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Article ; Online: Hypoxia-inducible factor 1 alpha protein increases without changes in mRNA during acute hypoxic exposure of the Gulf killifish, Fundulus grandis.

Murphy, Taylor E / Harris, Jasmine C / Rees, Bernard B

2023 Volume 12, Issue 12

Abstract: The hypoxia inducible factor 1 (HIF1) is a central regulator of the molecular responses of animals to low oxygen. While the hypoxia-responsiveness of HIF1 is generally attributed to the stabilization of the alpha protein subunit (HIF1α) at low oxygen, ... ...

Abstract	The hypoxia inducible factor 1 (HIF1) is a central regulator of the molecular responses of animals to low oxygen. While the hypoxia-responsiveness of HIF1 is generally attributed to the stabilization of the alpha protein subunit (HIF1α) at low oxygen, several studies on fish report increased tissue levels of HIF1A mRNA during hypoxia, suggesting transcriptional regulation. In the current study, HIF1α protein and HIF1A mRNA were determined in parallel in tissues of Gulf killifish, Fundulus grandis, exposed to short-term hypoxia (24 h at 1 mg O2 l-1). HIF1α protein was higher in brain, ovary, and skeletal muscle from fish exposed to hypoxia compared with normoxic controls by 6 h, and it remained elevated in brain and ovary at 24 h. In contrast, HIF1A mRNA levels were unaffected by hypoxia in any tissue. Moreover, HIF1α protein and HIF1A mRNA levels in the same tissues were not correlated with one another during either normoxia or hypoxia. Hence, an increase in HIF1α protein does not depend upon an increase in HIF1A mRNA during acute exposure to low oxygen in this species. The results support the widely accepted mechanism of post-translational protein stabilization, rather than new transcription, during the initial response of fish to hypoxia.
MeSH term(s)	Animals ; Female ; Fundulidae/genetics ; RNA, Messenger/genetics ; Hypoxia/genetics ; Hypoxia/metabolism ; Oxygen ; Hypoxia-Inducible Factor 1/metabolism
Chemical Substances	RNA, Messenger ; Oxygen (S88TT14065) ; Hypoxia-Inducible Factor 1
Language	English
Publishing date	2023-12-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2632264-X
ISSN	2046-6390 ; 2046-6390
ISSN (online)	2046-6390
ISSN	2046-6390
DOI	10.1242/bio.060167
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Variation in care and outcomes for people after hip fracture with and without cognitive impairment; results from the Australian and New Zealand Hip Fracture Registry.

Taylor, Morag E / Harvey, Lara A / Crotty, Maria / Harris, Ian A / Sherrington, Catherine / Close, Jacqueline C T

The journal of nutrition, health & aging

2024 Volume 28, Issue 2, Page(s) 100030

Abstract: Background: People with dementia have poorer outcomes after hip fracture and this may be due in part to variation in care. We aimed to compare care and outcomes for people with and without cognitive impairment after hip fracture.: Methods: ... ...

