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  1. Article ; Online: In Situ

    Sorouri, Farzaneh / Hosseini, Parastoo / Sharifzadeh, Mohammad / Kiani, Sahar / Khoobi, Mehdi

    ACS applied materials & interfaces

    2023  Volume 15, Issue 36, Page(s) 42251–42270

    Abstract: Dysfunctional clinical outcomes following spinal cord injury (SCI) result from glial scar formation, leading to the inhibition of new axon growth and impaired regeneration. Nevertheless, nerve regeneration after SCI is possible, provided that the state ... ...

    Abstract Dysfunctional clinical outcomes following spinal cord injury (SCI) result from glial scar formation, leading to the inhibition of new axon growth and impaired regeneration. Nevertheless, nerve regeneration after SCI is possible, provided that the state of neuron development in the injured environment is improved. Hence, biomaterial-based therapy would be a promising strategy to endow a desirable environment for tissue repair. Herein, we designed a novel multifunctional injectable hydrogel with antioxidant, neuroprotective, and neuroregenerative effects. Bucladesine-encapsulated chitosan nanoparticles (BCS NPs) were first prepared and embedded in a matrix of thiol-functionalized hyaluronic acid modified with ferulic acid (HASH-FA). The target hydrogel (HSP-F/BCS) was then created through Michael-type addition between HASH-FA containing BCS NPs and four-arm polyethylene glycol-maleimide (4-Arm-PEG-Mal). The obtained hydrogel with shear thinning behavior showed viscoelastic and mechanical properties similar to the normal nerve tissue. FA conjugation significantly improved the antioxidant activity of HA, and suppressed intracellular ROS formation.
    MeSH term(s) Animals ; Rats ; Bucladesine ; Axons ; Gliosis ; Spinal Cord Injuries/drug therapy ; Spinal Cord Regeneration ; Antioxidants/pharmacology ; Hydrogels/pharmacology
    Chemical Substances ferulic acid (AVM951ZWST) ; Bucladesine (63X7MBT2LQ) ; Antioxidants ; Hydrogels
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c08366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tannic acid-mediated synthesis of flower-like mesoporous MnO

    Sorouri, Farzaneh / Gholibegloo, Elham / Mortezazadeh, Tohid / Kiani, Sahar / Foroumadi, Alireza / Firoozpour, Loghman / Khoobi, Mehdi

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 14606

    Abstract: This study introduces a simple method for preparing a new generation of ... ...

    Abstract This study introduces a simple method for preparing a new generation of MnO
    MeSH term(s) Contrast Media ; Manganese Compounds ; Oxides ; Peroxidase ; Magnetic Resonance Imaging ; Nanostructures ; Peroxidases
    Chemical Substances Contrast Media ; Tannic Acid ; Manganese Compounds ; Oxides ; Peroxidase (EC 1.11.1.7) ; Peroxidases (EC 1.11.1.-)
    Language English
    Publishing date 2023-09-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-41598-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Situation of Small Molecules Targeting Key Proteins in combatting SARS-CoV-2: Synthesis, Metabolic Pathway, Mechanism of Action, and Potential Therapeutic Applications.

    Sorouri, Farzaneh / Emamgholipour, Zahra / Keykhaee, Maryam / Najafi, Alireza / Firoozpour, Loghman / Sabzevari, Omid / Sharifzadeh, Mohammad / Foroumadi, Alireza / Khoobi, Mehdi

    Mini reviews in medicinal chemistry

    2021  Volume 22, Issue 2, Page(s) 273–311

    Abstract: Due to the high mortality rate of the 2019 coronavirus disease (COVID-19) pandemic, there is an immediate need to discover drugs that can help before a vaccine becomes available. Given that the process of producing new drugs is so long, the strategy of ... ...

