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Article ; Online: Genetic analysis of milk minerals in dairy cattle: a review.

Singh, Akansha / Kumar, Amit / Thakur, Mohan Singh / Khare, Vaishali / Jain, Asit / Tiwari, Sita Prasad

2024 Volume 65, Issue 2, Page(s) 375–381

Abstract: Mineral composition in milk can affect its nutritional as well as physio-chemical properties of milk and is considered an important trait in the evaluation of milk quality. The composition and concentration of milk minerals could be altered with natural ... ...

Abstract	Mineral composition in milk can affect its nutritional as well as physio-chemical properties of milk and is considered an important trait in the evaluation of milk quality. The composition and concentration of milk minerals could be altered with natural source of variation including nutrition and genetics. The effect of diet on milk minerals is well studied. However, genetic effects on the milk minerals have recently gained the attention. This review provides an overview of the genetic variation of milk minerals, and the genomic regions associated with mineral concentration in the milk are also discussed. The difference of milk minerals between breeds and the genetic parameters including heritability estimates and correlation among minerals indicates that milk minerals are under strong genetic control. Recently, the genome-wide association study (GWAS) has explored several regions associated with milk minerals and thus provides a new genetic source for improving the milk quality through genomics-assisted breeding. Hence, a combination of the qualitative and molecular approaches can be exploited to improving the nutritional quality of cattle milk in terms of its mineral composition.
MeSH term(s)	Cattle/genetics ; Animals ; Female ; Milk/chemistry ; Genome-Wide Association Study/veterinary ; Minerals/analysis ; Minerals/chemistry ; Phenotype ; Diet/veterinary ; Lactation
Chemical Substances	Minerals
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1235302-4
ISSN	2190-3883 ; 1234-1983
ISSN (online)	2190-3883
ISSN	1234-1983
DOI	10.1007/s13353-024-00832-9
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Article ; Online: Review: genetic background of milk fatty acid synthesis in bovines.

Singh, Akansha / Malla, Waseem Akram / Kumar, Amit / Jain, Asit / Thakur, Mohan Singh / Khare, Vaishali / Tiwari, Sita Prasad

Tropical animal health and production

2023 Volume 55, Issue 5, Page(s) 328

Abstract: Milk fat composition is an important trait for the dairy industry as it directly influences the nutritional and technological properties of milk and other dairy products. The synthesis of milk fat is a complex process regulated by a network of genes. ... ...

Abstract	Milk fat composition is an important trait for the dairy industry as it directly influences the nutritional and technological properties of milk and other dairy products. The synthesis of milk fat is a complex process regulated by a network of genes. Thus, understanding the genetic variation and molecular mechanisms regulating milk fat synthesis will help to improve the nutritional quality of dairy products. In this review, we provide an overview of milk fat synthesis in bovines along with the candidate genes involved in the pathway. We also discuss de novo synthesis of fatty acids (ACSS, ACACA, FASN), uptake of FAs (FATP, FAT, LPL), intracellular activation and channelling of FAs (ACSL, FABP), elongation (EVOLV6), desaturation (SCD, FADS), formation of triglycerides (GPAM, AGPAT, LIPIN, DGAT), and milk lipid secretion (BTN1A1, XDH, PLIN2). The genetic variability of individual fatty acids will help to develop selection strategies for obtaining a healthier milk fat profile in bovines. Thus, this review will offer a potential understanding of the molecular mechanisms that regulate milk fat synthesis in bovines.
MeSH term(s)	Animals ; Cattle/genetics ; Female ; Milk ; Lactation ; Genetic Background ; Fatty Acids ; Nutritive Value
Chemical Substances	Fatty Acids
Language	English
Publishing date	2023-09-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603363-5
ISSN	1573-7438 ; 0049-4747
ISSN (online)	1573-7438
ISSN	0049-4747
DOI	10.1007/s11250-023-03754-6
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Article ; Online: Communication Strategies and Our Learners.

Germaine, Pauline / Catanzano, Tara / Patel, Amy / Mohan, Akansha / Patel, Kirang / Pryluck, David / Cooke, Erin

Current problems in diagnostic radiology

2020 Volume 50, Issue 3, Page(s) 297–300

Abstract: Communication is vital in healthcare to facilitate the best patient care at all times. During the COVID-19 pandemic, communication has become increasingly crucial, including devising innovative, novel, and effective ways to exchange information in ... ...

