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Article: The Japanese Catheter Ablation Registry (J-AB): Annual report in 2021.

Kusano, Kengo / Yamane, Teiichi / Inoue, Koichi / Takegami, Misa / Nakai, Michikazu / Kanaoka, Koshiro / Tonegawa-Kuji, Reina / Miyamoto, Koji / Iwasaki, Yu-Ki / Takatsuki, Seiji / Nakamura, Kohki / Iwanaga, Yoshitaka / Shimizu, Wataru

Journal of arrhythmia

2023 Volume 39, Issue 6, Page(s) 853–859

Abstract: The Japanese Catheter Ablation (J-AB) registry, started in August 2017, is a voluntary, nationwide ...

Abstract	The Japanese Catheter Ablation (J-AB) registry, started in August 2017, is a voluntary, nationwide, multicenter, prospective, observational registry, performed by the Japanese Heart Rhythm Society (JHRS) in collaboration with the National Cerebral and Cardiovascular Center using a Research Electronic Data Capture system. The purpose of this registry is to collect the details of target arrhythmias, the ablation procedures, including the type of target arrhythmias, outcomes, and acute complications in the real-world settings. During the year of 2021, we have collected a total of 89 609 procedures (mean age of 66.1 years and 65.9% male) from 506 participant hospitals. Detailed data are shown in Figures and Tables.
Language	English
Publishing date	2023-09-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2696593-8
ISSN	1883-2148 ; 1880-4276
ISSN (online)	1883-2148
ISSN	1880-4276
DOI	10.1002/joa3.12931
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Japanese Catheter Ablation Registry (J-AB): Annual report in 2020.

Kusano, Kengo / Yamane, Teiichi / Inoue, Koichi / Takegami, Misa / Nakao, Yoko M / Nakai, Michikazu / Kanaoka, Koshiro / Tonegawa-Kuji, Reina / Miyamoto, Koji / Iwasaki, Yu-Ki / Takatsuki, Seiji / Nakamura, Kohki / Iwanaga, Yoshitaka / Shimizu, Wataru

Journal of arrhythmia

2022 Volume 38, Issue 5, Page(s) 675–681

Abstract: The Japanese Catheter Ablation (J-AB) registry, started in August 2017, is a voluntary, nationwide ...

Abstract	The Japanese Catheter Ablation (J-AB) registry, started in August 2017, is a voluntary, nationwide, multicenter, prospective, observational registry, performed by the Japanese Heart Rhythm Society (JHRS) in collaboration with the National Cerebral and Cardiovascular Center using a Research Electronic Data Capture system. The purpose of this registry is to collect the details of target arrhythmias, the ablation procedures, including the type of target arrhythmias, outcomes, and acute complications in real-world settings. During the year 2020, we have collected a total of 84 591 procedures (mean age of 65.8 years and 66.6% male) from 466 participant hospitals. Detailed data were shown in Figures and Tables.
Language	English
Publishing date	2022-08-27
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2696593-8
ISSN	1883-2148 ; 1880-4276
ISSN (online)	1883-2148
ISSN	1880-4276
DOI	10.1002/joa3.12772
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Article ; Online: Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.

Lescale, Chloé / Lenden Hasse, Hélène / Blackford, Andrew N / Balmus, Gabriel / Bianchi, Joy J / Yu, Wei / Bacoccina, Léa / Jarade, Angélique / Clouin, Christophe / Sivapalan, Rohan / Reina-San-Martin, Bernardo / Jackson, Stephen P / Deriano, Ludovic

Cell reports

2016 Volume 16, Issue 11, Page(s) 2967–2979

Abstract: ... Here, we find that the functions of PAXX and XLF in V(D)J recombination are masked by redundant joining ... Additionally, we demonstrate that PAXX function in V(D)J recombination depends on its interaction with Ku ... with ATM and the RAG complex. Our findings illuminate the role of PAXX in V(D)J recombination and support ...

