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Article ; Online: Prebiotic Synthesis of

Green, Nicholas J / Russell, David A / Tanner, Sasha H / Sutherland, John D

Journal of the American Chemical Society

2023 Volume 145, Issue 19, Page(s) 10533–10541

Abstract: Amino acids and their derivatives were probably instrumental in the transition of prebiotic chemistry to early biology. Accordingly, amino acid formation under prebiotic conditions has been intensively investigated. Unsurprisingly, most of these studies ... ...

Abstract	Amino acids and their derivatives were probably instrumental in the transition of prebiotic chemistry to early biology. Accordingly, amino acid formation under prebiotic conditions has been intensively investigated. Unsurprisingly, most of these studies have taken place with water as the solvent. Herein, we describe an investigation into the formation and subsequent reactions of aminonitriles and their formylated derivatives in formamide. We find that
MeSH term(s)	Formamides/chemistry ; Amino Acids ; Nitriles ; Cyanides
Chemical Substances	formamide (4781T907ZS) ; Formamides ; Amino Acids ; Nitriles ; Cyanides
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c13306
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Article: Genetic diversity of a short-ranged endemic terrestrial snail.

Gretgrix, Lachlan J / Decker, Orsi / Green, Peter T / Köhler, Frank / Moussalli, Adnan / Murphy, Nicholas P

Ecology and evolution

2023 Volume 13, Issue 11, Page(s) e10785

Abstract: The factors that influence population structure and connectivity are unknown for most terrestrial invertebrates but are of particular interest both for understanding the impacts of disturbance and for determining accurate levels of biodiversity and local ...

Abstract	The factors that influence population structure and connectivity are unknown for most terrestrial invertebrates but are of particular interest both for understanding the impacts of disturbance and for determining accurate levels of biodiversity and local endemism. The main objective of this study was to determine the historical patterns of genetic differentiation and contemporary gene flow in the terrestrial snail,
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.10785
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Article ; Online: Integrin intracellular machinery in action.

Green, Hannah J / Brown, Nicholas H

Experimental cell research

2019 Volume 378, Issue 2, Page(s) 226–231

Abstract: Integrin-mediated adhesion to the extracellular matrix involves a surprisingly large number of intracellular proteins, the integrin-associated proteins (IAPs), which are a fraction of the total integrin adhesome. In this review we discuss how genetic ... ...

Abstract	Integrin-mediated adhesion to the extracellular matrix involves a surprisingly large number of intracellular proteins, the integrin-associated proteins (IAPs), which are a fraction of the total integrin adhesome. In this review we discuss how genetic approaches have improved our understanding of how each IAP contributes to integrin function, especially in the context of building a functional organism during development. We then begin the process of assembling IAP roles together into an integrated mechanism.
MeSH term(s)	Animals ; Cell Adhesion ; Humans ; Integrins/physiology ; Mechanotransduction, Cellular ; Membrane Proteins/physiology
Chemical Substances	Integrins ; Membrane Proteins
Language	English
Publishing date	2019-03-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1016/j.yexcr.2019.03.011
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Article: Intracranial fungal

Kilbourn, Kent J / Green, Jaquise / Zacharewski, Nicholas / Aferzon, Joseph / Lawlor, Michael / Jaffa, Matthew

Surgical neurology international

2022 Volume 13, Page(s) 165

Abstract: Background: Cladophialophora bantiana: Case description: An 81-year-old female with a remote history of renal cell carcinoma presented with progressive headache and an expressive aphasia for 3 days. Computed tomography imaging revealed a left ... ...

Abstract	Background: Cladophialophora bantiana Case description: An 81-year-old female with a remote history of renal cell carcinoma presented with progressive headache and an expressive aphasia for 3 days. Computed tomography imaging revealed a left frontotemporal mass with surrounding vasogenic edema. A left frontotemporal craniotomy was performed and cultures revealed Conclusion: C. bantiana
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Case Reports
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_116_2022
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Article ; Online: Response to comment on 'The clinical pharmacology of tafenoquine in the radical cure of

Watson, James A / Commons, Robert J / Tarning, Joel / Simpson, Julie A / Llanos Cuentas, Alejandro / Lacerda, Marcus V G / Green, Justin A / Koh, Gavin C K W / Chu, Cindy S / Nosten, François H / Price, Richard N / Day, Nicholas P J / White, Nicholas J

eLife

2024 Volume 13

Abstract: In our recent paper on the clinical pharmacology of tafenoquine (Watson et al., 2022), we used all available individual patient pharmacometric data from the tafenoquine pre-registration clinical efficacy trials to characterise the determinants of anti- ... ...

Abstract	In our recent paper on the clinical pharmacology of tafenoquine (Watson et al., 2022), we used all available individual patient pharmacometric data from the tafenoquine pre-registration clinical efficacy trials to characterise the determinants of anti-relapse efficacy in tropical vivax malaria. We concluded that the currently recommended dose of tafenoquine (300 mg in adults, average dose of 5 mg/kg) is insufficient for cure in all adults, and a 50% increase to 450 mg (7.5 mg/kg) would halve the risk of vivax recurrence by four months. We recommended that clinical trials of higher doses should be carried out to assess their safety and tolerability. Sharma and colleagues at the pharmaceutical company GSK defend the currently recommended adult dose of 300 mg as the optimum balance between radical curative efficacy and haemolytic toxicity (Sharma et al., 2024). We contend that the relative haemolytic risks of the 300 mg and 450 mg doses have not been sufficiently well characterised to justify this opinion. In contrast, we provided evidence that the currently recommended 300 mg dose results in sub-maximal efficacy, and that prospective clinical trials of higher doses are warranted to assess their risks and benefits.
MeSH term(s)	Adult ; Humans ; Aminoquinolines ; Antimalarials/therapeutic use ; Hemolysis ; Malaria, Vivax/drug therapy ; Primaquine/therapeutic use ; Prospective Studies ; Meta-Analysis as Topic
Chemical Substances	Aminoquinolines ; Antimalarials ; Primaquine (MVR3634GX1) ; tafenoquine (262P8GS9L9)
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.91283
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Article: Comparative Metabolomics of Reproductive Organs in the Genus

Green, Alison / Padilla-Gonzalez, Guillermo Federico / Phumthum, Methee / Simmonds, Monique S J / Sadgrove, Nicholas J

Plants (Basel, Switzerland)

2021 Volume 10, Issue 12

Abstract: ... Fruit ... ...