Abstract	Background: People with dementia have poorer outcomes after hip fracture and this may be due in part to variation in care. We aimed to compare care and outcomes for people with and without cognitive impairment after hip fracture. Methods: Retrospective cohort study using Australian and New Zealand Hip Fracture Registry data for people ≥50 years of age who underwent hip fracture surgery (n = 49,063). Cognitive impairment or known dementia and cognitively healthy groups were defined using preadmission cognitive status. Descriptive statistics and multivariable mixed effects models were used to compare groups. Results: In general, cognitively impaired people had worse care and outcomes compared to cognitively healthy older people. A lower proportion of the cognitively impaired group had timely pain assessment (≤30 min of presentation: 61% vs 68%; p < 0.0001), were given the opportunity to mobilise (89% vs 93%; p < 0.0001) and achieved day-1 mobility (34% vs 58%; p < 0.0001) than the cognitively healthy group. A higher proportion of the cognitively impaired group had delayed pain management (>30 mins of presentation: 26% vs 20%; p < 0.0001), were malnourished (27% vs 15%; p < 0.0001), had delirium (44% vs 13%; p < 0.0001) and developed a new pressure injury (4% vs 3%; p < 0.0001) than the cognitively healthy group. Fewer of the cognitively impaired group received rehabilitation (35% vs 64%; p < 0.0001), particularly patients from RACFs (16% vs 39%; p < 0.0001) and were prescribed bone protection medication on discharge (24% vs 27%; p < 0.0001). Significantly more of the cognitively impaired group had a new transfer to residential care (46% vs 11% from private residence; p < 0.0001) and died at 30-days (7% vs 3% from private residence; 15% vs 10% from RACF; both p < 0.0001). In multivariable models adjusting for covariates with facility as the random effect, the cognitively impaired group had a greater odds of being malnourished, not achieving day-1 walking, having delirium in the week after surgery, dying within 30 days, and in those from private residences, having a new transfer to a residential care facility than the cognitively healthy group. Conclusions: We have identified several aspects of care that could be improved for patients with cognitive impairment - management of pain, mobility, nutrition and bone health, as well as delirium assessment, prevention and management strategies and access to rehabilitation. Further research is needed to determine whether improvements in care will reduce hospital complications and improve outcomes for people with dementia after hip fracture.
MeSH term(s)	Humans ; Aged ; Retrospective Studies ; New Zealand/epidemiology ; Australia/epidemiology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/complications ; Hip Fractures/complications ; Hip Fractures/surgery ; Hip Fractures/rehabilitation ; Dementia/complications ; Delirium ; Registries
Language	English
Publishing date	2024-01-04
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1016/j.jnha.2023.100030
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Article ; Online: Hypoxia-inducible factor 1 alpha protein increases without changes in mRNA during acute hypoxic exposure of the Gulf killifish, Fundulus grandis

Taylor E. Murphy / Jasmine C. Harris / Bernard B. Rees

Biology Open, Vol 12, Iss

2023 Volume 12

Keywords	oxygen ; teleost fish ; transcription factor ; individual variation ; Science ; Q ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	The Company of Biologists
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of type 2 diabetes with central centrifugal cicatricial alopecia: A follow-up study.

Roche, Fritzlaine C / Harris, Jasmine / Ogunleye, Temitayo / Taylor, Susan C

Journal of the American Academy of Dermatology

2021 Volume 86, Issue 3, Page(s) 661–662

MeSH term(s)	Alopecia/complications ; Alopecia/pathology ; Cicatrix/complications ; Cicatrix/pathology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Follow-Up Studies ; Hair/pathology ; Humans
Language	English
Publishing date	2021-02-18
Publishing country	United States
Document type	Letter
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2021.02.036
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Article ; Online: Propofol Related Infusion Syndrome

Brandon Harris / Elizabeth C. Taylor / John W. Pickstone / Errington C. Thompson

Marshall Journal of Medicine, Vol 9, Iss

A Subtle Adversary

2023 Volume 1

Abstract: Propofol Related Infusion Syndrome (PRIS) was first described in 1998. It has a strange collection of symptoms, including marked bradycardia, persistent, recalcitrant metabolic acidosis, liver enlargement, rhabdomyolysis, and lipemic blood. We present ... ...

Abstract	Propofol Related Infusion Syndrome (PRIS) was first described in 1998. It has a strange collection of symptoms, including marked bradycardia, persistent, recalcitrant metabolic acidosis, liver enlargement, rhabdomyolysis, and lipemic blood. We present two recent patients who appeared to have had PRIS. Creatinine kinase seems to be an early detector of PRIS. If PRIS is recognized early, this complex metabolic process seems to be completely reversible.
Keywords	propofol ; propofol related infusion syndrome ; metabolic acidosis ; rhabdomyolysis ; pris ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Marshall University
Document type	Article ; Online
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Article: Arthroscopic Peripheral Compartment Iliopsoas Release for Iliopsoas Impingement After Primary Total Hip Arthroplasty.

