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  1. Article ; Online: The SARS-CoV-2 pandemic in Germany may represent the sum of a large number of local but independent epidemics each initiated by individuals aged 10-19 years, middle-aged males, or elderly individuals.

    Häusler, Martin / Kleines, Michael

    Journal of medical virology

    2022  Volume 94, Issue 7, Page(s) 3087–3095

    Abstract: Many epidemiological aspects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemics, particularly those affecting children, are still sparsely elucidated. Data on the first pandemic phase during the year 2020 indicated that ... ...

    Abstract Many epidemiological aspects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemics, particularly those affecting children, are still sparsely elucidated. Data on the first pandemic phase during the year 2020 indicated that children might serve as a virus reservoir. We now analyzed data on more than 530 000 SARS-CoV-2 polymerase chain reaction (PCR) and 12 503 anti-SARS-CoV-2 antibody tests performed in the west of Germany until Week 4 of 2021. We show that children of at least 10 years of age may play a prominent role in the pandemic showing highest PCR-positive rates in the first (Weeks 28-35), second (Weeks 42-48), and third wave (Week 50 of 2020-Week 2 2021) of the second pandemic phase, although the waves were not mainly initiated by children. The waves' kinetics differed even in nearby cities. Low PCR-positive rates were confined to areas of lower population density. PCR-positive rates were higher among middle-aged males compared with women and among very old females compared with males. From Week 25, seroprevalence rates slowly increased to 50%, indicating ongoing virus activity. In conclusion, the SARS-CoV-2 pandemics is characterized by many local but interacting epidemics, initiated and driven by different social groups. Children may not be the main initiators of virus spreading but older children may significantly affect the course of the pandemic. High population density is associated with higher SARS-CoV-2 incidence.
    MeSH term(s) Adolescent ; Aged ; Antibodies, Viral ; COVID-19/epidemiology ; Child ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2 ; Seroepidemiologic Studies
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27682
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  2. Article ; Online: Equine-Assisted Therapies for Children With Cerebral Palsy: A Meta-analysis.

    Heussen, Nicole / Häusler, Martin

    Pediatrics

    2022  Volume 150, Issue 1

    Abstract: Context: Equine-assisted therapy in different facets aims to improve the clinical condition of children with cerebral palsy. A more comprehensive overview on the overall effects and on the differences between different treatment modalities seems ... ...

    Abstract Context: Equine-assisted therapy in different facets aims to improve the clinical condition of children with cerebral palsy. A more comprehensive overview on the overall effects and on the differences between different treatment modalities seems desirable.
    Objective: We compared the effectiveness of various equine-assisted treatments on motor capabilities and quality of life of children with cerebral palsy.
    Data sources: We conducted systematic searches of PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials.
    Study selection: Randomized and nonrandomized controlled parallel-group or crossover studies on equine-assisted therapies in comparison with standard of care were included.
    Data extraction: Data on motor function assessed by different instruments were considered as the primary outcome. Secondary outcomes included global, social, physical, and emotional scores of quality of life.
    Results: Strong evidence for a positive effect of equine-assisted therapies, particularly hippotherapy, on global gross motor function and motor capabilities during walking in children with cerebral palsy was identified (SMD 0.24, 95% CI 0.05 to 0.43, P = .01, t2 = 0.00, I2 = 15%; SMD 2.68, 95% CI 1.02 to 4.34, P = .002, t2 = 0.0, I2 = 0%). No evidence for the improvement in quality of life could be shown in the global assessment, nor in any subscore.
    Conclusions: Equine-assisted therapy, particularly hippotherapy, can be a therapeutic tool for children who are learning to walk.
    Limitation: The heterogeneity of tools used in different studies and the low number of studies addressing quality of life issues limited the number of studies available for distinct analyses.
    MeSH term(s) Animals ; Cerebral Palsy/therapy ; Child ; Cross-Over Studies ; Equine-Assisted Therapy ; Horses ; Humans ; Quality of Life
    Language English
    Publishing date 2022-06-03
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-055229
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  3. Book ; Thesis: Herpesvirusinfektionen, die verkannte Ursache für entzündliche ZNS-Erkrankungen bei Kindern und Jugendlichen

    Häusler, Martin Georg

    2004  

    Author's details vorgelegt von Martin Georg Häusler
    Language German
    Size 95 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Habil.-Schr., 2004
    HBZ-ID HT015986607
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Natalizumab Promotes Activation of Peripheral Monocytes in Patients With Multiple Sclerosis.

