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Article: Arthroscopic Resection of Symptomatic Tibial Tubercle Ossicles for Recalcitrant Osgood-Schlatter Disease Using a 2-Portal Technique.

McDonough, Gregory R / Rossi, Michael J

2022 Volume 11, Issue 5, Page(s) e813–e818

Abstract: Arthroscopic resection of symptomatic unfused tibial tubercle ossicles causing chronic anterior knee pain due to recalcitrant Osgood-Schlatter disease has been shown to be a reproducible arthroscopic technique. Although a number of other surgical ... ...

Abstract	Arthroscopic resection of symptomatic unfused tibial tubercle ossicles causing chronic anterior knee pain due to recalcitrant Osgood-Schlatter disease has been shown to be a reproducible arthroscopic technique. Although a number of other surgical techniques have been described, including ossicle excision and tubercle-plasty, drilling of the tibial tubercle, bone peg insertion to induce fusion, open excision of loose fragments, direct bursoscopic ossicle resection, and closing-wedge tubercle osteotomy, with varied outcomes, this technique offers a minimally invasive approach with low risk. Complications including injury to the patellar tendon and scarring of the anterior fat pad have been previously reported, but this approach can be performed with minimal fat pad debridement and direct visualization of the patellar tendon during all resections. This article presents a technique for arthroscopic resection and debridement of unfused ossicles in patients with chronic anterior knee pain due to Osgood-Schlatter disease by use of minimally invasive arthroscopic techniques that are used in standard knee arthroscopy and should be familiar to most arthroscopists.
Language	English
Publishing date	2022-04-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2653101-X
ISSN	2212-6287
ISSN	2212-6287
DOI	10.1016/j.eats.2021.12.041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Proximal humerus fracture management and outcomes are distinctly different for individuals 60 years of age or younger: a systematic review.

Cognetti, Daniel J / Hughes, Jonathan D / Sprowls, Gregory R / McDonough, Christine M / Sabzevari, Soheil / Barrow, Aaron E / Lin, Albert

JSES reviews, reports, and techniques

2023 Volume 3, Issue 2, Page(s) 142–149

Abstract: Background: Proximal humerus fractures (PHFs) occur most commonly in an elderly and osteoporotic population, but a considerable proportion of these injuries occur in relatively younger individuals. Differences in treatment principles and outcomes in ... ...

Abstract	Background: Proximal humerus fractures (PHFs) occur most commonly in an elderly and osteoporotic population, but a considerable proportion of these injuries occur in relatively younger individuals. Differences in treatment principles and outcomes in this younger population remain poorly understood. The purpose of this review was to characterize the treatment algorithms and outcomes for patients less than or equal to 60 years of age with PHFs. Methods: A comprehensive search of the Medline, Pubmed, Embase, and Cochrane databases for articles published between January 2005 and December 2020 was performed in January 2021. Levels of evidence I-IV analyzing outcomes (patient reported outcomes and/or complications) following PHFs in adult patients less than or equal to 60 years of age were included. The search was carried out in accordance with the preferred reported items for systematic reviews and meta-analyses guidelines. The risk of bias 2 tool and methodological index for nonrandomized studies score were utilized to evaluate included studies. Results: Fourteen studies met the inclusion criteria (open reduction internal fixation: 5, intramedullary nail: 4, hemiarthroplasty: 2, nonoperative: 1, and reverse total shoulder arthroplasty (RTSA): 1). Seven studies reported differences in outcomes between younger and older patient populations, with three studies noting separate management algorithms for those 60 years of age or younger. There were no studies comparing different treatments modalities in those less than 60 years of age, and the lone study on RTSA did not include patient-reported outcomes. Conclusion: Treatment algorithms and outcomes following PHFs in patients less than or equal to 60 years of age are distinctly different from that of a more elderly population. However, evidence-based treatment recommendations for this younger population are limited by the lack of studies comparing treatment modalities and the absence of patient-reported outcomes for individuals undergoing RTSA.
Language	English
Publishing date	2023-02-01
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-6391
ISSN (online)	2666-6391
DOI	10.1016/j.xrrt.2023.01.002
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Article ; Online: Knowing but not doing

Dulcinea V. Groff / Caitlin McDonough MacKenzie / Jaleigh Q. Pier / Austin B. Shaffer / Gregory P. Dietl

Frontiers in Ecology and Evolution, Vol

Quantifying the research-implementation gap in conservation paleobiology

2023 Volume 11

Abstract: Conservation paleobiology aims to provide a longer-term perspective on environmental problems to inform decisions about natural resource conservation. As such, conservation paleobiology research falls short when geohistorical data and insights do not ... ...

