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  1. Book ; Online ; E-Book: Diagnosis and Management of Autoimmune Hepatitis

    Russo, Mark W.

    A Clinical Guide

    2020  

    Abstract: This text provides a concise yet comprehensive overview of autoimmune hepatitis (AIH). The book reviews diagnosis criteria for AIH, biochemical and histologic findings in typical and atypical cases, and treatment with first, second, and third line ... ...

    Author's details edited by Mark W. Russo
    Abstract This text provides a concise yet comprehensive overview of autoimmune hepatitis (AIH). The book reviews diagnosis criteria for AIH, biochemical and histologic findings in typical and atypical cases, and treatment with first, second, and third line therapies. Furthermore, the book discusses management of AIH for specific patient populations, including pediatric patients, pregnant patients, and patients undergoing liver transplantation. Criteria for stopping therapy and risk of relapse, studies demonstrating the efficacy and safety of alternatives to corticosteroids, and diagnosis and treatment of overlap syndromes are also explored in the text. Written by experts in the field, Diagnosis and Treatment of Autoimmune Hepatitis: A Clinical Guide is a state-of-the-art resource for clinicians and practitioners who treat and manage patients with AIH.
    Keywords Gastroenterology  ; Hepatology ; Gastroenterology
    Subject code 616.3623
    Language English
    Size 1 online resource (X, 166 p. 35 illus., 33 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-33628-X ; 3-030-33627-1 ; 978-3-030-33628-8 ; 978-3-030-33627-1
    DOI 10.1007/978-3-030-33628-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Noninvasive prognostic models, imaging, and elastography to predict clinical events in primary sclerosing cholangitis: A review.

    Russo, Mark W

    World journal of hepatology

    2023  Volume 15, Issue 9, Page(s) 1013–1020

    Abstract: Surrogate endpoints are needed to estimate clinical outcomes in primary sclerosing cholangitis (PSC). Serum alkaline phosphatase was among the first markers studied, but there is substantial variability in alkaline phosphatase levels during the natural ... ...

    Abstract Surrogate endpoints are needed to estimate clinical outcomes in primary sclerosing cholangitis (PSC). Serum alkaline phosphatase was among the first markers studied, but there is substantial variability in alkaline phosphatase levels during the natural history of PSC without intervention. The Mayo risk score incorporates noninvasive variables and has served as a surrogate endpoint for survival for more than two decades. Newer models have better test performance than the Mayo risk score, including the primary sclerosing risk estimate tool (PREsTo) model and UK-PSC score that estimate hepatic decompensation and transplant free survival, respectively. The c-statistics for transplant-free survival for the Mayo risk model and the long-term UK-PSC model are 0.68 and 0.85, respectively. The c-statistics for hepatic decompensation for the Mayo risk model and PREsTo model are 0.85 and 0.90, respectively. The Amsterdam-Oxford model included patients with large duct and small duct PSC and patients with PSC-autoimmune hepatitis overlap and had a c-statistic of 0.68 for transplant-free survival. Other noninvasive tests that warrant further validation include magnetic resonance imaging, elastography and the enhanced liver fibrosis score. Prognostic models, noninvasive tests or a combination of these surrogate endpoints may not only serve to be useful in clinical trials of investigational agents, but also serve to inform our patients about their prognosis.
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v15.i9.1013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identifying barriers first-Then developing keys to open doors and expand access to liver transplantation.

    Russo, Mark W

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2022  Volume 28, Issue 9, Page(s) 1421–1422

    MeSH term(s) Humans ; Liver Transplantation/adverse effects
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.26508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4702: Show issues Location:
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  4. Article ; Online: Management of long-term complications from immunosuppression.

    Russo, Mark W / Wheless, William / Vrochides, Dionisios

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2024  

    Abstract: This review discusses long-term complications from immunosuppressants after liver transplantation and the management of these complications. Common complications of calcineurin inhibitors include nephrotoxicity and metabolic diseases. Nephrotoxicity can ... ...

