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  1. Article ; Online: Vitamin C for Patients With COVID-19: More Evidence of Lack of Efficacy in Patients With Sepsis.

    Jabaley, Craig S / Coopersmith, Craig M

    JAMA

    2023  Volume 330, Issue 18, Page(s) 1739–1741

    MeSH term(s) Humans ; Antioxidants/therapeutic use ; Ascorbic Acid/therapeutic use ; COVID-19/therapy ; Sepsis/drug therapy ; Vitamins/therapeutic use ; COVID-19 Drug Treatment
    Chemical Substances Antioxidants ; Ascorbic Acid (PQ6CK8PD0R) ; Vitamins
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.18592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.88: Show issues Location:
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  2. Article ; Online: Let's treat the untreatable, but first we need to diagnose it!

    Reintam Blaser, Annika / Coopersmith, Craig M / Acosta, Stefan

    Intensive care medicine

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07423-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1089: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Gut Microbiome in Sepsis.

    Klingensmith, Nathan J / Coopersmith, Craig M

    Surgical infections

    2023  Volume 24, Issue 3, Page(s) 250–257

    Abstract: ... ...

    Abstract Abstract
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Intestinal Mucosa/microbiology ; Probiotics ; Prebiotics ; Bacteria ; Sepsis/therapy
    Chemical Substances Prebiotics
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1440120-4
    ISSN 1557-8674 ; 1096-2964
    ISSN (online) 1557-8674
    ISSN 1096-2964
    DOI 10.1089/sur.2022.420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5617: Show issues Location:
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  4. Article ; Online: Managing acute mesenteric ischaemia.

    Reintam Blaser, Annika / Coopersmith, Craig M / Acosta, Stefan

    Intensive care medicine

    2024  Volume 50, Issue 4, Page(s) 593–596

    MeSH term(s) Humans ; Mesenteric Ischemia/surgery ; Acute Disease ; Ischemia/therapy
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07363-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1089: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Nomenclature issues: non-occlusive mesenteric ischaemia and colon ischaemia.

    Acosta, Stefan / Coopersmith, Craig M / Reintam Blaser, Annika

    Intensive care medicine

    2024  

    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07447-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1089: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Cell death proteins in sepsis: key players and modern therapeutic approaches.

    Yang, Chloe S / Coopersmith, Craig M / Lyons, John D

    Frontiers in immunology

    2024  Volume 14, Page(s) 1347401

    Abstract: Cell death proteins play a central role in host immune signaling during sepsis. These interconnected mechanisms trigger cell demise via apoptosis, necroptosis, and pyroptosis while also driving inflammatory signaling. Targeting cell death mediators with ... ...

    Abstract Cell death proteins play a central role in host immune signaling during sepsis. These interconnected mechanisms trigger cell demise via apoptosis, necroptosis, and pyroptosis while also driving inflammatory signaling. Targeting cell death mediators with novel therapies may correct the dysregulated inflammation seen during sepsis and improve outcomes for septic patients.
    MeSH term(s) Humans ; Cell Death ; Apoptosis ; Pyroptosis ; Inflammation ; Sepsis/metabolism
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1347401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: OXIDATIVE study: A pilot prospective observational cohort study protocol examining the influence of peri-reperfusion hyperoxemia and immune dysregulation on early allograft dysfunction after orthotopic liver transplantation.

    Wilson, Elizabeth A / Woodbury, Anna / Williams, Kirsten M / Coopersmith, Craig M

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0301281

    Abstract: Early allograft dysfunction (EAD) is a functional hepatic insufficiency within a week of orthotopic liver transplantation (OLT) and is associated with morbidity and mortality. The etiology of EAD is multifactorial and largely driven by ischemia ... ...