Abstract	Conservation paleobiology aims to provide a longer-term perspective on environmental problems to inform decisions about natural resource conservation. As such, conservation paleobiology research falls short when geohistorical data and insights do not inform conservation practice, contributing to the well-known idea that a “gap” exists between the production and use of science in the environmental realm. Our study quantified the extent of this research-implementation (or knowing-doing) gap through a systematic literature review and survey questionnaire. We determined whether empirical studies in conservation paleobiology with a link to conservation, management, or restoration documented the use of geohistorical data to implement some form of action or if there was a specific mention of how the geohistorical data could be used in theory. Results indicate that “applied” conservation paleobiology has a poor record of translating research into action. Tangible conservation impacts were evident in only 10.8% of studies. Over half of these studies included coauthors affiliated with a conservation organization. Among the studies coded as having a theoretical application, 25.2% specified how the geohistorical data could be implemented to enhance conservation, management, or restoration actions. All studies documenting action used geohistorical data from the geologically recent past where the species and habitats are familiar to those found today. Drawing insights from the bright spots we identified, we offer some practical suggestions to narrow the gap between knowing and doing in conservation paleobiology.
Keywords	boundary science ; conservation bright spots ; paleoecology ; research-implementation gap ; resource management ; restoration ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
Subject code	333
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: 96-week retention in treatment with extended-release subcutaneous buprenorphine depot injections among people with opioid dependence: Extended follow-up after a single-arm trial.

Farrell, Michael / Shahbazi, Jeyran / Chambers, Mark / Byrne, Marianne / Gholami, Jaleh / Zahra, Emma / Grebely, Jason / Lintzeris, Nicholas / Larance, Briony / Ali, Robert / Nielsen, Suzanne / Dunlop, Adrian / Dore, Gregory J / McDonough, Michael / Montebello, Mark / Weiss, Rob / Rodgers, Craig / Cook, Jon / Degenhardt, Louisa

The International journal on drug policy

2024 Volume 127, Page(s) 104390

Abstract: Background: The most recent formulation of buprenorphine treatment is extended-release depot injections (BUP-XR) that are administered subcutaneously by health care professionals. This study aimed to observe treatment outcomes of BUP-XR delivered in ... ...

Abstract	Background: The most recent formulation of buprenorphine treatment is extended-release depot injections (BUP-XR) that are administered subcutaneously by health care professionals. This study aimed to observe treatment outcomes of BUP-XR delivered in standard practice during a 96-week follow-up period in a community setting. Methods: This study is an extension of the CoLAB study, a prospective single-arm, multicentre, open label trial (N=100, 7 sites in Australia) among people with opioid dependence who received monthly injections of BUP-XR to evaluate the retention in treatment. Participants were followed for 96 weeks, comprising 48 weeks of the CoLAB study followed by a 48-week extension. Results: Of 100 participants at baseline, 47 were retained on BUP-XR at 96 weeks. The median time retained on monthly depot was 90 weeks. Heroin use (adjusted OR=0.19, P=0.012) in the month prior to baseline was associated with lower odds of retention on BUP-XR. Older age at first opioid use (adjusted OR= 1.08, P=0.009) and longer duration in OAT at baseline (adjusted OR= 1.12, P=0.001) were associated with increased retention. Prevalence of past four-weeks opioid use was estimated at 4% at 96 weeks of treatment (prevalence 0.04, 95%CI: 0.00-0.11) compared to 15% at baseline. Quality of life and medication treatment satisfaction improved over time for those retained in treatment. Conclusion: This is one of the few studies to describe long term (96 week) retention in treatment with BUP-XR in a community setting. It displayed retention rates with 47% of participants completing 96 weeks of treatment with BUP-XR. Patient reported outcomes suggest improvements in client wellbeing. Funding: Indivior.
Language	English
Publishing date	2024-03-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2010000-0
ISSN	1873-4758 ; 0955-3959
ISSN (online)	1873-4758
ISSN	0955-3959
DOI	10.1016/j.drugpo.2024.104390
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Article: A retrospective cohort study of short-stay admissions to the medical intensive care unit: Defining patient characteristics and critical care resource utilization.