Abstract	Paralog of XRCC4 and XLF (PAXX) is a member of the XRCC4 superfamily and plays a role in nonhomologous end-joining (NHEJ), a DNA repair pathway critical for lymphocyte antigen receptor gene assembly. Here, we find that the functions of PAXX and XLF in V(D)J recombination are masked by redundant joining activities. Thus, combined PAXX and XLF deficiency leads to an inability to join RAG-cleaved DNA ends. Additionally, we demonstrate that PAXX function in V(D)J recombination depends on its interaction with Ku. Importantly, we show that, unlike XLF, the role of PAXX during the repair of DNA breaks does not overlap with ATM and the RAG complex. Our findings illuminate the role of PAXX in V(D)J recombination and support a model in which PAXX and XLF function during NHEJ repair of DNA breaks, whereas XLF, the RAG complex, and the ATM-dependent DNA damage response promote end joining by stabilizing DNA ends.
MeSH term(s)	Animals ; Ataxia Telangiectasia Mutated Proteins/metabolism ; B-Lymphocytes/metabolism ; CRISPR-Cas Systems/genetics ; DNA Damage ; DNA Repair ; DNA Repair Enzymes/metabolism ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Gene Deletion ; Gene Editing ; Gene Rearrangement, B-Lymphocyte ; Immunoglobulins/genetics ; Ku Autoantigen/metabolism ; Models, Biological ; Oncogene Proteins v-abl/metabolism ; Sequence Homology, Amino Acid ; V(D)J Recombination/genetics
Chemical Substances	DNA-Binding Proteins ; IgK ; Immunoglobulins ; Oncogene Proteins v-abl ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; Ku Autoantigen (EC 4.2.99.-) ; DNA Repair Enzymes (EC 6.5.1.-)
Language	English
Publishing date	2016-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2016.08.069
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Article ; Online: Effectiveness of the J-Tip Guidewire for Selective Biliary Cannulation Compared to Conventional Guidewires (The JANGLE Study).

Tsuchiya, Takayoshi / Itoi, Takao / Maetani, Iruru / Shigoka, Hiroaki / Ikeuchi, Nobuhito / Umeda, Junko / Sofuni, Atsushi / Itokawa, Fumihide / Ishii, Kentaro / Kurihara, Toshio / Tsuji, Shujiro / Tanaka, Reina / Tonozuka, Ryosuke / Honjyo, Mitsuyoshi / Mukai, Shuntaro / Moriyasu, Fuminori

Digestive diseases and sciences

2015 Volume 60, Issue 8, Page(s) 2502–2508

Abstract: ... according to the type of guidewire used.: Aims: We evaluated the effectiveness of the J-tip guidewire ... patients with a native papilla who required biliary cannulation. We allocated the patients to the J-tip ... guidewire or angled-tip guidewire groups (groups J and A, respectively). If biliary cannulation was not ...

Abstract	Background: Wire-guided cannulation has become a common biliary cannulation technique worldwide. Different guidewires with various tip shapes and materials have been reportedly used for wire-guided cannulation. However, there are apparently no studies reporting changes in the biliary cannulation rate according to the type of guidewire used. Aims: We evaluated the effectiveness of the J-tip guidewire for biliary cannulation. Methods: We conducted a prospective, multicenter, controlled study involving patients with a native papilla who required biliary cannulation. We allocated the patients to the J-tip guidewire or angled-tip guidewire groups (groups J and A, respectively). If biliary cannulation was not achieved within 10 min, the GW was changed and cannulation was continued. Results: Groups J and A consisted of 66 and 65 enrolled patients, respectively. The biliary cannulation rate with a single guidewire for the first 10 min was 84.8 % (56/66) for group J and 80.0 % (52/65) for group A. The final success rate for biliary cannulation was 100 % in both groups. The mean times necessary for biliary cannulation were 285.8 and 267.6 s in group J and group A, respectively. The incidence rates of complications (i.e., all mild pancreatitis) were 3.0 % (2/66) and 6.2 % (4/65) in group J and group A, respectively. The mean amylase concentrations were 168.0 and 297.7 IU/L in group J and group A, respectively. There were no significant differences in any results between both groups. Conclusion: The biliary cannulation rate of the J-tip guidewire was not significantly different from those of standard guidewires.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biliary Tract Diseases/diagnosis ; Catheterization/instrumentation ; Cholangiopancreatography, Endoscopic Retrograde/instrumentation ; Equipment Design ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies
Language	English
Publishing date	2015-08
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-015-3658-0
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Article ; Online: Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

Chloé Lescale / Hélène Lenden Hasse / Andrew N. Blackford / Gabriel Balmus / Joy J. Bianchi / Wei Yu / Léa Bacoccina / Angélique Jarade / Christophe Clouin / Rohan Sivapalan / Bernardo Reina-San-Martin / Stephen P. Jackson / Ludovic Deriano

