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  1. Article ; Online: Correction: Correction: Seagrass on the brink: Decline of threatened seagrass Posidonia australis continues following protection.

    Evans, Suzanna M / Griffin, Kingsley J / Blick, Ray A J / Poore, Alistair G B / Vergés, Adriana

    PloS one

    2022  Volume 17, Issue 6, Page(s) e0271005

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0216107.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0216107.].
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0271005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction

    Suzanna M Evans / Kingsley J Griffin / Ray A J Blick / Alistair G B Poore / Adriana Vergés

    PLoS ONE, Vol 17, Iss 6, p e

    Correction: Seagrass on the brink: Decline of threatened seagrass Posidonia australis continues following protection.

    2022  Volume 0271005

    Abstract: This corrects the article DOI:10.1371/journal.pone.0216107.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0216107.].
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A Smartphone Application as an Exploratory Endpoint in a Phase 3 Parkinson’s Disease Clinical Trial

    Alex Page / Norman Yung / Peggy Auinger / Charles Venuto / Alistair Glidden / Eric Macklin / Larsson Omberg / Michael A. Schwarzschild / E. Ray Dorsey

    Digital Biomarkers, Vol 6, Iss 1, Pp 1-

    A Pilot Study

    2022  Volume 8

    Abstract: Background: Smartphones can generate objective measures of Parkinson’s disease (PD) and supplement traditional in-person rating scales. However, smartphone use in clinical trials has been limited. Objective: This study aimed to determine the feasibility ... ...

    Abstract Background: Smartphones can generate objective measures of Parkinson’s disease (PD) and supplement traditional in-person rating scales. However, smartphone use in clinical trials has been limited. Objective: This study aimed to determine the feasibility of introducing a smartphone research application into a PD clinical trial and to evaluate the resulting measures. Methods: A smartphone application was introduced part-way into a phase 3 randomized clinical trial of inosine. The application included finger tapping, gait, and cognition tests, and participants were asked to complete an assessment battery at home and in clinic alongside the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). Results: Of 236 eligible participants in the parent study, 88 (37%) consented to participate, and 59 (27 randomized to inosine and 32 to placebo) completed a baseline smartphone assessment. These 59 participants collectively completed 1,292 batteries of assessments. The proportion of participants who completed at least one smartphone assessment was 61% at 3, 54% at 6, and 35% at 12 months. Finger tapping speed correlated weakly with the part III motor portion (r = −0.16, left hand; r = −0.04, right hand) and total (r = −0.14) MDS-UPDRS. Gait speed correlated better with the same measures (r = −0.25, part III motor; r = −0.34, total). Over 6 months, finger tapping speed, gait speed, and memory scores did not differ between those randomized to active drug or placebo. Conclusions: Introducing a smartphone application midway into a phase 3 clinical trial was challenging. Measures of bradykinesia and gait speed correlated modestly with traditional outcomes and were consistent with the study’s overall findings, which found no benefit of the active drug.
    Keywords smartphone ; parkinson disease ; clinical trial ; inosine ; telemedicine ; gait ; movement ; cognition ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Karger Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A Smartphone Application as an Exploratory Endpoint in a Phase 3 Parkinson's Disease Clinical Trial: A Pilot Study.

    Page, Alex / Yung, Norman / Auinger, Peggy / Venuto, Charles / Glidden, Alistair / Macklin, Eric / Omberg, Larsson / Schwarzschild, Michael A / Dorsey, E Ray

    Digital biomarkers

    2022  Volume 6, Issue 1, Page(s) 1–8

    Abstract: Background: Smartphones can generate objective measures of Parkinson's disease (PD) and supplement traditional in-person rating scales. However, smartphone use in clinical trials has been limited.: Objective: This study aimed to determine the ... ...