Pandit, Pooja N / Mallozzi, Mark / Mohammed, Rahed / McDonough, Gregory / Treacy, Taylor / Zahustecher, Nathaniel / Yoo, Erika J

International journal of critical illness and injury science

2022 Volume 12, Issue 3, Page(s) 127–132

Abstract: Background: Little is known about the mortality and utilization outcomes of short-stay intensive care unit (ICU) patients who require <24 h of critical care. We aimed to define characteristics and outcomes of short-stay ICU patients whose need for ICU ... ...

Abstract	Background: Little is known about the mortality and utilization outcomes of short-stay intensive care unit (ICU) patients who require <24 h of critical care. We aimed to define characteristics and outcomes of short-stay ICU patients whose need for ICU level-of-care is ≤24 h compared to nonshort-stay patients. Methods: Single-center retrospective cohort study of patients admitted to the medical ICU at an academic tertiary care center in 2019. Fisher's exact test or Chi-square for descriptive categorical variables, Results: Of 819 patients, 206 (25.2%) were short-stay compared to 613 (74.8%) nonshort-stay. The severity of illness as measured by the Mortality Probability Model-III was significantly lower among short-stay compared to nonshort-stay patients ( Conclusions: Despite their lower illness severity and fewer ICU-level care needs, short-stay patients spend an equally substantial amount of time occupying an ICU bed while waiting for a floor bed as nonshort-stay patients. Further investigation into the factors influencing ICU triage of these subacute patients and contributors to system inefficiencies prohibiting their timely transfer may improve ICU resource allocation, hospital throughput, and patient outcomes.
Language	English
Publishing date	2022-09-20
Publishing country	India
Document type	Journal Article
ZDB-ID	2638865-0
ISSN	2231-5004 ; 2229-5151
ISSN (online)	2231-5004
ISSN	2229-5151
DOI	10.4103/ijciis.ijciis_6_22
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Article ; Online: Mechanically ventilated COVID-19 patients admitted to the intensive care unit in the United States with or without respiratory failure secondary to COVID-19 pneumonia: a retrospective comparison of characteristics and outcomes.

Johnson, Jesse A / Mallari, Kashka F / Pepe, Vincent M / Treacy, Taylor / McDonough, Gregory / Khaing, Phue / McGrath, Christopher / George, Brandon J / Yoo, Erika J

Acute and critical care

2023 Volume 38, Issue 3, Page(s) 298–307

Abstract: Background: There is increasing heterogeneity in the clinical phenotype of patients admitted to the intensive care unit (ICU) with coronavirus disease 2019 (COVID-19,) and reasons for mechanical ventilation are not limited to COVID pneumonia. We aimed ... ...

Abstract	Background: There is increasing heterogeneity in the clinical phenotype of patients admitted to the intensive care unit (ICU) with coronavirus disease 2019 (COVID-19,) and reasons for mechanical ventilation are not limited to COVID pneumonia. We aimed to compare the characteristics and outcomes of intubated patients admitted to the ICU with the primary diagnosis of acute hypoxemic respiratory failure (AHRF) from COVID-19 pneumonia to those patients admitted for an alternative diagnosis. Methods: Retrospective cohort study of adults with confirmed SARS-CoV-2 infection admitted to nine ICUs between March 18, 2020, and April 30, 2021, at an urban university institution. We compared characteristics between the two groups using appropriate statistics. We performed logistic regression to identify risk factors for death in the mechanically ventilated COVID-19 population. Results: After exclusions, the final sample consisted of 319 patients with respiratory failure secondary to COVID pneumonia and 150 patients intubated for alternative diagnoses. The former group had higher ICU and hospital mortality rates (57.7% vs. 36.7%, P<0.001 and 58.9% vs. 39.3%, P<0.001, respectively). Patients with AHRF secondary to COVID-19 pneumonia also had longer ICU and hospital lengths-of-stay (12 vs. 6 days, P<0.001 and 20 vs. 13.5 days, P=0.001). After risk-adjustment, these patients had 2.25 times higher odds of death (95% confidence interval, 1.42-3.56; P=0.001). Conclusions: Mechanically ventilated COVID-19 patients admitted to the ICU with COVID-19-associated respiratory failure are at higher risk of hospital death and have worse ICU utilization outcomes than those whose reason for admission is unrelated to COVID pneumonia.
Language	English
Publishing date	2023-08-23
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3003021-3
ISSN	2586-6060 ; 2586-6052
ISSN (online)	2586-6060
ISSN	2586-6052
DOI	10.4266/acc.2022.01123
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Article ; Online: Mycobacterial phosphodiesterase Rv0805 is a virulence determinant and its cyclic nucleotide hydrolytic activity is required for propionate detoxification.

