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Article ; Online: CBGA ameliorates inflammation and fibrosis in nephropathy.

Suzuki, Sayuri / Fleig, Andrea / Penner, Reinhold

2023 Volume 13, Issue 1, Page(s) 6341

Abstract: Cannabidiol (CBD) is thought to have multiple biological effects, including the ability to attenuate inflammatory processes. Cannabigerols (CBGA and its decarboxylated CBG molecule) have pharmacological profiles similar to CBD. The endocannabinoid system ...

Abstract	Cannabidiol (CBD) is thought to have multiple biological effects, including the ability to attenuate inflammatory processes. Cannabigerols (CBGA and its decarboxylated CBG molecule) have pharmacological profiles similar to CBD. The endocannabinoid system has recently emerged to contribute to kidney disease, however, the therapeutic properties of cannabinoids in kidney disease remain largely unknown. In this study, we determined whether CBD and CBGA can attenuate kidney damage in an acute kidney disease model induced by the chemotherapeutic cisplatin. In addition, we evaluated the anti-fibrosis effects of these cannabinoids in a chronic kidney disease model induced by unilateral ureteral obstruction (UUO). We find that CBGA, but not CBD, protects the kidney from cisplatin-induced nephrotoxicity. CBGA also strongly suppressed mRNA of inflammatory cytokines in cisplatin-induced nephropathy, whereas CBD treatment was only partially effective. Furthermore, both CBGA and CBD treatment significantly reduced apoptosis through inhibition of caspase-3 activity. In UUO kidneys, both CBGA and CBD strongly reduced renal fibrosis. Finally, we find that CBGA, but not CBD, has a potent inhibitory effect on the channel-kinase TRPM7. We conclude that CBGA and CBD possess reno-protective properties, with CBGA having a higher efficacy, likely due to its dual anti-inflammatory and anti-fibrotic effects paired with TRPM7 inhibition.
MeSH term(s)	Humans ; TRPM Cation Channels ; Cisplatin/pharmacology ; Kidney/pathology ; Ureteral Obstruction/complications ; Ureteral Obstruction/drug therapy ; Ureteral Obstruction/genetics ; Renal Insufficiency, Chronic/pathology ; Inflammation/drug therapy ; Inflammation/pathology ; Cannabinoids/pharmacology ; Fibrosis ; Protein Serine-Threonine Kinases
Chemical Substances	TRPM Cation Channels ; Cisplatin (Q20Q21Q62J) ; Cannabinoids ; TRPM7 protein, human (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2023-04-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-33507-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biomodulation of Induced Tooth Movement by Three Methods, Corticopuncture, Photobiomodulation, and Their Combination: An Animal Study.

Botelho, Bruno Ferreira / Torres, Martha Carolina / Paredes, Ney / Garcez, Aguinaldo Silva / Moon, Won / Suzuki, Selly Sayuri

Photobiomodulation, photomedicine, and laser surgery

2023 Volume 41, Issue 7, Page(s) 328–342

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Animals ; Low-Level Light Therapy/methods ; Tooth Movement Techniques/methods ; Lasers, Semiconductor ; Molar ; Osteogenesis
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article
ISSN	2578-5478
ISSN (online)	2578-5478
DOI	10.1089/photob.2022.0119
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Article ; Online: In vitro effects of photobiomodulation on cell migration and gene expression of ALP, COL-1, RUNX-2, and osterix in cementoblasts.

de Farias, Cleisson Sampaio / Garcez, Aguinaldo Silva / Teixeira, Lucas Novaes / Suzuki, Selly Sayuri

Lasers in medical science

2023 Volume 38, Issue 1, Page(s) 121

Abstract: The aim of this study was to evaluate the effects of photobiomodulation (PBM) on cell migration and alkaline phosphatase (ALP), type I collagen (Col-1), runt-related transcription factor 2 (RUNX-2), and Osterix (OSX) gene expression in a cementoblast ... ...