    Abstract Early allograft dysfunction (EAD) is a functional hepatic insufficiency within a week of orthotopic liver transplantation (OLT) and is associated with morbidity and mortality. The etiology of EAD is multifactorial and largely driven by ischemia reperfusion injury (IRI), a phenomenon characterized by oxygen scarcity followed by paradoxical oxidative stress and inflammation. With the expanded use of marginal allografts more susceptible to IRI, the incidence of EAD may be increasing. This necessitates an in-depth understanding of the innate molecular mechanisms underlying EAD and interventions to mitigate its impact. Our central hypothesis is peri-reperfusion hyperoxemia and immune dysregulation exacerbate IRI and increase the risk of EAD. We will perform a pilot prospective single-center observational cohort study of 40 patients. The aims are to determine (1) the association between peri-reperfusion hyperoxemia and EAD and (2) whether peri-reperfusion perturbed cytokine, protein, and hypoxia inducible factor-1 alpha (HIF-1α) levels correlate with EAD after OLT. Inclusion criteria include age ≥ 18 years, liver failure, and donation after brain or circulatory death. Exclusion criteria include living donor donation, repeat OLT within a week of transplantation, multiple organ transplantation, and pregnancy. Partial pressure of arterial oxygen (PaO2) as the study measure allows for the examination of oxygen exposure within the confines of existing variability in anesthesiologist-administered fraction of inspired oxygen (FiO2) and the inclusion of patients with intrapulmonary shunting. The Olthoff et al. definition of EAD is the primary outcome. Secondary outcomes include postoperative acute kidney injury, pulmonary and biliary complications, surgical wound dehiscence and infection, and mortality. The goal of this study protocol is to identify EAD contributors that could be targeted to attenuate its impact and improve OLT outcomes. If validated, peri-reperfusion hyperoxemia and immune perturbations could be targeted via FiO2 titration to a goal PaO2 and/or administration of an immunomodulatory agent by the anesthesiologist intraoperatively.
    MeSH term(s) Humans ; Adolescent ; Liver Transplantation/adverse effects ; Prospective Studies ; Risk Factors ; Graft Survival ; Liver/metabolism ; Liver Failure ; Cohort Studies ; Allografts ; Reperfusion ; Oxygen/metabolism ; Observational Studies as Topic
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0301281
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  8. Article ; Online: Does Crystalloid Composition or Rate of Fluid Administration Make a Difference When Resuscitating Patients in the ICU?

    Connor, Michael J / Coopersmith, Craig M

    JAMA

    2021  

    Language English
    Publishing date 2021-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.11119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.88: Show issues Location:
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  9. Article ; Online: Crystalloid Composition and Rate of Fluid Administration When Resuscitating Patients in the Intensive Care Unit-Reply.

    Coopersmith, Craig M / Connor, Michael J

    JAMA

    2021  Volume 326, Issue 24, Page(s) 2532–2533

    MeSH term(s) Crystalloid Solutions ; Fluid Therapy ; Humans ; Intensive Care Units
    Chemical Substances Crystalloid Solutions
    Language English
    Publishing date 2021-12-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.20276
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    Ua VI Zs.88: Show issues Location:
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  10. Article ; Online: Cancer and sepsis.

    Williams, Jeroson C / Ford, Mandy L / Coopersmith, Craig M

    Clinical science (London, England : 1979)

    2023  Volume 137, Issue 11, Page(s) 881–893

    Abstract: Sepsis is one of the leading causes of death worldwide. While mortality is high regardless of inciting infection or comorbidities, mortality in patients with cancer and sepsis is significantly higher than mortality in patients with sepsis without cancer. ...

    Abstract Sepsis is one of the leading causes of death worldwide. While mortality is high regardless of inciting infection or comorbidities, mortality in patients with cancer and sepsis is significantly higher than mortality in patients with sepsis without cancer. Cancer patients are also significantly more likely to develop sepsis than the general population. The mechanisms underlying increased mortality in cancer and sepsis patients are multifactorial. Cancer treatment alters the host immune response and can increase susceptibility to infection. Preclinical data also suggests that cancer, in and of itself, increases mortality from sepsis with dysregulation of the adaptive immune system playing a key role. Further, preclinical data demonstrate that sepsis can alter subsequent tumor growth while tumoral immunity impacts survival from sepsis. Checkpoint inhibition is a well-accepted treatment for many types of cancer, and there is increasing evidence suggesting this may be a useful strategy in sepsis as well. However, preclinical studies of checkpoint inhibition in cancer and sepsis demonstrate results that could not have been predicted by examining either variable in isolation. As sepsis management transitions from a 'one size fits all' model to a more individualized approach, understanding the mechanistic impact of cancer on outcomes from sepsis represents an important strategy towards delivering on the promise of precision medicine in the intensive care unit.
    MeSH term(s) Humans ; Neoplasms/complications ; Sepsis ; Precision Medicine
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20220713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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