Cell Reports, Vol 16, Iss 11, Pp 2967-

2016 Volume 2979

Abstract	Paralog of XRCC4 and XLF (PAXX) is a member of the XRCC4 superfamily and plays a role in nonhomologous end-joining (NHEJ), a DNA repair pathway critical for lymphocyte antigen receptor gene assembly. Here, we find that the functions of PAXX and XLF in V(D)J recombination are masked by redundant joining activities. Thus, combined PAXX and XLF deficiency leads to an inability to join RAG-cleaved DNA ends. Additionally, we demonstrate that PAXX function in V(D)J recombination depends on its interaction with Ku. Importantly, we show that, unlike XLF, the role of PAXX during the repair of DNA breaks does not overlap with ATM and the RAG complex. Our findings illuminate the role of PAXX in V(D)J recombination and support a model in which PAXX and XLF function during NHEJ repair of DNA breaks, whereas XLF, the RAG complex, and the ATM-dependent DNA damage response promote end joining by stabilizing DNA ends.
Keywords	V(D)J recombination ; DNA repair ; NHEJ ; PAXX ; XLF ; XRCC4 ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2016-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Los linajes Victoria y Yamagata de los virus gripales B, desconocidos y poco valorados.

Reina, J

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

2022 Volume 35, Issue 3, Page(s) 231–235

Abstract: The influenza virus B belongs to the family Orthomyxoviriridae and to the genus Influenzavirus B. It has a negative RNA-type genome made up of about 14,648 nucleotides divided into eight different segments that encode about 11 proteins. Before 1980 all ... ...

Title translation	The Victoria and Yamagata Lineages of Influenza B Viruses, unknown and undervalued.
Abstract	The influenza virus B belongs to the family Orthomyxoviriridae and to the genus Influenzavirus B. It has a negative RNA-type genome made up of about 14,648 nucleotides divided into eight different segments that encode about 11 proteins. Before 1980 all influenza B viruses belonged to a single genetic lineage; but in this year two antigenically and genetically distinct lineages emerged which were named B/Victoria/2/1987 and B/Yamagata/16/1988. Intralineage and interlineage genetic exchange processes have been demonstrated; The most frequent of them are those in which the Victoria lineage acquires genes from the Yamagata lineage. It has been proposed that the differences in the evolutionary dynamics of the two lineages are due to the different binding preferences of influenza hemagglutinin to the cellular receptor. The Victoria lineage has shown the ability to bind to cell receptors with sialic acid residues at the α-2,3 and α-2,6 positions; whereas the Yamagata lineage does so exclusively in the human α-2,6 positions of the respiratory tract. Low circulation in recent months may have contributed to the temporary elimination ("extinction") of the Yamagata lineage. Since 2017, almost all of the strains of this lineage belong to clade 3A, when previously multiple circulating clades were detected. Although this clade 3A is diverse at the genetic level and has acquired surrogate mutations in the hemagglutinin gene, these have not determined significant antigenic changes that have made it necessary to replace its antigenic component (B/Pukhet/3073/2013) in the influenza vaccine since 2015.
MeSH term(s)	Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Hemagglutinins ; Humans ; Influenza B virus/genetics ; Influenza Vaccines ; Influenza, Human/prevention & control ; Phylogeny
Chemical Substances	Hemagglutinin Glycoproteins, Influenza Virus ; Hemagglutinins ; Influenza Vaccines
Language	Spanish
Publishing date	2022-02-18
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	1018135-0
ISSN	1988-9518 ; 0214-3429
ISSN (online)	1988-9518
ISSN	0214-3429
DOI	10.37201/req/159.2021
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Article ; Online: The new generation of messenger RNA (mRNA) vaccines against influenza.

Reina, Jordi

Enfermedades infecciosas y microbiologia clinica (English ed.)

2022 Volume 41, Issue 5, Page(s) 301–304

Abstract: Today there are multiple types of flu vaccines. The emergence of nucleic acid technology used in vaccines against SARS-CoV-2 suggests its future application against this infection. Against influenza, two types of vaccines have been developed based on ... ...

