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Article ; Online: Second cancer in Philadelphia negative myeloproliferative neoplasms (MPN-K). A nested case-control study.

Barbui, Tiziano / Ghirardi, Arianna / Masciulli, Arianna / Carobbio, Alessandra / Palandri, Francesca / Vianelli, Nicola / De Stefano, Valerio / Betti, Silvia / Di Veroli, Ambra / Iurlo, Alessandra / Cattaneo, Daniele / Delaini, Federica / Bonifacio, Massimiliano / Scaffidi, Luigi / Patriarca, Andrea / Rumi, Elisa / Casetti, Ilaria Carola / Stephenson, Clemency / Guglielmelli, Paola /

Leukemia

2019 Volume 33, Issue 8, Page(s) 1996–2005

Abstract: We conducted a large international nested case-control study including 1881 patients with Philadelphia-negative myeloproliferative neoplasms (MPN). Cases (n = 647) were patients with second cancer (SC: carcinoma, non-melanoma skin cancer, hematological ... ...

Abstract	We conducted a large international nested case-control study including 1881 patients with Philadelphia-negative myeloproliferative neoplasms (MPN). Cases (n = 647) were patients with second cancer (SC: carcinoma, non-melanoma skin cancer, hematological second cancer, and melanoma) and controls (n = 1234) were patients without SC, matched with cases for sex, age at MPN diagnosis, date of MPN diagnosis, and MPN disease duration. The aim was to evaluate the risk of SC after exposure to cytoreductive drugs. Patients exposed to hydroxyurea (HU) (median: 3 years) had a risk of SC similar to unexposed patients (OR = 1.06, 95% CI 0.82-1.38). In contrast, in cancer-specific stratified multivariable analysis, HU had two-fold higher risk of non-melanoma (NM) skin cancer (OR = 2.28, 95% CI 1.15-4.51). A significantly higher risk of NM-skin cancer was also documented for pipobroman (OR = 3.74, 95% CI 1.00-14.01), ruxolitinib (OR = 3.87, 95% CI 1.18-12.75), and for drug combination (OR = 3.47, 95% CI 1.55-7.75). These three drugs did not show excess risk of carcinoma and hematological second cancer compared with unexposed patients. Exposure to interferon, busulfan, and anagrelide did not increase the risk. In summary, while it is reassuring that no excess of carcinoma was documented, a careful dermatologic active surveillance before and during the course of treatments is recommended.
MeSH term(s)	Antineoplastic Agents/adverse effects ; Case-Control Studies ; Humans ; Hydroxyurea/adverse effects ; Neoplasms, Second Primary/chemically induced ; Philadelphia Chromosome ; Pipobroman/adverse effects ; Polycythemia Vera/drug therapy ; Polycythemia Vera/genetics ; Primary Myelofibrosis/drug therapy ; Pyrazoles/adverse effects ; Thrombocythemia, Essential/drug therapy ; Thrombocythemia, Essential/genetics
Chemical Substances	Antineoplastic Agents ; Pyrazoles ; Pipobroman (6Q99RDT97R) ; ruxolitinib (82S8X8XX8H) ; Hydroxyurea (X6Q56QN5QC)
Language	English
Publishing date	2019-05-29
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/s41375-019-0487-8
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Article ; Online: Erratum: Azimuthal Anisotropy of K_{S}^{0} and Λ+Λ[over ¯] Production at Midrapidity from Au+Au Collisions at sqrt[s]_{NN}=130 GeV [Phys. Rev. Lett. 89, 132301 (2002)].

Adler, C / Ahammed, Z / Allgower, C / Amonett, J / Anderson, B D / Anderson, M / Averichev, G S / Balewski, J / Barannikova, O / Barnby, L S / Baudot, J / Bekele, S / Belaga, V V / Bellwied, R / Berger, J / Bichsel, H / Billmeier, A / Bland, L C / Blyth, C O /

