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  1. Article ; Online: Substance use among older adults: a review of the literature.

    Arcadepani, Felipe B / Fidalgo, Thiago M

    Journal of addictive diseases

    2022  Volume 41, Issue 4, Page(s) 289–299

    Abstract: Objectives: To explore studies that have examined the effectiveness of possible interventions to reduce the substance use among older adults.: Methods: From the search, 295 abstracts were identified and 200 were excluded. Ninety-five remaining ... ...

    Abstract Objectives: To explore studies that have examined the effectiveness of possible interventions to reduce the substance use among older adults.
    Methods: From the search, 295 abstracts were identified and 200 were excluded. Ninety-five remaining articles were reviewed, and 90 were excluded after full text review. Nine articles were included after reviewing bibliographic references on the topic. A total of 14 articles, which all met the inclusion criteria, were considered in the review.
    Results: All 14 studies found that pharmacological and non-pharmacological interventions can reduce substance use (alcohol, cocaine, nicotine and benzodiazepines) among older adults (mean age 45 years or older).
    Conclusions: There are promising possibly pharmacological and non-pharmacological interventions that can be used to reduce substance use among older adults. In addition, other studies are needed to expand the therapeutic arsenal in this population.
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1077616-3
    ISSN 1545-0848 ; 1055-0887
    ISSN (online) 1545-0848
    ISSN 1055-0887
    DOI 10.1080/10550887.2022.2109923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mutation of GPR143 Associated With Ocular Albinism Type 1, Intellectual Disability, and Schizophrenia: The Complex Biological and Social Interactions Between Genetic Syndromes and Mental Illness.

    Arcadepani, Felipe B / Gadelha, Ary / Margolis, Russell L

    Journal of psychiatric practice

    2023  Volume 29, Issue 1, Page(s) 77–81

    Abstract: Copy number variations, which manifest primarily as deletions and duplications, contribute significantly to the genetic risk of schizophrenia. Specific syndromes associated with copy number variations, exemplified by the 22q11 deletion syndrome, confer ... ...

    Abstract Copy number variations, which manifest primarily as deletions and duplications, contribute significantly to the genetic risk of schizophrenia. Specific syndromes associated with copy number variations, exemplified by the 22q11 deletion syndrome, confer both congenital abnormalities and an elevated risk of schizophrenia. We report the case of a patient with a deletion of exons 2 through 8 of GPR143. In addition to having the ophthalmologic disorder ocular albinism type 1 (OA1), a well-established consequence of mutations of GPR143, the patient is also intellectually impaired and impulsive, and he developed schizophrenia at age 15. Psychiatric manifestations of OA1 have not previously been reported, yet remain plausible, as the GPR143 protein is widely distributed in the brain and may function as an L-DOPA receptor. However, the patient described here also had a family history of psychiatric disorders independent of OA1, in utero exposure to heroin and cocaine, and challenging family circumstances. We suggest that the relationship between his GPR143 mutation and his psychiatric disorders is complex. The mutation may have directly contributed to his cognitive and psychiatric disorders, but we also suspect that OA1, present in multiple family members, contributed to multigenerational familial instability. Further, OA1 likely exacerbated our patient's cognitive and social impairment by interfering with his education, while his neuropsychiatric status frequently interfered with the assessment and treatment of his OA1. We conclude that the psychiatric and nonpsychiatric manifestations of a genetic syndrome are best managed in parallel and that psychiatrists and other mental health providers may be in the best position to assure that patients receive appropriate genetic and medical care.
    MeSH term(s) Male ; Humans ; Adolescent ; Schizophrenia/genetics ; Membrane Glycoproteins/genetics ; Intellectual Disability/genetics ; Social Interaction ; DNA Copy Number Variations ; Eye Proteins/genetics ; Mutation
    Chemical Substances Membrane Glycoproteins ; Eye Proteins ; GPR143 protein, human
    Language English
    Publishing date 2023-01-01
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2022726-7
    ISSN 1538-1145 ; 1527-4160
    ISSN (online) 1538-1145
    ISSN 1527-4160
    DOI 10.1097/PRA.0000000000000685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Violent behavior, perceived safety, and assault experiences among adolescents: results from the Brazilian National Adolescent School-based Health Survey.