    Abstract Background: Smartphones can generate objective measures of Parkinson's disease (PD) and supplement traditional in-person rating scales. However, smartphone use in clinical trials has been limited.
    Objective: This study aimed to determine the feasibility of introducing a smartphone research application into a PD clinical trial and to evaluate the resulting measures.
    Methods: A smartphone application was introduced part-way into a phase 3 randomized clinical trial of inosine. The application included finger tapping, gait, and cognition tests, and participants were asked to complete an assessment battery at home and in clinic alongside the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS).
    Results: Of 236 eligible participants in the parent study, 88 (37%) consented to participate, and 59 (27 randomized to inosine and 32 to placebo) completed a baseline smartphone assessment. These 59 participants collectively completed 1,292 batteries of assessments. The proportion of participants who completed at least one smartphone assessment was 61% at 3, 54% at 6, and 35% at 12 months. Finger tapping speed correlated weakly with the part III motor portion (
    Conclusions: Introducing a smartphone application midway into a phase 3 clinical trial was challenging. Measures of bradykinesia and gait speed correlated modestly with traditional outcomes and were consistent with the study's overall findings, which found no benefit of the active drug.
    Language English
    Publishing date 2022-01-10
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2504-110X
    ISSN (online) 2504-110X
    DOI 10.1159/000521232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction: Seagrass on the brink: Decline of threatened seagrass Posidonia australis continues following protection.

    Evans, Suzanna M / Griffin, Kingsley J / Blick, Ray A J / Poore, Alistair G B / Vergés, Adriana

    PloS one

    2019  Volume 14, Issue 4, Page(s) e0216107

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0190370.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0190370.].
    Language English
    Publishing date 2019-04-23
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0216107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus.

    Antonopoulos, Alistair / Doyle, Stephen R / Bartley, David J / Morrison, Alison A / Kaplan, Ray / Howell, Sue / Neveu, Cedric / Busin, Valentina / Devaney, Eileen / Laing, Roz

    International journal for parasitology. Drugs and drug resistance

    2022  Volume 20, Page(s) 17–26

    Abstract: Haemonchus contortus is a haematophagous parasitic nematode that infects small ruminants and causes significant animal health concerns and economic losses within the livestock industry on a global scale. Treatment primarily depends on broad-spectrum ... ...

    Abstract Haemonchus contortus is a haematophagous parasitic nematode that infects small ruminants and causes significant animal health concerns and economic losses within the livestock industry on a global scale. Treatment primarily depends on broad-spectrum anthelmintics, however, resistance is established or rapidly emerging against all major drug classes. Levamisole (LEV) remains an important treatment option for parasite control, as resistance to LEV is less prevalent than to members of other major classes of anthelmintics. LEV is an acetylcholine receptor (AChR) agonist that, when bound, results in paralysis of the worm. Numerous studies implicated the AChR sub-unit, ACR-8, in LEV sensitivity and in particular, the presence of a truncated acr-8 transcript or a deletion in the acr-8 locus in some resistant isolates. Recently, a single non-synonymous SNP in acr-8 conferring a serine-to-threonine substitution (S168T) was identified that was strongly associated with LEV resistance. Here, we investigate the role of genetic variation at the acr-8 locus in a controlled genetic cross between the LEV susceptible MHco3(ISE) and LEV resistant MHco18(UGA2004) isolates of H. contortus. Using single worm PCR assays, we found that the presence of S168T was strongly associated with LEV resistance in the parental isolates and F3 progeny of the genetic cross surviving LEV treatment. We developed and optimised an allele-specific PCR assay for the detection of S168T and validated the assay using laboratory isolates and field samples that were phenotyped for LEV resistance. In the LEV-resistant field population, a high proportion (>75%) of L
    MeSH term(s) Animals ; Haemonchus ; Levamisole/pharmacology ; Drug Resistance/genetics ; Anthelmintics/pharmacology ; Anthelmintics/therapeutic use ; Receptors, Cholinergic/genetics ; Haemonchiasis/drug therapy ; Haemonchiasis/veterinary ; Haemonchiasis/parasitology
    Chemical Substances Levamisole (2880D3468G) ; Anthelmintics ; Receptors, Cholinergic
    Language English
    Publishing date 2022-08-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2751132-7
    ISSN 2211-3207 ; 2211-3207
    ISSN (online) 2211-3207
    ISSN 2211-3207
    DOI 10.1016/j.ijpddr.2022.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Thopaz+ Portable Digital System for Managing Chest Drains: A NICE Medical Technology Guidance.

    Evans, James Michael / Ray, Alistair / Dale, Megan / Morgan, Helen / Dimmock, Paul / Carolan-Rees, Grace

    Applied health economics and health policy

    2019  Volume 17, Issue 3, Page(s) 285–294

    Abstract: The Thopaz+ portable digital system was evaluated by the Medical Technologies Advisory Committee (MTAC) of the National Institute for Health and Care Excellence (NICE). The manufacturer, Medela, submitted a case for the adoption of Thopaz+ that was ... ...

