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Article: An

Yamada, Shigehiro / Ou, Tiffany / Nachadalingam, Sibani / Yang, Shuo / Johnson, Aaron N

bioRxiv : the preprint server for biology

2024

Abstract: Rare genetic disease discovery efforts typically lead to the identification of new disease genes. PreMIER ( Pre cision M edicine Integrated E xperimental R esources) is a collaborative platform designed to facilitate functional evaluation of human ... ...

Abstract	Rare genetic disease discovery efforts typically lead to the identification of new disease genes. PreMIER ( Pre cision M edicine Integrated E xperimental R esources) is a collaborative platform designed to facilitate functional evaluation of human genetic variants in model systems, and to date the PreMIER Consortium has evaluated over 50 variants in patients with genetic disorders. To understand if
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.11.01.565153
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Article ; Online: The serine/threonine kinase Back seat driver prevents cell fusion to maintain cell identity.

Yang, Shuo / Johnson, Aaron N

Developmental biology

2022 Volume 495, Page(s) 35–41

Abstract: Cell fate specification is essential for every major event of embryogenesis, and subsequent cell maturation ensures individual cell types acquire specialized functions. The mechanisms that regulate cell fate specification have been studied exhaustively, ... ...

Abstract	Cell fate specification is essential for every major event of embryogenesis, and subsequent cell maturation ensures individual cell types acquire specialized functions. The mechanisms that regulate cell fate specification have been studied exhaustively, and each technological advance in developmental biology ushers in a new era of studies aimed at uncovering the most fundamental processes by which cells acquire unique identities. What is less appreciated is that mechanisms are in place to ensure cell identity is maintained throughout the life of the organism. The body wall musculature in the Drosophila embryo is a well-established model to study cell fate specification, as each hemisegment in the embryo generates and maintains thirty muscles with distinct identities. Once specified, the thirty body wall muscles fuse with mononucleate muscle precursors that lack a specific identity to form multinucleate striated muscles. Multinucleate body wall muscles do not fuse with each other, which maintains a diversification of muscle cell identities. Here we show the serine/threonine kinase Back seat driver (Bsd) prevents inappropriate muscle fusion to maintain cell identity. Thus, the regulation of cell fusion is one mechanism that maintains cell identity.
MeSH term(s)	Animals ; Drosophila Proteins/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Cell Fusion ; Drosophila/metabolism ; Muscle, Skeletal/metabolism ; Serine/metabolism ; Gene Expression Regulation, Developmental
Chemical Substances	Drosophila Proteins ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Serine (452VLY9402)
Language	English
Publishing date	2022-12-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1114-9
ISSN	1095-564X ; 0012-1606
ISSN (online)	1095-564X
ISSN	0012-1606
DOI	10.1016/j.ydbio.2022.12.004
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Article ; Online: The serine/threonine kinase Back seat driver prevents cell fusion to maintain cell identity

Yang, Shuo / Johnson, Aaron N.

Developmental Biology. 2023 Mar., v. 495 p.35-41

2023

Abstract	Cell fate specification is essential for every major event of embryogenesis, and subsequent cell maturation ensures individual cell types acquire specialized functions. The mechanisms that regulate cell fate specification have been studied exhaustively, and each technological advance in developmental biology ushers in a new era of studies aimed at uncovering the most fundamental processes by which cells acquire unique identities. What is less appreciated is that mechanisms are in place to ensure cell identity is maintained throughout the life of the organism. The body wall musculature in the Drosophila embryo is a well-established model to study cell fate specification, as each hemisegment in the embryo generates and maintains thirty muscles with distinct identities. Once specified, the thirty body wall muscles fuse with mononucleate muscle precursors that lack a specific identity to form multinucleate striated muscles. Multinucleate body wall muscles do not fuse with each other, which maintains a diversification of muscle cell identities. Here we show the serine/threonine kinase Back seat driver (Bsd) prevents inappropriate muscle fusion to maintain cell identity. Thus, the regulation of cell fusion is one mechanism that maintains cell identity.
Keywords	Drosophila ; cell fusion ; embryogenesis ; integument ; models ; muscles ; serine ; threonine ; Cell identity ; Muscle development ; Myoblast fusion ; Bsd ; Htl ; Jumu
Language	English
Dates of publication	2023-03
Size	p. 35-41.
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	1114-9
ISSN	1095-564X ; 0012-1606
ISSN (online)	1095-564X
ISSN	0012-1606
DOI	10.1016/j.ydbio.2022.12.004
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Article ; Online: The impact of the COVID-19 pandemic on the lifestyle and behaviours, mental health and education of students studying healthcare-related courses at a British university.