    Arcadepani, Felipe B / Fernandes, Arthur G / Castaldelli-Maia, João M / Fidalgo, Thiago M

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2023  Volume 45, Issue 1, Page(s) 5–10

    Abstract: Objective: To investigate factors associated with violent behavior in a large nationally representative sample of Brazilian adolescents.: Methods: The data were derived from the 2015 National Adolescent School-based Health Survey (Pesquisa Nacional ... ...

    Abstract Objective: To investigate factors associated with violent behavior in a large nationally representative sample of Brazilian adolescents.
    Methods: The data were derived from the 2015 National Adolescent School-based Health Survey (Pesquisa Nacional de Saúde do Escolar [PeNSE]). The independent variables of interest included feelings of safety while on the way to and at school. The outcome was violent behavior, including bullying. Logistic regression models were developed to examine the relationship between violent behavior and each independent and control variable.
    Results: In the adjusted regression model, male sex (aOR: 1.75; 95%CI 1.65-1.86), being assaulted by a family member (aOR: 1.74; 95%CI 1.59-1.90), and being assaulted in the past year (aOR: 1.70; 95%CI 1.57-1.85) all increased the chance of violent behavior. Feeling safe on the way to school (aOR: 0.82; 95%CI 0.74-0.92) and at school (aOR: 0.82; 95%CI 0.73-0.92) reduced the chance of violent behavior.
    Conclusions: This study extends the body of literature on violent behavior among adolescents, demonstrating a correlation between school, domestic, family, or community violence and violent behavior. Our research supports the idea that adolescents who experience violence act violently with greater frequency. This finding has significant implications for pediatricians, child psychiatrists and psychologists, other health care professionals, school professionals, and other professionals involved in adolescent health. School professionals must be prepared to identify adolescents with violent behavior due to its potential consequences for their mental and physical health.
    MeSH term(s) Child ; Humans ; Male ; Adolescent ; Adolescent Health ; Brazil ; Crime Victims ; Violence ; Health Surveys ; Adolescent Behavior
    Language English
    Publishing date 2023-03-11
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2024119-7
    ISSN 1809-452X ; 1809-452X
    ISSN (online) 1809-452X
    ISSN 1809-452X
    DOI 10.47626/1516-4446-2022-2623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Meta-analysis: an intelligent way to tackle the economic crisis of Brazilian science.

    Tardelli, Vitor S / Arcadepani, Felipe B / Fidalgo, Thiago M

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2020  Volume 42, Issue 2, Page(s) 120

    MeSH term(s) Biomedical Research/economics ; Biomedical Research/standards ; Brazil ; Economic Recession ; Evidence-Based Practice/economics ; Evidence-Based Practice/standards ; Humans ; Meta-Analysis as Topic
    Language English
    Publishing date 2020-03-16
    Publishing country Brazil
    Document type Journal Article
    ISSN 1809-452X
    ISSN (online) 1809-452X
    DOI 10.1590/1516-4446-2020-0003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The SARS-Cov-2 threat in Cracolândia, an open-air drug use scene in Brazil.

    Arcadepani, Felipe B / Tardelli, Vitor S / Fidalgo, Thiago M

    The International journal on drug policy

    2020  Volume 83, Page(s) 102835

    MeSH term(s) Brazil ; COVID-19 ; Humans ; Illicit Drugs ; SARS-CoV-2 ; Substance-Related Disorders
    Chemical Substances Illicit Drugs
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2010000-0
    ISSN 1873-4758 ; 0955-3959
    ISSN (online) 1873-4758
    ISSN 0955-3959
    DOI 10.1016/j.drugpo.2020.102835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID-19 vaccination among socially vulnerable people who use drugs.

    Arcadepani, Felipe B / De Macedo, Marcos Antonio C F / Tardelli, Vitor Soares / Martins, Silvia S / Fidalgo, Thiago M

    Addiction (Abingdon, England)

    2021  Volume 116, Issue 9, Page(s) 2590–2591

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Drug Users/statistics & numerical data ; Humans ; Internationality ; SARS-CoV-2 ; Vulnerable Populations/statistics & numerical data
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-05-03
    Publishing country England
    Document type Letter
    ZDB-ID 1141051-6
    ISSN 1360-0443 ; 0965-2140
    ISSN (online) 1360-0443
    ISSN 0965-2140
    DOI 10.1111/add.15500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prescription psychostimulants for the treatment of stimulant use disorder: a systematic review and meta-analysis.

