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Article ; Online: Enhancing health span: muscle stem cells and hormesis.

Calabrese, Edward J / Calabrese, Vittorio

2022 Volume 23, Issue 2, Page(s) 151–167

Abstract: ... e.g., resveratrol), pharmaceuticals (e.g., dexamethasone), endogenous ligands (e.g ... tumor necrosis factor α), environmental contaminants (e.g., cadmium) and physical agents (e.g., low level laser ...

Abstract	Sarcopenia is a significant public health and medical concern confronting the elderly. Considerable research is being directed to identify ways in which the onset and severity of sarcopenia may be delayed/minimized. This paper provides a detailed identification and assessment of hormetic dose responses in animal model muscle stem cells, with particular emphasis on cell proliferation, differentiation, and enhancing resilience to inflammatory stresses and how this information may be useful in preventing sarcopenia. Hormetic dose responses were observed following administration of a broad range of agents, including dietary supplements (e.g., resveratrol), pharmaceuticals (e.g., dexamethasone), endogenous ligands (e.g., tumor necrosis factor α), environmental contaminants (e.g., cadmium) and physical agents (e.g., low level laser). The paper assesses both putative mechanisms of hormetic responses in muscle stem cells, and potential therapeutic implications and application(s) of hormetic frameworks for slowing muscle loss and reduced functionality during the aging process.
MeSH term(s)	Animals ; Cell Differentiation ; Hormesis ; Muscles ; Sarcopenia/prevention & control ; Stem Cells
Language	English
Publishing date	2022-03-07
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2047160-9
ISSN	1573-6768 ; 1389-5729
ISSN (online)	1573-6768
ISSN	1389-5729
DOI	10.1007/s10522-022-09949-y
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Article: Hormesis and Endothelial Progenitor Cells.

Calabrese, Edward J

Dose-response : a publication of International Hormesis Society

2022 Volume 20, Issue 1, Page(s) 15593258211068625

Abstract: ... e.g., stroke), as well as damage from chronic conditions (e.g., atherosclerosis) and normal aging ...

Abstract	Hormetic-biphasic dose response relationships are reported herein for human endothelial progenitor cells involving estradiol, nicotine, the anti-diabetic agent pioglitazone, resveratrol, and progesterone. In general, these studies demonstrate the capacity of these agents to enhance EPC proliferation and angiogenesis functional applications, having a focus on repairing endothelial tissue damage due to acute injury (e.g., stroke), as well as damage from chronic conditions (e.g., atherosclerosis) and normal aging processes.
Language	English
Publishing date	2022-02-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2440820-7
ISSN	1559-3258
ISSN	1559-3258
DOI	10.1177/15593258211068625
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Article ; Online: Hormesis and dental apical papilla stem cells.

Calabrese, Edward J

Chemico-biological interactions

2022 Volume 357, Page(s) 109887

Abstract: ... dietary supplements (e.g., berberine, EGCG, resveratrol), pharmaceutical/commercial substances (e.g. fluoride ... platelet rich plasma, lithium), and endogenous agents (e.g., insulin growth factor-2, transforming growth factor β ...

Abstract	This paper provides an assessment of hormetic dose responses by stem cells of the apical papilla (SCAPs) from humans. Hormetic dose responses were induced in vitro by a broad range of agents, including dietary supplements (e.g., berberine, EGCG, resveratrol), pharmaceutical/commercial substances (e.g. fluoride, platelet rich plasma, lithium), and endogenous agents (e.g., insulin growth factor-2, transforming growth factor β, lipopolysaccharide). This paper clarifies underlying mechanistic foundations of the SCAP- hormetic dose responses, the need for in vivo evaluation studies, and potential therapeutic implications of the present findings. Of particular significance is that approximately 90% of examples of hormetic effects reported with SCAPs occurred during the past two years, suggesting strong recent interest in their potential therapeutic applications.
MeSH term(s)	Hormesis ; Humans ; Stem Cells/metabolism
Language	English
Publishing date	2022-03-11
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2022.109887
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Article ; Online: Muller and mutations: mouse study of George Snell (a postdoc of Muller) fails to confirm Muller's fruit fly findings, and Muller fails to cite Snell's findings.

Calabrese, Edward J / Selby, Paul B

Archives of toxicology

2024

Abstract: In 1931, Hermann J. Muller's postdoctoral student, George D. Snell (Nobel Prize recipient--1980 ... concerning how Snell wrote the paper (e.g., ignoring the significance of not providing support for Muller's ...