    Abstract Due to the high mortality rate of the 2019 coronavirus disease (COVID-19) pandemic, there is an immediate need to discover drugs that can help before a vaccine becomes available. Given that the process of producing new drugs is so long, the strategy of repurposing existing drugs is one of the promising options for the urgent treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease. Although FDA has approved Remdesivir for the use in hospitalized adults and pediatric patients suffering from COVID-19, no fully effective and reliable drug has been yet identified worldwide to treat COVID-19 specifically. Thus, scientists are still trying to find antivirals specific to COVID-19. This work reviews the chemical structure, metabolic pathway, and mechanism of action of the existing drugs with potential therapeutic applications for COVID-19. Furthermore, we summarized the molecular docking stimulation of the medications related to key protein targets. These already established drugs could be further developed, and after their testing through clinical trials, they could be used as suitable therapeutic options for patients suffering from COVID-19.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Humans ; Metabolic Networks and Pathways/drug effects ; Molecular Docking Simulation ; SARS-CoV-2/drug effects ; SARS-CoV-2/growth & development ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-03-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2104081-3
    ISSN 1875-5607 ; 1389-5575
    ISSN (online) 1875-5607
    ISSN 1389-5575
    DOI 10.2174/1389557521666210308144302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5891: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Variants in ACE2; potential influences on virus infection and COVID-19 severity.

    Bakhshandeh, Behnaz / Sorboni, Shokufeh Ghasemian / Javanmard, Amir-Reza / Mottaghi, Seyed Saeed / Mehrabi, Mohammad-Reza / Sorouri, Farzaneh / Abbasi, Ardeshir / Jahanafrooz, Zohreh

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2021  Volume 90, Page(s) 104773

    Abstract: The third pandemic of coronavirus infection, called COVID-19 disease, was first detected in November 2019th. Various determinants of disease progression such as age, sex, virus mutations, comorbidity, lifestyle, host immune response, and genetic ... ...

    Abstract The third pandemic of coronavirus infection, called COVID-19 disease, was first detected in November 2019th. Various determinants of disease progression such as age, sex, virus mutations, comorbidity, lifestyle, host immune response, and genetic background variation have caused clinical variability of COVID-19. The causative agent of COVID-19 is an enveloped coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that invades host cells using an endocytic pathway. The SARS-CoV-2 spike protein is the main viral protein that contributes to the fusion of the virus particle to the host cell through angiotensin-converting enzyme 2 (ACE2). The highly conserved expression of ACE2 is found in various animals, which indicates its pivotal physiological function. The ACE2 has a crucial role in vascular, renal, and myocardial physiology. Genetic factors contributing to the outcome of SARS-CoV-2 infection are unknown; however, variants in the specific sites of ACE2 gene could be regarded as a main genetic risk factor for COVID-19. Given that ACE2 is the main site for virus landing on host cells, the effect of amino acid sequences of ACE2 on host susceptibility to COVID-19 seems reasonable. It would likely have a substantial role in the occurrence of a wide range of clinical symptoms. Several ACE2 variants can affect the protein stability, influencing the interaction between spike protein and ACE2 through imposing conformational changes while some other variants are known to cause a decrease or an increase in the ligand-receptor affinity. The other variations are located at the proteolytic cleavage site, which can influence virus infection; because soluble ACE2 can act as a decoy receptor for virus and decrease virus intake by cell surface ACE2. Notably, polymorphisms of regulatory and non-coding regions such as promoter in ACE2, can play crucial role in different expression levels of ACE2 among different individuals. Many studies should be performed to investigate the involvement of ACE2 polymorphism with susceptibility to COVID-19. Herein, we discuss some reported associations between variants of ACE2 and COVID-19 in details. In addition, the mode of action of ACE2 and its role in SARS-CoV-2 infection are highlighted which is followed by addressing the effects of several ACE2 variants on its protein stability, viral tropism or ligand-receptor affinity, secondary and tertiary structure or protein conformation, proteolytic cleavage site, and finally inter-individual clinical variability in COVID-19. The polymorphisms of regulatory regions of ACE2 and their effect on expression levels of ACE2 are also provided in this review. Such studies can improve the prediction of the affinity of mutant ACE2 variations with spike protein, and help the biopharmaceutical industry to design effective approaches for recombinant hACE2 therapy and vaccination of COVID-19 disease.
    MeSH term(s) Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/diagnosis ; COVID-19/genetics ; COVID-19/metabolism ; COVID-19/virology ; Cytokine Release Syndrome/etiology ; Cytokine Release Syndrome/metabolism ; Disease Management ; Disease Susceptibility ; Genetic Variation ; Host-Pathogen Interactions/immunology ; Humans ; Immune Evasion ; Immunity, Innate ; Polymorphism, Single Nucleotide ; Prognosis ; Protein Binding ; Receptors, Virus/metabolism ; SARS-CoV-2/physiology ; Severity of Illness Index
    Chemical Substances Receptors, Virus ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2021-02-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2021.104773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Human embryonic stem cell-derived neural stem cells encapsulated in hyaluronic acid promotes regeneration in a contusion spinal cord injured rat.

