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  1. Article ; Online: Enhanced UV protection in silk fibroin based electrospun fabrics realized via orientation induced high efficiency of azobenzene isomerization.

    Liu, Kang / Zhang, Panpan / Müller-Buschbaum, Peter / Zhong, Qi

    International journal of biological macromolecules

    2024  Volume 268, Issue Pt 2, Page(s) 131638

    Abstract: ... electrospinning together with light-responsive copolymer P(MEO ...

    Abstract Due to the poor UV protection capability, natural silk fabrics not only suffer from easy damage by sunshine but also induce possible sunburn in the human body. Efficient azobenzene isomerization and enhanced UV shielding are realized by replacing the natural silk with natural protein silk fibroin (SF) and electrospinning together with light-responsive copolymer P(MEO
    Language English
    Publishing date 2024-04-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131638
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    Zs.B 2374: Show issues Location:
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  2. Article ; Online: A call to embrace a culture of openness in cardiovascular research.

    Cobey, Kelly D / Liu, Peter P

    European heart journal

    2022  Volume 43, Issue 24, Page(s) 2261–2263

    MeSH term(s) Cardiovascular System ; Heart ; Humans
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac189
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    Zs.MO 640: Show issues

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  3. Article ; Online: COVID-19 Vaccine Myocarditis: Cautious Reassurance in an Era of Dynamic Uncertainty.

    Liu, Peter P / Kafil, Tahir S

    Journal of the American College of Cardiology

    2022  Volume 80, Issue 24, Page(s) 2266–2268

    MeSH term(s) Humans ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Myocarditis/chemically induced
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2022.10.010
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    Zs.MO 196: Show issues

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  4. Article: The Contribution of Phytate-Degrading Enzymes to Chicken-Meat Production.

    Selle, Peter H / Macelline, Shemil P / Chrystal, Peter V / Liu, Sonia Yun

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 4

    Abstract: ... phosphorus (P) utilization, thereby reducing P excretion. This was amplified by an expanding appreciation ...

    Abstract The contribution that exogenous phytases have made towards sustainable chicken-meat production over the past two decades has been unequivocally immense. Initially, their acceptance by the global industry was negligible, but today, exogenous phytases are routine additions to broiler diets, very often at elevated inclusion levels. The genesis of this remarkable development is based on the capacity of phytases to enhance phosphorus (P) utilization, thereby reducing P excretion. This was amplified by an expanding appreciation of the powerful anti-nutritive properties of the substrate, phytate (
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13040603
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  5. Article ; Online: Echocardiographic predictors of outcome in severe aortic stenosis patients with preserved or reduced ejection fraction.

    Sokalski, Victoria / Liu, Dan / Hu, Kai / Frantz, Stefan / Nordbeck, Peter

    Clinical research in cardiology : official journal of the German Cardiac Society

    2024  Volume 113, Issue 3, Page(s) 481–495

    Abstract: ... death.: Results: All-cause mortality rate was 5.2% (LVEF > 50%: 4.3% vs. LVEF ≤ 50%: 7.7%, p = 0.141 ... at 30 days and 15.4% (LVEF > 50%: 14.7% vs. LVEF ≤ 50%: 17.3%, p = 0.443) at 12 months post TAVI ... Overall all-cause mortality rate was 45.1% (LVEF > 50%: 44.6% vs. LVEF ≤ 50%: 46.8%, p = 0.643 ...