    Abstract This review discusses long-term complications from immunosuppressants after liver transplantation and the management of these complications. Common complications of calcineurin inhibitors include nephrotoxicity and metabolic diseases. Nephrotoxicity can be managed by targeting a lower drug level and/or adding an immunosuppressant of a different class. Metabolic disorders can be managed by treating the underlying condition and targeting a lower drug level. Gastrointestinal adverse effects and myelosuppression are common complications of antimetabolites that are initially managed with dose reduction or discontinuation if adverse events persist. Mammalian targets of rapamycin inhibitors are associated with myelosuppression, proteinuria, impaired wound healing, and stomatitis, which may require dose reduction or discontinuation. Induction agents and agents used for steroid-refractory rejection or antibody-mediated rejection are reviewed. Other rare complications of immunosuppressants are discussed as well.
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1097/LVT.0000000000000341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Treatment of Primary Sclerosing Cholangitis Including Transplantation.

    Wheless, William H / Russo, Mark W

    Clinics in liver disease

    2023  Volume 28, Issue 1, Page(s) 171–182

    Abstract: Primary sclerosing cholangitis is a progressive cholestatic liver disease that causes stricturing of the intra and extrahepatic bile ducts that can lead to cirrhosis and end stage liver disease. Effective medical therapy has been elusive, but a course of ...

    Abstract Primary sclerosing cholangitis is a progressive cholestatic liver disease that causes stricturing of the intra and extrahepatic bile ducts that can lead to cirrhosis and end stage liver disease. Effective medical therapy has been elusive, but a course of ursodeoxycholic acid may be prescribed at doses of 17-23 mg/kg/day for up to a year to determine if a reduction in serum alkaline phosphatase is observed. A number of drugs are under investigation, including FXR agonists with choleretic and antimicrobial properties. Liver transplantation for PSC has one of the highest survival rates, but recurrent PSC is seen in up to 25% of recipients.
    MeSH term(s) Humans ; Cholangitis, Sclerosing/drug therapy ; Ursodeoxycholic Acid/therapeutic use ; Cholagogues and Choleretics/therapeutic use ; Liver Transplantation ; Liver Cirrhosis
    Chemical Substances Ursodeoxycholic Acid (724L30Y2QR) ; Cholagogues and Choleretics
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1472315-3
    ISSN 1557-8224 ; 1089-3261
    ISSN (online) 1557-8224
    ISSN 1089-3261
    DOI 10.1016/j.cld.2023.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prognostic modeling in biliary diseases.

    Ciobanu, Camelia / Russo, Mark W

    Current opinion in gastroenterology

    2023  Volume 39, Issue 2, Page(s) 89–94

    Abstract: Purpose of review: To discuss the prognostic models for the cholestatic diseases focusing on primary sclerosing cholangitis and primary biliary cholangitis.: Recent findings: Noninvasive prognostic models that outperform alkaline phosphatase and Mayo ...

    Abstract Purpose of review: To discuss the prognostic models for the cholestatic diseases focusing on primary sclerosing cholangitis and primary biliary cholangitis.
    Recent findings: Noninvasive prognostic models that outperform alkaline phosphatase and Mayo Risk Score have been developed to predict clinically significant events, such as transplant free survival or hepatic decompensation. Models for primary sclerosing cholangitis (PSC) include UK-PSC, Primary Sclerosing Cholangitis Risk Estimate Tool, and Amsterdam Oxford models. Models for primary biliary cirrhosis (PBC) include UK-PBC, Global primary biliary cholangitis group score (GLOBE) and Paris II scores. Other models have incorporated elastography with or without findings on magnetic resonance imaging.
    Summary: Noninvasive prognostic models can inform patients about their risk for clinical outcomes and serve as surrogate intermediate outcomes to determine efficacy of novel agents in clinical trials.
    MeSH term(s) Humans ; Prognosis ; Liver Cirrhosis, Biliary/drug therapy ; Cholangitis, Sclerosing/drug therapy ; Liver Transplantation
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000000911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2072: Show issues Location:
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  7. Article ; Online: Editorial: variceal haemorrhage-under pressure, not the probe pushing down on me.

