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Article: Stay Strong: Aboriginal leaders deliver COVID-19 health messages.

Kerrigan, Vicki / Lee, Anne Marie / Ralph, Anna P / Lawton, Paul D

Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals

2020 Volume 32 Suppl 1, Page(s) 203–204

MeSH term(s)	Australia/epidemiology ; COVID-19/ethnology ; Consumer Health Information ; Health Promotion/organization & administration ; Humans ; Leadership ; Native Hawaiian or Other Pacific Islander ; Pandemics ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-30
Publishing country	Australia
Document type	Letter
ZDB-ID	2250864-8
ISSN	2201-1617 ; 1036-1073
ISSN (online)	2201-1617
ISSN	1036-1073
DOI	10.1002/hpja.364
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Article: Stay Strong: Aboriginal leaders deliver COVID-19 health messages

Kerrigan, Vicki / Lee, Anne Marie / Ralph, Anna P / Lawton, Paul D

Health promotion journal of Australia :official journal of Australian Association of Health Promotion Professionals

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #306098
Database	COVID19

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Article ; Online: Stay Strong

Kerrigan, Vicki / Lee, Anne Marie / Ralph, Anna P. / Lawton, Paul D.

Health Promotion Journal of Australia ; ISSN 1036-1073 2201-1617

Aboriginal leaders deliver COVID‐19 health messages

2020

Keywords	Public Health, Environmental and Occupational Health ; Community and Home Care ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1002/hpja.364
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Article ; Online: A Review of Preoperative Embolization Effectiveness in Patients With Arteriovenous Malformations.

Catapano, Joshua S / Koester, Stefan W / Rumalla, Kavelin / Rangel, India C / Stonnington, Henry O / Singh, Rohin / Memon, Ali / Kimata, Anna R / Winkler, Ethan A / Baranoski, Jacob F / Cole, Tyler S / Graffeo, Christopher S / Srinivasan, Visish M / Jadhav, Ashutosh P / Ducruet, Andrew F / Albuquerque, Felipe C / Lawton, Michael T

Neurosurgery

2023 Volume 94, Issue 1, Page(s) 129–139

Abstract: ... than in the nonembolization group ($117 594 [$102 295] vs $84 348 [$82 326]; P < .001). The mean (SD) CE was higher ... in the embolization cohort ($336 476 [$1 303 842]) than in the nonembolization cohort ($100 237 [$246 255]; P < .001 ... 40) than in the nonembolization (n = 72) cohort ($164 950 [$348 286] vs $69 021 [$114 938]; P = .004 ...

Abstract	Background and objectives: Preoperative embolization of arteriovenous malformations (AVMs) remains controversial. This study sought to analyze the cost-effectiveness of preoperative embolization of AVMs. Methods: Patients who underwent AVM resection at a single institute (January 1, 2015-December 31, 2020) were analyzed. Patients with preoperative embolization (embolization cohort) were compared with those without preoperative embolization (nonembolization cohort). Cost-effectiveness score (CE) was the primary outcome of interest and was determined by dividing the total 1-year cost by effectiveness, which was derived from a validated preoperative to last follow-up change in the modified Rankin Scale utility score. A lower CE signifies a more cost-effective treatment strategy. Results: Of 188 patients, 88 (47%) underwent preoperative embolization. The mean (SD) total cost was higher in the embolization group than in the nonembolization group ($117 594 [$102 295] vs $84 348 [$82 326]; P < .001). The mean (SD) CE was higher in the embolization cohort ($336 476 [$1 303 842]) than in the nonembolization cohort ($100 237 [$246 255]; P < .001). Among patients with Spetzler-Martin (SM) grade I and II AVMs, the mean (SD) CE was higher in the embolization (n = 40) than in the nonembolization (n = 72) cohort ($164 950 [$348 286] vs $69 021 [$114 938]; P = .004). Among patients with SM grade III AVMs, the mean (SD) CE was lower in the embolization (n = 33) than in the nonembolization (n = 25) cohort ($151 577 [$219 130] vs $189 195 [$446 335]; P = .006). The mean (SD) CE was not significantly different between cohorts among patients with higher-grade AVMs (embolization cohort [n = 3] vs nonembolization cohort [n = 15]: $503 639 [$776 492] vs $2 048 419 [$4 794 758]; P = .49). The mean CE for embolized SM grade III aneurysms was nonsignificant in the ruptured group; however, for the unruptured group, CE was significantly higher in the embolization cohort (n = 26; $160 871 [$240 535]) relative to the nonembolization cohort (n = 15; $108 152 [$166 446]) ( P = .006). Conclusion: Preoperative embolization was cost-effective for patients with SM grade III AVMs but not for patients with lower-grade AVMs.
MeSH term(s)	Humans ; Intracranial Arteriovenous Malformations/surgery ; Retrospective Studies ; Treatment Outcome ; Embolization, Therapeutic ; Radiosurgery
Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/neu.0000000000002629
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Article ; Online: Degradation of okadaic acid in seawater by UV/TiO