Abstract	Today there are multiple types of flu vaccines. The emergence of nucleic acid technology used in vaccines against SARS-CoV-2 suggests its future application against this infection. Against influenza, two types of vaccines have been developed based on messenger RNA (mRNA): conventional or non-replicative and self-amplifying or replicative (auRNA), both included in lipid nanoparticles. Animal studies carried out with the former have shown their strong capacity to induce Th-1 antibodies and cellular immunity against influenza haemagglutinin (HA) with few side effects. Human trials have shown 87% seroconversion and 100% seroprotection. The auRNA vaccines have obtained similar results in animals but at a concentration 64 times lower than the conventional one. Vaccines based on mRNA platforms meet the WHO requirements for next generation influenza vaccines.
MeSH term(s)	Animals ; Humans ; Influenza, Human/prevention & control ; Influenza Vaccines ; mRNA Vaccines ; COVID-19 Vaccines ; COVID-19/prevention & control ; SARS-CoV-2 ; RNA, Messenger/genetics
Chemical Substances	Influenza Vaccines ; mRNA Vaccines ; COVID-19 Vaccines ; RNA, Messenger
Language	English
Publishing date	2022-07-26
Publishing country	Spain
Document type	Journal Article ; Review
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2022.07.006
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Article ; Online: Possible effect of the "original antigenic sin" in vaccination against new variants of SARS-CoV-2.

Reina, J

Revista clinica espanola

2021 Volume 222, Issue 2, Page(s) 91–92

MeSH term(s)	COVID-19 ; Humans ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Vaccination
Chemical Substances	Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2021-09-14
Publishing country	Spain
Document type	Editorial ; Comment
ISSN	2254-8874
ISSN (online)	2254-8874
DOI	10.1016/j.rceng.2021.05.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Posible efecto del «pecado antigénico original» en la vacunación frente a las nuevas variantes del SARS-CoV-2.

Reina, J

Revista clinica espanola

2021 Volume 222, Issue 2, Page(s) 91–92

Title translation	Possible effect of the "original antigenic sin" in vaccination against new variants of SARS-CoV-2.
Language	Spanish
Publishing date	2021-06-05
Publishing country	Spain
Document type	Editorial
ZDB-ID	123597-7
ISSN	1578-1860 ; 0014-2565 ; 0014-2565
ISSN (online)	1578-1860 ; 0014-2565
ISSN	0014-2565
DOI	10.1016/j.rce.2021.05.003
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Article ; Online: Plitidepsina, un inhibidor del factor de elongación celular eEF1a y molnupiravir un análogo del ribonucleósido citidina, dos nuevos compuestos químicos con intensa actividad frente al SARS-CoV-2.

Reina, J

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

2021 Volume 34, Issue 5, Page(s) 402–407

Abstract: The knowledge of the replicative cycle of SARS-CoV-2 and its interactions with cellular proteins has opened a new therapeutic possibility based on blocking those essential for the virus. The cellular protein elongation factor eEF1A could be a good target. ...

Title translation	Plitidepsin, an inhibitor of the cell elongation factor eEF1a, and molnupiravir an analogue of the ribonucleoside cytidine, two new chemical compounds with intense activity against SARS-CoV-2.
Abstract	The knowledge of the replicative cycle of SARS-CoV-2 and its interactions with cellular proteins has opened a new therapeutic possibility based on blocking those essential for the virus. The cellular protein elongation factor eEF1A could be a good target. Among its natural inhibitors are didemnins and their related chemical compounds such as plitidepsin. In human cell culture, this compound is capable of inhibiting the virus with a potency 27,5 times that of remdesivir. It must be administered intravenously. Of the ribonucleoside analogues, molnupiravir (MK-4483/EIDD-2801) (hydroxy-cytidine) determines a lethal mutagenesis on SARS-CoV-2. In animals, after oral administration, the pulmonary viral load decreases 25,000 times and when administered as prophylaxis, approximately 100,000 times. It prevents the transmission of the virus and eliminates its presence in the oropharynx. Both chemicals have started Phase I / II human clinical trials.
MeSH term(s)	Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19 ; Cytidine/analogs & derivatives ; Depsipeptides ; Humans ; Hydroxylamines ; Peptide Elongation Factors ; Peptides, Cyclic ; Ribonucleosides ; SARS-CoV-2
Chemical Substances	Antiviral Agents ; Depsipeptides ; Hydroxylamines ; Peptide Elongation Factors ; Peptides, Cyclic ; Ribonucleosides ; Cytidine (5CSZ8459RP) ; plitidepsin (Y76ID234HW) ; molnupiravir (YA84KI1VEW)
Language	Spanish
Publishing date	2021-04-27
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	1018135-0
ISSN	1988-9518 ; 0214-3429
ISSN (online)	1988-9518
ISSN	0214-3429
DOI	10.37201/req/042.2021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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