Abstract	Communication is vital in healthcare to facilitate the best patient care at all times. During the COVID-19 pandemic, communication has become increasingly crucial, including devising innovative, novel, and effective ways to exchange information in graduate medical education, multidisciplinary teams, and patient care, all which affect our learners. This article will provide a comprehensive review of generational characteristics, including communication preferences. Effective communication strategies and communication challenges with learners (millennial generation) will be discussed in detail.
MeSH term(s)	COVID-19/prevention & control ; Communication ; Education, Medical, Graduate/methods ; Humans ; Information Dissemination/methods ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2020-11-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	198954-6
ISSN	1535-6302 ; 0363-0188
ISSN (online)	1535-6302
ISSN	0363-0188
DOI	10.1067/j.cpradiol.2020.10.009
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Article: Position Statement of IACDE for managing dental patients during COVID-19.

Mazumdar, Paromita / Kaushik, Mamta / Chandrasekhar, Veeramachaneni / Mohan Kumar, R S / Rajawat, Akansha

Journal of conservative dentistry : JCD

2020 Volume 23, Issue 2, Page(s) 114–120

Abstract: Coronavirus disease 2019 (COVID-19) has been a major health concern globally ever since it was declared as Pandemic by the World Health Organization in March 2020. Due to the evolving and contagious nature of coronavirus, it continues to remain a threat ... ...

Abstract	Coronavirus disease 2019 (COVID-19) has been a major health concern globally ever since it was declared as Pandemic by the World Health Organization in March 2020. Due to the evolving and contagious nature of coronavirus, it continues to remain a threat for dental health-care personnel. As the virus travels from person-to-person via direct contact through droplet inhalation, cough, and sneeze or through contact transmission, it remains infectious even through inanimate surfaces. A seemingly healthy asymptomatic person may have the potential to trigger the spread of this disease. Coronavirus has the capability of spreading through community transmission. There is no specific treatment or vaccine as of now for stopping the spread of COVID-19, hence universal precautions and awareness with mass involvement is required to ward off this pandemic. Dental health-care personnel are at immense risk due to the near proximity with patients and continual exposure to saliva, blood, and other body fluids. Management protocol regarding awareness and preventive measures should be laid down for dental clinic/hospital to contain the outspread of this infectious disease.
Language	English
Publishing date	2020-11-05
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2064481-4
ISSN	0972-0707
ISSN	0972-0707
DOI	10.4103/JCD.JCD_361_20
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Article: Conservation, propagation, and redistribution (CPR) of Hill’s thistle: paradigm for plant species at risk

Bi, Wenlu / Saxena, Akansha / Ayyanath, Murali-Mohan / Harpur, Cavan / Shukla, Mukund R / Saxena, Praveen K

Plant cell, tissue, and organ culture. 2021 Apr., v. 145, no. 1

2021

Abstract: Cryopreservation is a valuable tool that could potentially create an alternate plant preservation strategy for species at risk such as Hill’s thistle. The present study is focused on a successful paradigm involving conservation, propagation and ... ...

Abstract	Cryopreservation is a valuable tool that could potentially create an alternate plant preservation strategy for species at risk such as Hill’s thistle. The present study is focused on a successful paradigm involving conservation, propagation and redistribution (CPR), emaphasizing the usefulness of cryopreservation techniques for plant conservation using Hill’s thistle (Cirsium hillii. (Canby) Fernald). A cryopreservation protocol was established using the droplet-vitrification method for 5-week-old shoot tips of in vitro grown cultures. More than 90% of shoot tips showed regrowth and nearly all regenerated plants were able to survive in the greenhouse. The survival, growth, and development of plants from cryopreserved shoot buds and their performance in field conditions were all comparable or better than the plants from non-cryopreserved buds. Reintroduced plants flowered following overwintering and the magnitude of flowering was site dependent with ca. 80% flowering observed in one site. The site dependent flowering patterns were assessed using phytohormone profiling and compared to herbivory, a common biotic stressor of these plants. Lower tryptophan concentrations led to higher flowering except in alvars, where the limestone resisted root penetration resulting in poor flowering. The presence of tryptamine in the greenhouse acclimatized or alvar field leaves suggested the preparedness of the plants for herbivory/grazing. Serotonin and melatonin concentrations were lower in flowering plants and in sites where the biotic/abiotic stress was minimal. This study provides evidence of the effectiveness of the CPR model in species recovery programs for endangered species. Physiological characterization of plants developed from cryopreserved tissues can be useful for fundamental and applied research in stress adaptation and reproductive biology of plants.
Keywords	Cirsium ; abiotic stress ; applied research ; cryopreservation ; endangered species ; greenhouses ; herbivores ; limestone ; melatonin ; models ; organ culture ; overwintering ; plant hormones ; protocols ; regrowth ; risk ; serotonin ; tryptamine ; tryptophan
Language	English
Dates of publication	2021-04
Size	p. 75-88.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	406394-6
ISSN	1573-5044 ; 0167-6857
ISSN (online)	1573-5044
ISSN	0167-6857
DOI	10.1007/s11240-020-01993-1
Database	NAL-Catalogue (AGRICOLA)

