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  1. Article ; Online: Impact of Smoking on Salivary Lipid Profile and Oxidative Stress in Young Adults: A Comparative Analysis between Traditional Cigarettes, E-Cigarettes, and Heat-Not-Burn Products.

    Zięba, Sara / Błachnio-Zabielska, Agnieszka / Maciejczyk, Mateusz / Pogodzińska, Karolina / Szuta, Mariusz / Lo Giudice, Giuseppe / Lo Giudice, Roberto / Zalewska, Anna

    Medical science monitor : international medical journal of experimental and clinical research

    2024  Volume 30, Page(s) e942507

    Abstract: BACKGROUND Smoking nicotine is considered to be one of the most harmful addictions, leading to the development of a number of health complications, including many pathologies in the oral cavity. The aim of this study was to examine the effect of smoking ... ...

    Abstract BACKGROUND Smoking nicotine is considered to be one of the most harmful addictions, leading to the development of a number of health complications, including many pathologies in the oral cavity. The aim of this study was to examine the effect of smoking traditional cigarettes, e-cigarettes, and heat-not-burn products on profiles of salivary lipids and lipid peroxidation products in the unstimulated and stimulated saliva of healthy young adults with a smoking habit of up to 3 years. MATERIAL AND METHODS We enrolled 3 groups of 25 smoking patients each and a control group matched for age, gender, and oral status. In saliva collected from patients from the study groups and participants from the control group, the concentrations of sphingolipids: sphingosine, sphinganine, sphingosine-1-phosphate, ceramides, and salivary lipid peroxidation products - malondialdehyde (MDA) and 4-hydroxynonenal (HNE) - were measured. The normality of distribution was assessed using the Shapiro-Wilk test. For comparison of the results, one-way analysis of variance (ANOVA) followed by post hoc Tukey test was used. RESULTS We demonstrated that each type of smoking causes a decrease in the concentration of salivary lipids, and there was an increased concentration of salivary MDA and 4-HNE. CONCLUSIONS Smoking in the initial period of addiction leads to an increase in the concentration of lipid peroxidation products through increased oxidative stress, leading to disturbance of the lipid balance of the oral cavity (eg, due to damage to cell membranes).
    MeSH term(s) Humans ; Young Adult ; Smoking/adverse effects ; Electronic Nicotine Delivery Systems ; Hot Temperature ; Tobacco Products ; Oxidative Stress ; Lipids ; Saliva/metabolism
    Chemical Substances Lipids
    Language English
    Publishing date 2024-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
    DOI 10.12659/MSM.942507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Long-Term Chromatic Durability of White Spot Lesions through Employment of Infiltration Resin Treatment.

    Puleio, Francesco / Di Spirito, Federica / Lo Giudice, Giuseppe / Pantaleo, Giuseppe / Rizzo, David / Lo Giudice, Roberto

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 4

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Color ; Resins, Synthetic/therapeutic use ; Spectrophotometry ; Employment ; Dental Caries/therapy
    Chemical Substances Resins, Synthetic
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59040749
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  3. Article ; Online: The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) in Dentistry. Management of Biological Risk in Dental Practice.

    Lo Giudice, Roberto

    International journal of environmental research and public health

    2020  Volume 17, Issue 9

    Abstract: The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel coronavirus first identified in Wuhan, China, and the etiological agent of Coronavirus Disease-2019 (COVID-19). This infection spreads mainly through direct contact with Flügge ... ...

    Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel coronavirus first identified in Wuhan, China, and the etiological agent of Coronavirus Disease-2019 (COVID-19). This infection spreads mainly through direct contact with Flügge micro droplets or core droplets that remain suspended as aerosol. Moreover, it has been reported that infected subjects, both with and without clinical signs of COVID-19, can transmit the virus. Since the infection typically enters through mouth, nose, and eyes, dentistry is one of the medical practices at highest risk of infection due to the frequent production of aerosol and the constant presence of saliva. The World Health Organization (WHO) has suggested that only emergency/urgent procedures should be performed during the coronavirus outbreak. Considering the virus' route of transmission, a specific protocol should be applied to reduce the risk of infection in addition to measures that prevent the spread of infection from a patient to another person or medical tools and equipment (cross-infection). This protocol should be implemented by modifying both patient management and clinical practice, introducing particular devices and organizational practices. This paper aims to discuss and suggest the most appropriate procedures in every aspect of dental practice to reduce infection risk.
    MeSH term(s) Betacoronavirus ; COVID-19 ; China/epidemiology ; Coronavirus ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Cross Infection/epidemiology ; Cross Infection/prevention & control ; Dentistry ; Disease Outbreaks/prevention & control ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Practice Management, Dental ; Practice Patterns, Dentists' ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/prevention & control ; Severe Acute Respiratory Syndrome/transmission ; United States ; World Health Organization
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17093067
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  4. Article ; Online: Does Low-Taper Root Canal Shaping Decrease the Risk of Root Fracture? A Systematic Review.

    Puleio, Francesco / Lo Giudice, Giuseppe / Militi, Angela / Bellezza, Ugo / Lo Giudice, Roberto

    Dentistry journal

    2022  Volume 10, Issue 6

    Abstract: Minimal root-canal preparation has been suggested to reduce the risk of root fracture, but as a result, satisfactory cleaning and shaping do not take place. Large-scale taper instrumentation can contribute to removing infected tissue; however, it may ... ...

    Abstract Minimal root-canal preparation has been suggested to reduce the risk of root fracture, but as a result, satisfactory cleaning and shaping do not take place. Large-scale taper instrumentation can contribute to removing infected tissue; however, it may weaken the tooth structure. The aim of this systematic review is to evaluate whether root-canal shaping with low-taper instruments decreases the risk of root fracture, compared to high-conicity shaping. A search was performed on Ovid MEDLINE, PubMed, and the Web of Science. The inclusion criteria were: studies comparing the root fracture resistance of endodontically treated teeth, shaped with low- and high-conicity taper instruments, in human trials, and via in vitro study. The review includes all types of endodontically treated teeth, with various instrument tapers. The scientific search engines produced 328 results. Only 20 of the results were evaluated after screening. Based on the articles analyzed, it is not clear whether a taper difference can determine differences in root fracture resistance. No randomized controlled trial (RCTs) with long follow-ups have been published to date. It must also be taken into account that the in vitro studies do not consider the numerous differences that there are between in vitro and clinical evaluation. The review was registered on the PROSPERO website, with the protocol number CRD42020151451.
    Language English
    Publishing date 2022-06-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681351-8
    ISSN 2304-6767 ; 2304-6767
    ISSN (online) 2304-6767
    ISSN 2304-6767
    DOI 10.3390/dj10060094
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  5. Article ; Online: Health Care and Health Service Digital Revolution.

    Lo Giudice, Roberto / Famà, Fausto

    International journal of environmental research and public health

    2020  Volume 17, Issue 14

    Abstract: The digital revolution has changed many aspects of the medical profession. Medical doctors and doctors in the dental sciences have been pushed to modify their workflow using new instruments such as decisional software, intraoral and extraoral scanners, ... ...

    Abstract The digital revolution has changed many aspects of the medical profession. Medical doctors and doctors in the dental sciences have been pushed to modify their workflow using new instruments such as decisional software, intraoral and extraoral scanners, and CAD-CAM technologies, which have improved diagnostics and the clinical/surgical phase of treatment and follow-up, and nowadays it is clear that medical professional life will continue in the era of digital medicine.
    MeSH term(s) Computer-Aided Design ; Delivery of Health Care ; Humans ; Software ; Workflow
    Language English
    Publishing date 2020-07-08
    Publishing country Switzerland
    Document type Editorial
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17144913
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  6. Book ; Online: The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) in Dentistry. Management of Biological Risk in Dental Practice

    Roberto Lo Giudice

    International Journal of Environmental Research and Public Health ; Volume 17 ; Issue 9

    2020  

    Abstract: The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel coronavirus first identified in Wuhan, China, and the etiological agent of Coronavirus Disease-2019 (COVID-19). This infection spreads mainly through direct contact with Flü ... ...

    Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel coronavirus first identified in Wuhan, China, and the etiological agent of Coronavirus Disease-2019 (COVID-19). This infection spreads mainly through direct contact with Flü

    gge micro droplets or core droplets that remain suspended as aerosol. Moreover, it has been reported that infected subjects, both with and without clinical signs of COVID-19, can transmit the virus. Since the infection typically enters through mouth, nose, and eyes, dentistry is one of the medical practices at highest risk of infection due to the frequent production of aerosol and the constant presence of saliva. The World Health Organization (WHO) has suggested that only emergency/urgent procedures should be performed during the coronavirus outbreak. Considering the virus’

    route of transmission, a specific protocol should be applied to reduce the risk of infection in addition to measures that prevent the spread of infection from a patient to another person or medical tools and equipment (cross-infection). This protocol should be implemented by modifying both patient management and clinical practice, introducing particular devices and organizational practices. This paper aims to discuss and suggest the most appropriate procedures in every aspect of dental practice to reduce infection risk.
    Keywords COVID-19 ; SARS-CoV-2 ; dentistry ; biological risk ; infection prevention ; procedures ; covid19
    Language English
    Publishing date 2020-04-28
    Publisher Multidisciplinary Digital Publishing Institute
    Publishing country ch
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) in Dentistry. Management of Biological Risk in Dental Practice

    Roberto Lo Giudice

    International Journal of Environmental Research and Public Health, Vol 17, Iss 3067, p

    2020  Volume 3067

    Abstract: The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel coronavirus first identified in Wuhan, China, and the etiological agent of Coronavirus Disease-2019 (COVID-19). This infection spreads mainly through direct contact with Flügge ... ...

    Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel coronavirus first identified in Wuhan, China, and the etiological agent of Coronavirus Disease-2019 (COVID-19). This infection spreads mainly through direct contact with Flügge micro droplets or core droplets that remain suspended as aerosol. Moreover, it has been reported that infected subjects, both with and without clinical signs of COVID-19, can transmit the virus. Since the infection typically enters through mouth, nose, and eyes, dentistry is one of the medical practices at highest risk of infection due to the frequent production of aerosol and the constant presence of saliva. The World Health Organization (WHO) has suggested that only emergency/urgent procedures should be performed during the coronavirus outbreak. Considering the virus’ route of transmission, a specific protocol should be applied to reduce the risk of infection in addition to measures that prevent the spread of infection from a patient to another person or medical tools and equipment (cross-infection). This protocol should be implemented by modifying both patient management and clinical practice, introducing particular devices and organizational practices. This paper aims to discuss and suggest the most appropriate procedures in every aspect of dental practice to reduce infection risk.
    Keywords COVID-19 ; SARS-CoV-2 ; dentistry ; biological risk ; infection prevention ; procedures ; Medicine ; R ; covid19
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The "Dedicated" C.B.C.T. in Dentistry.

    Distefano, Salvatore / Cannarozzo, Maria Grazia / Spagnuolo, Gianrico / Bucci, Marco Brady / Lo Giudice, Roberto

    International journal of environmental research and public health

    2023  Volume 20, Issue 11

    Abstract: This position statement represents a consensus of an expert committee composed by the Italian Academy of General Dentistry (Accademia Italiana Odontoiatria Generale COI-AIOG) and Italian Academy of Legal and Forensic Dentistry (Accademia Italiana di ... ...

    Abstract This position statement represents a consensus of an expert committee composed by the Italian Academy of General Dentistry (Accademia Italiana Odontoiatria Generale COI-AIOG) and Italian Academy of Legal and Forensic Dentistry (Accademia Italiana di Odontoiatria Legale e Forense OL-F) on the appropriate use of cone beam computed tomography (C.B.C.T.) in dentistry. This paper analyzes the use of C.B.C.T. in light of the rapid evolution of volumetric technologies, with the new low- and ultra-low-dose exposure programs. These upgrades are determining an improvement in the precision and safety of this methodology; therefore, the need of a guideline revision of the use of C.B.C.T. for treatment planning is mandatory. It appears necessary to develop a new model of use, which, in compliance with the principle of justification and as low as reasonably achievable (ALARA) and as low as diagnostically acceptable (ALADA), can allow a functional "Dedicated C.B.C.T." exam optimized for the individuality of the patient.
    MeSH term(s) Humans ; Radiation Dosage ; Italy ; Cone-Beam Computed Tomography/methods ; Forensic Dentistry ; Patient Care Planning
    Language English
    Publishing date 2023-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20115954
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  9. Article ; Online: A new software architecture proposal for an evidence-based Decision Support System in dentistry.

