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Article ; Online: Increased

Sherman, Tyler J / Petty, Douglas / Schountz, Tony / Hodges, Natasha / Hawkinson, Ann C

2022 Volume 14, Issue 5

Abstract: Flaviviruses present an ongoing threat to global public health, although the factors that contribute to the disease remain incompletely understood. We examined an acute Modoc virus (MODV) infection of two rodent models. Viral RNA was detected in the ... ...

Abstract	Flaviviruses present an ongoing threat to global public health, although the factors that contribute to the disease remain incompletely understood. We examined an acute Modoc virus (MODV) infection of two rodent models. Viral RNA was detected in the kidneys, spleen, liver, brain, urine, and sera of experimentally infected deer mice, a reservoir host of MODV, and Syrian hamsters, a known disease model. As expected, clinical outcomes differed between species, and the levels of viral RNA recovered from various tissues demonstrated signs of differential replication and tissue tropism. Multivariate analysis indicated significance in the profile of expressed genes between species when analyzed across tissues and over time (
MeSH term(s)	Animals ; Cricetinae ; Flavivirus/genetics ; Interferon-gamma ; Interleukin-10/genetics ; RNA, Viral/genetics ; Rodentia
Chemical Substances	RNA, Viral ; Interleukin-10 (130068-27-8) ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2022-05-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14051026
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Article: Feasibility of a prospective, longitudinal study of resilience among young military recruits with embedded laboratory sub-study: the ARMOR pilot trial.

Hitz, Andrea C / Hubbling, Shelly Bachelors Degree / Hodges, Annika / Campbell, Emily M Hagel / Bangerter, Ann / Polusny, Melissa A

Research square

2023

Abstract: Background: Multilevel, longitudinal studies are integral to resilience research; however, they are costly and present unique methodological challenges. The objective of this study was to examine the feasibility of study methods (recruitment, retention, ...

Abstract	Background: Multilevel, longitudinal studies are integral to resilience research; however, they are costly and present unique methodological challenges. The objective of this study was to examine the feasibility of study methods (recruitment, retention, data collection) for a large-scale prospective, longitudinal study of resilience among young National Guard recruits. Methods: This feasibility trial used a pre-test/post-test design with embedded laboratory sub-study. Participants were young military recruits who had recently enlisted in the Army National Guard and had not yet shipped to Basic Combat Training (BCT). Recruitment and baseline data collection (Time 1), which included a battery of computerized self-report measures and neurocognitive tests, were conducted at local armories. Participants completed an online follow-up (Time 2) survey outside of drill training after returning from BCT. A subset of participants was recruited to complete extensive laboratory procedures pre-and post-BCT, including clinical interview, additional self-report measures, and performance on a series of neurobehavioral tasks during electroencephalogram recordings and, at pre-BCT only, magnetic resonances imaging. Feasibility outcomes assessed our ability to recruit, retain, and collect data from participants. Analysis of outcomes was based on descriptive statistics and evaluation of the feasibility of the larger study was based on pre-determined go/no go progression criteria. Results: All pre-determined progression criteria were met. A total of 102 (97.1%) of eligible military service members consented to participate. Of these, 73 (73.7%) completed the Time 2 survey. Of the 24 participants approached, 14 agreed to participate in the laboratory sub-study, 13 completed follow-up laboratory visits. Overall, completion of online surveys and laboratory tasks was excellent. However, participants had difficulties completing online surveys during BCT and the computerized neurocognitive testing battery at Time 2. Conclusions: Study methods were feasible, and all predetermined criteria for progression to the large-scale longitudinal study were met. Some minor protocol adaptations were identified from this feasibility study. Lessons learned and recommendations for future research are discussed.
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3112652/v1
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Article ; Online: Cascading consequences of armed conflict and famine on child health: a time for peace.

Oberg, Charles / Hodges, H R / Masten, Ann

BMJ paediatrics open

2022 Volume 6, Issue 1

MeSH term(s)	Child ; Humans ; Famine ; Child Health ; Social Conditions ; Armed Conflicts ; Social Status
Language	English
Publishing date	2022-10-13
Publishing country	England
Document type	Journal Article
ISSN	2399-9772
ISSN (online)	2399-9772
DOI	10.1136/bmjpo-2022-001608
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Article ; Online: The thriving kids and parents schools project: protocol of an incomplete stepped wedged cluster randomised trial evaluating the effectiveness of a Triple P seminar series.

