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  1. Article ; Online: Evolving understanding of the type VII secretion system in Gram-positive bacteria.

    Spencer, Brady L / Doran, Kelly S

    PLoS pathogens

    2022  Volume 18, Issue 7, Page(s) e1010680

    MeSH term(s) Bacterial Proteins ; Gram-Positive Bacteria ; Type VII Secretion Systems
    Chemical Substances Bacterial Proteins ; Type VII Secretion Systems
    Language English
    Publishing date 2022-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010680
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  2. Article ; Online: Evolving understanding of the type VII secretion system in Gram-positive bacteria.

    Brady L Spencer / Kelly S Doran

    PLoS Pathogens, Vol 18, Iss 7, p e

    2022  Volume 1010680

    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: The Virtual Streptococcal Seminar Series and Trainee Symposium: Adaptations of a Research Community during the COVID-19 Pandemic.

    Spencer, Brady L / Doran, Kelly S / Burcham, Lindsey R

    Journal of microbiology & biology education

    2021  Volume 22, Issue 1

    Abstract: The COVID-19 pandemic has forced academic research communities to develop online means of learning, networking, and engaging in new research. To allow increased interaction and engagement of the streptococcal research community during the COVID-19 ... ...

    Abstract The COVID-19 pandemic has forced academic research communities to develop online means of learning, networking, and engaging in new research. To allow increased interaction and engagement of the streptococcal research community during the COVID-19 shutdown, we organized the Virtual Streptococcal Seminar Series and Virtual Streptococcal Trainee Symposium and advertised via e-mail and social media outlets. The seminar series initially met weekly on Thursdays at 12 pm Eastern Daylight Time and transitioned to monthly seminars, while the trainee symposium spanned 3 days in September 2020. In this study, we analyzed seminar attendance data and online recording accesses from the first 20 seminars and found community engagement to be independent of speaker gender, career stage, geographic location, and organism of interest, with an average of 124 live attendees and 1,683 recording accesses per seminar. We also report attendance and speaker statistics from the 3-day Virtual Streptococcal Trainee Symposium, which hosted a total of 38 trainees from five continents presenting on
    Language English
    Publishing date 2021-03-31
    Publishing country United States
    Document type Journal Article
    ISSN 1935-7877
    ISSN 1935-7877
    DOI 10.1128/jmbe.v22i1.2479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Complete Genome Sequence of Neonatal Clinical Group B Streptococcal Isolate CJB111.

    Spencer, Brady L / Chatterjee, Anushila / Duerkop, Breck A / Baker, Carol J / Doran, Kelly S

    Microbiology resource announcements

    2021  Volume 10, Issue 2

    Abstract: ... Group ... ...

    Abstract Group B
    Language English
    Publishing date 2021-01-14
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.01268-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A type VII secretion system in Group B Streptococcus mediates cytotoxicity and virulence.

    Spencer, Brady L / Tak, Uday / Mendonça, Jéssica C / Nagao, Prescilla E / Niederweis, Michael / Doran, Kelly S

    PLoS pathogens

    2021  Volume 17, Issue 12, Page(s) e1010121

    Abstract: Type VII secretion systems (T7SS) have been identified in Actinobacteria and Firmicutes and have been shown to secrete effector proteins with functions in virulence, host toxicity, and/or interbacterial killing in a few genera. Bioinformatic analysis ... ...

    Abstract Type VII secretion systems (T7SS) have been identified in Actinobacteria and Firmicutes and have been shown to secrete effector proteins with functions in virulence, host toxicity, and/or interbacterial killing in a few genera. Bioinformatic analysis indicates that isolates of Group B Streptococcus (GBS) encode at least four distinct subtypes of T7SS machinery, three of which encode adjacent putative T7SS effectors with WXG and LXG motifs. However, the function of T7SS in GBS pathogenesis is unknown. Here we assessed the role of the most abundant GBS T7SS subtype during GBS pathogenesis. In a murine model of hematogenous meningitis, mice infected with GBS lacking a functional T7SS or lacking the secreted WXG100 effector EsxA exhibited less mortality, lower bacterial burdens in tissues, and decreased inflammation in the brain compared to mice infected with the parental GBS strain. We further showed that this T7SS induces cytotoxicity in brain endothelium and that EsxA contributes to these cytotoxicity phenotypes in a WXG motif-dependent manner. Finally, we determined that EsxA is a pore-forming protein, thus demonstrating the first role for a non-mycobacterial EsxA homolog in pore formation. This work reveals the importance of a T7SS in host-GBS interactions and has implications for T7SS effector function in other Gram-positive bacteria.
    MeSH term(s) Animals ; Bacterial Proteins/metabolism ; Cells, Cultured ; Humans ; Mice ; Streptococcal Infections/metabolism ; Streptococcus agalactiae/metabolism ; Streptococcus agalactiae/pathogenicity ; Type VII Secretion Systems/metabolism ; Virulence/physiology
    Chemical Substances Bacterial Proteins ; Type VII Secretion Systems
    Language English
    Publishing date 2021-12-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Enhanced Vulnerability of Diabetic Mice to Hypervirulent

    da Conceição Mendonça, Jéssica / Sobral Pena, João Matheus / Dos Santos Macêdo, Noemi / de Souza Rodrigues, Dayane / de Oliveira, Dayane Alvarinho / Spencer, Brady L / Lopes-Torres, Eduardo José / Burcham, Lindsey R / Doran, Kelly S / Nagao, Prescilla Emy

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Streptococcus ... ...

    Abstract Streptococcus agalactiae
    Language English
    Publishing date 2023-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12040580
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  7. Article ; Online: Formation and function of the meningeal arachnoid barrier around the developing mouse brain.