Abstract	Fruit from
Language	English
Publishing date	2021-12-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants10122695
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Article ; Online: Illuminating Life's Origins: UV Photochemistry in Abiotic Synthesis of Biomolecules.

Green, Nicholas J / Xu, Jianfeng / Sutherland, John D

Journal of the American Chemical Society

2021 Volume 143, Issue 19, Page(s) 7219–7236

Abstract: Solar radiation is the principal source of energy available to Earth and has unmatched potential for the synthesis of organic material from primordial molecular building blocks. As well as providing the energy for photochemical synthesis of (proto) ... ...

Abstract	Solar radiation is the principal source of energy available to Earth and has unmatched potential for the synthesis of organic material from primordial molecular building blocks. As well as providing the energy for photochemical synthesis of (proto)biomolecules of interest in origins of life-related research, light has also been found to often provide remarkable selectivity in these processes, for molecules that function in extant biology and against those that do not. As such, light is heavily implicated as an environmental input on the nascent Earth that was important for the emergence of complex yet selective chemical systems underpinning life. Reactivity and selectivity in photochemical prebiotic synthesis are discussed, as are their implications for origins of life scenarios and their plausibility, and the future directions of this research.
MeSH term(s)	Earth, Planet ; Nitriles/chemical synthesis ; Nitriles/chemistry ; Origin of Life ; Photochemical Processes ; Solar Energy ; Ultraviolet Rays
Chemical Substances	Nitriles ; diaminomaleonitrile (18514-52-8)
Language	English
Publishing date	2021-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.1c01839
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Article: Illuminating Life’s Origins: UV Photochemistry in Abiotic Synthesis of Biomolecules

Green, Nicholas J / Xu, Jianfeng / Sutherland, John D

Journal of the American Chemical Society. 2021 Apr. 21, v. 143, no. 19

2021

Abstract	Solar radiation is the principal source of energy available to Earth and has unmatched potential for the synthesis of organic material from primordial molecular building blocks. As well as providing the energy for photochemical synthesis of (proto)biomolecules of interest in origins of life-related research, light has also been found to often provide remarkable selectivity in these processes, for molecules that function in extant biology and against those that do not. As such, light is heavily implicated as an environmental input on the nascent Earth that was important for the emergence of complex yet selective chemical systems underpinning life. Reactivity and selectivity in photochemical prebiotic synthesis are discussed, as are their implications for origins of life scenarios and their plausibility, and the future directions of this research.
Keywords	biochemical compounds ; energy ; photochemistry ; prebiotics ; solar radiation
Language	English
Dates of publication	2021-0421
Size	p. 7219-7236.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.1c01839
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Is Arthroscopic Meniscectomy Associated With an Increased Risk of Total Knee Arthroplasty for Claimants in the Workers' Compensation System? A 10-Year Study of Workers' Compensation Claims From a Large Nationwide Workers' Compensation Insurance Carrier.

Tsourmas, Nicholas F / Bernacki, Edward J / Hunt, Dan L / Kalia, Nimisha / Lavin, Robert A / Yuspeh, Larry / Leung, Nina / Green-McKenzie, Judith / Tao, Xuguang Grant

Journal of occupational and environmental medicine

2024 Volume 66, Issue 4, Page(s) 280–285

Abstract: Background: Total knee arthroplasty (TKA) is a commonly performed knee surgery and prior arthroscopic meniscectomy (AM) has been linked to an increased risk of TKA in the general population.: Objective: To study the relationship between AM and TKA ... ...

Abstract	Background: Total knee arthroplasty (TKA) is a commonly performed knee surgery and prior arthroscopic meniscectomy (AM) has been linked to an increased risk of TKA in the general population. Objective: To study the relationship between AM and TKA among injured workers whose medical care is paid for under workers' compensation (WC). Method: A total of 17,247 lost-time claims depicting all arthroscopic knee surgical procedures performed from 2007 to 2017 were followed to the end of 2022 and analyzed. Results: The odds ratio of undergoing a TKA for those with a preceding AM is 2.20, controlling for age, sex, and attorney involvement. Conclusions: Undergoing an AM is associated with an increased risk of TKA in WC claimants.
MeSH term(s)	Humans ; Workers' Compensation ; Arthroplasty, Replacement, Knee ; Meniscectomy ; Insurance Carriers ; Time Factors
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223932-x
ISSN	1536-5948 ; 1076-2752
ISSN (online)	1536-5948
ISSN	1076-2752
DOI	10.1097/JOM.0000000000003044
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Article ; Online: Whole-genome sequencing for neonatal intensive care unit outbreak investigations: Insights and lessons learned - ADDENDUM.

Sansom, Sarah E / Logan, Latania K / Green, Stefan J / Moore, Nicholas M / Hayden, Mary K

Antimicrobial stewardship & healthcare epidemiology : ASHE

2021 Volume 1, Issue 1, Page(s) e18

Language	English
Publishing date	2021-08-03
Publishing country	England
Document type	Journal Article ; Published Erratum
ISSN	2732-494X
ISSN (online)	2732-494X
DOI	10.1017/ash.2021.182
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