Abstract	In 1931, Hermann J. Muller's postdoctoral student, George D. Snell (Nobel Prize recipient--1980) initiated research to replicate with mice Muller's X-ray-induced mutational findings with fruit flies. Snell failed to induce the two types of mutations of interest, based on fly data (sex-linked lethals/recessive visible mutations) even though the study was well designed, used large doses of X-rays, and was published in Genetics. These findings were never cited by Muller, and the Snell paper (Snell, Genetics 20:545-567, 1935) did not cite the 1927 Muller paper (Muller, Science 66:84, 1927). This situation raises questions concerning how Snell wrote the paper (e.g., ignoring the significance of not providing support for Muller's findings in a mammal). The question may be raised whether professional pressures were placed upon Snell to downplay the significance of his findings, which could have negatively impacted the career of Muller and the LNT theory. While Muller would receive worldwide attention, and receive the Nobel Prize in 1946 "for the discovery that mutations can be induced by X-rays," Snell's negative mutation data were almost entirely ignored by his contemporary and subsequent radiation genetics/mutation researchers. This raises questions concerning how the apparent lack of interest in Snell's negative findings helped Muller professionally, including his success in using his fruit fly data to influence hereditary and cancer risk assessment and to obtain the Nobel Prize.
Language	English
Publishing date	2024-04-04
Publishing country	Germany
Document type	Letter
ZDB-ID	124992-7
ISSN	1432-0738 ; 0340-5761
ISSN (online)	1432-0738
ISSN	0340-5761
DOI	10.1007/s00204-024-03718-1
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Article ; Online: Evolution of hormesis research: a bibliometric analysis.

Agathokleous, Evgenios / Calabrese, Edward J

Archives of toxicology

2023 Volume 98, Issue 2, Page(s) 577–578

MeSH term(s)	Hormesis ; Bibliometrics
Language	English
Publishing date	2023-11-28
Publishing country	Germany
Document type	Editorial
ZDB-ID	124992-7
ISSN	1432-0738 ; 0340-5761
ISSN (online)	1432-0738
ISSN	0340-5761
DOI	10.1007/s00204-023-03635-9
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Article ; Online: Nitric oxide, hormesis and plant biology.

Calabrese, Edward J / Agathokleous, Evgenios

The Science of the total environment

2022 Volume 866, Page(s) 161299

Abstract: ... to protect plants from a wide range of chemical (i.e., multiple toxic metals) and physical stressors (i.e., heat ...

Abstract	The present paper provides the first integrative assessment of the occurrence of nitric oxide (NO) induced hormetic effects in plant biology. Hormetic dose responses were commonly reported for NO donors on numerous plant species of agricultural and other commercial value. The NO donors were also shown to protect plants from a wide range of chemical (i.e., multiple toxic metals) and physical stressors (i.e., heat, drought) in preconditioning (aka priming) experimental protocols showing hormetic dose responses. Practical approaches for the use of NO donors to enhance plant growth using optimized dose response frameworks were also assessed. Considerable mechanistic findings indicate that NO donors have the capacity to enhance a broad range of adaptive responses, including highly integrated antioxidant activities. The integration of the hormesis concept with NO donors is likely to become a valuable practical general strategy to enhance plant productivity across a wide range of valuable plant species facing environmental pollution and climate changes.
MeSH term(s)	Hormesis ; Nitric Oxide ; Antioxidants/pharmacology ; Plants ; Biology
Chemical Substances	Nitric Oxide (31C4KY9ESH) ; Antioxidants
Language	English
Publishing date	2022-12-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.161299
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Article ; Online: Hormesis and bone marrow stem cells: Enhancing cell proliferation, differentiation and resilience to inflammatory stress.

Calabrese, Edward J

Chemico-biological interactions

2021 Volume 351, Page(s) 109730

Abstract: ... Such hormetic dose responses are commonly reported, being induced by a broad range of chemicals, including pharmaceuticals (e.g ... caffeine, dexamethasone, nicotine), dietary supplements (e.g., curcumin, Ginkgo biloba, green tea extracts ... resveratrol, sulforaphane), endogenous agents (e.g., hydrogen sulfide, interleukin 10 ...

Abstract	This paper identifies and provides the first detailed assessment of hormetic dose responses by bone marrow stem cells (BMSCs) from a broad range of animal models and humans with particular emphasis on cell renewal (proliferation), cell differentiation and enhancing resilience to inflammatory stress. Such hormetic dose responses are commonly reported, being induced by a broad range of chemicals, including pharmaceuticals (e.g., caffeine, dexamethasone, nicotine), dietary supplements (e.g., curcumin, Ginkgo biloba, green tea extracts. resveratrol, sulforaphane), endogenous agents (e.g., hydrogen sulfide, interleukin 10), environmental contaminants (e.g., arsenic, PFOS) and physical stressor agents (e.g., EMF, shockwaves). Hormetic dose responses reported here for BMSCs are similar to those induced with other stem cell types [e.g., adipose-derived stem cells (ADSCs), dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), neuro stem cells (NSCs), embryonic stem cells (ESCs)], indicating a substantial degree of generality for hormetic responses in stem cells. The paper assesses both the underlying mechanistic foundations of BMSC hormetic responses and their potential therapeutic implications.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Dietary Supplements ; Hormesis/drug effects ; Humans ; Inflammation/metabolism ; Mesenchymal Stem Cells/drug effects
Chemical Substances	Anti-Inflammatory Agents
Language	English
Publishing date	2021-10-30
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2021.109730
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Article ; Online: Human periodontal ligament stem cells and hormesis: Enhancing cell renewal and cell differentiation.

