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  1. Article ; Online: Associations between Conflict Negotiation Strategies, Sexual Comfort, and Sexual Satisfaction in Adolescent Romantic Relationships.

    Couture, Stéphanie / Vaillancourt-Morel, Marie-Pier / Hébert, Martine / Fernet, Mylène

    Journal of sex research

    2022  Volume 60, Issue 3, Page(s) 305–314

    Abstract: Achieving healthy and satisfying sexual relationships is a major developmental task in adolescence, but factors promoting sexual satisfaction among adolescent romantic relationships remain underexplored. Since sexuality is shaped by relational ... ...

    Abstract Achieving healthy and satisfying sexual relationships is a major developmental task in adolescence, but factors promoting sexual satisfaction among adolescent romantic relationships remain underexplored. Since sexuality is shaped by relational experiences, strategies mobilized to negotiate conflicts in romantic relationships could be related to sexual satisfaction through comfort in negotiating sexual experiences. Sexual comfort refers to the ease of discussing sexuality, and feeling comfortable with one's own sexual life and with others' sexual behaviors. This cross-sectional dyadic study examined the mediating role of sexual comfort in the associations between perceived conflict negotiation strategies and sexual satisfaction among adolescent romantic dyads. The actor-partner interdependence model guided the analyses of self-reported questionnaires from 104 mixed- and same-sex dyads (M
    MeSH term(s) Adolescent ; Humans ; Young Adult ; Adult ; Negotiating ; Orgasm ; Cross-Sectional Studies ; Interpersonal Relations ; Sexual Behavior ; Sexual Partners ; Personal Satisfaction
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 220889-1
    ISSN 1559-8519 ; 0022-4499
    ISSN (online) 1559-8519
    ISSN 0022-4499
    DOI 10.1080/00224499.2022.2043230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The Unrecognized Threat of Secondary Bacterial Infections with COVID-19.

    Vaillancourt, Mylene / Jorth, Peter

    mBio

    2020  Volume 11, Issue 4

    Abstract: Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significantly associated with worse outcomes and death despite antimicrobial therapies. In the past, the intensive use of antibiotics during the severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic led to increases in the prevalence of multidrug-resistant bacteria. The rising number of antibiotic-resistant bacteria and our decreasing capacity to eradicate them not only render us more vulnerable to bacterial infections but also weaken us during viral pandemics. The COVID-19 pandemic reminds us of the great health challenges we are facing, especially regarding antibiotic-resistant bacteria.
    MeSH term(s) Adult ; Bacteria ; Bacterial Infections ; Betacoronavirus ; COVID-19 ; China ; Coronavirus ; Coronavirus Infections/epidemiology ; Humans ; Inpatients ; Pandemics ; Pneumonia, Viral ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.01806-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Unrecognized Threat of Secondary Bacterial Infections with COVID-19

    Mylene Vaillancourt / Peter Jorth

    mBio, Vol 11, Iss 4, p e01806-

    2020  Volume 20

    Abstract: Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significantly associated with worse outcomes and death despite antimicrobial therapies. In the past, the intensive use of antibiotics during the severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic led to increases in the prevalence of multidrug-resistant bacteria.Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significantly associated with worse outcomes and death despite antimicrobial therapies. In the past, the intensive use of antibiotics during the severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic led to increases in the prevalence of multidrug-resistant bacteria. The rising number of antibiotic-resistant bacteria and our decreasing capacity to eradicate them not only render us more vulnerable to bacterial infections but also weaken us during viral pandemics. The COVID-19 pandemic reminds us of the great health challenges we are facing, especially regarding antibiotic-resistant bacteria.
    Keywords covid-19 ; sars-cov-2 ; antibiotic resistance ; coinfection ; secondary bacterial infection ; Microbiology ; QR1-502 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher American Society for Microbiology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Siderophores promote cooperative interspecies and intraspecies cross-protection against antibiotics in vitro.

    Galdino, Anna Clara M / Vaillancourt, Mylene / Celedonio, Diana / Huse, Kara / Doi, Yohei / Lee, Janet S / Jorth, Peter

    Nature microbiology

    2024  Volume 9, Issue 3, Page(s) 631–646

    Abstract: The antibiotic cefiderocol hijacks iron transporters to facilitate its uptake and resists β-lactamase degradation. While effective, resistance has been detected clinically with unknown mechanisms. Here, using experimental evolution, we identified ... ...