    Frisch, Esther S / Häusler, Darius / Weber, Martin S

    Neurology(R) neuroimmunology & neuroinflammation

    2023  Volume 10, Issue 4

    Abstract: Objectives: Natalizumab (NTZ), a monoclonal antibody against very late antigen-4 (VLA-4), is one of the most efficient therapies to prevent acute relapses in multiple sclerosis (MS). VLA-4 is the key adhesion molecule for peripheral immune cells, ... ...

    Abstract Objectives: Natalizumab (NTZ), a monoclonal antibody against very late antigen-4 (VLA-4), is one of the most efficient therapies to prevent acute relapses in multiple sclerosis (MS). VLA-4 is the key adhesion molecule for peripheral immune cells, especially lymphocytes to enter the CNS. While its blockade thus virtually abrogates CNS infiltration of these cells, long-term exposure to natalizumab may also affect immune cell function.
    Methods: In this study, we report that in patients with MS, NTZ treatment is associated with an enhanced activation status of peripheral monocytes.
    Results: Expression of 2 independent activation markers, CD69 and CD150, was significantly higher on blood monocytes from NTZ-treated patients when compared with those from matched untreated patients with MS, while other properties such as cytokine production remained unchanged.
    Discussion: These findings consolidate the concept that peripheral immune cells remain fully competent on NTZ treatment, an excellent asset rare among MS treatments. However, they also suggest that NTZ may exert nondesirable effects on the progressive aspect of MS, where myeloid cells and their chronic activation are attributed a prominent pathophysiologic role.
    MeSH term(s) Humans ; Natalizumab/pharmacology ; Multiple Sclerosis/drug therapy ; Integrin alpha4beta1/metabolism ; Monocytes
    Chemical Substances Natalizumab ; Integrin alpha4beta1 ; nitazoxanide (SOA12P041N)
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2767740-0
    ISSN 2332-7812 ; 2332-7812
    ISSN (online) 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000200114
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  5. Book: Clinical and molecular teratology

    Boyd, Patricia A. / Häusler, Martin / Barišic, Ingeborg

    EUROCAT supplement

    (Birth defects research : A ; 91,S1 = Spec. iss. ; EUROCAT report ; 9)

    2011  

    Author's details guest ed.: Patricia A. Boyd, Martin Haeusler and Ingeborg Barisic
    Series title Birth defects research : A ; 91,S1 = Spec. iss.
    EUROCAT report ; 9
    Birth defects research
    Birth defects research ; A
    Collection Birth defects research
    Birth defects research ; A
    Language English
    Size S100 S. : graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT016800846
    Database Catalogue ZB MED Medicine, Health

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    Zs A 749 -91,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  6. Book ; Thesis: Der Abheilprozess verletzter Papillarmuskeln aus dem Rattenherzen

    Häusler, Martin

    1995  

    Author's details vorgelegt von Martin Häusler
    Language German
    Size 116 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Saarbrücken, Univ., Diss., 1995
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT007301154
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: Enhancing the Follow-up Assessment of Very Preterm Children with Regard to 5-Year IQ Considering Socioeconomic Status.

    Hoberg, Kathrin / Häusler, Martin / Orlikowsky, Thorsten / Lidzba, Karen

    Zeitschrift fur Geburtshilfe und Neonatologie

    2022  Volume 226, Issue 6, Page(s) 405–415

    Abstract: Background: Specifying peri- and postnatal factors in children born very preterm (VPT) that affect later outcome helps to improve long-term treatment.: Aim: To enhance the predictability of 5-year cognitive outcome by perinatal, 2-year developmental ... ...