    Abstract The Thopaz+ portable digital system was evaluated by the Medical Technologies Advisory Committee (MTAC) of the National Institute for Health and Care Excellence (NICE). The manufacturer, Medela, submitted a case for the adoption of Thopaz+ that was critiqued by Cedar, on behalf of NICE. Due to a lack of clinical evidence submitted by the manufacturer, Cedar carried out its own literature search. Clinical evidence showed that the use of Thopaz+ led to shorter drainage times, a shorter hospital stay, lower rates of chest drain re-insertion and higher patient satisfaction compared to conventional chest drainage when used in patients following pulmonary resection. One comparative study of the use of Thopaz+ in patients with spontaneous pneumothorax was identified and showed shorter drainage times and a shorter length of hospital stay compared to conventional drainage. No economic evidence was submitted by the manufacturer, but a simple decision tree model was included. The model was improved by Cedar and showed a cost saving of £111.33 per patient when Thopaz+ was used instead of conventional chest drainage in patients following pulmonary resection. Cedar also carried out a sub-group analysis of the use of Thopaz+ instead of conventional drainage in patients with pneumothorax where a cost saving of £550.90 was observed. The main cost driver for the model and sub-group analysis was length of stay. The sub-group analysis was based on a single comparative study. However, the MTAC received details of an unpublished audit of Thopaz+ which confirmed its efficacy in treating patients with pneumothorax. Thopaz+ received a positive recommendation in Medical Technologies Guidance 37.
    MeSH term(s) Chest Tubes/standards ; Cost-Benefit Analysis ; Drainage/methods ; Drainage/standards ; Humans ; Monitoring, Physiologic/methods ; Monitoring, Physiologic/standards ; Practice Guidelines as Topic ; Technology Assessment, Biomedical/standards
    Language English
    Publishing date 2019-01-22
    Publishing country New Zealand
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2171420-4
    ISSN 1179-1896 ; 1175-5652
    ISSN (online) 1179-1896
    ISSN 1175-5652
    DOI 10.1007/s40258-019-00461-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6060: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Collecting data on treatments for varicose veins: Getting the focus right.

    Campbell, W Bruce / Poole, Ruth L / Ray, Alistair F / Patrick, Hannah E

    Phlebology

    2016  Volume 32, Issue 4, Page(s) 224–226

    MeSH term(s) Cardiology/methods ; Cardiology/statistics & numerical data ; Data Collection/methods ; Europe ; Female ; Humans ; Male ; Patient Safety ; Registries ; United Kingdom ; United States ; Varicose Veins/therapy
    Language English
    Publishing date 2016-06-20
    Publishing country England
    Document type Editorial
    ZDB-ID 645172-x
    ISSN 1758-1125 ; 0268-3555
    ISSN (online) 1758-1125
    ISSN 0268-3555
    DOI 10.1177/0268355516655247
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2538: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Correction

    Suzanna M Evans / Kingsley J Griffin / Ray A J Blick / Alistair G B Poore / Adriana Vergés

    PLoS ONE, Vol 14, Iss 4, p e

    Seagrass on the brink: Decline of threatened seagrass Posidonia australis continues following protection.

    2019  Volume 0216107

    Abstract: This corrects the article DOI:10.1371/journal.pone.0190370.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0190370.].
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Diagnostic reliability of sterile speculum exam for rupture of membranes.

    Peirce, Susan / Ray, Alistair / Carolan-Rees, Grace

    Acta obstetricia et gynecologica Scandinavica

    2013  Volume 92, Issue 9, Page(s) 1116–1117

    MeSH term(s) Adult ; Amniotic Fluid ; Female ; Fetal Membranes, Premature Rupture/diagnosis ; Humans ; Physical Examination/instrumentation ; Pregnancy ; Reproducibility of Results ; Surgical Instruments
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Letter
    ZDB-ID 80019-3
    ISSN 1600-0412 ; 0001-6349
    ISSN (online) 1600-0412
    ISSN 0001-6349
    DOI 10.1111/aogs.12177
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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.168: Show issues Location:
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    Zs.MA 5: Show issues

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