Bonner, B E / Boucham, A / Brandin, A / Bravar, A / Cadman, R V / Caines, H / Calderón de la Barca Sánchez, M / Cardenas, A / Carroll, J / Castillo, J / Castro, M / Cebra, D / Chaloupka, P / Chattopadhyay, S / Chen, Y / Chernenko, S P / Cherney, M / Chikanian, A / Choi, B / Christie, W / Coffin, J P / Cormier, T M / Cramer, J G / Crawford, H J / Csanád, M / Deng, W S / Derevschikov, A A / Didenko, L / Dietel, T / Draper, J E / Dunin, V B / Dunlop, J C / Eckardt, V / Efimov, L G / Emelianov, V / Engelage, J / Eppley, G / Erazmus, B / Fachini, P / Faine, V / Filimonov, K / Finch, E / Fisyak, Y / Flierl, D / Foley, K J / Fu, J / Gagliardi, C A / Gagunashvili, N / Gans, J / Gaudichet, L / Germain, M / Geurts, F / Ghazikhanian, V / Grachov, O / Grigoriev, V / Guedon, M / Gushin, E / Hallman, T J / Hardtke, D / Harris, J W / Henry, T W / Heppelmann, S / Herston, T / Hippolyte, B / Hirsch, A / Hjort, E / Hoffmann, G W / Horsley, M / Huang, H Z / Humanic, T J / Igo, G / Ishihara, A / Ivanshin, Yu I / Jacobs, P / Jacobs, W W / Janik, M / Johnson, I / Jones, P G / Judd, E G / Kaneta, M / Kaplan, M / Keane, D / Kiryluk, J / Kisiel, A / Klay, J / Klein, S R / Klyachko, A / Konstantinov, A S / Kopytine, M / Kotchenda, L / Kovalenko, A D / Kramer, M / Kravtsov, P / Krueger, K / Kuhn, C / Kulikov, A I / Kunde, G J / Kunz, C L / Kutuev, R Kh / Kuznetsov, A A / Lakehal-Ayat, L / Lamont, M A C / Landgraf, J M / Lange, S / Lansdell, C P / Lasiuk, B / Laue, F / Lebedev, A / Lednický, R / Leontiev, V M / LeVine, M J / Li, Q / Lindenbaum, S J / Lisa, M A / Liu, F / Liu, L / Liu, Z / Liu, Q J / Ljubicic, T / Llope, W J / LoCurto, G / Long, H / Longacre, R S / Lopez-Noriega, M / Love, W A / Ludlam, T / Lynn, D / Ma, J / Ma, R / Majka, R / Margetis, S / Markert, C / Martin, L / Marx, J / Matis, H S / Matulenko, Yu A / McShane, T S / Meissner, F / Melnick, Yu / Meschanin, A / Messer, M / Miller, M L / Milosevich, Z / Minaev, N G / Mitchell, J / Moiseenko, V A / Moore, C F / Morozov, V / de Moura, M M / Munhoz, M G / Nelson, J M / Nevski, P / Niida, T / Nikitin, V A / Nogach, L V / Norman, B / Nurushev, S B / Odyniec, G / Ogawa, A / Okorokov, V / Oldenburg, M / Olson, D / Paic, G / Pandey, S U / Panebratsev, Y / Panitkin, S Y / Pavlinov, A I / Pawlak, T / Perevoztchikov, V / Peryt, W / Petrov, V A / Planinic, M / Pluta, J / Porile, N / Porter, J / Poskanzer, A M / Potrebenikova, E / Prindle, D / Pruneau, C / Putschke, J / Rai, G / Rakness, G / Ravel, O / Ray, R L / Razin, S V / Reichhold, D / Reid, J G / Retiere, F / Ridiger, A / Ritter, H G / Roberts, J B / Rogachevski, O V / Romero, J L / Rose, A / Roy, C / Rykov, V / Sakrejda, I / Salur, S / Sandweiss, J / Saulys, A C / Savin, I / Schambach, J / Scharenberg, R P / Schmitz, N / Schroeder, L S / Schüttauf, A / Schweda, K / Seger, J / Seliverstov, D / Seyboth, P / Shahaliev, E / Shestermanov, K E / Shimanskii, S S / Shvetcov, V S / Skoro, G / Smirnov, N / Snellings, R / Sorensen, P / Sowinski, J / Spinka, H M / Srivastava, B / Stephenson, E J / Stock, R / Stolpovsky, A / Strikhanov, M / Stringfellow, B / Struck, C / Suaide, A A P / Sugarbaker, E / Suire, C / Šumbera, M / Surrow, B / Symons, T J M / Szanto de Toledo, A / Szarwas, P / Tai, A / Takahashi, J / Tang, A H / Thomas, J H / Thompson, M / Tikhomirov, V / Todoroki, T / Tokarev, M / Tonjes, M B / Trainor, T A / Trentalange, S / Tribble, R E / Trofimov, V / Tsai, O / Ullrich, T / Underwood, D G / Van Buren, G / VanderMolen, A M / Vasilevski, I M / Vasiliev, A N / Vigdor, S E / Voloshin, S A / Wang, F / Ward, H / Watson, J W / Wells, R / Westfall, G D / Whitten, C / Wieman, H / Willson, R / Wissink, S W / Witt, R / Wood, J / Xu, N / Xu, Z / Yakutin, A E / Yamamoto, E / Yang, J / Yepes, P / Yurevich, V I / Zanevski, Y V / Zborovský, I / Zhang, H / Zhang, W M / Zoulkarneev, R / Zubarev, A N

