutic agents across the BBB into glioma tissue. We show that this biomimetic delivery of TMZ with a diameter of 22 nm efficiently slowed the growth of glioblastoma multiforme (GBM) and increased the survival rate of the 30 d from 0% to 100%.
    MeSH term(s) Humans ; Temozolomide/pharmacology ; Temozolomide/therapeutic use ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Erythrocyte Membrane ; Biomimetics ; Glioma ; Cell Line, Tumor ; Brain Neoplasms/drug therapy
    Chemical Substances Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ad2d0d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Corrigendum: The correlation between posttraumatic growth and social support in people with breast cancer: A meta-analysis.

    Ma, Xiaojing / Wan, Xiao / Chen, Chaoran

    Frontiers in psychology

    2023  Volume 14, Page(s) 1129481

    Abstract: This corrects the article DOI: 10.3389/fpsyg.2022.1060150.]. ...

    Abstract [This corrects the article DOI: 10.3389/fpsyg.2022.1060150.].
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1129481
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  4. Article ; Online: Fast analysis of straw proximates based on partial least squares using near-infrared spectroscopy.

    Zhao, Yifan / Zhu, Yingying / Li, Chaoran / Chen, Geng / Yao, Yan

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2024  Volume 309, Page(s) 123855

    Abstract: Near-infrared spectroscopy (NIRS) is a rapid measurement technique based on the spectroscopic absorption bands of specific functional groups within biomass. Its main advantages include simple preparation, precise analysis, and the ability to analyze ... ...

    Abstract Near-infrared spectroscopy (NIRS) is a rapid measurement technique based on the spectroscopic absorption bands of specific functional groups within biomass. Its main advantages include simple preparation, precise analysis, and the ability to analyze multiple components simultaneously. Fast analysis of straw proximates (moisture, ash, and fixed carbon) has been investigated by means of NIRS. A total of 144 samples were collected, the spectral data were analyzed by partial least squares (PLS) regression and support vector regression (SVR) with four wavelength selection methods. PLS combined with competitive adaptive reweighted sampling (CARS) provided excellent predictive performance for moisture, ash, and fixed carbon. For moisture prediction, the values of R
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2024.123855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 51/98: Show issues
    Z 1611 a: Show issues
    924/340: Show issues

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  5. Article ; Online: Achieving Environmentally-Adaptive and Multifunctional Hydrodynamic Metamaterials through Active Control.

    Jiang, Chaoran / Nie, Haoran / Chen, Mengyao / Shen, Xiangying / Xu, Lei

    Advanced materials (Deerfield Beach, Fla.)

    2024  , Page(s) e2313986

    Abstract: As hydrodynamic metamaterials continue to develop, the inherent limitations of passive-mode metamaterials become increasingly apparent. First, passive devices are typically designed for specific environments and lack the adaptability to environmental ... ...

    Abstract As hydrodynamic metamaterials continue to develop, the inherent limitations of passive-mode metamaterials become increasingly apparent. First, passive devices are typically designed for specific environments and lack the adaptability to environmental changes. Second, their unique functions often rely on intricate structures, or challenging material properties, or a combination of both. These limitations considerably hinder the potential applications of hydrodynamic metamaterials. In this study, an active-mode hydrodynamic metamaterial is theoretically proposed and experimentally demonstrated by incorporating source-and-sink flow-dipoles into the system, enabling active manipulation of the flow field with various functionalities. By adjusting the magnitude and direction of the flow-dipole moment, this device can easily achieve invisibility, flow shielding, and flow enhancing. Furthermore, it is environmentally adaptive and can maintain proper functions in different environments. It is anticipated that this design will significantly enhance tunability and adaptability of hydrodynamic metamaterials in complex and ever-changing environments.
    Language English
    Publishing date 2024-03-20
    Publishing country Germany
    Document type Letter
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202313986
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  6. Article: The impact of perceived organizational justice on young nurses' job performance: a chain mediating role of organizational climate and job embeddedness.