McDowell, James R / Bai, Guangchun / Lasek-Nesselquist, Erica / Eisele, Leslie E / Wu, Yan / Hurteau, Gregory / Johnson, Richard / Bai, Yinlan / Chen, Yong / Chan, John / McDonough, Kathleen A

Molecular microbiology

2023 Volume 119, Issue 4, Page(s) 401–422

Abstract: Cyclic AMP (cAMP) signaling is essential to Mycobacterium tuberculosis (Mtb) pathogenesis. However, the roles of phosphodiesterases (PDEs) Rv0805, and the recently identified Rv1339, in cAMP homeostasis and Mtb biology are unclear. We found that Rv0805 ... ...

Abstract	Cyclic AMP (cAMP) signaling is essential to Mycobacterium tuberculosis (Mtb) pathogenesis. However, the roles of phosphodiesterases (PDEs) Rv0805, and the recently identified Rv1339, in cAMP homeostasis and Mtb biology are unclear. We found that Rv0805 modulates Mtb growth within mice, macrophages and on host-associated carbon sources. Mycobacterium bovis BCG grown on a combination of propionate and glycerol as carbon sources showed high levels of cAMP and had a strict requirement for Rv0805 cNMP hydrolytic activity. Supplementation with vitamin B12 or spontaneous genetic mutations in the pta-ackA operon restored the growth of BCGΔRv0805 and eliminated propionate-associated cAMP increases. Surprisingly, reduction of total cAMP levels by ectopic expression of Rv1339 restored only 20% of growth, while Rv0805 complementation fully restored growth despite a smaller effect on total cAMP levels. Deletion of an Rv0805 localization domain also reduced BCG growth in the presence of propionate and glycerol. We propose that localized Rv0805 cAMP hydrolysis modulates activity of a specialized pathway associated with propionate metabolism, while Rv1339 has a broader role in cAMP homeostasis. Future studies will address the biological roles of Rv0805 and Rv1339, including their impacts on metabolism, cAMP signaling and Mtb pathogenesis.
MeSH term(s)	Animals ; Mice ; Phosphoric Diester Hydrolases/genetics ; Phosphoric Diester Hydrolases/metabolism ; Nucleotides, Cyclic/metabolism ; Propionates/metabolism ; Virulence ; Hydrolysis ; BCG Vaccine/metabolism ; Glycerol/metabolism ; Cyclic AMP/metabolism ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/metabolism ; 3',5'-Cyclic-AMP Phosphodiesterases/genetics ; 3',5'-Cyclic-AMP Phosphodiesterases/metabolism
Chemical Substances	Phosphoric Diester Hydrolases (EC 3.1.4.-) ; Nucleotides, Cyclic ; Propionates ; BCG Vaccine ; Glycerol (PDC6A3C0OX) ; Cyclic AMP (E0399OZS9N) ; 3',5'-Cyclic-AMP Phosphodiesterases (EC 3.1.4.17)
Language	English
Publishing date	2023-03-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	619315-8
ISSN	1365-2958 ; 0950-382X
ISSN (online)	1365-2958
ISSN	0950-382X
DOI	10.1111/mmi.15030
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Article ; Online: The Use of High-Flow Nasal Oxygen in the ICU as a First-Line Therapy for Acute Hypoxemic Respiratory Failure Secondary to Coronavirus Disease 2019.

McDonough, Gregory / Khaing, Phue / Treacy, Taylor / McGrath, Christopher / Yoo, Erika J

Critical care explorations

2020 Volume 2, Issue 10, Page(s) e0257

Abstract: Objectives: Limited evidence is available regarding the role of high-flow nasal oxygen in the management of acute hypoxemic respiratory failure secondary to coronavirus disease 2019. Our objective was to characterize outcomes associated with high-flow ... ...