    Title translation Optimierung der Nachuntersuchung Frühgeborener im Hinblick auf ihren IQ mit 5 Jahren unter besonderer Berücksichtigung des Sozioökonomischen Status.
    Abstract Background: Specifying peri- and postnatal factors in children born very preterm (VPT) that affect later outcome helps to improve long-term treatment.
    Aim: To enhance the predictability of 5-year cognitive outcome by perinatal, 2-year developmental and socio-economic data.
    Subjects and outcome measures: 92 VPT infants, born 2007-2009, gestational age<32 weeks and/or birthweight of 1500 g, were assessed longitudinally including basic neonatal, socio-economic (SES), 2-year Mental Developmental Index (MDI, Bayley Scales II), 5-year Mental Processing Composite (MPC, Kaufman-Assessment Battery for Children), and Language Screening for Preschoolers data. 5-year infants born VPT were compared to 34 term controls.
    Results: The IQ of 5-year infants born VPT was 10 points lower than that of term controls and influenced independently by preterm birth and SES. MDI, SES, birth weight and birth complications explained 48% of the variance of the MPC. The MDI proved highly predictive (r=0.6, R2=36%) for MPC but tended to underestimate the cognitive outcome. A total of 61% of the 2-year infants born VPT were already correctly classified (specificity of .93, sensitivity of .54). CHAID decision tree technique identified SES as decisive for the outcome for infants born VPT with medium MDI results (76-91): They benefit from effects associated to a higher SES, while those with a poor MDI outcome and a birth weight≤890 g do not.
    Conclusion: Developmental follow-up of preterm children enhances the quality of prognosis and later outcome when differentially considering perinatal risks and SES.
    MeSH term(s) Female ; Child ; Infant, Newborn ; Humans ; Infant ; Birth Weight ; Premature Birth ; Social Class ; Infant, Very Low Birth Weight
    Language English
    Publishing date 2022-08-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0300-967X ; 0948-2393 ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0300-967X ; 0948-2393 ; 1615-5300
    DOI 10.1055/a-1864-9895
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  8. Article ; Online: Protocol for a systematic review and meta-analysis on the effect of hippotherapy and related equine-assisted therapies on motor capabilities in children with cerebral palsy.

    Häusler, Martin / Heussen, Nicole

    Systematic reviews

    2020  Volume 9, Issue 1, Page(s) 48

    Abstract: Background: Equine-assisted treatments of the motor system appear to have an effect on the neuromuscular system and aim to improve the pathological condition of children with cerebral palsy. Hippotherapy is a distinct form of equine-assisted therapy ... ...

    Abstract Background: Equine-assisted treatments of the motor system appear to have an effect on the neuromuscular system and aim to improve the pathological condition of children with cerebral palsy. Hippotherapy is a distinct form of equine-assisted therapy where certified physiotherapists use the horse as a dynamic tool in a medical treatment setting. The objective of the proposed review is to summarize and critically appraise the evidence on the effect of equine-assisted treatments on motor capabilities of children with cerebral palsy.
    Methods: We will identify trials through systematic searches of PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL). Quality assessment of retrieved articles will be conducted using the criteria outlined in the revised tool to assess risk of bias in randomized trials (RoB 2.0) or the ROBINS-I tool (Risk Of Bias In Non-randomized Studies - of interventions), respectively. Quantitative data synthesis will be performed if treatments, participants, and the underlying clinical question are homogenous and provide adequate outcome data for meta-analysis. Otherwise, data will be synthesized, using the narrative synthesis approach.
    Conclusion: This review will provide a critical summary of the evidence regarding the impact of equine-assisted treatments on motor capabilities of children with cerebral palsy. The result from this review will help to inform healthcare practitioners and policymakers on the additional effect of equine-assisted treatments on reducing the burden of cerebral palsy among children.
    Systematic review registration: This systematic review protocol is registered with the International Prospective Register of Systematic Reviews (PROSPERO). Registration number: CRD42018096403. This protocol was prepared using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Protocols checklist (PRISMA-P).
    MeSH term(s) Animals ; Cerebral Palsy/therapy ; Child ; Equine-Assisted Therapy ; Horses ; Humans ; Meta-Analysis as Topic ; Systematic Reviews as Topic
    Language English
    Publishing date 2020-03-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2662257-9
    ISSN 2046-4053 ; 2046-4053
    ISSN (online) 2046-4053
    ISSN 2046-4053
    DOI 10.1186/s13643-020-01297-7
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  9. Article: Phylogenetic reduction of the magnocellular red nucleus in primates and inter-subject variability in humans.

    Stacho, Martin / Häusler, A Niklas / Brandstetter, Andrea / Iannilli, Francesca / Mohlberg, Hartmut / Schiffer, Christian / Smaers, Jeroen B / Amunts, Katrin

    Frontiers in neuroanatomy

    2024  Volume 18, Page(s) 1331305

    Abstract: Introduction: The red nucleus is part of the motor system controlling limb movements. While this seems to be a function common in many vertebrates, its organization and circuitry have undergone massive changes during evolution. In primates, it is sub- ... ...

