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  1. Article ; Online: Veterinary endectocides for malaria control and elimination: prospects and challenges.

    Chaccour, Carlos

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2020  Volume 376, Issue 1818, Page(s) 20190810

    Abstract: Residual transmission is the persistence of malaria transmission after scale-up of appropriate vector control tools and is one of the key challenges for malaria elimination today. Although long associated with outdoor biting, other mosquito behaviours ... ...

    Abstract Residual transmission is the persistence of malaria transmission after scale-up of appropriate vector control tools and is one of the key challenges for malaria elimination today. Although long associated with outdoor biting, other mosquito behaviours such as partly feeding upon animals contribute greatly to sustaining transmission. Peri-domestic livestock can be used as decoy to protect humans from blood-seeking vectors but this approach often leads to an increased malaria risk in a phenomenon known as zoopotentiation. Treating the said livestock with drugs capable of killing intestinal parasites as well as mosquitoes that feed upon them has the potential to tackle malaria through a previously unexplored mechanism. The advantages and challenges associated with this approach are briefly discussed here. Numerous references are purposely provided. This article is part of the theme issue 'Novel control strategies for mosquito-borne diseases'.
    MeSH term(s) Animals ; Antimalarials/administration & dosage ; Cattle ; Culicidae ; Malaria/prevention & control ; Malaria/transmission ; Mosquito Control ; Mosquito Vectors ; Sus scrofa
    Chemical Substances Antimalarials
    Language English
    Publishing date 2020-12-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2019.0810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  2. Article: Effectiveness of Antiviral Therapy in Highly-Transmissible Variants of SARS-CoV-2: A Modeling and Simulation Study.

    Schöning, Verena / Kern, Charlotte / Chaccour, Carlos / Hammann, Felix

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 816429

    Abstract: As of October 2021, neither established agents (e.g., hydroxychloroquine) nor experimental drugs have lived up to their initial promise as antiviral treatment against SARS-CoV-2 infection. While vaccines are being globally deployed, variants of concern ( ... ...

    Abstract As of October 2021, neither established agents (e.g., hydroxychloroquine) nor experimental drugs have lived up to their initial promise as antiviral treatment against SARS-CoV-2 infection. While vaccines are being globally deployed, variants of concern (VOCs) are emerging with the potential for vaccine escape. VOCs are characterized by a higher within-host transmissibility, and this may alter their susceptibility to antiviral treatment. Here we describe a model to understand the effect of changes in within-host reproduction number R
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.816429
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  3. Article ; Online: Adapt or perish: SARS-CoV-2 antibody escape variants defined by deletions in the Spike N-terminal Domain.

    Ribes, Marta / Chaccour, Carlos / Moncunill, Gemma

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 164

    MeSH term(s) COVID-19 ; Glycoproteins ; Humans ; SARS-CoV-2
    Chemical Substances Glycoproteins
    Language English
    Publishing date 2021-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00601-8
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  4. Article ; Online: Human Botfly Infestation in an Amerindian Girl in Southern Venezuela.

    Gabaldon-Figueira, Juan C / Pritt, Bobbi S / Chaccour, Carlos

    The American journal of tropical medicine and hygiene

    2021  Volume 104, Issue 4, Page(s) 1167–1168

    MeSH term(s) Animals ; Child ; Diptera/anatomy & histology ; Female ; Humans ; Myiasis/diagnosis
    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-1531
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  5. Article ; Online: Advancing the repurposing of ivermectin for malaria.

    Chaccour, Carlos / Rabinovich, N Regina

    Lancet (London, England)

    2019  Volume 393, Issue 10180, Page(s) 1480–1481

    MeSH term(s) Animals ; Anopheles ; Drug Repositioning ; Ivermectin ; Malaria ; Mass Drug Administration
    Chemical Substances Ivermectin (70288-86-7)
    Language English
    Publishing date 2019-03-14
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(18)32613-8
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  6. Article ; Online: Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes.

    Kern, Charlotte / Müller, Pie / Chaccour, Carlos / Liechti, Matthias E / Hammann, Felix / Duthaler, Urs

    Malaria journal

    2023  Volume 22, Issue 1, Page(s) 194

    Abstract: Background: Ivermectin (22,23-dihydroavermectin B: Methods: Ivermectin was incubated in the presence of recombinant human cytochrome P: Results: Human CYP3A4 metabolised ivermectin more rapidly than CYP3A5. Ivermectin metabolites M1-M8 were ... ...