    Lo Giudice, Giuseppe / Lizio, Angelo S / Lo Giudice, Roberto

    Minerva dental and oral science

    2020  Volume 70, Issue 1, Page(s) 7–14

    Abstract: Background: in dentistry, clinical problems could be resolved using many therapeutic approaches that may results in very different therapies. In order to choose the best option, a good evaluation of therapy long-term survival and success rate is ... ...

    Abstract Background: in dentistry, clinical problems could be resolved using many therapeutic approaches that may results in very different therapies. In order to choose the best option, a good evaluation of therapy long-term survival and success rate is mandatory. The routine use of a decision support analysis software is nowadays limited due to the lack of software's flexibility especially when a variety of possible therapeutic option are present. The aim of this research was to develop a new algorithm model for a Decision Support System software to give diagnosis support in dentistry.
    Methods: Beta tests were designed to study the computer software in different clinical situations based on clinical data. The therapeutic options can be conservative/endodontic or extractive/prosthetic therapies. In two of clinical situation selected could be possible to choose both therapies.
    Results: in clinical situations tested, the DDS software correctly identified the several therapeutic options. When multiple treatments were possible the beta test showed an output mask that correctly showed a range of options with their corresponding survival and success rate.
    Conclusions: The software architecture proposed by the authors is technically feasible, can support the clinician choices based on scientific evidence and up-to-date references and gain informed consent based on data easily understandable for the patient.
    MeSH term(s) Algorithms ; Dentistry ; Humans ; Informed Consent ; Software
    Language English
    Publishing date 2020-10-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062693-6
    ISSN 2724-6337
    ISSN (online) 2724-6337
    DOI 10.23736/S2724-6329.20.04416-7
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    Zs.B 159: Show issues Location:
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  10. Article: Characterization of the Oral Microbiome in Wearers of Fixed and Removable Implant or Non-Implant-Supported Prostheses in Healthy and Pathological Oral Conditions: A Narrative Review.

    D'Ambrosio, Francesco / Santella, Biagio / Di Palo, Maria Pia / Giordano, Francesco / Lo Giudice, Roberto

    Microorganisms

    2023  Volume 11, Issue 4

    Abstract: Oral commensal microorganisms perform very important functions such as contributing to the health of the host. However, the oral microbiota also plays an important role in the pathogenesis and development of various oral and systemic diseases. The oral ... ...

    Abstract Oral commensal microorganisms perform very important functions such as contributing to the health of the host. However, the oral microbiota also plays an important role in the pathogenesis and development of various oral and systemic diseases. The oral microbiome may be characterized by a higher prevalence of some microorganisms than others in subjects with removable or fixed prostheses, depending on oral health conditions, the prosthetic materials used, and any pathological conditions brought about by inadequate prosthetic manufacturing or poor oral hygiene. Both biotic and abiotic surfaces of removable and fixed prostheses can be easily colonized by bacteria, fungi, and viruses, which can become potential pathogens. The oral hygiene of denture wearers is often inadequate, and this can promote oral dysbiosis and the switch of microorganisms from commensal to pathogens. In light of what emerged from this review, fixed and removable dental prostheses on teeth and on implants are subject to bacterial colonization and can contribute to the formation of bacterial plaque. It is of fundamental importance to carry out the daily hygiene procedures of prosthetic products, to design the prosthesis to facilitate the patient's home oral hygiene practices, and to use products against plaque accumulation or capable of reducing oral dysbiosis to improve patients' home oral practices. Therefore, this review primarily aimed to analyze the oral microbiome composition in fixed and removable implant or non-implant-supported prostheses wearers in healthy and pathological oral conditions. Secondly, this review aims to point out related periodontal self-care recommendations for oral dysbiosis prevention and periodontal health maintenance in fixed and removable implant or non-implant-supported prostheses wearers.
    Language English
    Publishing date 2023-04-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11041041
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