    Song, Jiamei / Shi, Xindi / Zheng, Xiaojia / Lu, Guangli / Chen, Chaoran

    BMC nursing

    2024  Volume 23, Issue 1, Page(s) 231

    Abstract: Background: The level of nurses' job performance has always been of great concern, which not only represents the level of nursing service quality but is also closely related to patients' treatment and prognosis. The aim of this study was to analyze the ... ...

    Abstract Background: The level of nurses' job performance has always been of great concern, which not only represents the level of nursing service quality but is also closely related to patients' treatment and prognosis. The aim of this study was to analyze the relationship between perceived organizational justice and job performance and to explore the mediating role of organizational climate and job embeddedness among young Chinese nurses.
    Methods: A cross-sectional survey of 1136 young nurses was conducted between March and May 2023 using convenience sampling. Data were collected using the Job Performance Scale, Organizational Justice Assessment Scale, Nursing Organizational Climate Scale, and Job Embeddedness Scale, and the resulting data were analyzed using SPSS 25.0 and AMOS 26.0.
    Results: There was a significant positive correlation between job performance and perceived organizational justice (r = 0.477, p < 0.01), organizational climate (r = 0.500, p < 0.01), and job embeddedness (r = 0.476, p < 0.01). Organizational climate and job embeddedness acted as chain mediators between perceived organizational justice and job performance. The total effect of perceived organizational justice on job performance (β = 0.513) consisted of a direct effect (β = 0.311) as well as an indirect effect (β = 0.202) mediated through organizational climate and job embeddedness, with the mediating effect accounting for 39.38% of the total effect.
    Conclusions: Organizational climate and job embeddedness play a chain mediating role between perceived organizational justice and job performance, so hospital managers should pay attention to the level of perceived organizational justice among young nurses, and develop a series of targeted measures to improve their job performance using organizational climate and job embeddedness as entry points.
    Language English
    Publishing date 2024-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091496-9
    ISSN 1472-6955
    ISSN 1472-6955
    DOI 10.1186/s12912-024-01898-w
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  7. Article ; Online: Regulating the Electrical Double Layer with Supramolecular Cyclodextrin Anions for Dendrite-Free Zinc Electrodeposition.

    Wang, Lulu / Shen, Chengzhen / Huang, Chaoran / Chen, Jitao / Zheng, Junrong

    ACS nano

    2023  Volume 17, Issue 24, Page(s) 24619–24631

    Abstract: The interfacial stability of a Zn battery is dependent on the electrical double layer (EDL) that forms at the interface between the electrolyte and the Zn metal anode. A fundamental understanding of the regulation of the EDL structure and stability on ... ...

    Abstract The interfacial stability of a Zn battery is dependent on the electrical double layer (EDL) that forms at the interface between the electrolyte and the Zn metal anode. A fundamental understanding of the regulation of the EDL structure and stability on the Zn surface is highly desirable for practical applications of aqueous batteries. Herein, the interfacial chemistry of the EDL is regulated by the adsorption of supramolecular cyclodextrin anions in the inner Helmholtz plane (IHP). The nucleation overpotential and the charge transfer activation energy for Zn
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c03220
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  8. Article ; Online: Development of microRNA-based therapeutics for central nervous system diseases.

    Xia, Siqi / Xu, Chaoran / Liu, Fuyi / Chen, Gao

    European journal of pharmacology

    2023  Volume 956, Page(s) 175956

    Abstract: MicroRNA (miRNA)-mediated gene silencing is a method of RNA interference in which a miRNA binds to messenger RNA sequences and regulates target gene expression. MiRNA-based therapeutics have shown promise in treating a variety of central nervous system ... ...