    Abstract Background: Ivermectin (22,23-dihydroavermectin B
    Methods: Ivermectin was incubated in the presence of recombinant human cytochrome P
    Results: Human CYP3A4 metabolised ivermectin more rapidly than CYP3A5. Ivermectin metabolites M1-M8 were predominantly formed by CYP3A4, whereas metabolite M9 (hydroxy-H
    Conclusion: In conclusion, the ivermectin metabolites M1 and M2 contribute to the activity of ivermectin against An. stephensi mosquitoes and could be responsible for the "post-ivermectin effect".
    MeSH term(s) Animals ; Humans ; Ivermectin/pharmacology ; Cytochrome P-450 CYP3A ; Anopheles ; Insecticides/pharmacology ; Malaria/prevention & control ; Mosquito Vectors
    Chemical Substances Ivermectin (70288-86-7) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Insecticides
    Language English
    Publishing date 2023-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091229-8
    ISSN 1475-2875 ; 1475-2875
    ISSN (online) 1475-2875
    ISSN 1475-2875
    DOI 10.1186/s12936-023-04624-0
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  7. Article: Modeling of SARS-CoV-2 Treatment Effects for Informed Drug Repurposing.

    Kern, Charlotte / Schöning, Verena / Chaccour, Carlos / Hammann, Felix

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 625678

    Abstract: Several repurposed drugs are currently under investigation in the fight against coronavirus disease 2019 (COVID-19). Candidates are often selected solely by their effective ... ...

    Abstract Several repurposed drugs are currently under investigation in the fight against coronavirus disease 2019 (COVID-19). Candidates are often selected solely by their effective concentrations
    Language English
    Publishing date 2021-03-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.625678
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  8. Article ; Online: Update on malaria.

    Varo, Rosauro / Chaccour, Carlos / Bassat, Quique

    Medicina clinica

    2020  Volume 155, Issue 9, Page(s) 395–402

    Abstract: Despite recent successful efforts to reduce the global malaria burden, this disease remains a significant global health problem. Only in 2018, malaria caused 228 million clinical episodes, 2-4 million of which were severe malaria cases, and 405,000 were ... ...

    Abstract Despite recent successful efforts to reduce the global malaria burden, this disease remains a significant global health problem. Only in 2018, malaria caused 228 million clinical episodes, 2-4 million of which were severe malaria cases, and 405,000 were fatal. Most of the malaria attributable mortality occurred among children in sub-Saharan Africa. Nowadays, rapid diagnostic tests and artemisinin derivatives are two of the main pillars for the management of malaria. However, considering the current situation, these strategies are not sufficient to maintain a reducing trend in malaria incidence and mortality. New insights into the pathophysiology of malaria have highlighted the importance of the host response to infection. Understanding this response would help to develop new diagnostic and therapeutic tools. Vector and parasite drug resistance are two major challenges for malaria control that require special attention. The most advanced malaria vaccine (RTS,S) is currently being piloted in 3 African countries.
    MeSH term(s) Africa South of the Sahara/epidemiology ; Antimalarials/therapeutic use ; Child ; Diagnostic Tests, Routine ; Drug Resistance ; Humans ; Malaria/diagnosis ; Malaria/drug therapy ; Malaria/epidemiology
    Chemical Substances Antimalarials
    Language Spanish
    Publishing date 2020-06-30
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2020.05.010
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  9. Article ; Online: Insecticide-treated livestock: a potential One Health approach to malaria control in Africa.

    Ruiz-Castillo, Paula / Rist, Cassidy / Rabinovich, Regina / Chaccour, Carlos

    Trends in parasitology

    2021  Volume 38, Issue 2, Page(s) 112–123

    Abstract: New vector-control tools are urgently needed to reduce malaria in areas where there is significant transmission after deployment of indoor residual spraying (IRS) and insecticide treated nets. Insecticide-treated livestock (ITL) is a potential novel ... ...

    Abstract New vector-control tools are urgently needed to reduce malaria in areas where there is significant transmission after deployment of indoor residual spraying (IRS) and insecticide treated nets. Insecticide-treated livestock (ITL) is a potential novel strategy by which zoophagic mosquitos are killed after feeding upon animals treated with an insecticide. Although there are several insecticide candidates in the pipeline with a wide efficacy range against mosquitos, additional field studies with epidemiological outcomes are required to test the impact of this intervention on malaria transmission. Insecticides under consideration have long been used in livestock to improve animal health and productivity, but each has food and environmental safety considerations. Therefore, moving ITL from a concept to implementation will require a One Health framework.
    MeSH term(s) Africa/epidemiology ; Animals ; Anopheles ; Insecticide-Treated Bednets ; Insecticides ; Livestock ; Malaria/prevention & control ; Mosquito Control ; Mosquito Vectors ; One Health
    Chemical Substances Insecticides
    Language English
    Publishing date 2021-10-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2021.09.006
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  10. Article ; Online: Adapt or perish

    Marta Ribes / Carlos Chaccour / Gemma Moncunill

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    SARS-CoV-2 antibody escape variants defined by deletions in the Spike N-terminal Domain

    2021  Volume 2

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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