Boyle, Christopher / Sanders, Matthew R / Ma, Tianyi / Hodges, Julie / Allen, Kelly-Ann / Cobham, Vanessa E / Darmawan, Igusti / Dittman, Cassandra K / Healy, Karyn L / Hepburn, Stevie-Jae / MacLeod, Lynda M / Teng, Jiachen / Trompf, Madilyn

BMC public health

2023 Volume 23, Issue 1, Page(s) 2021

Abstract: Background: The COVID-19 pandemic disrupted the normality of daily life for many children, their families, and schools, resulting in heightened levels of anxiety, depression, social isolation, and loneliness among young people. An integrated public ... ...

Abstract	Background: The COVID-19 pandemic disrupted the normality of daily life for many children, their families, and schools, resulting in heightened levels of anxiety, depression, social isolation, and loneliness among young people. An integrated public health model of interventions is needed to address the problem and to safeguard the mental health and wellbeing of children. The Triple P - Positive Parenting Program is one system of parenting support with a strong evidence-base and wide international reach. When implemented as a public health approach, Triple P has demonstrated population level positive effects on child wellbeing. This study will be the first large-scale, multi-site randomised controlled trial of a newly developed, low-intensity variant of Triple P, a school-based seminar series, as a response to the impacts of the pandemic. Methods: The evaluation will employ an Incomplete Batched Stepped Wedge Cluster Randomised Trial Design. At least 300 Australian primary schools, from South Australia, Queensland, and Victoria will be recruited and randomised in three batches. Within each batch, schools will be randomly assigned to either start the intervention immediately or start in six weeks. Parents will be recruited from participating schools. The Triple P seminar series includes three seminars titled: "The Power of Positive Parenting", "Helping Your Child to Manage Anxiety", and "Keeping your Child Safe from Bullying". Parents will complete measures about child wellbeing, parenting, parenting self-regulation and other key intervention targets at baseline, six weeks after baseline, and 12 weeks after baseline. Intervention effectiveness will be evaluated with a Multilevel Piecewise Latent Growth Curve Modelling approach. Data collection is currently underway, and the current phase of the project is anticipated to be completed in January 2024. Discussion: The findings from this study will extend the current knowledge of the effects of evidence-based parenting support delivered through brief, universally offered, low intensity, school-based parenting seminars in a post pandemic world. Trial registration: The trial is registered at the Australian New Zealand Clinical Trials Registry (Trial Registration Number: ACTRN12623000852651).
MeSH term(s)	Child ; Humans ; Adolescent ; Pandemics/prevention & control ; COVID-19 ; Parents/psychology ; Parenting/psychology ; Schools ; Victoria ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-10-17
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-16962-4
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Article ; Online: The relationship between severe hypertensive diseases of pregnancy and moderate-severe bronchopulmonary dysplasia.

Wymore, Erica M / Lynch, Anne M / Singh, Jasleen K / Thevarajah, Tamara S / Hodges, Jennifer K / Kinsella, John P / Auer, Emily / Wagner, Brandie D

Journal of perinatology : official journal of the California Perinatal Association

2024

Abstract: Objective: Determine the association between severe hypertensive disease of pregnancy (HDP) with moderate-severe bronchopulmonary dysplasia (BPD) in preterm infants (< 31 weeks' gestation).: Study design: Preterm birth cohort study of 693 mother- ... ...