    Tardelli, Vitor S / Bisaga, Adam / Arcadepani, Felipe B / Gerra, Gilberto / Levin, Frances R / Fidalgo, Thiago M

    Psychopharmacology

    2020  Volume 237, Issue 8, Page(s) 2233–2255

    Abstract: Rationale: Agonist-based pharmacologic intervention is an accepted approach in treatment of opioid and tobacco use disorders.: Objectives: We conducted a systematic review and meta-analysis to evaluate usefulness of an agonist approach as treatment ... ...

    Abstract Rationale: Agonist-based pharmacologic intervention is an accepted approach in treatment of opioid and tobacco use disorders.
    Objectives: We conducted a systematic review and meta-analysis to evaluate usefulness of an agonist approach as treatment of (psycho)stimulant use disorder (PSUD).
    Methods: We reviewed PubMed/Medline, LILACS, and ClinicalTrials.gov databases searching for randomized, double-blind, placebo-controlled, parallel-design studies evaluating outcomes of individuals treated for cocaine- or amphetamine-type substance use disorder. We combined results of all trials that included the following prescription psychostimulants (PPs): modafinil, methylphenidate, or amphetamines (mixed amphetamine salts, lisdexamphetamine, and dextroamphetamine). The combined sample consisted of 2889 patients. Outcomes of interest included the following: drug abstinence (defined as 2-3 weeks of sustained abstinence and the average maximum days of consecutive abstinence), percentage of drug-negative urine tests across trial, and retention in treatment. We conducted random-effects meta-analyses and assessed quality of evidence using the GRADE system.
    Results: Thirty-eight trials were included. Treatment with PPs increases rates of sustained abstinence [risk ratio (RR) = 1.45, 95% confidence interval (CI) = (1.10, 1.92)] and duration of abstinence [mean difference (MD) = 3.34, 95% CI = (1.06, 5.62)] in patients with PSUD, particularly those with cocaine use disorder (very low-quality evidence). Prescription amphetamines were particularly efficacious in promoting sustained abstinence in patients with cocaine use disorder [RR = 2.44, 95% CI = (1.66, 3.58)], and higher doses of PPs were particularly efficacious for treatment of cocaine use disorder [RR = 1.95, 95% CI = (1.38, 2.77)] (moderate-quality evidence). Treatment with prescription amphetamines also yielded more cocaine-negative urines [MD = 8.37%, 95% CI = (3.75, 12.98)]. There was no effect of PPs on the retention in treatment.
    Conclusion: Prescription psychostimulants, particularly prescription amphetamines given in robust doses, have a clinically significant beneficial effect to promote abstinence in the treatment of individuals with PSUD, specifically the population with cocaine use disorder.
    MeSH term(s) Amphetamine/therapeutic use ; Central Nervous System Stimulants/therapeutic use ; Cocaine/therapeutic use ; Double-Blind Method ; Humans ; Lisdexamfetamine Dimesylate/therapeutic use ; Methylphenidate/therapeutic use ; Modafinil/therapeutic use ; Prescription Drugs/therapeutic use ; Randomized Controlled Trials as Topic/methods ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/drug therapy ; Substance-Related Disorders/psychology ; Treatment Outcome
    Chemical Substances Central Nervous System Stimulants ; Prescription Drugs ; Methylphenidate (207ZZ9QZ49) ; Amphetamine (CK833KGX7E) ; Cocaine (I5Y540LHVR) ; Modafinil (R3UK8X3U3D) ; Lisdexamfetamine Dimesylate (SJT761GEGS)
    Language English
    Publishing date 2020-06-29
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-020-05563-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An Exploration of the Link Between Bullying Perpetration and Substance Use: A Review of the Literature.