Abstract	The aim of this study was to evaluate the effects of photobiomodulation (PBM) on cell migration and alkaline phosphatase (ALP), type I collagen (Col-1), runt-related transcription factor 2 (RUNX-2), and Osterix (OSX) gene expression in a cementoblast culture (OCCM-30), in a microenvironment mimicking an injury on the cementoblast layer, such as it occurs during root resorption. For this, OCCM-30 cells were cultured in 6-well plates and the following parameters were assayed: (1) migration by scratch assay and ALP, Col-1, Runx2, and Osx by real-time PCR. PBM was performed in two protocols using a LED device emitting light at 660 nm (± 30 nm). OCCM-30 cementoblasts were grown and divided into four groups: (1) negative control; (2) positive control (scratch); (3) scratch + PBM with a total energy of 36 J and energy density 1.6 J/cm
MeSH term(s)	Alkaline Phosphatase/genetics ; Cell Movement/genetics ; Coloring Agents ; Core Binding Factor Alpha 1 Subunit/genetics ; Dental Cementum/cytology ; Gene Expression ; Animals ; Mice
Chemical Substances	Alkaline Phosphatase (EC 3.1.3.1) ; Coloring Agents ; Core Binding Factor Alpha 1 Subunit
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-023-03775-5
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Article ; Online: Cannabigerolic Acid (CBGA) Inhibits the TRPM7 Ion Channel Through its Kinase Domain.

Suzuki, Sayuri / Wakano, Clay / Monteilh-Zoller, Mahealani K / Cullen, Aaron J / Fleig, Andrea / Penner, Reinhold

Function (Oxford, England)

2023 Volume 5, Issue 1, Page(s) zqad069

Abstract: Cannabinoids are a major class of compounds produced by the plant Cannabis sativa. Previous work has demonstrated that the main cannabinoids cannabidiol (CBD) and tetrahydrocannabinol (THC) can have some beneficial effects on pain, inflammation, epilepsy, ...

Abstract	Cannabinoids are a major class of compounds produced by the plant Cannabis sativa. Previous work has demonstrated that the main cannabinoids cannabidiol (CBD) and tetrahydrocannabinol (THC) can have some beneficial effects on pain, inflammation, epilepsy, and chemotherapy-induced nausea and vomiting. While CBD and THC represent the two major plant cannabinoids, some hemp varieties with enzymatic deficiencies produce mainly cannabigerolic acid (CBGA). We recently reported that CBGA has a potent inhibitory effect on both Store-Operated Calcium Entry (SOCE) via inhibition of Calcium Release-Activated Calcium (CRAC) channels as well as currents carried by the channel-kinase TRPM7. Importantly, CBGA prevented kidney damage and suppressed mRNA expression of inflammatory cytokines through inhibition of these mechanisms in an acute nephropathic mouse model. In the present study, we investigate the most common major and minor cannabinoids to determine their potential efficacy on TRPM7 channel function. We find that approximately half of the tested cannabinoids suppress TRPM7 currents to some degree, with CBGA having the strongest inhibitory effect on TRPM7. We determined that the CBGA-mediated inhibition of TRPM7 requires a functional kinase domain, is sensitized by both intracellular Mg⋅ATP and free Mg
MeSH term(s)	Animals ; Mice ; Cannabinoids/pharmacology ; TRPM Cation Channels/antagonists & inhibitors
Chemical Substances	cannabigerolic acid (25555-57-1) ; Cannabinoids ; TRPM Cation Channels
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Journal Article
ISSN	2633-8823
ISSN (online)	2633-8823
DOI	10.1093/function/zqad069
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Article ; Online: Route of pesticide spread on the body surface of Blattella germanica (Linnaeus): a NanoSuit-energy dispersive X-ray spectroscopy analysis.

Takaku, Yasuharu / Shiraki, Katsumi / Suzuki, Chiaki / Takehara, Sayuri / Nishii, Hiroyuki / Sasaki, Tomonori / Hariyama, Takahiko

Scientific reports

2023 Volume 13, Issue 1, Page(s) 14335

Abstract: Numerous studies have focussed on the mechanisms of entry of pesticides into insect body parts such as oral intake, penetration through the integument of the body wall, and inhalation through spiracles. However, little is known about how insecticides ... ...