Abstract	Objective: Determine the association between severe hypertensive disease of pregnancy (HDP) with moderate-severe bronchopulmonary dysplasia (BPD) in preterm infants (< 31 weeks' gestation). Study design: Preterm birth cohort study of 693 mother-infant dyads. Severe HDP was defined as severe preeclampsia, HELLP syndrome or eclampsia. The outcome was moderate-severe BPD classified at 36 weeks corrected gestational age, per the NICHD Consensus statement. Results: 225 (32%) mothers developed severe HDP and 234 (34%) infants had moderate-severe BPD. There was an interaction between severe HDP and gestational age (p = 0.03). Infants born at < 25 weeks gestation to mothers with HDP had increased odds for moderate-severe BPD compared to infants of normotensive mothers delivering at the same gestational age. Infants born > 28 weeks to mothers with severe HDP had decreased odds for the outcome, though not statistically significant. Conclusions: Severe HDP has a differential effect on the development of moderate-severe BPD based on gestational age.
Language	English
Publishing date	2024-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	645021-0
ISSN	1476-5543 ; 0743-8346
ISSN (online)	1476-5543
ISSN	0743-8346
DOI	10.1038/s41372-024-01910-w
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Article ; Online: Quantification of Proteus syndrome-associated lung disease.

Ours, Christopher A / Buser, Anna / Hodges, Mia B / Chen, Marcus Y / Sapp, Julie C / Gochuico, Bernadette R / Biesecker, Leslie G

Orphanet journal of rare diseases

2024 Volume 19, Issue 1, Page(s) 44

Abstract: Background: Proteus syndrome is an ultra-rare mosaic overgrowth disorder. Individuals with Proteus syndrome can develop emphysematous and cystic changes of the lung that may lead to progressive respiratory symptoms and require surgical intervention. ... ...

Abstract	Background: Proteus syndrome is an ultra-rare mosaic overgrowth disorder. Individuals with Proteus syndrome can develop emphysematous and cystic changes of the lung that may lead to progressive respiratory symptoms and require surgical intervention. This retrospective study seeks to quantify the radiographic features of Proteus syndrome-associated lung disease using computed tomography (CT) of the chest. The first method derives a Cystic Lung Score (CLS) by using a computer-aided diagnostic tool to quantify the fraction of cystic involvement of the lung. The second method yields a Clinician Visual Score (CVS), an observer reported scale of severity based on multiple radiographic features. The aim of this study was to determine if these measurements are associated with clinical symptoms, pulmonary function test (PFT) measurements, and if they may be used to assess progression of pulmonary disease. Results: One hundred and thirteen imaging studies from 44 individuals with Proteus syndrome were included. Dyspnea and oxygen use were each associated with higher CLS (p = 0.001 and < 0.001, respectively) and higher CVS (p < 0.001 and < 0.001). Decreases in percent predicted FVC, FEV Conclusions: Proteus syndrome-associated lung disease is progressive. The rate of cystic progression is increased in children. Increased scores in CLS and CVS were associated with clinical symptoms and decreased pulmonary function. Both methods were able to detect change over time and were associated with clinically meaningful outcomes which may enable their use in interventional studies.
MeSH term(s)	Adult ; Child ; Humans ; Proteus Syndrome/complications ; Proteus Syndrome/diagnosis ; Proteus Syndrome/surgery ; Retrospective Studies ; Lung ; Tomography, X-Ray Computed ; Lung Diseases/complications
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2225857-7
ISSN	1750-1172 ; 1750-1172
ISSN (online)	1750-1172
ISSN	1750-1172
DOI	10.1186/s13023-023-03013-9
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Article ; Online: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans.

Doloff, Joshua C / Veiseh, Omid / de Mezerville, Roberto / Sforza, Marcos / Perry, Tracy Ann / Haupt, Jennifer / Jamiel, Morgan / Chambers, Courtney / Nash, Amanda / Aghlara-Fotovat, Samira / Stelzel, Jessica L / Bauer, Stuart J / Neshat, Sarah Y / Hancock, John / Romero, Natalia Araujo / Hidalgo, Yessica Elizondo / Leiva, Isaac Mora / Munhoz, Alexandre Mendonça / Bayat, Ardeshir /

Kinney, Brian M / Hodges, H Courtney / Miranda, Roberto N / Clemens, Mark W / Langer, Robert

Nature biomedical engineering

2021 Volume 5, Issue 10, Page(s) 1115–1130

Abstract: Silicone is widely used in chronic implants and is generally perceived to be safe. However, textured breast implants have been associated with immune-related complications, including malignancies. Here, by examining for up to one year the foreign body ... ...