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Article: Current status of pesticide effects on environment, human health and it's eco-friendly management as bioremediation: A comprehensive review.

Pathak, Vinay Mohan / Verma, Vijay K / Rawat, Balwant Singh / Kaur, Baljinder / Babu, Neelesh / Sharma, Akansha / Dewali, Seeta / Yadav, Monika / Kumari, Reshma / Singh, Sevaram / Mohapatra, Asutosh / Pandey, Varsha / Rana, Nitika / Cunill, Jose Maria

Frontiers in microbiology

2022 Volume 13, Page(s) 962619

Abstract: Pesticides are either natural or chemically synthesized compounds that are used to control a variety of pests. These chemical compounds are used in a variety of sectors like food, forestry, agriculture and aquaculture. Pesticides shows their toxicity ... ...

Abstract	Pesticides are either natural or chemically synthesized compounds that are used to control a variety of pests. These chemical compounds are used in a variety of sectors like food, forestry, agriculture and aquaculture. Pesticides shows their toxicity into the living systems. The World Health Organization (WHO) categorizes them based on their detrimental effects, emphasizing the relevance of public health. The usage can be minimized to a least level by using them sparingly with a complete grasp of their categorization, which is beneficial to both human health and the environment. In this review, we have discussed pesticides with respect to their global scenarios, such as worldwide distribution and environmental impacts. Major literature focused on potential uses of pesticides, classification according to their properties and toxicity and their adverse effect on natural system (soil and aquatic), water, plants (growth, metabolism, genotypic and phenotypic changes and impact on plants defense system), human health (genetic alteration, cancer, allergies, and asthma), and preserve food products. We have also described eco-friendly management strategies for pesticides as a green solution, including bacterial degradation, myco-remediation, phytoremediation, and microalgae-based bioremediation. The microbes, using catabolic enzymes for degradation of pesticides and clean-up from the environment. This review shows the importance of finding potent microbes, novel genes, and biotechnological applications for pesticide waste management to create a sustainable environment.
Language	English
Publishing date	2022-08-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.962619
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Article: Quality of Life of the Elderly during the COVID-19 Pandemic in Asian Countries: A Cross-Sectional Study across Six Countries.

Marzo, Roy Rillera / Khanal, Praval / Ahmad, Absar / Rathore, Farooq Azam / Chauhan, Shekhar / Singh, Akansha / Shrestha, Sunil / AlRifai, Ayesha / Lotfizadeh, Masoud / Younus, Delan Ameen / Billah, Md Arif / Rahman, Farzana / Sivaladchanam, Yalini / Mohan, Devi / Su, Tin Tin

Life (Basel, Switzerland)

2022 Volume 12, Issue 3

Abstract: Background: Few studies have explored the determinants of health-related quality of life (HRQoL) in the elderly during the COVID-19 pandemic. Identifying these factors may help implement appropriate policies to enhance HRQoL in the elderly. Therefore, we ...