Paraschos, Olivia A / Harris, W Taylor / Owens, Jade S / Lall, Ajay C / Domb, Benjamin G

Arthroscopy techniques

2023 Volume 12, Issue 1, Page(s) e115–e120

Abstract: Anterior iliopsoas (IP) impingement after total hip arthroplasty is an underrecognized and continued cause for postoperative pain. There are multiple etiologies for this impingement from cup positioning and sizing to changes in the leg length, and offset ...

Abstract	Anterior iliopsoas (IP) impingement after total hip arthroplasty is an underrecognized and continued cause for postoperative pain. There are multiple etiologies for this impingement from cup positioning and sizing to changes in the leg length, and offset must be evaluated to confirm no need for implant revision. Additionally, tension of the IP tendon can be increased in patients with diminished spinal mobility, either from prior fusion or with increasing age. Managing this surgically after failing conservative treatment options is best done arthroscopically to prevent additional large, open procedures that place the arthroplasty at unnecessary risk of infection and potential instability. In this article, we describe an arthroscopic technique using fluoroscopy to guide the release of the iliopsoas tendon from the peripheral compartment.
Language	English
Publishing date	2023-01-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2653101-X
ISSN	2212-6287
ISSN	2212-6287
DOI	10.1016/j.eats.2022.08.066
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Article ; Online: Computer Prompt Software to Reduce Sedentary Behavior and Promote Physical Activity Among Desk-Based Workers: A Systematic Review.

Taylor, Wendell C / Williams, Jordan R / Harris, Lauren E / Shegog, Ross

Human factors

2021 Volume 65, Issue 5, Page(s) 891–908

Abstract: Objective: Do computer prompt software programs at the workplace reduce sitting time and/or increase physical activity at work?: Background: Many products are promoted and being used in the workplace; however, their effectiveness and use are unknown ... ...

Abstract	Objective: Do computer prompt software programs at the workplace reduce sitting time and/or increase physical activity at work? Background: Many products are promoted and being used in the workplace; however, their effectiveness and use are unknown or the evidence base that they work to change behavior is lacking. Method: We searched for relevant papers published between 2005 and 2020. The inclusion criteria were computer prompt software programs installed as behavioral change interventions; interventions implemented during work hours and delivered through a work personal computer or laptop; and measures of sedentary behavior and/or physical activity. To minimize risk of bias, three recommended best-evidence synthesis criteria were used: random assignment, sample size, and external validity. Based on these criteria, articles were selected and evaluated. Results: Six publications met the quality threshold for review. Seven articles did not meet the quality threshold. Four of the six included publications found that computer prompt software programs decreased sedentary behavior and/or increased physical activity. Two publications reported inconsistent results. Conclusions: The promising results from this systematic review indicate that there is potential for computer prompt software programs to improve the health of desk-based workers. For conclusive findings, more high-quality, scientific studies are needed. Application: The best-evidence publications in this review can serve as a guide in selecting and implementing computer prompt software programs at the workplace to decrease sedentary behavior and increase physical activity.
MeSH term(s)	Humans ; Sedentary Behavior ; Exercise ; Workplace ; Software ; Computers
Language	English
Publishing date	2021-08-15
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	212725-8
ISSN	1547-8181 ; 0018-7208
ISSN (online)	1547-8181
ISSN	0018-7208
DOI	10.1177/00187208211034271
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Article ; Online: Access to American College of Surgeons Committee on Trauma-Verified Trauma Centers in the US, 2013-2019.

Choi, Jeff / Karr, Sarah / Jain, Arjun / Harris, Taylor C / Chavez, Janelle C / Spain, David A

JAMA

2022 Volume 328, Issue 4, Page(s) 391–393

MeSH term(s)	Health Services Accessibility/standards ; Humans ; Injury Severity Score ; Trauma Centers/standards ; Traumatology/standards ; United States ; Wounds and Injuries/surgery ; Wounds and Injuries/therapy
Language	English
Publishing date	2022-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2022.8097
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Article ; Online: Improving hip fracture care: A five-year review of the early contributors to the Australian and New Zealand Hip Fracture Registry.