Abstract	Silicone is widely used in chronic implants and is generally perceived to be safe. However, textured breast implants have been associated with immune-related complications, including malignancies. Here, by examining for up to one year the foreign body response and capsular fibrosis triggered by miniaturized or full-scale clinically approved breast implants with different surface topography (average roughness, 0-90 μm) placed in the mammary fat pads of mice or rabbits, respectively, we show that surface topography mediates immune responses to the implants. We also show that the surface surrounding human breast implants collected during revision surgeries also differentially alters the individual's immune responses to the implant. Moreover, miniaturized implants with an average roughness of 4 μm can largely suppress the foreign body response and fibrosis (but not in T-cell-deficient mice), and that tissue surrounding these implants displayed higher levels of immunosuppressive FOXP3
MeSH term(s)	Animals ; Breast Implantation/adverse effects ; Breast Implants/adverse effects ; Foreign Bodies ; Foreign-Body Reaction/etiology ; Humans ; Mice ; Rabbits ; Silicones/adverse effects
Chemical Substances	Silicones
Language	English
Publishing date	2021-06-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2157-846X
ISSN (online)	2157-846X
DOI	10.1038/s41551-021-00739-4
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Article ; Online: Career persistence in baccalaureate-prepared acute care nurses.

Hodges, Helen F / Troyan, Patricia J / Keeley, Ann C

Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing

2010 Volume 42, Issue 1, Page(s) 83–91

Abstract: Purpose: To explain how baccalaureate-prepared acute care nurses understand, adapt to, and negotiate challenge and change in acute care settings in the context of social and structural features and consequently develop career persistence there.: ... ...

Abstract	Purpose: To explain how baccalaureate-prepared acute care nurses understand, adapt to, and negotiate challenge and change in acute care settings in the context of social and structural features and consequently develop career persistence there. Design: Grounded theory method based on the research of Strauss and Corbin. Methods: A research team conducted open-ended interviews with a theoretic sample of 19 new and experienced baccalaureate-prepared (BSN) nurses in the southeast United States during 2007 and 2008 until saturation was achieved. Interviews were audiotaped and transcribed verbatim. Constant comparative method was used to analyze data to three increasingly abstract levels culminating in theory emergence. A diagram was developed to better understand relationships and processes. Findings: A central category, building professional resilience, emerged as the central social process with three core processes of verifying fit, stage setting, and optimizing the environment contributing to career persistence in acute care. Core processes include skills and practices nurses have learned to negotiate changing acute care environments while sustaining patient advocacy. Definitions, properties, and dimensions of each were established. Conclusions: The study offers a systematic framework for understanding and promoting career persistence for acute care nurses. Findings broaden theories of resilience to the unique settings of acute care nursing and further extend theoretical understanding of the nursing shortage and market issues of supply and demand. Clinical relevance: A middle range theory of professional resilience and career persistence makes visible skills and practices acute-care nurses use to weather continuous change and challenge in health care. Teachable practices can be integrated into nursing education and staff development to improve professional career longevity of experienced nurses at the bedside.
MeSH term(s)	Adult ; Burnout, Professional/prevention & control ; Education, Nursing, Baccalaureate ; Female ; Humans ; Male ; Middle Aged ; Models, Theoretical ; Nursing Staff, Hospital/education ; Nursing Staff, Hospital/psychology ; Nursing Staff, Hospital/supply & distribution ; Personnel Management ; Personnel Turnover ; Resilience, Psychological ; Southeastern United States ; Staff Development
Language	English
Publishing date	2010-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2008214-9
ISSN	1547-5069 ; 1527-6546
ISSN (online)	1547-5069
ISSN	1527-6546
DOI	10.1111/j.1547-5069.2009.01325.x
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Article ; Online: Differential Diagnosis of Autism Spectrum Disorder Versus Language Disorder in Children Ages 2 to 5 Years: Contributions of Parent-Reported Development and Behavior.

Richard, Annette E / Hodges, Elise K / Carlson, Martha D

Clinical pediatrics

2019 Volume 58, Issue 11-12, Page(s) 1232–1238

Abstract: Early diagnosis of autism spectrum disorder (ASD) has focused on differentiating children with ASD from neurotypical children. However, many children presenting with concern for ASD are ultimately diagnosed with language disorder (LD). This study aimed ... ...