Abstract	Numerous studies have focussed on the mechanisms of entry of pesticides into insect body parts such as oral intake, penetration through the integument of the body wall, and inhalation through spiracles. However, little is known about how insecticides spread to the points of entry or the paths on the body surface that are used to reach the target sites. In this study, elemental signals of pesticide-mimicking test solutions were tracked and their routes of spreading in experimental insects (Blattella germanica L.) were investigated using NanoSuit (a method of surface modification) and energy dispersive X-ray spectroscopy, combined with high-resolution scanning electron microscopy. When the test solution initially adhered to the dorsal and/or ventral body surface, it tended to spread horizontally to reach lateral plates. Whereas, when the solution directly adhered to the anterior side of the lateral plates, it spread to posterior segments. In this case, however, spreading in the opposite direction (i.e., the solution directly adhered to the posterior side of the lateral plates) was interrupted at a boundary erected by different groups of fine structures; each protrusion was large, and the arrangement was rather dense in the posterior segments. Morphological features of these fine structures and chemical characteristics of the hydrophobic surface substances potentially regulate the strength of the capillary force, which determines pesticide spreading.
MeSH term(s)	Animals ; Pesticides ; Insecticides ; Blattellidae ; Integumentary System ; Microscopy, Electron, Scanning
Chemical Substances	Pesticides ; Insecticides
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41474-x
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Article ; Online: Frailty and visual, auditory, olfactory, and taste senses in older patients visiting a frailty outpatient clinic.

Sable-Morita, Sayuri / Sugiura, Saiko / Suzuki, Hirokazu / Fukuoka, Hideki / Matsui, Yasumoto / Arai, Hidenori

Geriatrics & gerontology international

2023 Volume 23, Issue 11, Page(s) 871–876

Abstract: Aim: Although studies have analyzed the relationship between frailty and human senses, few have comprehensively evaluated and examined their correlations. This study aimed to clarify the relationship between frailty and the senses of sight, hearing, ... ...

Abstract	Aim: Although studies have analyzed the relationship between frailty and human senses, few have comprehensively evaluated and examined their correlations. This study aimed to clarify the relationship between frailty and the senses of sight, hearing, smell, and taste. Methods: The subjects were outpatients at the Locomo Frail Outpatient Clinic. Sensory organ items were evaluated subjectively, and frailty was classified as nonfrail or frail using the Kihon Checklist. Univariate analysis was performed using the presence or absence of frailty as the dependent variable. Logistic regression analysis (forced entry method) was performed for the variables that showed significant differences. Results: A total of 269 and 226 participants were assigned to the nonfrail and frail groups, respectively. The frequency of sensory organ impairment was 10.1% for taste, 12.7% for smell, 44.6% for vision, and 58.3% for hearing. Univariate analysis using the presence or absence of frailty as the dependent variable was determined to be significant for years of education, number of medications, Geriatric Depression Scale, Mini-Mental State Examination, Mini Nutritional Assessment-Short Form, grip strength, gait speed, sense of taste, sense of smell, sense of vision, and sense of hearing. Logistic regression analysis using the presence or absence of frailty as the dependent variable, adjusted for age, showed significant correlations with the Geriatric Depression Scale, gait speed, Mini Nutritional Assessment-Short Form, and olfactory impairment. Conclusions: Olfactory impairment had the strongest correlation with frailty. Although the sense of smell decreases with disease and aging, olfactory impairment may be correlated with frailty as a symptom of neurodegenerative diseases. Geriatr Gerontol Int 2023; 23: 871-876.
MeSH term(s)	Humans ; Aged ; Frailty/diagnosis ; Smell ; Taste ; Geriatric Assessment/methods ; Olfaction Disorders/diagnosis ; Olfaction Disorders/epidemiology ; Frail Elderly
Language	English
Publishing date	2023-10-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14674
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Article ; Online: Body Roundness Index Is Better Correlated with Insulin Sensitivity than Body Shape Index in Young and Middle-Aged Japanese Persons.

Murai, Norimitsu / Saito, Naoko / Oka, Rie / Nii, Sayuri / Nishikawa, Hiroto / Suzuki, Asami / Kodama, Eriko / Iida, Tatsuya / Mikura, Kentaro / Imai, Hideyuki / Hashizume, Mai / Tadokoro, Rie / Sugisawa, Chiho / Iizaka, Toru / Otsuka, Fumiko / Ishibashi, Shun / Nagasaka, Shoichiro

Metabolic syndrome and related disorders

2024 Volume 22, Issue 2, Page(s) 151–159

Abstract: Aims: ...

Abstract	Aims:
MeSH term(s)	Male ; Middle Aged ; Humans ; Adult ; Body Mass Index ; Insulin Resistance ; Obesity/diagnosis ; Risk Factors ; Glucose Intolerance/diagnosis ; Japan ; Anthropometry ; Waist Circumference
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2151220-6
ISSN	1557-8518 ; 1540-4196
ISSN (online)	1557-8518
ISSN	1540-4196
DOI	10.1089/met.2023.0175
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Article ; Online: Analysis of factors associated with the success of microimplant-assisted rapid palatal expansion.