    Adlakha, Natasha / Russo, Mark W

    Alimentary pharmacology & therapeutics

    2022  Volume 55, Issue 9, Page(s) 1224–1225

    MeSH term(s) Humans ; Esophageal and Gastric Varices/diagnosis ; Esophageal and Gastric Varices/etiology ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/etiology ; Varicose Veins
    Language English
    Publishing date 2022-04-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2206: Show issues Location:
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  8. Article ; Online: Pros and Cons of the Safety Net Rule for Prioritization of Liver Transplant Recipients Who Receive Liver Alone Transplant but Develop End-Stage Renal Disease.

    Russo, Mark W / Casingal, Vincent

    Clinics in liver disease

    2022  Volume 26, Issue 2, Page(s) 269–281

    Abstract: The number of patients presenting with cirrhosis with kidney injury and the potential need for SLKT is increasing. In 2017, standardized criteria were implemented to identify candidates for SLKT as well as criteria for prioritizing LTA recipients for ... ...

    Abstract The number of patients presenting with cirrhosis with kidney injury and the potential need for SLKT is increasing. In 2017, standardized criteria were implemented to identify candidates for SLKT as well as criteria for prioritizing LTA recipients for kidney transplant if they developed kidney failure, which is referred to as the 'safety net rule.' Goal of the safety net rule is to provide a pathway that provides increased priority to LTA recipients with renal failure who may have previously undergone SLKT. This article reviews the pros and cons of the safety net rule for liver transplant recipients who develop ESRD.
    MeSH term(s) Female ; Humans ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Liver ; Liver Transplantation ; Male ; Renal Insufficiency
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1472315-3
    ISSN 1557-8224 ; 1089-3261
    ISSN (online) 1557-8224
    ISSN 1089-3261
    DOI 10.1016/j.cld.2022.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Letter: the use of magnetic resonance scores (Anali) for risk stratification in PSC-authors' reply.

    Russo, Mark W / Mazhar, Areej

    Alimentary pharmacology & therapeutics

    2021  Volume 53, Issue 12, Page(s) 1331

    MeSH term(s) Cholangitis, Sclerosing ; Humans ; Magnetic Resonance Spectroscopy ; Prognosis ; Risk Assessment
    Language English
    Publishing date 2021-05-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.16397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Systematic Review of Prognostic Models Compared to the Mayo Risk Score for Primary Sclerosing Cholangitis.

    Schmeltzer, Paul A / Russo, Mark W

    Journal of clinical medicine

    2021  Volume 10, Issue 19

    Abstract: Background: Primary sclerosing cholangitis (PSC) is a cholestatic liver disease with a variable clinical course that can ultimately lead to end-stage liver disease, cholangiocarcinoma, and the need for liver transplantation. Several prognostic models ... ...

    Abstract Background: Primary sclerosing cholangitis (PSC) is a cholestatic liver disease with a variable clinical course that can ultimately lead to end-stage liver disease, cholangiocarcinoma, and the need for liver transplantation. Several prognostic models have been developed to predict clinical outcomes and have been compared to the revised Mayo Risk Score (rMRS).
    Aim: To conduct a systematic review comparing the rMRS to other non-invasive prognostic tests for PSC.
    Methods: A systematic review of studies from 2000 to 2020 was performed that compared non-invasive biochemical prognostic models to the rMRS in predicting outcomes in patients with PSC.
    Results: Thirty-seven studies were identified, of which five studies that collectively included 3230 patients were reviewed. Outcomes included transplant-free survival or composite clinical outcomes. The rMRS was better than the Amsterdam-Oxford model for predicting 1-year transplant-free survival, c-statistics 0.75 and 0.70, respectively. The UK-PSC score outperformed the rMRS for 10-year transplant-free survival, c-statistics 0.85 and 0.69, respectively. An enhanced liver fibrosis score was independently associated with transplant-free survival after adjusting for rMRS. PREsTo predicts 5-year hepatic decompensation with a c-statistic modestly higher than rMRS; 0.90 and 0.85, respectively.
    Conclusion: Newer prognostic models, including the UK-PSC score and PREsTo, are more accurate at predicting clinical endpoints in PSC compared to the rMRS. Time frames and clinical endpoints are not standard among studies.
    Language English
    Publishing date 2021-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10194476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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