    Abstract Aims: Transcatheter aortic valve implantation (TAVI) has emerged as the treatment of choice for many patients with severe symptomatic aortic stenosis. We sought to identify the echocardiographic predictors of 30-day and 1-year outcomes after TAVI in patients with preserved or reduced left ventricular ejection fraction (LVEF).
    Methods: This single-centre study included 618 aortic stenosis patients (mean age 82 ± 6 years, 47.1% male; 74.8% LVEF > 50%) who underwent balloon-expandable TAVI between July 2009 and October 2018 in our hospital. All patients completed at least 6 months of follow-up by medical history review or telephone interview (median 24, quartiles 12-42 months). The primary endpoint was all-cause death.
    Results: All-cause mortality rate was 5.2% (LVEF > 50%: 4.3% vs. LVEF ≤ 50%: 7.7%, p = 0.141) at 30 days and 15.4% (LVEF > 50%: 14.7% vs. LVEF ≤ 50%: 17.3%, p = 0.443) at 12 months post TAVI. Overall all-cause mortality rate was 45.1% (LVEF > 50%: 44.6% vs. LVEF ≤ 50%: 46.8%, p = 0.643). Mean survival time post TAVI was 51 months [95% CI (48; 55)]. In TAVI patients with LVEF > 50%, multivariate Cox regression analysis revealed several independent predictors for increased risk of death after adjusting for echocardiographic and clinical covariates: TAPSE (≤ 17 vs. > 17 mm, HR 1.528, p = 0.016) and sPAP (> 30 vs. ≤ 30 mmHg, HR 1.900, p = 0.002) for overall mortality, E/E' septal for 30-day mortality (> 21 vs. ≤ 21, HR 14.462, p = 0.010) and 12-month mortality (> 21 vs. ≤ 21, HR 1.881, p = 0.026). In TAVI patients with LVEF ≤ 50%, no independent echocardiographic predictors for outcome could be identified.
    Conclusions: LVEF is not a predictor of short- and long-term mortality after TAVI. In patients with preserved LVEF, left ventricular filling pressure (E/E´), systolic pulmonary artery pressure (sPAP), and TAPSE are echocardiographic risk factors for increased mortality post TAVI.
    MeSH term(s) Humans ; Male ; Aged ; Aged, 80 and over ; Female ; Stroke Volume ; Ventricular Function, Left ; Treatment Outcome ; Ventricular Dysfunction, Left ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Transcatheter Aortic Valve Replacement/adverse effects ; Echocardiography ; Aortic Valve/surgery ; Retrospective Studies
    Language English
    Publishing date 2024-01-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2213295-8
    ISSN 1861-0692 ; 1861-0684
    ISSN (online) 1861-0692
    ISSN 1861-0684
    DOI 10.1007/s00392-023-02350-w
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  6. Article ; Online: Germline Cancer Gene Expression Quantitative Trait Loci Are Associated with Local and Global Tumor Mutations.

    Liu, Yuxi / Gusev, Alexander / Kraft, Peter

    Cancer research

    2023  Volume 83, Issue 8, Page(s) 1191–1202

    Abstract: ... genes. See related commentary by Kar, p. 1165. ...

    Abstract Somatic mutations drive cancer development and are relevant to patient responses to treatment. Emerging evidence shows that variations in the somatic genome can be influenced by the germline genetic background. However, the mechanisms underlying these germline-somatic associations remain largely obscure. We hypothesized that germline variants can influence somatic mutations in a nearby cancer gene ("local impact") or a set of recurrently mutated cancer genes across the genome ("global impact") through their regulatory effect on gene expression. To test this hypothesis, tumor targeted sequencing data from 12,413 patients across 11 cancer types in the Dana-Farber Profile cohort were integrated with germline cancer gene expression quantitative trait loci (eQTL) from the Genotype-Tissue Expression Project. Variants that upregulate ATM expression were associated with a decreased risk of somatic ATM mutations across 8 cancer types. GLI2, WRN, and CBFB eQTL were associated with global tumor mutational burden of cancer genes in ovarian cancer, glioma, and esophagogastric carcinoma, respectively. An EPHA5 eQTL was associated with mutations in cancer genes specific to colorectal cancer, and eQTL related to expression of APC, WRN, GLI1, FANCA, and TP53 were associated with mutations in genes specific to endometrial cancer. These findings provide evidence that germline-somatic associations are mediated through expression of specific cancer genes, opening new avenues for research on the underlying biological processes.
    Significance: Analysis of associations between the germline genetic background and somatic mutations in patients with cancer suggests that germline variants can influence local and global tumor mutations by altering expression of cancer-related genes. See related commentary by Kar, p. 1165.
    MeSH term(s) Female ; Humans ; Quantitative Trait Loci ; Mutation ; Oncogenes ; Germ-Line Mutation ; Ovarian Neoplasms/genetics ; Gene Expression ; Genetic Predisposition to Disease
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-22-2624
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  7. Article ; Online: Pathogenic or benign?