Abstract	Background: Few studies have explored the determinants of health-related quality of life (HRQoL) in the elderly during the COVID-19 pandemic. Identifying these factors may help implement appropriate policies to enhance HRQoL in the elderly. Therefore, we aimed to identify the predictors of physical and mental component summary (PCS and MCS) scores of HRQoL in selected six low- and middle-income Asian countries. Methods: We conducted an online survey of older people aged ≥55 years in six countries: Bangladesh, Iran, Iraq, Malaysia, Palestine, and Sri Lanka. The Stark QoL questionnaire was used to measure the PCS and MCS scores. Univariate and multiple variable analyses after adjusting for confounders were performed to identify the possible predictors of PCS and MCS. Results: A total of 1644 older people (69.1 ± 7.8 years, range 55−97 years, Female: 50.9%) responded to the survey. We documented age, country of residence, marital status, number of male children, current employment status, and health insurance, ability to pay household bills, frequency of family members visits and receiving support during COVID-19 pandemic predicted both PCS and MCS. However, gender, residence, and number of female children were associated with PCS only (all p < 0.05). Conclusion: Socio-demographic factors such as age, country of residence, marital status, number of male children, current employment status, health insurance, ability to pay household bills, frequency of family members visiting family members, and receiving support during the COVID-19 pandemic affecting both physical and mental quality of life. These results can guide formulating health care planning policies to enhance QoL during COVID-19 and future pandemics in the elderly.
Language	English
Publishing date	2022-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12030365
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Article ; Online: Quality of Life of the Elderly during the COVID-19 Pandemic in Asian Countries

Roy Rillera Marzo / Praval Khanal / Absar Ahmad / Farooq Azam Rathore / Shekhar Chauhan / Akansha Singh / Sunil Shrestha / Ayesha AlRifai / Masoud Lotfizadeh / Delan Ameen Younus / Md. Arif Billah / Farzana Rahman / Yalini Sivaladchanam / Devi Mohan / Tin Tin Su

Life, Vol 12, Iss 365, p

A Cross-Sectional Study across Six Countries

2022 Volume 365

Abstract	Background: Few studies have explored the determinants of health-related quality of life (HRQoL) in the elderly during the COVID-19 pandemic. Identifying these factors may help implement appropriate policies to enhance HRQoL in the elderly. Therefore, we aimed to identify the predictors of physical and mental component summary (PCS and MCS) scores of HRQoL in selected six low- and middle-income Asian countries. Methods: We conducted an online survey of older people aged ≥55 years in six countries: Bangladesh, Iran, Iraq, Malaysia, Palestine, and Sri Lanka. The Stark QoL questionnaire was used to measure the PCS and MCS scores. Univariate and multiple variable analyses after adjusting for confounders were performed to identify the possible predictors of PCS and MCS. Results: A total of 1644 older people (69.1 ± 7.8 years, range 55–97 years, Female: 50.9%) responded to the survey. We documented age, country of residence, marital status, number of male children, current employment status, and health insurance, ability to pay household bills, frequency of family members visits and receiving support during COVID-19 pandemic predicted both PCS and MCS. However, gender, residence, and number of female children were associated with PCS only (all p < 0.05). Conclusion: Socio-demographic factors such as age, country of residence, marital status, number of male children, current employment status, health insurance, ability to pay household bills, frequency of family members visiting family members, and receiving support during the COVID-19 pandemic affecting both physical and mental quality of life. These results can guide formulating health care planning policies to enhance QoL during COVID-19 and future pandemics in the elderly.
Keywords	quality of life ; older people ; COVID-19 ; mental health ; physical health ; Science ; Q
Subject code	360
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Significance of the Default Mode Network (DMN) in Neurological and Neuropsychiatric Disorders: A Review.

Mohan, Akansha / Roberto, Aaron J / Mohan, Abhishek / Lorenzo, Aileen / Jones, Kathryn / Carney, Martin J / Liogier-Weyback, Luis / Hwang, Soonjo / Lapidus, Kyle A B

The Yale journal of biology and medicine

2016 Volume 89, Issue 1, Page(s) 49–57

Abstract: The relationship of cortical structure and specific neuronal circuitry to global brain function, particularly its perturbations related to the development and progression of neuropathology, is an area of great interest in neurobehavioral science. ... ...