    Arcadepani, Felipe B / Eskenazi, Deborah Y G / Fidalgo, Thiago M / Hong, Jun Sung

    Trauma, violence & abuse

    2019  Volume 22, Issue 1, Page(s) 207–214

    Abstract: Bullying and substance use are serious public health concerns. The aim of this article is to review empirical studies that examined the association between bullying perpetration and substance use among adolescence in various countries. Research studies ... ...

    Abstract Bullying and substance use are serious public health concerns. The aim of this article is to review empirical studies that examined the association between bullying perpetration and substance use among adolescence in various countries. Research studies that found a correlation between bullying perpetration and substance use in children and adolescents were reviewed. From the search, 7,844 abstracts were identified and 7,795 were excluded. Fifty-four remaining articles were reviewed, and 23 were excluded after full text review. A total of 31 articles, which all met the inclusion criteria, were considered in the review. Findings from the review suggest that children who engaged in bullying are more likely to be involved in alcohol, tobacco, and illicit drug use. Substance use prevention efforts require an examination of peer dynamics and peer relationships. In addition, bullying and substance use prevention require family dynamics and how they may increase the risk of bullying and drugs abuse.
    MeSH term(s) Adolescent ; Bullying ; Child ; Child Abuse ; Humans ; Peer Group ; Substance-Related Disorders/epidemiology
    Language English
    Publishing date 2019-05-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2070884-1
    ISSN 1552-8324 ; 1524-8380
    ISSN (online) 1552-8324
    ISSN 1524-8380
    DOI 10.1177/1524838019837593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Childhood trauma and adolescent psychotic experiences in a community-based cohort: The potential role of positive attributes as a protective factor.

    Pan, Pedro M / Gadelha, Ary / Argolo, Felipe C / Hoffmann, Mauricio S / Arcadepani, Felipe B / Miguel, Euripedes C / Rohde, Luis A / McGuire, Philip / Salum, Giovanni A / Bressan, Rodrigo A

    Schizophrenia research

    2018  Volume 205, Page(s) 23–29

    Abstract: ... follow-up.: Results: Higher levels of baseline PE (B = 0.157, p < .001) and higher childhood trauma (B ... lower PE after 3 years, adjusting for the prevalence of baseline PE and childhood trauma (B = -0.042, p ...

    Abstract Objective: To investigate how a set of positive social and personality characteristics called 'positive attributes' affects the emergence and persistence of Psychotic Experiences (PE) in adolescence.
    Method: We used data from a community-based Brazilian High-Risk Cohort (HRC). 2511 6-12 year-old children were evaluated at baseline, and 80.05% completed a 3-year follow-up interview. At baseline, childhood trauma was assessed using parent- and self-report, and positive attributes were assessed by parent-report. Trained psychologists rated self-reported PE at both time points. Linear models evaluated the effect of childhood trauma and positive attributes on PE at follow-up. Mediation models tested i.) the indirect effect of positive attributes on the association between childhood trauma and follow-up PE and, ii.) the indirect effect of childhood trauma and positive attributes on the relationship between PE at baseline and follow-up.
    Results: Higher levels of baseline PE (B = 0.157, p < .001) and higher childhood trauma (B = 0.110, p < .001) were associated with increased follow-up PE. Higher positive attributes predicted lower PE after 3 years, adjusting for the prevalence of baseline PE and childhood trauma (B = -0.042, p < .022). Positive attributes partially mediated the relationship between childhood trauma and follow-up PE. The indirect pathway of childhood trauma and positive attributes mediated the association between baseline and follow-up PE.
    Conclusions: Higher levels of positive social and behavioral traits in childhood may diminish the subsequent emergence of PE. As these attributes can be promoted, our findings suggest that positive attributes may represent a novel target for preventive interventions in children at risk of developing PE.
    MeSH term(s) Adaptation, Psychological/physiology ; Adolescent ; Adverse Childhood Experiences/statistics & numerical data ; Brazil/epidemiology ; Child ; Female ; Follow-Up Studies ; Humans ; Male ; Personality/physiology ; Protective Factors ; Psychological Trauma/epidemiology ; Psychological Trauma/physiopathology ; Psychotic Disorders/epidemiology ; Psychotic Disorders/physiopathology ; Risk ; Social Skills
    Language English
    Publishing date 2018-06-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2018.06.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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