Physical review letters

2021 Volume 127, Issue 8, Page(s) 89901

Abstract: This corrects the article DOI: 10.1103/PhysRevLett.89.132301. ...

Abstract	This corrects the article DOI: 10.1103/PhysRevLett.89.132301.
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Published Erratum
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.089901
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Article: Population and Reproductive Health in India: An Assessment of the Current Situation and Future Needs by Shireen J. Jejeebhoy, P.M. Kulkarni, K.G. Santhya, and Firoza Mehrotra.

Stephenson, Rob

Studies in family planning

2015 Volume 46, Issue 3, Page(s) 341–342

Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	862445-8
ISSN	0039-3665
ISSN	0039-3665
DOI	10.1111/j.1728-4465.2015.00035.x
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Article: Excitability of the T-tubular system in rat skeletal muscle: roles of K+ and Na+ gradients and Na+-K+ pump activity.

Nielsen, O B / Ørtenblad, N / Lamb, G D / Stephenson, D G

The Journal of physiology

2004 Volume 557, Issue Pt 1, Page(s) 133–146

Abstract: Strenuous exercise causes an increase in extracellular [K(+)] and intracellular Na(+) ([Na ... however, to some extent protected by a concomitant increase in the activity of muscle Na(+)-K(+) pumps. The exercise ... induced build-up of extracellular K(+) is most likely larger in the T-tubules than in the interstitium ...

Abstract	Strenuous exercise causes an increase in extracellular [K(+)] and intracellular Na(+) ([Na(+)](i)) of working muscles, which may reduce sarcolemma excitability. The excitability of the sarcolemma is, however, to some extent protected by a concomitant increase in the activity of muscle Na(+)-K(+) pumps. The exercise-induced build-up of extracellular K(+) is most likely larger in the T-tubules than in the interstitium but the significance of the cation shifts and Na(+)-K(+) pump for the excitability of the T-tubular membrane and the voltage sensors is largely unknown. Using mechanically skinned fibres, we here study the role of the Na(+)-K(+) pump in maintaining T-tubular function in fibres with reduced chemical K(+) gradient. The Na(+)-K(+) pump activity was manipulated by changing [Na(+)](i). The responsiveness of the T-tubules was evaluated from the excitation-induced force production of the fibres. Compared to control twitch force in fibres with a close to normal intracellular [K(+)] ([K(+)](i)), a reduction in [K(+)](i) to below 60 mM significantly reduced twitch force. Between 10 and 50 mM Na(+), the reduction in force depended on [Na(+)](i), the twitch force at 40 mM K(+) being 22 +/- 4 and 54 +/- 9% (of control force) at a [Na(+)](i) of 10 and 20 mM, respectively (n= 4). Double pulse stimulation of fibres at low [K(+)](i) showed that although elevated [Na(+)](i) increased the responsiveness to single action potentials, it reduced the capacity of the T-tubules to respond to high frequency stimulation. It is concluded that a reduction in the chemical gradient for K(+), as takes place during intensive exercise, may depress T-tubular function, but that a concomitant exercise-induced increase in [Na(+)](i) protects T-tubular function by stimulating the Na(+)-K(+) pump.
MeSH term(s)	Action Potentials/physiology ; Animals ; Electric Stimulation ; Electrochemistry ; In Vitro Techniques ; Male ; Microtubules/physiology ; Muscle Contraction/physiology ; Muscle Fibers, Fast-Twitch/physiology ; Muscle Fibers, Slow-Twitch/physiology ; Muscle, Skeletal/physiology ; Potassium/metabolism ; Rats ; Rats, Long-Evans ; Sarcolemma/metabolism ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism ; Solutions
Chemical Substances	Solutions ; Sodium (9NEZ333N27) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2004-03-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/jphysiol.2003.059014
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Article: Azimuthal anisotropy of K(0)(S) and Lambda+Lambda production at midrapidity from Au+Au collisions at sqrt[s(NN)]=130 GeV.