Camacho-Muñoz, Dolores / Lawton, Linda Ann / Edwards, Christine

The Science of the total environment

2020 Volume 733, Page(s) 139346

Abstract: ... The profiling, characterization and quantification of DSP toxins in the culture of P. lima were achieved ...

Abstract	The consumption of contaminated shellfish with marine toxins causes adverse socioeconomical, environmental and health impacts. The marine toxin okadaic acid (OA) provokes diarrhetic shellfish poisoning (DSP) syndrome characterized by severe gastrointestinal symptoms. Therefore, there is increasing interest in removing these toxins from the marine environment to protect shellfish harvesting sites. Photocatalysis is proposed as an efficient method to detoxify the marine environment. In this study, Prorocentrum lima was used to produce high purity DSP toxins, in particular OA, for degradation studies. The profiling, characterization and quantification of DSP toxins in the culture of P. lima were achieved by ultrahigh performance liquid chromatography coupled to quadrupole-time of flight mass spectrometry (UPLC-QTOF-MS
MeSH term(s)	Animals ; Marine Toxins ; Okadaic Acid ; Seawater ; Shellfish Poisoning ; Titanium
Chemical Substances	Marine Toxins ; titanium dioxide (15FIX9V2JP) ; Okadaic Acid (1W21G5Q4N2) ; Titanium (D1JT611TNE)
Language	English
Publishing date	2020-05-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.139346
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Article ; Online: External validation of the Lawton brainstem cavernous malformation grading system in a cohort of 277 microsurgical patients.

Catapano, Joshua S / Rutledge, Caleb / Rumalla, Kavelin / Raygor, Kunal P / Srinivasan, Visish M / Koester, Stefan W / Kimata, Anna R / Ma, Kevin L / Labib, Mohamed A / Spetzler, Robert F / Lawton, Michael T

Journal of neurosurgery

2021 Volume 136, Issue 5, Page(s) 1231–1239

Abstract: ... 10.4; p < 0.001). The receiver operating characteristic analysis demonstrated acceptable ... with an area under the curve of 0.74 (95% CI 0.68-0.80; p < 0.001).: Conclusions: This study validates the BSCM grading ...