    Abstract MicroRNA (miRNA)-mediated gene silencing is a method of RNA interference in which a miRNA binds to messenger RNA sequences and regulates target gene expression. MiRNA-based therapeutics have shown promise in treating a variety of central nervous system diseases, as verified by results from diverse preclinical model organisms. Over the last decade, several miRNA-based therapeutics have entered clinical trials for various kinds of diseases, such as tumors, infections, and inherited diseases. However, such clinical trials for central nervous system diseases are scarce, and many central nervous system diseases, including hemorrhagic stroke, ischemic stroke, traumatic brain injury, intractable epilepsy, and Alzheimer's disease, lack effective treatment. Considering its effectiveness for central nervous system diseases in preclinical experiments, microRNA-based intervention may serve as a promising treatment for these kinds of diseases. This paper reviews basic principles and recent progress of miRNA-based therapeutics and summarizes general procedures to develop such therapeutics for treating central nervous system diseases. Then, the current obstacles in drug development are discussed. This review also provides a new perspective on possible solutions to these obstacles in the future.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/therapeutic use ; MicroRNAs/metabolism ; Neoplasms/drug therapy ; RNA Interference ; Treatment Outcome ; Brain Injuries, Traumatic/drug therapy ; Central Nervous System Diseases/therapy ; Central Nervous System Diseases/drug therapy
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-08-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2023.175956
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 522: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Formation and Transformation of CdS Clusters during the Prenucleation Stage and in a Dilute Dispersion at Room Temperature.

    Xu, Rongkuan / Wang, Zhe / Yang, Yusha / Gu, Cheng / Luan, Chaoran / Wang, Shanling / Chen, Xiaoqin / Yu, Kui

    Nano letters

    2024  Volume 24, Issue 4, Page(s) 1294–1302

    Abstract: The formation and transformation of colloidal semiconductor clusters remain poorly understood. With CdS as a model system, we show that, in the reaction of cadmium myristate (Cd(MA) ...

    Abstract The formation and transformation of colloidal semiconductor clusters remain poorly understood. With CdS as a model system, we show that, in the reaction of cadmium myristate (Cd(MA)
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c04287
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  10. Article ; Online: Hydrophobization of Ribonucleic Acids for Facile Systemic Delivery and Multifaceted Cancer Immunotherapy.

    Zhang, Yuxi / Chen, Chaoran / Su, Miao / Wang, Junxia / Li, Cheng / Yang, Xianzhu

    Nano letters

    2024  Volume 24, Issue 4, Page(s) 1376–1384

    Abstract: Ribonucleic acids (RNAs) enable disease-related gene inhibition, expression, and editing and represent promising therapeutics in various diseases. The efficacy of RNA relies heavily on the presence of a secure and effective delivery system. Herein, we ... ...

    Abstract Ribonucleic acids (RNAs) enable disease-related gene inhibition, expression, and editing and represent promising therapeutics in various diseases. The efficacy of RNA relies heavily on the presence of a secure and effective delivery system. Herein, we found that RNA could be hydrophobized by cationic lipid and ionizable lipid and conveniently coassemble with amphiphilic polymer to achieve micelle-like nanoparticles (MNP). The results of the study indicate that MNP exhibits a high level of efficiency in delivering RNA. Besides, the MNP encapsulating siRNA that targets CD47 and PD-L1 remarkably blocked these immune checkpoints in a melanoma tumor model and elicited a robust immune response. Moreover, the MNP encapsulating the mRNA of OVA achieved antigen translation and presentation, leading to an effective antitumor immunoprophylaxis outcome against OVA-expressing melanoma model. Our findings suggest that RNA hydrophobization could serve as a viable approach for delivering RNA, thereby facilitating the exploration of RNA therapy in disease treatment.
    MeSH term(s) Humans ; Melanoma ; Immunotherapy ; Nanoparticles/therapeutic use ; RNA, Small Interfering/genetics ; RNA, Small Interfering/therapeutic use ; Micelles ; Lipids ; Neoplasms/therapy
    Chemical Substances RNA, Small Interfering ; Micelles ; Lipids
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c04507
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