Bonner, B E / Boucham, A / Brandin, A / Bravar, A / Cadman, R V / Caines, H / Calderón de la Barca Sánchez, M / Cardenas, A / Carroll, J / Castillo, J / Castro, M / Cebra, D / Chaloupka, P / Chattopadhyay, S / Chen, Y / Chernenko, S P / Cherney, M / Chikanian, A / Choi, B / Christie, W / Coffin, J P / Cormier, T M / Cramer, J G / Crawford, H J / Deng, W S / Derevschikov, A A / Didenko, L / Dietel, T / Draper, J E / Dunin, V B / Dunlop, J C / Eckardt, V / Efimov, L G / Emelianov, V / Engelage, J / Eppley, G / Erazmus, B / Fachini, P / Faine, V / Filimonov, K / Finch, E / Fisyak, Y / Flierl, D / Foley, K J / Fu, J / Gagliardi, C A / Gagunashvili, N / Gans, J / Gaudichet, L / Germain, M / Geurts, F / Ghazikhanian, V / Grachov, O / Grigoriev, V / Guedon, M / Gushin, E / Hallman, T J / Hardtke, D / Harris, J W / Henry, T W / Heppelmann, S / Herston, T / Hippolyte, B / Hirsch, A / Hjort, E / Hoffmann, G W / Horsley, M / Huang, H Z / Humanic, T J / Igo, G / Ishihara, A / Ivanshin, Yu I / Jacobs, P / Jacobs, W W / Janik, M / Johnson, I / Jones, P G / Judd, E G / Kaneta, M / Kaplan, M / Keane, D / Kiryluk, J / Kisiel, A / Klay, J / Klein, S R / Klyachko, A / Konstantinov, A S / Kopytine, M / Kotchenda, L / Kovalenko, A D / Kramer, M / Kravtsov, P / Krueger, K / Kuhn, C / Kulikov, A I / Kunde, G J / Kunz, C L / Kutuev, R Kh / Kuznetsov, A A / Lakehal-Ayat, L / Lamont, M A C / Landgraf, J M / Lange, S / Lansdell, C P / Lasiuk, B / Laue, F / Lebedev, A / Lednický, R / Leontiev, V M / LeVine, M J / Li, Q / Lindenbaum, S J / Lisa, M A / Liu, F / Liu, L / Liu, Z / Liu, Q J / Ljubicic, T / Llope, W J / LoCurto, G / Long, H / Longacre, R S / Lopez-Noriega, M / Love, W A / Ludlam, T / Lynn, D / Ma, J / Majka, R / Margetis, S / Markert, C / Martin, L / Marx, J / Matis, H S / Matulenko, Yu A / McShane, T S / Meissner, F / Melnick, Yu / Meschanin, A / Messer, M / Miller, M L / Milosevich, Z / Minaev, N G / Mitchell, J / Moiseenko, V A / Moore, C F / Morozov, V / de Moura, M M / Munhoz, M G / Nelson, J M / Nevski, P / Nikitin, V A / Nogach, L V / Norman, B / Nurushev, S B / Odyniec, G / Ogawa, A / Okorokov, V / Oldenburg, M / Olson, D / Paic, G / Pandey, S U / Panebratsev, Y / Panitkin, S Y / Pavlinov, A I / Pawlak, T / Perevoztchikov, V / Peryt, W / Petrov, V A / Planinic, M / Pluta, J / Porile, N / Porter, J / Poskanzer, A M / Potrebenikova, E / Prindle, D / Pruneau, C / Putschke, J / Rai, G / Rakness, G / Ravel, O / Ray, R L / Razin, S V / Reichhold, D / Reid, J G / Retiere, F / Ridiger, A / Ritter, H G / Roberts, J B / Rogachevski, O V / Romero, J L / Rose, A / Roy, C / Rykov, V / Sakrejda, I / Salur, S / Sandweiss, J / Saulys, A C / Savin, I / Schambach, J / Scharenberg, R P / Schmitz, N / Schroeder, L S / Schüttauf, A / Schweda, K / Seger, J / Seliverstov, D / Seyboth, P / Shahaliev, E / Shestermanov, K E / Shimanskii, S S / Shvetcov, V S / Skoro, G / Smirnov, N / Snellings, R / Sorensen, P / Sowinski, J / Spinka, H M / Srivastava, B / Stephenson, E J / Stock, R / Stolpovsky, A / Strikhanov, M / Stringfellow, B / Struck, C / Suaide, A A P / Sugarbaker, E / Suire, C / Sumbera, M / Surrow, B / Symons, T J M / Szanto de Toledo, A / Szarwas, P / Tai, A / Takahashi, J / Tang, A H / Thomas, J H / Thompson, M / Tikhomirov, V / Tokarev, M / Tonjes, M B / Trainor, T A / Trentalange, S / Tribble, R E / Trofimov, V / Tsai, O / Ullrich, T / Underwood, D G / Van Buren, G / VanderMolen, A M / Vasilevski, I M / Vasiliev, A N / Vigdor, S E / Voloshin, S A / Wang, F / Ward, H / Watson, J W / Wells, R / Westfall, G D / Whitten, C / Wieman, H / Willson, R / Wissink, S W / Witt, R / Wood, J / Xu, N / Xu, Z / Yakutin, A E / Yamamoto, E / Yang, J / Yepes, P / Yurevich, V I / Zanevski, Y V / Zborovský, I / Zhang, H / Zhang, W M / Zoulkarneev, R / Zubarev, A N