Abstract	Objective: The brainstem cavernous malformation (BSCM) grading system predicts neurological outcomes associated with microsurgical resection and assists neurosurgeons in selecting patients for treatment. The predictive accuracy of the BSCM grading system should be validated in a large cohort from high-volume centers to generalize its use. Methods: An external validation cohort comprised patients with a BSCM resected by the senior author (M.T.L.) since the publication of the BSCM grading system and those resected by another neurosurgeon (R.F.S.) over a 16-year period. Size, crossing the axial midpoint, the presence of a developmental venous anomaly, patient age, and timing of last hemorrhage were used to assign BSCM grades from 0 to VII. Poor neurological outcomes were recorded as modified Rankin Scale scores > 2 at last follow-up examination. Results: A total of 277 patients were included in the study. The average BSCM grade was 3.9, and the majority of BSCMs (181 patients, 65%) were intermediate grade (grades III-V). Outcomes were predicted by BSCM grade, with good outcomes observed in 47 of 54 patients (87%) with low-grade BSCMs, in 135 of 181 patients (75%) with intermediate-grade BSCMs, and in 21 of 42 patients (50%) with high-grade BSCMs. Conversely, proportions of patients with neurological deterioration increased with increasing BSCM grade, with worsening observed in 2 of 54 patients (4%) with low-grade BSCMs, in 29 of 181 patients (16%) with intermediate-grade BSCMs, and in 17 of 42 patients (40%) with high-grade BSCMs. In the chi-square analysis, high-grade BSCMs were associated with increased odds of neurological worsening compared to low- and intermediate-grade BSCMs (OR 5.0, 95% CI 2.4-10.4; p < 0.001). The receiver operating characteristic analysis demonstrated acceptable discrimination for predicting unfavorable functional outcomes (modified Rankin Scale score > 2) with an area under the curve of 0.74 (95% CI 0.68-0.80; p < 0.001). Conclusions: This study validates the BSCM grading system in a large cohort of patients from two high-volume surgeons. BSCM grade predicted neurological outcomes with accuracy comparable to that of other grading systems in widespread use. The BSCM grading system establishes categories of low-, intermediate-, and high-grade BSCMs and a boundary or cutoff for surgery at BSCM grade V. BSCM grading guides the analysis of a particular patient's condition, but treatment recommendations must be individualized, and neurosurgeons must calibrate BSCM grading to their own outcome results, unique abilities, and practices.
Language	English
Publishing date	2021-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2021.3.JNS204291
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Article ; Online: He Tamariki Kokoti Tau

Anna Adcock / Fiona Cram / Liza Edmonds / Beverley Lawton

International Journal of Environmental Research and Public Health, Vol 18, Iss 9835, p

Families of Indigenous Infants Talk about Their Experiences of Preterm Birth and Neonatal Intensive Care

2021 Volume 9835

Abstract: Māori (Indigenous peoples of Aotearoa New Zealand) bear an unequal burden of poor perinatal health outcomes, including preterm birth. An infant arriving preterm disrupts the birth imaginary of whānau (family collectives) and situates them in a foreign ... ...

Abstract	Māori (Indigenous peoples of Aotearoa New Zealand) bear an unequal burden of poor perinatal health outcomes, including preterm birth. An infant arriving preterm disrupts the birth imaginary of whānau (family collectives) and situates them in a foreign health environment that may not be culturally safe and nurturing. A cross-sectional interpretative phenomenological analysis of first interviews with 19 whānau participating in a Kaupapa Māori (by, with, for Māori) qualitative longitudinal study of preterm birth identified themes from their experiences and the meanings they attributed to them. Preterm birth was an emotional roller coaster, with the birth imaginary and anticipated roles disrupted as health practitioners took over the care of their infants. Whānau expressed the desire to be close to their infants, holding them, loving them, nurturing them, and emplacing them within whakapapa (genealogy, continual layering of foundations) networks. When health practitioners or hospital policies inhibited this intimacy by isolating, excluding, or discriminating, whānau were frustrated. Being familiar with hospital routines, staff, peers, infant cares, and being wrapped in wider whānau support were key for whānau coping. Whakawhanaungatanga (processes of establishing relationships) create safe spaces for whānau to be themselves. This quietens the ‘storm’ and returns whānau to a sense of calm, through the reclamation of their environment.
Keywords	cultural competence or cultural safety ; family collectives ; indigenous health and well-being ; Kaupapa Māori Research ; NICU ; perinatal care ; Medicine ; R
Subject code	360
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Prospective multiparametric CMR characterization and MicroRNA profiling of anthracycline cardiotoxicity: A pilot translational study.