Calabrese, Edward J

Pharmacological research

2021 Volume 173, Page(s) 105914

Abstract: ... dietary supplements (e.g., curcumin, ginsenoside Rg1), pharmaceutical/commercial substances (e.g., metformin) and ... endogenous agents (e.g., periostin, TNF-α) for cell proliferation/viability and osteogenic/adipocyte ...

Abstract	This paper provides a detailed assessment of hormetic dose responses by human periodontal ligament stem cells (hPDLSCs). Hormetic dose responses were induced by a broad range of chemicals, including dietary supplements (e.g., curcumin, ginsenoside Rg1), pharmaceutical/commercial substances (e.g., metformin) and endogenous agents (e.g., periostin, TNF-α) for cell proliferation/viability and osteogenic/adipocyte differentiation. This paper clarifies underlying mechanistic foundations of the hPLDSC hormetic dose responses and explores their therapeutic implications. Emerging evidence based on assessments of multiple types of stem cells shows hormetic dose responses to be widespread, reflecting considerable generality and a highly conserved evolutionary trait.
MeSH term(s)	Cell Differentiation ; Cell Proliferation ; Hormesis ; Humans ; Periodontal Ligament/cytology ; Stem Cells/cytology
Language	English
Publishing date	2021-09-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2021.105914
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Article ; Online: Hormesis and embryonic stem cells.

Calabrese, Edward J

Chemico-biological interactions

2021 Volume 352, Page(s) 109783

Abstract: ... being induced by a broad range of chemicals, including pharmaceuticals (e.g., atorvastatin ... isoproterenol, lithium, nicotine, ouabain), dietary supplements (e.g., curcumin, multiple ginsenosides ... resveratrol), endogenous agents (e.g., estrogen, hydrogen peroxide, melatonin), and physical stressor agents ...

Abstract	This paper provides an identification and detailed assessment of hormetic dose responses of embryonic stem cells (ESCs) with particular emphasis on cell renewal (proliferation) and differentiation, underlying mechanistic foundations and potential therapeutic implications. Hormetic dose responses were commonly reported, being induced by a broad range of chemicals, including pharmaceuticals (e.g., atorvastatin, isoproterenol, lithium, nicotine, ouabain), dietary supplements (e.g., curcumin, multiple ginsenosides, resveratrol), endogenous agents (e.g., estrogen, hydrogen peroxide, melatonin), and physical stressor agents (e.g., hypoxia, ionizing radiation). ESC-hormetic dose responses are similar for other stem cell types (e.g., adipose-derived stem cells, apical papilla, bone marrow stem cells, dental pulp stem cells, endothelial stem cells, muscle stem cells, periodontal ligament stem cells, neural stem cells), indicating a high degree of generality for the hormetic-stem cells response. The widespread occurrence of hormetic dose responses shown by ESCs and other stem cells suggests that the hormetic dose response may represent a fundamental and highly conserved evolutionary strategy.
MeSH term(s)	Animals ; Biological Evolution ; Cell Differentiation/drug effects ; Cell Hypoxia/physiology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dietary Supplements ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/drug effects ; Embryonic Stem Cells/physiology ; Fatty Acids/administration & dosage ; Hormesis/physiology ; Humans
Chemical Substances	Fatty Acids
Language	English
Publishing date	2021-12-18
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2021.109783
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Article ; Online: Hormesis Mediates Acquired Resilience: Using Plant-Derived Chemicals to Enhance Health.

Calabrese, Edward J

Annual review of food science and technology

2021 Volume 12, Page(s) 355–381

Abstract: ... provides a focus on the adaptive features of hormesis, i.e., its capacity to upregulate acquired resilience ...

Abstract	This review provides an assessment of hormesis, a highly conserved evolutionary dose-response adaptive strategy that leads to the development of acquired resilience within well-defined temporal windows. The hormetic-based acquired resilience has a central role in affecting healthy aging, slowing the onset and progression of numerous neurodegenerative and other age-related diseases, and reducing risks and damage due to heart attacks, stroke, and other serious conditions of public health and medical importance. The review provides the historical foundations of hormesis, its dose-response features, its capacity for generalization across biological models and endpoints measured, and its mechanistic foundations. The review also provides a focus on the adaptive features of hormesis, i.e., its capacity to upregulate acquired resilience and how this can be mediated by numerous plant-derived extracts, such as curcumin, ginseng,
MeSH term(s)	Hormesis ; Models, Biological ; Phytochemicals
Chemical Substances	Phytochemicals
Language	English
Publishing date	2021-01-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2516759-5
ISSN	1941-1421 ; 1941-1413
ISSN (online)	1941-1421
ISSN	1941-1413
DOI	10.1146/annurev-food-062420-124437
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