    Abstract Introduction: The red nucleus is part of the motor system controlling limb movements. While this seems to be a function common in many vertebrates, its organization and circuitry have undergone massive changes during evolution. In primates, it is sub-divided into the magnocellular and parvocellular parts that give rise to rubrospinal and rubro-olivary connection, respectively. These two subdivisions are subject to striking variation within the primates and the size of the magnocellular part is markedly reduced in bipedal primates including humans. The parvocellular part is part of the olivo-cerebellar circuitry that is prominent in humans. Despite the well-described differences between species in the literature, systematic comparative studies of the red nucleus remain rare.
    Methods: We therefore mapped the red nucleus in cytoarchitectonic sections of 20 primate species belonging to 5 primate groups including prosimians, new world monkeys, old world monkeys, non-human apes and humans. We used Ornstein-Uhlenbeck modelling, ancestral state estimation and phylogenetic analysis of covariance to scrutinize the phylogenetic relations of the red nucleus volume.
    Results: We created openly available high-resolution cytoarchitectonic delineations of the human red nucleus in the microscopic BigBrain model and human probabilistic maps that capture inter-subject variations in quantitative terms. Further, we compared the volume of the nucleus across primates and showed that the parvocellular subdivision scaled proportionally to the brain volume across the groups while the magnocellular part deviated significantly from the scaling in humans and non-human apes. These two groups showed the lowest size of the magnocellular red nucleus relative to the whole brain volume and the largest relative difference between the parvocellular and magnocellular subdivision.
    Discussion: That is, the red nucleus has transformed from a magnocellular-dominated to a parvocellular-dominated station. It is reasonable to assume that these changes are intertwined with evolutionary developments in other brain regions, in particular the motor system. We speculate that the interspecies variations might partly reflect the differences in hand dexterity but also the tentative involvement of the red nucleus in sensory and cognitive functions.
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452969-2
    ISSN 1662-5129
    ISSN 1662-5129
    DOI 10.3389/fnana.2024.1331305
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  10. Article ; Online: Spectrum, Evolution, and Clinical Relationship of Magnetic Resonance Imaging in 31 Children with Febrile Infection-Related Epilepsy Syndrome.

    Moreno-Brauer, Darinka / Häusler, Martin / Kluger, Gerhard / Hensler, Johannes / van Baalen, Andreas

    Neuropediatrics

    2023  Volume 55, Issue 1, Page(s) 9–15

    Abstract: Objective: Describing spectrum, evolution, and clinical relationship of brain magnetic resonance imaging (MRI) findings in a large case series of children with febrile infection-related epilepsy syndrome (FIRES).: Methods: This retrospective study ... ...

    Abstract Objective: Describing spectrum, evolution, and clinical relationship of brain magnetic resonance imaging (MRI) findings in a large case series of children with febrile infection-related epilepsy syndrome (FIRES).
    Methods: This retrospective study included 31 children with FIRES. Clinical data and MRI findings of the brain were evaluated. Poor clinical outcome was defined as severe disability, persistent vegetative state or stupor, very low intelligence quotient (<80), or death (modified Rankin scale 4-6 and Glasgow Outcome Score 1-3).
    Results: Seventeen (54.8%) children with FIRES showed no abnormalities in the initial MRI, whereas 28 (90.3%) children showed MRI abnormalities at follow-up. The most frequent abnormalities were brain atrophy (74.2%) and T2/fluid-attenuated inversion recovery changes (64.5%), mostly hippocampal (45.2%). Generalized brain atrophy was the most frequent type of atrophy (58%). The earliest atrophy was recorded 9 days after the onset of disease. It progressed even beyond the acute phase in most children (51.6%). The exploratory data analysis revealed nominal significance between all MRI abnormalities considered together and poor outcome (
    Conclusion: In contrast to the uniform clinical course, MRI demonstrated a broad spectrum of findings. Initially, these were mostly normal and therefore indicative of FIRES but then changed rapidly and were mostly progressive despite the stable chronic course. The cause may be ongoing disease, treatment intensity, or both. Future studies should focus on what process underlies the onset and the progression of brain atrophy. However, brain atrophy was not always related to poor outcomes in children despite FIRES.
    MeSH term(s) Child ; Humans ; Retrospective Studies ; Seizures ; Drug Resistant Epilepsy/diagnostic imaging ; Drug Resistant Epilepsy/etiology ; Drug Resistant Epilepsy/pathology ; Brain/diagnostic imaging ; Brain/pathology ; Magnetic Resonance Imaging ; Encephalitis ; Epileptic Syndromes ; Atrophy/pathology
    Language English
    Publishing date 2023-10-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 573291-8
    ISSN 1439-1899 ; 0174-304X
    ISSN (online) 1439-1899
    ISSN 0174-304X
    DOI 10.1055/s-0043-1774318
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