Physical review letters

2002 Volume 89, Issue 13, Page(s) 132301

Abstract: We report STAR results on the azimuthal anisotropy parameter v(2) for strange particles K(0)(S ...

Abstract	We report STAR results on the azimuthal anisotropy parameter v(2) for strange particles K(0)(S), Lambda, and Lambda at midrapidity in Au+Au collisions at sqrt[s(NN)]=130 GeV at the Relativistic Heavy Ion Collider. The value of v(2) as a function of transverse momentum, p(t), of the produced particle and collision centrality is presented for both particles up to p(t) approximately 3.0 GeV/c. A strong p(t) dependence in v(2) is observed up to 2.0 GeV/c. The v(2) measurement is compared with hydrodynamic model calculations. The physics implications of the p(t) integrated v(2) magnitude as a function of particle mass are also discussed.
Language	English
Publishing date	2002-09-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.89.132301
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Article: Regulation of K transport in a mathematical model of the cortical collecting tubule.

Strieter, J / Weinstein, A M / Giebisch, G / Stephenson, J L

The American journal of physiology

1992 Volume 263, Issue 6 Pt 2, Page(s) F1076–86

Abstract: The effect of luminal flow rate and peritubular pH on Na and K transport is investigated ... produce luminal profiles of Na, K, Cl, HCO3, and phosphate, as well as of electrical potential and pH ... the range of values between 0.1 and 30 nl/min. A marked flow-dependent enhancement of Na reabsorption and K ...