Gadi, Nishita / Saleh, Saman / Johnson, Jo-Anne / Trinidade, Aaron

BMC medical education

2022 Volume 22, Issue 1, Page(s) 115

Abstract: ... to the questionnaire. Lifestyle and behaviours: 51.5% of the participants changed their diet (n=120); 45.5% (n=106 ... exercised less; 66.5% (n=155) experienced a change in sleep; 51.1% (n=119) reported a change in appetite ... Mental health: 84.2% (n=196) reported worrying too much about different things; 61.9% (n=144) could not stop or ...

Abstract	Background: The COVID-19 pandemic has affected most industries, including health education. In this study, we surveyed students studying healthcare-related courses at our university on how their lifestyles and behaviours, mental health and education had been affected by the pandemic. Methods: Mixed methods cross-sectional study. Results: Two hundred thirty-three students responded to the questionnaire. Lifestyle and behaviours: 51.5% of the participants changed their diet (n=120); 45.5% (n=106) exercised less; 66.5% (n=155) experienced a change in sleep; 51.1% (n=119) reported a change in appetite. Mental health: 84.2% (n=196) reported worrying too much about different things; 61.9% (n=144) could not stop or control worrying; 71.2% experienced trouble relaxing on several days or more (n=166). At least sometimes, 72.1% (n=168) felt unable to cope with things they had to do; 8.5% (n=20) never, or almost never, felt confident about handling personal problems. Education: 65.7% (n=153) struggled to complete learning outcomes with online delivery; 82% (n=191) worried about practical skills being affected; 60.5% (n=141) worried about the impact of COVID-19 on their future career. Almost half (48.9%, n=114) believed that online teaching should be part of the standard curriculum. Conclusion: In general, there was a negative impact on behaviours, lifestyle and mental health and virtual education was perceived as necessary in making up for the loss of face to face experiences. Students' mental health and educational needs have been affected by the current pandemic and healthcare educational facilities must respond to these needs to ensure students continue to receive the support they need.
MeSH term(s)	COVID-19 ; Cross-Sectional Studies ; Delivery of Health Care ; Humans ; Life Style ; Mental Health ; Pandemics ; SARS-CoV-2 ; Students ; Universities
Language	English
Publishing date	2022-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-022-03179-z
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Article ; Online: Executive function differences as a function of parent-reported binge eating and weight: Results from the adolescent brain cognitive development study.

Rozzell-Voss, Kaitlin N / Klimek-Johnson, Patrycja / Eichen, Dawn M / Brown, Tiffany A / Blashill, Aaron J

Obesity science & practice

2023 Volume 10, Issue 1, Page(s) e703

Abstract: Background: Binge eating is a relatively common disordered eating behavior among children, and is associated with poor health outcomes. Executive function (EF)-higher order cognitive abilities related to planning and impulse control-may be implicated in ...

Abstract	Background: Binge eating is a relatively common disordered eating behavior among children, and is associated with poor health outcomes. Executive function (EF)-higher order cognitive abilities related to planning and impulse control-may be implicated in both binge eating and pediatric obesity. Although EF deficits are evident among individuals with obesity and/or binge eating, findings are mixed across the lifespan. Methods: The present study examined differences in EF among children with varying weight statuses and parent-reported binge eating. The sample included 10,017 children from the Adolescent Brain Cognitive Development study, aged 9-10 years. Results: Children with parent-reported binge eating-either with overweight/obesity or normal weight-had significantly lower EF than those with no binge eating and a normal weight status but did not differ from those with no binge eating and overweight/obesity. Children with no binge eating and overweight/obesity also had statistically significantly lower EF than those with normal weight status. Although all significant differences between groups were negligible to very small, results may indicate similar neurocognitive profiles among children with binge eating and those with overweight/obesity. Conclusions: Alterations in EF among children with binge eating may not be solely related to weight-specific factors, as significant differences also emerged among children with normal weight status, with versus without parent-reported binge eating. Future research is needed to understand temporal associations between obesity, disordered eating, and neurocognition in children using multi-informant methods for assessing binge eating.
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2836381-4
ISSN	2055-2238 ; 2055-2238
ISSN (online)	2055-2238
ISSN	2055-2238
DOI	10.1002/osp4.703
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Article ; Online: My problem or yours? Interpersonal problems and marital quality.