International journal of cardiology. Heart & vasculature

2022 Volume 43, Page(s) 101134

Abstract: ... and completion of chemotherapy (61 ± 3 vs 53 ± 3 %, p < 0.001), before recovering significantly at 6 ... month follow-up (55 ± 3 %, p = 0.018). Similar results were observed for 3D echocardiography-derived ... and good recovery (15.7 ± 3.1 mm; p = 0.028). Furthermore, baseline miRNA-181-5p and miRNA-221-3p ...

Abstract	Background: Anthracycline cardiotoxicity is a significant clinical challenge. Biomarkers to improve risk stratification and identify early cardiac injury are required. Objectives: The purpose of this pilot study was to prospectively characterize anthracycline cardiotoxicity using cardiovascular magnetic resonance (CMR), echocardiography and MicroRNAs (MiRNAs), and identify baseline predictors of LVEF recovery. Methods: Twenty-four patients (age 56 range 18-75 years; 42 % female) with haematological malignancy scheduled to receive anthracycline chemotherapy (median dose 272 mg/m Results: Seventeen complete datasets were obtained. CMR left ventricular ejection fraction (LVEF) fell significantly between baseline and completion of chemotherapy (61 ± 3 vs 53 ± 3 %, p < 0.001), before recovering significantly at 6-month follow-up (55 ± 3 %, p = 0.018). Similar results were observed for 3D echocardiography-derived LVEF and CMR-derived longitudinal, circumferential and radial feature-tracking strain. Patients were divided into tertiles according to LVEF recovery (poor recovery, partial recovery, good recovery). CMR-derived mitral annular plane systolic excursion (MAPSE) was significantly different at baseline in patients exhibiting poor LVEF recovery (11.7 ± 1.5 mm) in comparison to partial recovery (13.7 ± 2.7 mm), and good recovery (15.7 ± 3.1 mm; p = 0.028). Furthermore, baseline miRNA-181-5p and miRNA-221-3p expression were significantly higher in this group. T2 mapping increased significantly on completion of chemotherapy compared to baseline (54.0 ± 4.6 to 57.8 ± 4.9 ms, p = 0.001), but was not predictive of LVEF recovery. No changes to LV mass, extracellular volume fraction, T Conclusions: Baseline CMR-derived MAPSE, circulating miRNA-181-5p, and miRNA-221-3p were associated with poor recovery of LVEF 6 months after completion of anthracycline chemotherapy, suggesting their potential predictive role in this context. T2 mapping increased significantly on completion of chemotherapy but was not predictive of LVEF recovery.
Language	English
Publishing date	2022-11-08
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2022.101134
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Article ; Online: Reaching under-screened/never-screened indigenous peoples with human papilloma virus self-testing: A community-based cluster randomised controlled trial.

MacDonald, Evelyn Jane / Geller, Stacie / Sibanda, Nokuthaba / Stevenson, Kendall / Denmead, Lorna / Adcock, Anna / Cram, Fiona / Hibma, Merilyn / Sykes, Peter / Lawton, Bev

The Australian & New Zealand journal of obstetrics & gynaecology

2020 Volume 61, Issue 1, Page(s) 135–141

Abstract: ... 95% CI: 2.4-3.1, P-value <0.0001).: Conclusions: Offer of HPV self-testing could potentially halve ...