Meirelles, Carolina Marques / Ferreira, Rafael Malagutti / Suzuki, Hideo / Oliveira, Cibele Braga / Souza de Jesus, Adriana / Garcez, Aguinaldo Silva / Suzuki, Selly Sayuri

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

2023 Volume 164, Issue 1, Page(s) 67–77

Abstract: Introduction: Success-related factors of microimplant-assisted rapid palatal expansion (MARPE) were evaluated, including age, palatal depth, suture, and parassutural bone thickness, suture density and maturation, and the relation to corticopuncture (CP) ...

Abstract	Introduction: Success-related factors of microimplant-assisted rapid palatal expansion (MARPE) were evaluated, including age, palatal depth, suture, and parassutural bone thickness, suture density and maturation, and the relation to corticopuncture (CP) technique, as well as skeletal and dental effects. Methods: Sixty-six cone-beam computed tomography scans were analyzed before and after rapid maxillary expansion procedures in 33 patients aged 18-52 years for both sexes. The scans were generated in digital imaging and communications in medicine file format and analyzed in the multiplanar reconstruction of the regions of interest. Palatal depth, suture thickness, density and maturation, age, and CP were assessed. To evaluate dental and skeletal effects, the sample was divided into 4 groups: successful MARPE (SM), SM + CP technique (SMCP), failure MARPE (FM), and FM + CP (FMCP). Results: Successful groups presented more skeletal expansion and dental tipping than failure groups (P <0.05). The mean age of the FMCP group was significantly higher than the SM groups; suture and parassutural thickness significantly related to the success, and patients who received CP showed a success rate of 81.2% compared with 33.3% in the no CP group (P <0.05). Suture density and palatal depth did not show a difference between the success and failure groups. Suture maturation was higher in SMCP and FM groups (P <0.05). Conclusions: Older age, thin palatal bone, and higher stage of maturation can influence the success of MARPE. CP technique in these patients appears to have a positive impact, increasing the chance of treatment success.
MeSH term(s)	Male ; Female ; Humans ; Palatal Expansion Technique ; Maxilla ; Cone-Beam Computed Tomography ; Palate/diagnostic imaging ; Sutures
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	356699-7
ISSN	1097-6752 ; 0889-5406 ; 0002-9416
ISSN (online)	1097-6752
ISSN	0889-5406 ; 0002-9416
DOI	10.1016/j.ajodo.2022.10.029
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Article ; Online: Single Molecule Fluorescence Imaging Reveals the Stoichiometry of BKγ1 Subunit in Living HEK293 Cell Expression System.

Noda, Sayuri / Suzuki, Yoshiaki / Yamamura, Hisao / Imaizumi, Yuji

Biological & pharmaceutical bulletin

2020 Volume 43, Issue 7, Page(s) 1118–1122

Abstract: Large conductance ... ...

Abstract	Large conductance Ca
MeSH term(s)	HEK293 Cells ; Humans ; Large-Conductance Calcium-Activated Potassium Channels/physiology ; Optical Imaging ; Protein Subunits/physiology ; Single Molecule Imaging
Chemical Substances	Large-Conductance Calcium-Activated Potassium Channels ; Protein Subunits
Language	English
Publishing date	2020-07-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b20-00125
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Article: Assessment of a Biosafety Device to Control Contamination by Airborne Transmission during Orthodontic/Dental Procedures.

Santa Rita de Assis, Josilene / Garcez, Aguinaldo Silva / Suzuki, Hideo / Montalli, Victor Angelo Martins / Fujii, Denise Nami / Prouvot, Michelle Bertini / Suzuki, Selly Sayuri

International journal of dentistry

2022 Volume 2022, Page(s) 8302826

Abstract: During the COVID-19 pandemic, dental professionals have faced high risk of airborne contamination between dentists, staff, and patients. The objective of this study was to evaluate the effect of an individual biosafety capsule in dentistry (IBCD) on ... ...

Abstract	During the COVID-19 pandemic, dental professionals have faced high risk of airborne contamination between dentists, staff, and patients. The objective of this study was to evaluate the effect of an individual biosafety capsule in dentistry (IBCD) on reducing the dispersion of droplets and aerosols during orthodontic treatment and evaluate the clinician and patient's perception of using the IBCD. For the
Language	English
Publishing date	2022-04-15
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2546524-7
ISSN	1687-8736 ; 1687-8728
ISSN (online)	1687-8736
ISSN	1687-8728
DOI	10.1155/2022/8302826
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