Bliton, Chloe F / Johnson, Benjamin N / Pincus, Aaron L

Journal of personality

2021 Volume 90, Issue 4, Page(s) 595–614

Abstract: ... married couples (N = 110), we used expanded APIMs, integrating both self-report and spouse-rating, to test ...

Abstract	Objective: Research has consistently illustrated the impact of personality on marital quality. Given the inherent dyadic nature of relationships, recent investigations have integrated spouse-rated personality to account for both spouses' perspectives. Grounded in Contemporary Integrative Interpersonal Theory, we viewed personality through an interpersonal lens and conceptualized maladaptive interpersonal functioning as interpersonal problems. The present study examined the incremental validity of spouse-rated interpersonal problems beyond self-reported interpersonal problems to predict marital quality within an expanded actor-partner interdependence model (APIM). Method: Within a community sample of heterosexual, married couples (N = 110), we used expanded APIMs, integrating both self-report and spouse-rating, to test the incremental validity of spouse-perceived interpersonal problems over self-perceived interpersonal problems on marital quality through a model comparison approach. We tested for possible gender differences in effects. Results: Spouse perception, notably spouse-rated partner effects, appears to be the most frequent predictor of marital quality, and self-perception had less impact. Conclusion: Given the implications marital quality has on health and well-being, intervention efforts capitalizing on acceptance of spouses' perspectives are likely to lead to greater improvements in quality and overall health.
MeSH term(s)	Humans ; Interpersonal Relations ; Marriage ; Personality ; Self Concept ; Spouses
Language	English
Publishing date	2021-11-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	420745-2
ISSN	1467-6494 ; 0022-3506
ISSN (online)	1467-6494
ISSN	0022-3506
DOI	10.1111/jopy.12685
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Article ; Online: Non-nulling protocols for fast, accurate, 3-D velocity measurements in stacks.

Shinder, Iosif I / Johnson, Aaron N / Filla, B James / Khromchenko, Vladimir B / Moldover, Michael R / Boyd, Joey / Wright, John D / Stoup, John

Journal of the Air & Waste Management Association (1995)

2023 Volume 73, Issue 8, Page(s) 600–617

Abstract: The authors present protocols for making fast, accurate, 3D velocity measurements in the stacks of coal-fired power plants. The measurements are traceable to internationally-recognized standards; therefore, they provide a rigorous basis for measuring and/ ...

Abstract	The authors present protocols for making fast, accurate, 3D velocity measurements in the stacks of coal-fired power plants. The measurements are traceable to internationally-recognized standards; therefore, they provide a rigorous basis for measuring and/or regulating the emissions from stacks. The authors used novel, five-hole, hemispherical, differential-pressure probes optimized for non-nulling (no-probe rotation) measurements. The probes resist plugging from ash and water droplets. Integrating the differential pressures for only 5 seconds determined the axial velocity
MeSH term(s)	Coal ; Calibration ; Power Plants ; Environmental Monitoring/methods
Chemical Substances	2-chloroethyl methyl sulfide (542-81-4) ; Coal
Language	English
Publishing date	2023-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1003064-5
ISSN	2162-2906 ; 0894-0630 ; 1047-3289 ; 1096-2247
ISSN (online)	2162-2906
ISSN	0894-0630 ; 1047-3289 ; 1096-2247
DOI	10.1080/10962247.2023.2218827
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Article ; Online: Spatiotemporal expression of regulatory kinases directs the transition from mitosis to cellular morphogenesis in Drosophila.

Yang, Shuo / McAdow, Jennifer / Du, Yingqiu / Trigg, Jennifer / Taghert, Paul H / Johnson, Aaron N

Nature communications

2022 Volume 13, Issue 1, Page(s) 772

Abstract: Embryogenesis depends on a tightly regulated balance between mitosis, differentiation, and morphogenesis. Understanding how the embryo uses a relatively small number of proteins to transition between growth and morphogenesis is a central question of ... ...