    Zarei-Kheirabadi, Masoumeh / Sadrosadat, Hoda / Mohammadshirazi, Atiyeh / Jaberi, Razieh / Sorouri, Farzaneh / Khayyatan, Fahimeh / Kiani, Sahar

    International journal of biological macromolecules

    2020  Volume 148, Page(s) 1118–1129

    Abstract: spinal cord injury (SCI) is a traumatic damage that can causes a loss of neurons around the lesion site and resulting in locomotor and sensory deficits. Currently, there is widely attempts in improvement of treatment strategy and cell delivering to the ... ...

    Abstract spinal cord injury (SCI) is a traumatic damage that can causes a loss of neurons around the lesion site and resulting in locomotor and sensory deficits. Currently, there is widely attempts in improvement of treatment strategy and cell delivering to the central nervous system (CNS). The usage of hyaluronic acid (HA), the main components of the ECM in CNS tissue and neural stem cells (NSCs) niche, is a good selection that can increase of viability and differentiation of NSCs. Importantly, we demonstrate that encapsulation of human embryonic stem cell derived-neural stem cells (hESC-NS) in HA-based hydrogel can increased differentiation these cells into oligodendrocytes and improved locomotor function.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Survival ; Cells, Cultured ; Disease Management ; Fluorescent Antibody Technique ; Human Embryonic Stem Cells/cytology ; Human Embryonic Stem Cells/metabolism ; Humans ; Hyaluronic Acid ; Hydrogels ; Male ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Rats ; Regeneration ; Spinal Cord Injuries/therapy ; Stem Cell Transplantation ; Tissue Scaffolds
    Chemical Substances Hydrogels ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2020-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2020.01.219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Human embryonic stem cell-derived neural stem cells encapsulated in hyaluronic acid promotes regeneration in a contusion spinal cord injured rat

    Zarei-Kheirabadi, Masoumeh / Sadrosadat, Hoda / Mohammadshirazi, Atiyeh / Jaberi, Razieh / Sorouri, Farzaneh / Khayyatan, Fahimeh / Kiani, Sahar

    International journal of biological macromolecules. 2020 Apr. 01, v. 148

    2020  

    Abstract: spinal cord injury (SCI) is a traumatic damage that can causes a loss of neurons around the lesion site and resulting in locomotor and sensory deficits. Currently, there is widely attempts in improvement of treatment strategy and cell delivering to the ... ...