    Abstract The antibiotic cefiderocol hijacks iron transporters to facilitate its uptake and resists β-lactamase degradation. While effective, resistance has been detected clinically with unknown mechanisms. Here, using experimental evolution, we identified cefiderocol resistance mutations in Pseudomonas aeruginosa. Resistance was multifactorial in host-mimicking growth media, led to multidrug resistance and paid fitness costs in cefiderocol-free environments. However, kin selection drove some resistant populations to cross-protect susceptible individuals from killing by increasing pyoverdine secretion via a two-component sensor mutation. While pyochelin sensitized P. aeruginosa to cefiderocol killing, pyoverdine and the enterobacteria siderophore enterobactin displaced iron from cefiderocol, preventing uptake by susceptible cells. Among 113 P. aeruginosa intensive care unit clinical isolates, pyoverdine production directly correlated with cefiderocol tolerance, and high pyoverdine producing isolates cross-protected susceptible P. aeruginosa and other Gram-negative bacteria. These in vitro data show that antibiotic cross-protection can occur via degradation-independent mechanisms and siderophores can serve unexpected protective cooperative roles in polymicrobial communities.
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Siderophores/metabolism ; Siderophores/pharmacology ; Cefiderocol ; Iron/metabolism ; Enterobacteriaceae/metabolism ; Pseudomonas aeruginosa/metabolism
    Chemical Substances Anti-Bacterial Agents ; Siderophores ; Cefiderocol (SZ34OMG6E8) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-024-01601-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Evolved bacterial siderophore-mediated antibiotic cross-protection.

    Galdino, Anna Clara M / Vaillancourt, Mylene / Celedonio, Diana / Huse, Kara / Doi, Yohei / Lee, Janet S / Jorth, Peter

    Research square

    2023  

    Abstract: Antibiotic cross-protection enables resistant bacteria to protect other bacteria that would be otherwise susceptible to the drug. Cefiderocol is the first siderophore cephalosporin antibiotic approved for treating Gram-negative bacterial infections, ... ...

    Abstract Antibiotic cross-protection enables resistant bacteria to protect other bacteria that would be otherwise susceptible to the drug. Cefiderocol is the first siderophore cephalosporin antibiotic approved for treating Gram-negative bacterial infections, including carbapenem-resistant
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2644953/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pseudomonas aeruginosa

    Vaillancourt, Mylene / Limsuwannarot, Sam P / Bresee, Catherine / Poopalarajah, Rahgavi / Jorth, Peter

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 10

    Abstract: Antibiotic- ... ...

    Abstract Antibiotic-resistant
    Language English
    Publishing date 2021-09-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10101164
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  7. Article ; Online: Pulmonary hypertension secondary to pulmonary fibrosis: clinical data, histopathology and molecular insights.

    Ruffenach, Grégoire / Hong, Jason / Vaillancourt, Mylène / Medzikovic, Lejla / Eghbali, Mansoureh

    Respiratory research

    2020  Volume 21, Issue 1, Page(s) 303

    Abstract: Pulmonary hypertension (PH) developing secondarily in pulmonary fibrosis (PF) patients (PF-PH) is a frequent co-morbidity. The high prevalence of PH in PF patients is very concerning since the presence of PH is a strong predictor of mortality in PF ... ...

    Abstract Pulmonary hypertension (PH) developing secondarily in pulmonary fibrosis (PF) patients (PF-PH) is a frequent co-morbidity. The high prevalence of PH in PF patients is very concerning since the presence of PH is a strong predictor of mortality in PF patients. Until recently, PH was thought to arise solely from fibrotic destruction of the lung parenchyma, leading to hypoxic vasoconstriction and loss of vascular bed density. Thus, potential cellular and molecular dysregulation of vascular remodeling as a driver of PF-PH has been under-investigated. The recent demonstrations that there is no correlation between the severity of the fibrosis and development of PH, along with the finding that significant vascular histological and molecular differences exist between patients with and without PH have shifted the etiological paradigm of PF-PH. This review aims to provide a comprehensive translational overview of PH in PF patients from clinical diagnosis and outcome to the latest understanding of the histology and molecular pathophysiology of PF-PH.
    MeSH term(s) Animals ; Echocardiography/methods ; Humans ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/pathology ; Inflammation Mediators/metabolism ; Lung/metabolism ; Lung/pathology ; Pulmonary Fibrosis/complications ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/pathology ; Respiratory Function Tests/methods ; Vascular Remodeling/physiology
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2020-11-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-9921
    ISSN (online) 1465-993X
    ISSN 1465-9921
    DOI 10.1186/s12931-020-01570-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Unrecognized Threat of Secondary Bacterial Infections with COVID-19