Abstract	The effect of luminal flow rate and peritubular pH on Na and K transport is investigated in a mathematical model of the rabbit cortical collecting tubule. The model is used to simulate a 0.4-cm segment of tubule comprised of principal cell, alpha- and beta-intercalated cells, and lateral interspace. Calculations produce luminal profiles of Na, K, Cl, HCO3, and phosphate, as well as of electrical potential and pH. Parameter sets are developed that permit representation of both unstimulated and deoxycorticosterone acetate-stimulated tubules. A series of simulations is performed in which initial luminal flow rate is varied over the range of values between 0.1 and 30 nl/min. A marked flow-dependent enhancement of Na reabsorption and K secretion is seen, especially at lower flows, while Cl and HCO3 transport remain relatively constant. In experimental studies, it has been observed that metabolic alkalosis stimulates and metabolic acidosis inhibits K secretion, while leaving Na transport relatively unaffected [B. A. Stanton and G. Giebisch. Am. J. Physiol. 242 (Renal Fluid Electrolyte Physiol. 11): F544-F551, 1982; K. Tabei, S. Muto, Y. Ando, Y. Sakairi, and Y. Asano. J. Am. Soc. Nephrol. 1: 693, 1990; and K. Tabei, S. Muto, H. Furuya, and Y. Asano. J. Am. Soc. Nephrol. 2: 752, 1991]. Model calculations indicate that, when ion permeabilities are fixed and not dependent on pH, the impact of peritubular HCO3 on K secretion cannot be simulated. When junctional Cl permeability decreases with increasing interspace pH (E. M. Wright and J. M. Diamond. Biochim. Biophys. Acta 163: 57-74, 1968) in the model, there is a marked stimulation of K secretion with alkalosis and inhibition with acidosis. Furthermore, inclusion of a pH-dependent apical Na permeability [L. G. Palmer and G. Frindt. Am. J. Physiol. 253 (Renal Fluid Electrolyte Physiol. 22): F333-F339, 1987] that increases with increasing principal cell pH significantly reduces the change in Na+ reabsorption seen with the pH-dependent junctional Cl permeability alone. In these calculations, a pH-dependent apical K permeability [W. Wang, A. Schwab, and G. Giebisch. Am. J. Physiol. 259 (Renal Fluid Electrolyte Physiol. 28): F494-F502, 1990] that increases with increasing principal cell pH shows relatively little impact on K secretion.
MeSH term(s)	Animals ; Bicarbonates/metabolism ; Biological Transport ; Desoxycorticosterone/pharmacology ; Hydrogen-Ion Concentration ; Kidney Cortex ; Kidney Tubules/physiology ; Kidney Tubules, Collecting/metabolism ; Models, Biological ; Potassium/metabolism ; Rabbits
Chemical Substances	Bicarbonates ; Desoxycorticosterone (40GP35YQ49) ; Potassium (RWP5GA015D)
Language	English
Publishing date	1992-12
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2948-8
ISSN	0002-9513
ISSN	0002-9513
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Article: Identifying dietary consumption patterns from survey data: a Bayesian nonparametric latent class model.

Stephenson, Briana J K / Wu, Stephanie M / Dominici, Francesca

Journal of the Royal Statistical Society. Series A, (Statistics in Society)

2023 Volume 187, Issue 2, Page(s) 496–512

Abstract: Dietary assessments provide the snapshots of population-based dietary habits. Questions remain about how generalisable those snapshots are in national survey data, where certain subgroups are sampled disproportionately. We propose a Bayesian overfitted ... ...

Abstract	Dietary assessments provide the snapshots of population-based dietary habits. Questions remain about how generalisable those snapshots are in national survey data, where certain subgroups are sampled disproportionately. We propose a Bayesian overfitted latent class model to derive dietary patterns, accounting for survey design and sampling variability. Compared to standard approaches, our model showed improved identifiability of the true population pattern and prevalence in simulation. We focus application of this model to identify the intake patterns of adults living at or below the 130% poverty income level. Five dietary patterns were identified and characterised by reproducible code/data made available to encourage further research.
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1490715-X
ISSN	1467-985X ; 0964-1998 ; 0035-9238
ISSN (online)	1467-985X
ISSN	0964-1998 ; 0035-9238
DOI	10.1093/jrsssa/qnad135
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Article: EDA Photochemistry: Mechanistic Investigations and Future Opportunities.

Wortman, Alan K / Stephenson, Corey R J

Chem

2023 Volume 9, Issue 9, Page(s) 2390–2415

Abstract: Recently, organic synthesis has seen a renaissance in radical chemistry due to the accessibility of mild methods for radical generation using visible light. While renewed interest in synthetic radical chemistry has been driven by the advent of photoredox ...

Abstract	Recently, organic synthesis has seen a renaissance in radical chemistry due to the accessibility of mild methods for radical generation using visible light. While renewed interest in synthetic radical chemistry has been driven by the advent of photoredox catalysis, a resurgence of electron donor-acceptor (EDA) photochemistry has also led to many new radical transformations. Similar to photoredox catalysis, EDA photochemistry involves light-promoted single-electron transfer pathways. However, the mechanism of electron transfer in EDA systems is unique wherein the lifetimes of radical intermediates are often shorter due to competitive back-electron transfer. Distinguishing between EDA and photoredox mechanisms can be challenging since they can form identical products. In this perspective, we seek to provide insight on the mechanistic studies which can distinguish between EDA and photoredox manifolds. Additionally, we highlight some key challenges in EDA photochemistry and suggest future goals which could advance the synthetic potential of this field of research.
Language	English
Publishing date	2023-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2869032-1
ISSN	2451-9294 ; 2451-9294 ; 2451-9308
ISSN (online)	2451-9294
ISSN	2451-9294 ; 2451-9308
DOI	10.1016/j.chempr.2023.06.013
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Article ; Online: Quantifying the risk of ectopic pregnancy with a transient diagnosis of pregnancy of unknown location.