Taylor, Morag E / Ramsay, Niamh / Mitchell, Rebecca / McDougall, Catherine / Harris, Ian A / Hallen, Jamie / Ward, Nicola / Hurring, Sarah / Harvey, Lara A / Armstrong, Elizabeth / Close, Jacqueline C T

Australasian journal on ageing

2024 Volume 43, Issue 1, Page(s) 31–42

Abstract: Objective: The aim of this study was to examine temporal trends (2016-2020) in hip fracture care in Australian and New Zealand (ANZ) hospitals that started providing patient-level data to the ANZ Hip Fracture Registry (ANZHFR) on/before 1 January 2016 ( ... ...

Abstract	Objective: The aim of this study was to examine temporal trends (2016-2020) in hip fracture care in Australian and New Zealand (ANZ) hospitals that started providing patient-level data to the ANZ Hip Fracture Registry (ANZHFR) on/before 1 January 2016 (early contributors). Methods: Retrospective cohort study of early contributor hospitals (n = 24) to the ANZHFR. The study cohort included patients aged ≥50 years admitted with a low trauma hip fracture between 1 January 2016 and 31 December 2020 (n = 26,937). Annual performance against 11 quality indicators and 30- and 365-day mortality were examined. Results: Compared to 2016/2017, year-on-year improvements were demonstrated for preoperative cognitive assessment (2020: OR 3.57, 95% confidence interval [95% CI] 3.29-3.87) and nerve block use prior to surgery (2020: OR 4.62, 95% CI 4.17-5.11). Less consistent improvements over time from 2016/2017 were demonstrated for emergency department (ED) stay of <4 h (2017; 2020), pain assessment ≤30 min of ED presentation (2020), surgery ≤48 h (2020) and bone protection medication prescribed on discharge (2017-2020; 2020 OR 2.22, 95% CI 2.03-2.42). The odds of sustaining a hospital-acquired pressure injury increased in 2019-2020 compared to 2016. The odds of receiving an orthogeriatric model of care and being offered the opportunity to mobilise on Day 1 following surgery fluctuated. There was a reduction in 365-day mortality in 2020 compared to 2016 (OR 0.86, 95% CI 0.74-0.98), whereas 30-day mortality did not change. Conclusions: Several quality indicators improved over time in early contributor hospitals. Indicators that did not improve may be targets for future care improvement activities, including considering incentivised hip fracture care, which has previously been shown to improve care/outcomes. COVID-19 and reporting practices may have impacted the study findings.
MeSH term(s)	Humans ; Australia ; New Zealand ; Retrospective Studies ; Length of Stay ; Hip Fractures ; Registries
Language	English
Publishing date	2024-01-25
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1457406-8
ISSN	1741-6612 ; 0726-4240 ; 1440-6381
ISSN (online)	1741-6612
ISSN	0726-4240 ; 1440-6381
DOI	10.1111/ajag.13270
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Article ; Online: The physiology of Venezillo arizonicus: water balance and the cuticular water barrier.

Harris, Zechariah C / Taylor, Charles J / Wright, Jonathan C

Journal of insect physiology

2019 Volume 120, Page(s) 103991

Abstract: This study investigated the water balance physiology of Venezillo arizonicus, a land isopod endemic to the Southwest Desert Ecoregion of North America. Evaporative water losses were measured in two ways: gravimetric in dry air, and by perfusing animals ... ...

Abstract	This study investigated the water balance physiology of Venezillo arizonicus, a land isopod endemic to the Southwest Desert Ecoregion of North America. Evaporative water losses were measured in two ways: gravimetric in dry air, and by perfusing animals with dry air in a respirometry chamber and monitoring downstream relative humidity (RH). The respective mean loss flux estimates were 0.140 and 0.177 μg h
MeSH term(s)	Animals ; California ; Humidity ; Isopoda/physiology ; Temperature ; Water Loss, Insensible/physiology ; Water-Electrolyte Balance/physiology
Language	English
Publishing date	2019-12-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1879-1611
ISSN (online)	1879-1611
DOI	10.1016/j.jinsphys.2019.103991
Database	MEDical Literature Analysis and Retrieval System OnLINE

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