Abstract	Background: Indigenous women in the high-income countries of Canada, Australia, New Zealand and USA, have a higher incidence and mortality from cervical cancer than non-Indigenous women. Increasing cervical screening coverage could ultimately decrease cervical cancer disparities. Aims: To increase cervical screening for under-screened/never-screened Māori women. Materials and methods: This study was a cluster randomised controlled trial. Inclusion criteria were women aged 25-69, last screened ≥4 years ago, in Northland, New Zealand. The intervention arm was the offer of a human papilloma virus (HPV) self-test and the control arm was the usual offer of standard care - a cervical smear. The primary outcome was rate of cervical screening in the intervention group compared to control in Māori, the Indigenous peoples of New Zealand. Six primary care clinics were randomly allocated to intervention or control. Results: Of 500 eligible Māori women in the intervention arm, 295 (59.0%) were screened. Of 431 eligible Māori women in the control arm, 94 (21.8%) were screened. Adjusting for age, time since last screen, deprivation index, Māori women in the intervention arm were 2.8 times more likely to be screened than women in the control arm (95% CI: 2.4-3.1, P-value <0.0001). Conclusions: Offer of HPV self-testing could potentially halve the number of under-screened/never-screened Māori women and decrease cervical morbidity and mortality. These results may be generalisable to benefit Indigenous peoples facing similar barriers in other high-income countries.
MeSH term(s)	Adult ; Aged ; Alphapapillomavirus ; Australia ; Early Detection of Cancer ; Female ; Humans ; Indigenous Peoples ; Middle Aged ; New Zealand ; Papillomavirus Infections/complications ; Papillomavirus Infections/diagnosis ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/etiology
Language	English
Publishing date	2020-12-22
Publishing country	Australia
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	390815-x
ISSN	1479-828X ; 0004-8666
ISSN (online)	1479-828X
ISSN	0004-8666
DOI	10.1111/ajo.13285
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Article ; Online: Te Ara Waiora-Implementing human papillomavirus (HPV) primary testing to prevent cervical cancer in Aotearoa New Zealand: A protocol for a non-inferiority trial.

Gibson-Helm, Melanie / Slater, Tania / MacDonald, Evelyn J / Stevenson, Kendall / Adcock, Anna / Geller, Stacie / Parag, Varsha / Lambert, Charles / Bennett, Matthew / Hibma, Merilyn / Sykes, Peter / Saville, Marion / Hawkes, David / Stanton, Jo-Ann / Clueard, Mary-Ann / Jelley, Grahame / Lawton, Bev

PloS one

2023 Volume 18, Issue 3, Page(s) e0280643

Abstract: Background: Cervical cancer is caused by high-risk types of human papillomavirus (HPV). Testing for high-risk HPV is a more sensitive screening method than cervical cytology for detecting cervical changes that may lead to cancer. Consistent with recent ... ...

Abstract	Background: Cervical cancer is caused by high-risk types of human papillomavirus (HPV). Testing for high-risk HPV is a more sensitive screening method than cervical cytology for detecting cervical changes that may lead to cancer. Consistent with recent evidence of efficacy and acceptability, Aotearoa New Zealand plans to introduce HPV testing as the primary approach to screening, replacing cervical cytology, from mid-2023. Any equitable cervical screening programme must be effective across a diverse population, including women that the current programme fails to reach, particularly Māori and those in rural areas. Currently, we do not know the best model for implementing an equitable HPV self-testing screening programme. Methods: This implementation trial aims to assess whether a universal offer of HPV self-testing (offered to all people eligible for cervical screening) achieves non-inferior screening coverage (equal) to a universal offer of cervical cytology alone (the present programme). The study population is all people aged from 24.5 to 70 years due for cervical screening in a 12-month period (including those whose screening is overdue or who have never had screening). A range of quantitative and qualitative secondary outcomes will be explored, including barriers and facilitators across screening and diagnostic pathways. This study takes place in Te Tai Tokerau/Northland which covers a diverse range of urban and rural areas and has a large Indigenous Māori population. A total of fourteen practices will be involved. Seven practices will offer HPV self-testing universally to approximately 2800 women and will be compared to seven practices providing routine clinical care (offer of cervical cytology) to an approximately equal number of women. Discussion: This trial will answer important questions about how to implement an equitable, high-quality, effective national programme offering HPV self-testing as the primary screening method for cervical cancer prevention. Trial registration: Prospectively registered with the Australian New Zealand Clinical Trials Registry 07/12/2021: ACTRN12621001675819.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Middle Aged ; Young Adult ; Australia ; Early Detection of Cancer/methods ; Human Papillomavirus Viruses ; Mass Screening/methods ; New Zealand/epidemiology ; Papillomaviridae ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/prevention & control ; Papillomavirus Infections/complications ; Uterine Cervical Dysplasia ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/prevention & control ; Vaginal Smears
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Equivalence Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0280643
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