Abstract	Embryogenesis depends on a tightly regulated balance between mitosis, differentiation, and morphogenesis. Understanding how the embryo uses a relatively small number of proteins to transition between growth and morphogenesis is a central question of developmental biology, but the mechanisms controlling mitosis and differentiation are considered to be fundamentally distinct. Here we show the mitotic kinase Polo, which regulates all steps of mitosis in Drosophila, also directs cellular morphogenesis after cell cycle exit. In mitotic cells, the Aurora kinases activate Polo to control a cytoskeletal regulatory module that directs cytokinesis. We show that in the post-mitotic mesoderm, the control of Polo activity transitions from the Aurora kinases to the uncharacterized kinase Back Seat Driver (Bsd), where Bsd and Polo cooperate to regulate muscle morphogenesis. Polo and its effectors therefore direct mitosis and cellular morphogenesis, but the transition from growth to morphogenesis is determined by the spatiotemporal expression of upstream activating kinases.
MeSH term(s)	Animals ; Aurora Kinases/metabolism ; Cell Cycle ; Cell Cycle Proteins/metabolism ; Cell Nucleus Division ; Cytokinesis ; Drosophila/genetics ; Drosophila/metabolism ; Drosophila Proteins ; Gene Expression Regulation, Developmental ; Microtubule-Associated Proteins ; Mitosis ; Morphogenesis/genetics ; Morphogenesis/physiology ; Phosphotransferases/genetics ; Phosphotransferases/metabolism ; Spindle Apparatus/metabolism
Chemical Substances	Cell Cycle Proteins ; Drosophila Proteins ; Microtubule-Associated Proteins ; asp protein, Drosophila ; Phosphotransferases (EC 2.7.-) ; Aurora Kinases (EC 2.7.11.1)
Language	English
Publishing date	2022-02-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-28322-8
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Article ; Online: Presumptive Diagnosis in Tele-Health Laryngology: A Multi-Center Observational Study.

Montalbaron, Michael B / Achlatis, Efstratios / Johnson, Aaron M / Ma, Yue / Young, VyVy N / Rosen, Clark A / Amin, Milan R / Kwak, Paul E

The Annals of otology, rhinology, and laryngology

2023 Volume 132, Issue 12, Page(s) 1511–1519

Abstract: Objectives: Early in the COVID-19 pandemic, outpatient visits were adapted for the virtual setting, forcing laryngologists to presume certain diagnoses without the aid of laryngoscopy, solely based on history and the limited physical exam available via ... ...

Abstract	Objectives: Early in the COVID-19 pandemic, outpatient visits were adapted for the virtual setting, forcing laryngologists to presume certain diagnoses without the aid of laryngoscopy, solely based on history and the limited physical exam available via video visit. This study aims to examine the accuracy of presumptive diagnoses made via telemedicine, compared to subsequent in-person follow up, where endoscopic examination could confirm or refute suspected diagnoses. Methods: A retrospective chart review was conducted of 38 patients evaluated for voice-related issues at NYU Langone Health and the University of California-San Francisco. Presumptive diagnoses at the initial telemedicine encounter were noted, along with diagnostic cues used for clinical reasoning and recommended treatment plans. These presumptive diagnoses were compared to diagnoses and plans established following laryngoscopy at follow-up in-person visits. Results: After laryngoscopy at the first in-person visit, 38% of presumptive diagnoses changed, as did 37% of treatment plans. The accuracy varied among conditions. Muscle tension dysphonia and Reinke's edema were accurately diagnosed without laryngoscopy, but other conditions, including vocal fold paralysis and subglottic stenosis, were not initially suspected, relying on laryngoscopy for diagnosis. Conclusions: While some laryngologic conditions may be reasonably identified without in-person examination, laryngoscopy remains central to definitive diagnosis and treatment. Telemedicine can increase access to care, but it may provide more utility as a screening tool, triaging which patients should present more urgently for in-person laryngoscopy. Level of evidence: 4.
MeSH term(s)	Humans ; Retrospective Studies ; Pandemics ; COVID-19/diagnosis ; COVID-19/epidemiology ; Dysphonia/diagnosis ; Laryngoscopy ; Otolaryngology ; Telemedicine ; COVID-19 Testing
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Multicenter Study ; Observational Study ; Journal Article
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/00034894231165811
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Article ; Online: Acupuncture Treatment for Breast Cancer-Related Lymphedema: A Randomized Pilot Study.

Friedman, Rosie / Johnson, Anna Rose / Shillue, Kathy / Fleishman, Aaron / Mistretta, Chris / Magrini, Leo / Tran, Bao Ngoc N / Rockson, Stanley G / Lu, Weidong / Yeh, Gloria Y / Singhal, Dhruv

Lymphatic research and biology

2023 Volume 21, Issue 5, Page(s) 488–494

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2147953-7
ISSN	1557-8585 ; 1539-6851
ISSN (online)	1557-8585
ISSN	1539-6851
DOI	10.1089/lrb.2022.0001
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