Abstract	The relationship of cortical structure and specific neuronal circuitry to global brain function, particularly its perturbations related to the development and progression of neuropathology, is an area of great interest in neurobehavioral science. Disruption of these neural networks can be associated with a wide range of neurological and neuropsychiatric disorders. Herein we review activity of the Default Mode Network (DMN) in neurological and neuropsychiatric disorders, including Alzheimer's disease, Parkinson's disease, Epilepsy (Temporal Lobe Epilepsy - TLE), attention deficit hyperactivity disorder (ADHD), and mood disorders. We discuss the implications of DMN disruptions and their relationship to the neurocognitive model of each disease entity, the utility of DMN assessment in clinical evaluation, and the changes of the DMN following treatment.
MeSH term(s)	Alzheimer Disease/metabolism ; Alzheimer Disease/physiopathology ; Animals ; Attention Deficit Disorder with Hyperactivity/metabolism ; Attention Deficit Disorder with Hyperactivity/physiopathology ; Brain Mapping ; Epilepsy, Temporal Lobe/metabolism ; Epilepsy, Temporal Lobe/physiopathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Mood Disorders/metabolism ; Mood Disorders/physiopathology
Language	English
Publishing date	2016-03-24
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	200515-3
ISSN	1551-4056 ; 0044-0086
ISSN (online)	1551-4056
ISSN	0044-0086
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Article: Low uptake of COVID-19 prevention behaviours and high socioeconomic impact of lockdown measures in South Asia: Evidence from a large-scale multi-country surveillance programme.

Kusuma, Dian / Pradeepa, Rajendra / Khawaja, Khadija I / Hasan, Mehedi / Siddiqui, Samreen / Mahmood, Sara / Ali Shah, Syed Mohsin / De Silva, Chamini K / de Silva, Laksara / Gamage, Manoja / Loomba, Menka / Rajakaruna, Vindya P / Hanif, Abu Am / Kamalesh, Rajan Babu / Kumarendran, Balachandran / Loh, Marie / Misra, Archa / Tassawar, Asma / Tyagi, Akansha /

Waghdhare, Swati / Burney, Saira / Ahmad, Sajjad / Mohan, Viswanathan / Sarker, Malabika / Goon, Ian Y / Kasturiratne, Anuradhani / Kooner, Jaspal S / Katulanda, Prasad / Jha, Sujeet / Anjana, Ranjit Mohan / Mridha, Malay K / Sassi, Franco / Chambers, John C

SSM - population health

2021 Volume 13, Page(s) 100751

Abstract: Background: South Asia has become a major epicentre of the COVID-19 pandemic. Understanding South Asians' awareness, attitudes and experiences of early measures for the prevention of COVID-19 is key to improving the effectiveness and mitigating the ... ...

Abstract	Background: South Asia has become a major epicentre of the COVID-19 pandemic. Understanding South Asians' awareness, attitudes and experiences of early measures for the prevention of COVID-19 is key to improving the effectiveness and mitigating the social and economic impacts of pandemic responses at a critical time for the Region. Methods: We assessed the knowledge, behaviours, health and socio-economic circumstances of 29,809 adult men and women, at 93 locations across four South Asian countries. Data were collected during the national lockdowns implemented from March to July 2020, and compared with data collected prior to the pandemic as part of an ongoing prospective surveillance initiative. Results: Participants were 61% female, mean age 45.1 years. Almost half had one or more chronic disease, including diabetes (16%), hypertension (23%) or obesity (16%). Knowledge of the primary COVID-19 symptoms and transmission routes was high, but access to hygiene and personal protection resources was low (running water 63%, hand sanitisers 53%, paper tissues 48%). Key preventive measures were not widely adopted. Knowledge, access to, and uptake of COVID-19 prevention measures were low amongst people from disadvantaged socio-economic groups. Fifteen percent of people receiving treatment for chronic diseases reported loss of access to long-term medications; 40% reported symptoms suggestive of anxiety or depression. The prevalence of unemployment rose from 9.3% to 39.4% (P < 0.001), and household income fell by 52% (P < 0.001) during the lockdown. Younger people and those from less affluent socio-economic groups were most severely impacted. Sedentary time increased by 32% and inadequate fruit and vegetable intake increased by 10% (P < 0.001 for both), while tobacco and alcohol consumption dropped by 41% and 80%, respectively (P < 0.001), during the lockdown. Conclusions: Our results identified important knowledge, access and uptake barriers to the prevention of COVID-19 in South Asia, and demonstrated major adverse impacts of the pandemic on chronic disease treatment, mental health, health-related behaviours, employment and household finances. We found important sociodemographic differences for impact, suggesting a widening of existing inequalities. Our findings underscore the need for immediate large-scale action to close gaps in knowledge and access to essential resources for prevention, along with measures to safeguard economic production and mitigate socio-economic impacts on the young and the poor.
Language	English
Publishing date	2021-02-13
Publishing country	England
Document type	Journal Article
ISSN	2352-8273
ISSN	2352-8273
DOI	10.1016/j.ssmph.2021.100751
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