Abstract	Objectives: Limited evidence is available regarding the role of high-flow nasal oxygen in the management of acute hypoxemic respiratory failure secondary to coronavirus disease 2019. Our objective was to characterize outcomes associated with high-flow nasal oxygen use in critically ill adult patients with coronavirus disease 2019-associated acute hypoxemic respiratory failure. Design: Observational cohort study between March 18, 2020, and June 3, 2020. Setting: Nine ICUs at three university-affiliated hospitals in Philadelphia, PA. Patients: Adult ICU patients with confirmed coronavirus disease 2019 infection admitted with acute hypoxemic respiratory failure. Interventions: None. Measurements and main results: Of 266 coronavirus disease 2019 ICU admissions during the study period, 124 (46.6%) received some form of noninvasive respiratory support. After exclusions, we analyzed 83 patients who were treated with high-flow nasal oxygen as a first-line therapy at or near the time of ICU admission. Patients were predominantly male (63.9%). The most common comorbidity was hypertension (60.2%). Progression to invasive mechanical ventilation was common, occurring in 58 patients (69.9%). Of these, 30 (51.7%) were intubated on the same day as ICU admission. As of June 30, 2020, hospital mortality rate was 32.9% and the median hospital length of stay was 15 days. Among survivors, the most frequent discharge disposition was home (51.0%). In comparing patients who received high-flow nasal oxygen alone ( Conclusions: We observed an overall high usage of high-flow nasal oxygen in our cohort of critically ill patients with acute hypoxemic respiratory failure secondary to coronavirus disease 2019. Rates of endotracheal intubation and mortality in this cohort were on par with and certainly not higher than other published series. These findings should prompt further considerations regarding the use of high-flow nasal oxygen in the management algorithm for coronavirus disease 2019-associated acute hypoxemic respiratory failure.
Keywords	covid19
Language	English
Publishing date	2020-10-16
Publishing country	United States
Document type	Journal Article
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000257
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Article: Why is EUS-guided cyst-gastrostomy more common than cyst-duodenostomy: A disease state or endoscopist preference.

Gabr, Moamen M / Frost, Taylor / Kudaravalli, Praneeth / Bills, Gregory S / Priyadarshini, Shista / McDonough, Stephanie / Adler, Douglas G

Endoscopic ultrasound

2020 Volume 9, Issue 5, Page(s) 352–353

Language	English
Publishing date	2020-07-17
Publishing country	China
Document type	Letter
ZDB-ID	2998317-4
ISSN	2226-7190 ; 2303-9027
ISSN (online)	2226-7190
ISSN	2303-9027
DOI	10.4103/eus.eus_39_20
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Article ; Online: Novel Disk Diffusion Assay on Magnesium Oxalate Agar To Evaluate the Susceptibility of Yersinia pestis to Type III Secretion System Inhibitors.

Prashar, Sukriti / Portales Guemes, Miguel / Shivbaran, Poorandai / Jimenez Alvarez, Eugenia / Soha, Christopher / Nacer, Samir / McDonough, Michael / Plano, Gregory V / Torruellas Garcia, Julie

Microbiology spectrum

2021 Volume 9, Issue 1, Page(s) e0000521

Abstract: Current methods for screening small molecules that inhibit the plasmid pCD1-encoded Yersinia pestis type III secretion system (T3SS) include lengthy growth curves followed by multistep luminescence assays or Western blot assays to detect secretion, or ... ...

Abstract	Current methods for screening small molecules that inhibit the plasmid pCD1-encoded Yersinia pestis type III secretion system (T3SS) include lengthy growth curves followed by multistep luminescence assays or Western blot assays to detect secretion, or lack thereof, of effector proteins. The goal of this research was to develop a novel disk diffusion assay on magnesium oxalate (MOX) agar as a simple way to evaluate the susceptibility of Y. pestis to type III secretion system inhibitors. MOX agar produces distinct Y. pestis growth characteristics based on the bacteria's ability or inability to secrete effector proteins; small, barely visible colonies are observed when secretion is activated versus larger, readily visible colonies when secretion is inhibited. Wild-type Y. pestis was diluted and spread onto a MOX agar plate. Disks containing 20 μl of various concentrations of imidocarb dipropionate, a known Y. pestis T3SS inhibitor, or distilled water (dH
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/metabolism ; Disk Diffusion Antimicrobial Tests/instrumentation ; Disk Diffusion Antimicrobial Tests/methods ; Humans ; Oxalic Acid/pharmacology ; Plague/microbiology ; Type III Secretion Systems/antagonists & inhibitors ; Type III Secretion Systems/metabolism ; Yersinia pestis/drug effects ; Yersinia pestis/growth & development ; Yersinia pestis/metabolism
Chemical Substances	Anti-Bacterial Agents ; Bacterial Proteins ; Type III Secretion Systems ; Oxalic Acid (9E7R5L6H31)
Language	English
Publishing date	2021-06-16
Publishing country	United States
Document type	Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/Spectrum.00005-21
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