    Abstract spinal cord injury (SCI) is a traumatic damage that can causes a loss of neurons around the lesion site and resulting in locomotor and sensory deficits. Currently, there is widely attempts in improvement of treatment strategy and cell delivering to the central nervous system (CNS). The usage of hyaluronic acid (HA), the main components of the ECM in CNS tissue and neural stem cells (NSCs) niche, is a good selection that can increase of viability and differentiation of NSCs. Importantly, we demonstrate that encapsulation of human embryonic stem cell derived-neural stem cells (hESC-NS) in HA-based hydrogel can increased differentiation these cells into oligodendrocytes and improved locomotor function.
    Keywords animal injuries ; cell viability ; embryonic stem cells ; encapsulation ; humans ; hyaluronic acid ; hydrogels ; neural stem cells ; neurons ; oligodendroglia ; rats ; spinal cord
    Language English
    Dates of publication 2020-0401
    Size p. 1118-1129.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2020.01.219
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Variants in ACE2; potential influences on virus infection and COVID-19 severity

    Bakhshandeh, Behnaz / Sorboni, Shokufeh Ghasemian / Javanmard, Amir-Reza / Mottaghi, Seyed Saeed / Mehrabi, Mohammad-reza / Sorouri, Farzaneh / Abbasi, Ardeshir / Jahanafrooz, Zohreh

    Infection, genetics, and evolution. 2021 June, v. 90

    2021  

    Abstract: The third pandemic of coronavirus infection, called COVID-19 disease, was first detected in November 2019th. Various determinants of disease progression such as age, sex, virus mutations, comorbidity, lifestyle, host immune response, and genetic ... ...

    Abstract The third pandemic of coronavirus infection, called COVID-19 disease, was first detected in November 2019th. Various determinants of disease progression such as age, sex, virus mutations, comorbidity, lifestyle, host immune response, and genetic background variation have caused clinical variability of COVID-19. The causative agent of COVID-19 is an enveloped coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that invades host cells using an endocytic pathway. The SARS-CoV-2 spike protein is the main viral protein that contributes to the fusion of the virus particle to the host cell through angiotensin-converting enzyme 2 (ACE2). The highly conserved expression of ACE2 is found in various animals, which indicates its pivotal physiological function. The ACE2 has a crucial role in vascular, renal, and myocardial physiology. Genetic factors contributing to the outcome of SARS-CoV-2 infection are unknown; however, variants in the specific sites of ACE2 gene could be regarded as a main genetic risk factor for COVID-19. Given that ACE2 is the main site for virus landing on host cells, the effect of amino acid sequences of ACE2 on host susceptibility to COVID-19 seems reasonable. It would likely have a substantial role in the occurrence of a wide range of clinical symptoms. Several ACE2 variants can affect the protein stability, influencing the interaction between spike protein and ACE2 through imposing conformational changes while some other variants are known to cause a decrease or an increase in the ligand-receptor affinity. The other variations are located at the proteolytic cleavage site, which can influence virus infection; because soluble ACE2 can act as a decoy receptor for virus and decrease virus intake by cell surface ACE2. Notably, polymorphisms of regulatory and non-coding regions such as promoter in ACE2, can play crucial role in different expression levels of ACE2 among different individuals. Many studies should be performed to investigate the involvement of ACE2 polymorphism with susceptibility to COVID-19. Herein, we discuss some reported associations between variants of ACE2 and COVID-19 in details. In addition, the mode of action of ACE2 and its role in SARS-CoV-2 infection are highlighted which is followed by addressing the effects of several ACE2 variants on its protein stability, viral tropism or ligand-receptor affinity, secondary and tertiary structure or protein conformation, proteolytic cleavage site, and finally inter-individual clinical variability in COVID-19. The polymorphisms of regulatory regions of ACE2 and their effect on expression levels of ACE2 are also provided in this review. Such studies can improve the prediction of the affinity of mutant ACE2 variations with spike protein, and help the biopharmaceutical industry to design effective approaches for recombinant hACE2 therapy and vaccination of COVID-19 disease.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; amino acids ; biopharmaceutical industry ; comorbidity ; disease progression ; etiological agents ; evolution ; genes ; genetic background ; immune response ; infection ; lifestyle ; mechanism of action ; mutants ; pandemic ; peptidyl-dipeptidase A ; physiology ; prediction ; protein conformation ; proteolysis ; risk factors ; vaccination ; virion ; viruses
    Language English
    Dates of publication 2021-06
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2021.104773
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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