Abstract	Early diagnosis of autism spectrum disorder (ASD) has focused on differentiating children with ASD from neurotypical children. However, many children presenting with concern for ASD are ultimately diagnosed with language disorder (LD). This study aimed to identify differences in parent-rated development and behavior among children ages 2 to 5 years presenting with concern for ASD who were diagnosed with either ASD or LD. Children with ASD were rated as more socially withdrawn and more delayed in social development and self-help skills than those with LD. Parent-rated developmental delays were positively correlated with scores on an autism screening measure and with social withdrawal and pervasive developmental problems among children with ASD. Among those with LD, parent-rated social and self-help development were positively correlated with social withdrawal and attention problems. Thus, parent ratings of social withdrawal and development of social and self-help skills may facilitate differential diagnosis of ASD and LD in children ages 2 to 5 years.
MeSH term(s)	Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/psychology ; Child Behavior/psychology ; Child Development ; Child, Preschool ; Diagnosis, Differential ; Female ; Humans ; Language Disorders/diagnosis ; Language Disorders/psychology ; Male ; Parents ; Retrospective Studies
Language	English
Publishing date	2019-07-26
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/0009922819865794
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Zs.A 454: Show issues

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Article ; Online: Understanding staff views and experiences of a clinical practice change to reduce stillbirth in South Asian women: A cross-sectional survey.

Davies-Tuck, Miranda / Ruzic, Mikayla / Davey, Mary-Ann / Hodges, Ryan / Nowotny, Benjamin / Flenady, Vicki / Andrews, Christine / Wallace, Euan M

Women and birth : journal of the Australian College of Midwives

2020 Volume 34, Issue 4, Page(s) e390–e395

Abstract: Background: In July 2017, Victoria's largest maternity service implemented a new clinical practice guideline to reduce the rates of term stillbirth in women of South Asian background.: Aim: To capture the views and experiences of clinical staff ... ...

Abstract	Background: In July 2017, Victoria's largest maternity service implemented a new clinical practice guideline to reduce the rates of term stillbirth in women of South Asian background. Aim: To capture the views and experiences of clinical staff following the implementation of the new clinical guideline. Methods: Cross sectional survey of clinical staff providing maternity care in August 2018, 12 months post implementation. Staff were asked to provide their agreement with ten statements assessing: perceived need for the guideline, implementation processes, guideline clarity, and clinical application. Open-ended questions provided opportunities to express concerns and offer suggestions for improvement. The frequency of responses to each question were tabulated. Open ended responses were grouped together to identify themes. Findings: A total of 120 staff completed the survey, most (n=89, 74%) of whom were midwives. Most staff thought the rationale (n=95, 79%), the criteria for whom they applied (83%, n=99), and the procedures and instructions within the guideline were clear (74%, n=89). Staff reported an increase in workload (72%, n=86) and expressed concerns related to rationale and evaluation of the guidelines, lack of education for both staff and pregnant South Asian women, increased workload and insufficient resources, patient safety and access to care. Challenges relating to shared decision making and communicating with women whose first language is not English were also identified. Discussion: This study has identified key barriers to and opportunities for improving implementation and highlighted additional challenges relating to new clinical guidelines which focus on culturally and linguistically diverse women.
MeSH term(s)	Adult ; Attitude of Health Personnel ; Cross-Sectional Studies ; Female ; Fetal Death/prevention & control ; Humans ; Maternal Health Services/standards ; Nurse Midwives/psychology ; Obstetrics and Gynecology Department, Hospital/organization & administration ; Obstetrics and Gynecology Department, Hospital/trends ; Organizational Innovation ; Practice Guidelines as Topic ; Pregnancy ; Program Evaluation ; Quality Improvement/organization & administration ; Stillbirth ; Surveys and Questionnaires
Language	English
Publishing date	2020-08-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2235085-8
ISSN	1878-1799 ; 1871-5192
ISSN (online)	1878-1799
ISSN	1871-5192
DOI	10.1016/j.wombi.2020.07.010
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