Thiyagarajan, Dhanalakshmi K / Class, Quetzal A / Stephenson, Mary D

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2023 Volume 162, Issue 3, Page(s) 950–956

Abstract: Objective: To quantify the risk of ectopic pregnancy among a transient diagnosis of pregnancy of unknown location (PUL).: Methods: Retrospective cohort study between August 2016 and November 2020. The final cohort included 244 patients with 255 PULs ... ...

Abstract	Objective: To quantify the risk of ectopic pregnancy among a transient diagnosis of pregnancy of unknown location (PUL). Methods: Retrospective cohort study between August 2016 and November 2020. The final cohort included 244 patients with 255 PULs who presented with vaginal bleeding and/or abdominal pain, positive serum quantitative β-human chorionic gonadotropin, and negative transvaginal ultrasound, with a subsequent definitive diagnosis. Two-way analysis of variance was used with significance set at P < 0.050. Bonferroni-corrected significance values were used in post hoc analysis. Multinominal logistic regression was used to predict adjusted risk for pregnancy outcome. Results: Definitive diagnosis consisted of 101 (39%) intrauterine pregnancies, 33 (13%) ectopic pregnancies, and 121 (48%) resolved PULs or resolved/treated persisting PULs. A total 68% of the PULs subsequently became nonviable. Vaginal bleeding was associated with increased risk of nonuterine pregnancies. Conclusion: A total of 13% of PULs were subsequently diagnosed as ectopic pregnancies, which is higher than the 2% to 3% risk of an ectopic pregnancy in the general reproductive population. A total of 68% of PULs were subsequently nonviable, which is higher than the 31% early pregnancy loss rate in the general reproductive population. This study quantitatively confirms that a transient diagnosis of a PUL increases the odds for ectopic pregnancy and early pregnancy loss.
MeSH term(s)	Female ; Humans ; Pregnancy ; Abortion, Spontaneous/epidemiology ; Retrospective Studies ; Pregnancy, Ectopic/diagnosis ; Pregnancy, Ectopic/epidemiology ; Chorionic Gonadotropin, beta Subunit, Human ; Uterine Hemorrhage/epidemiology ; Uterine Hemorrhage/etiology
Chemical Substances	Chorionic Gonadotropin, beta Subunit, Human
Language	English
Publishing date	2023-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.14784
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Article ; Online: The measurement of racism in health inequities research.

Wizentier, Marina Mautner / Stephenson, Briana Joy K / Goodman, Melody S

Epidemiologic reviews

2023 Volume 45, Issue 1, Page(s) 32–43

Abstract: There is limited literature on the measures and metrics used to examine racism in the health inequities literature. Health inequities research is continuously evolving, with the number of publications increasing over time. However, there is limited ... ...

Abstract	There is limited literature on the measures and metrics used to examine racism in the health inequities literature. Health inequities research is continuously evolving, with the number of publications increasing over time. However, there is limited knowledge on the best measures and methods to examine the impact of different levels of racism (institutionalized, personally mediated, and internalized) on health inequities. Advanced statistical methods have the potential to be used in new ways to examine the relationship between racism and health inequities. In this review, we conduct a descriptive examination of the measurement of racism in the health inequities epidemiologic literature. We examine the study design, methods used for analysis, types of measures used (e.g., composite, absolute, relative), number of measures used, phase of research (detect, understand, solutions), viewpoint (oppressor, oppressed), and components of structural racism measures (historical context, geographical context, multifaceted nature). We discuss methods (e.g., Peters-Belson, latent class analysis, difference in differences) that have demonstrated potential for future work. The articles reviewed were limited to the detect (25%) and understand (75%) phases, with no studies in the solutions phase. Although the majority (56%) of studies had cross-sectional designs, many authors pointed to the need for longitudinal and multilevel data for further exploration. We examined study design features as mutually exclusive elements. However, racism is a multifaceted system and the measurement of racism in many studies does not fit into a single category. As the literature grows, the significance of methodological and measurement triangulation to assess racism should be investigated.
MeSH term(s)	Humans ; Racism ; Cross-Sectional Studies ; Health Inequities ; Health Status Disparities ; Research Design
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	445346-3
ISSN	1478-6729 ; 0193-936X
ISSN (online)	1478-6729
ISSN	0193-936X
DOI	10.1093/epirev/mxad004
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