    Du, Peter P / Liu, Katherine / Bassik, Michael C / Hess, Gaelen T

    Nature biotechnology

    2022  Volume 40, Issue 6, Page(s) 834–836

    MeSH term(s) Genetic Predisposition to Disease ; Humans ; Mutation
    Language English
    Publishing date 2022-05-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-022-01333-y
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  8. Article ; Online: The influence of dietary crude protein concentrations, grain types and arginine:lysine ratios on the performance of broiler chickens.

    Macelline, Shemil P / Chrystal, Peter V / Inanan, Chanon / Toghyani, Mehdi / Selle, Peter H / Liu, Sonia Yun

    Animal nutrition (Zhongguo xu mu shou yi xue hui)

    2023  Volume 14, Page(s) 259–268

    Abstract: The objective of this study was to investigate the effects of dietary crude protein (CP) concentrations, grain types and arginine:lysine ratios on performance parameters of broiler chickens. The 2 × 2 × 2 factorial array of dietary treatments harnessed ... ...

    Abstract The objective of this study was to investigate the effects of dietary crude protein (CP) concentrations, grain types and arginine:lysine ratios on performance parameters of broiler chickens. The 2 × 2 × 2 factorial array of dietary treatments harnessed two CP concentrations (210 and 170 g/kg), two feed grains (wheat and sorghum), and two arginine:lysine ratios (104 and 110). Each dietary treatment was offered to 7 replicates of 14 birds per floor pen, a total of 784 off-sex male, Ross 308 broilers, from 14 to 35 d post-hatch. The dietary CP reduction compromised weight gain by 10.0% (2078 versus 2310 g/bird) as a main effect and FCR by 7.51% (1.474 versus 1.371), subject to an interaction. In a three-way interaction (
    Language English
    Publishing date 2023-05-26
    Publishing country China
    Document type Journal Article
    ISSN 2405-6383
    ISSN (online) 2405-6383
    DOI 10.1016/j.aninu.2023.05.007
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  9. Article ; Online: Dietary crude protein reductions in wheat-based diets with two energy densities compromised performance of broiler chickens from 15 to 36 days post-hatch.

    Macelline, Shemil P / Chrystal, Peter V / Toghyani, Mehdi / Selle, Peter H / Liu, Sonia Y

    Poultry science

    2023  Volume 102, Issue 10, Page(s) 102932

    Abstract: This study was designed to investigate the impacts of 2 energy densities (13.0 and 12.5 MJ/kg ME) in wheat-based diets with 3 tiers of CP concentrations (210, 190, and 170 g/kg) on the performance of broiler chickens. The parameters assessed included ... ...

    Abstract This study was designed to investigate the impacts of 2 energy densities (13.0 and 12.5 MJ/kg ME) in wheat-based diets with 3 tiers of CP concentrations (210, 190, and 170 g/kg) on the performance of broiler chickens. The parameters assessed included growth performance (15-36 d posthatch), carcass traits, nutrient utilization, starch-protein digestive dynamics, apparent ileal amino acid digestibility coefficients, and the free amino acid and ammonia (NH
    MeSH term(s) Animals ; Chickens ; Triticum/metabolism ; Ammonia/metabolism ; Dietary Proteins/metabolism ; Diet/veterinary ; Weight Gain ; Digestion ; Amino Acids/metabolism ; Glycine max/metabolism ; Brassica napus ; Animal Feed/analysis ; Animal Nutritional Physiological Phenomena ; Energy Metabolism
    Chemical Substances Ammonia (7664-41-7) ; Dietary Proteins ; Amino Acids
    Language English
    Publishing date 2023-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2023.102932
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    Zs.B 853: Show issues Location:
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  10. Article ; Online: Achieving Health Equities in Indigenous Peoples in Canada: Learnings Adaptable for Diverse Populations.

    Liu, Peter P / King, Malcolm / King, Alexandra

    Circulation

    2022  Volume 146, Issue 3, Page(s) 153–155

    MeSH term(s) Canada/epidemiology ; Health Equity ; Health Status Disparities ; Humans ; Indigenous Peoples ; Population Groups
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.060773
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