    Vaillancourt, Mylene / Jorth, Peter

    mBio (Online)

    Abstract: Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significantly associated with worse outcomes and death despite antimicrobial therapies. In the past, the intensive use of antibiotics during the severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic led to increases in the prevalence of multidrug-resistant bacteria. The rising number of antibiotic-resistant bacteria and our decreasing capacity to eradicate them not only render us more vulnerable to bacterial infections but also weaken us during viral pandemics. The COVID-19 pandemic reminds us of the great health challenges we are facing, especially regarding antibiotic-resistant bacteria.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #707423
    Database COVID19

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  9. Article ; Online: The Unrecognized Threat of Secondary Bacterial Infections with COVID-19

    Vaillancourt, Mylene / Jorth, Peter

    mBio

    2020  Volume 11, Issue 4

    Abstract: ABSTRACT Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent ... ...

    Abstract ABSTRACT Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significantly associated with worse outcomes and death despite antimicrobial therapies. In the past, the intensive use of antibiotics during the severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic led to increases in the prevalence of multidrug-resistant bacteria. The rising number of antibiotic-resistant bacteria and our decreasing capacity to eradicate them not only render us more vulnerable to bacterial infections but also weaken us during viral pandemics. The COVID-19 pandemic reminds us of the great health challenges we are facing, especially regarding antibiotic-resistant bacteria.
    Keywords covid19
    Language English
    Publisher American Society for Microbiology
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.01806-20
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A compensatory RNase E variation increases Iron Piracy and Virulence in multidrug-resistant Pseudomonas aeruginosa during Macrophage infection.

    Vaillancourt, Mylene / Galdino, Anna Clara Milesi / Limsuwannarot, Sam P / Celedonio, Diana / Dimitrova, Elizabeth / Broerman, Matthew / Bresee, Catherine / Doi, Yohei / Lee, Janet S / Parks, William C / Jorth, Peter

    PLoS pathogens

    2023  Volume 19, Issue 4, Page(s) e1010942

    Abstract: During chronic cystic fibrosis (CF) infections, evolved Pseudomonas aeruginosa antibiotic resistance is linked to increased pulmonary exacerbations, decreased lung function, and hospitalizations. However, the virulence mechanisms underlying worse ... ...

    Abstract During chronic cystic fibrosis (CF) infections, evolved Pseudomonas aeruginosa antibiotic resistance is linked to increased pulmonary exacerbations, decreased lung function, and hospitalizations. However, the virulence mechanisms underlying worse outcomes caused by antibiotic resistant infections are poorly understood. Here, we investigated evolved aztreonam resistant P. aeruginosa virulence mechanisms. Using a macrophage infection model combined with genomic and transcriptomic analyses, we show that a compensatory mutation in the rne gene, encoding RNase E, increased pyoverdine and pyochelin siderophore gene expression, causing macrophage ferroptosis and lysis. We show that iron-bound pyochelin was sufficient to cause macrophage ferroptosis and lysis, however, apo-pyochelin, iron-bound pyoverdine, or apo-pyoverdine were insufficient to kill macrophages. Macrophage killing could be eliminated by treatment with the iron mimetic gallium. RNase E variants were abundant in clinical isolates, and CF sputum gene expression data show that clinical isolates phenocopied RNase E variant functions during macrophage infection. Together these data show how P. aeruginosa RNase E variants can cause host damage via increased siderophore production and host cell ferroptosis but may also be targets for gallium precision therapy.
    MeSH term(s) Humans ; Iron/metabolism ; Siderophores/pharmacology ; Siderophores/metabolism ; Pseudomonas aeruginosa/metabolism ; Virulence ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/metabolism
    Chemical Substances Iron (E1UOL152H7) ; Siderophores ; pyochelin (69772-54-9) ; ribonuclease E (EC 3.1.4.-)
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010942
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