    Derk, Julia / Como, Christina N / Jones, Hannah E / Joyce, Luke R / Kim, Sol / Spencer, Brady L / Bonney, Stephanie / O'Rourke, Rebecca / Pawlikowski, Brad / Doran, Kelly S / Siegenthaler, Julie A

    Developmental cell

    2023  Volume 58, Issue 8, Page(s) 635–644.e4

    Abstract: The arachnoid barrier, a component of the blood-cerebrospinal fluid barrier (B-CSFB) in the meninges, is composed of epithelial-like, tight-junction-expressing cells. Unlike other central nervous system (CNS) barriers, its' developmental mechanisms and ... ...

    Abstract The arachnoid barrier, a component of the blood-cerebrospinal fluid barrier (B-CSFB) in the meninges, is composed of epithelial-like, tight-junction-expressing cells. Unlike other central nervous system (CNS) barriers, its' developmental mechanisms and timing are largely unknown. Here, we show that mouse arachnoid barrier cell specification requires the repression of Wnt-β-catenin signaling and that constitutively active β-catenin can prevent its formation. We also show that the arachnoid barrier is functional prenatally and, in its absence, a small molecular weight tracer and the bacterium group B Streptococcus can cross into the CNS following peripheral injection. Acquisition of barrier properties prenatally coincides with the junctional localization of Claudin 11, and increased E-cadherin and maturation continues after birth, where postnatal expansion is marked by proliferation and re-organization of junctional domains. This work identifies fundamental mechanisms that drive arachnoid barrier formation, highlights arachnoid barrier fetal functions, and provides novel tools for future studies on CNS barrier development.
    MeSH term(s) Mice ; Animals ; beta Catenin ; Meninges ; Arachnoid ; Blood-Brain Barrier ; Central Nervous System ; Tight Junctions
    Chemical Substances beta Catenin
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2023.03.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5742: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 76: Show issues

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  8. Article: Heterogeneity of the group B streptococcal type VII secretion system and influence on colonization of the female genital tract.

    Spencer, Brady L / Job, Alyx M / Robertson, Clare M / Hameed, Zainab A / Serchejian, Camille / Wiafe-Kwakye, Caitlin S / Mendonça, Jéssica C / Apolonio, Morgan A / Nagao, Prescilla E / Neely, Melody N / Korotkova, Natalia / Korotkov, Konstantin V / Patras, Kathryn A / Doran, Kelly S

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Type VIIb secretion systems (T7SSb) in Gram-positive bacteria facilitate physiology, interbacterial competition, and/or virulence via EssC ATPase-driven secretion of small ɑ-helical proteins and toxins. Recently, we characterized T7SSb in group ... ...

    Abstract Type VIIb secretion systems (T7SSb) in Gram-positive bacteria facilitate physiology, interbacterial competition, and/or virulence via EssC ATPase-driven secretion of small ɑ-helical proteins and toxins. Recently, we characterized T7SSb in group B
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.25.525443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Global Annotation, Expression Analysis, and Stability of Candidate sRNAs in Group B Streptococcus.

    Keogh, Rebecca A / Spencer, Brady L / Sorensen, Hailee M / Zapf, Rachel L / Briaud, Paul / Bonsall, Abigail E / Doran, Kelly S / Carroll, Ronan K

    mBio

    2021  Volume 12, Issue 6, Page(s) e0280321

    Abstract: Small, noncoding RNAs (sRNAs) are being increasingly identified as important regulatory molecules in prokaryotes. Due to the prevalence of next-generation sequencing-based techniques, such as RNA sequencing (RNA-seq), there is potential for increased ... ...

    Abstract Small, noncoding RNAs (sRNAs) are being increasingly identified as important regulatory molecules in prokaryotes. Due to the prevalence of next-generation sequencing-based techniques, such as RNA sequencing (RNA-seq), there is potential for increased discovery of sRNAs within bacterial genomes; however, these elements are rarely included in annotation files. Consequently, expression values for sRNAs are omitted from most transcriptomic analyses, and mechanistic studies have lagged behind those of protein regulators in numerous bacteria. Two previous studies have identified sRNAs in the human pathogen group B Streptococcus (GBS). Here, we utilize the data from these studies to create updated genome annotation files for the model GBS strains NEM316 and COH1. Using the updated COH1 annotation file, we reanalyze publicly available GBS RNA-seq whole-transcriptome data from GenBank to monitor GBS sRNA expression under a variety of conditions and genetic backgrounds. This analysis generated expression values for 232 putative sRNAs that were overlooked in previous transcriptomic analyses in 21 unique comparisons. To demonstrate the utility of these data, we identify an sRNA that is upregulated during vaginal colonization and demonstrate that overexpression of this sRNA leads to increased bacterial invasion into host epithelial cells. Finally, to monitor RNA degradation, we perform a transcript stability assay to identify highly stable sRNAs and compare stability profiles of sRNA- and protein-coding genes. Collectively, these data provide a wealth of transcriptomic data for putative sRNAs in GBS and a platform for future mechanistic studies.
    MeSH term(s) Gene Expression Profiling ; Gene Expression Regulation, Bacterial ; Genome, Bacterial ; Humans ; RNA Stability ; RNA, Bacterial/chemistry ; RNA, Bacterial/genetics ; RNA, Bacterial/metabolism ; RNA, Small Untranslated/chemistry ; RNA, Small Untranslated/genetics ; RNA, Small Untranslated/metabolism ; Streptococcal Infections/microbiology ; Streptococcus agalactiae/chemistry ; Streptococcus agalactiae/genetics ; Streptococcus agalactiae/metabolism
    Chemical Substances RNA, Bacterial ; RNA, Small Untranslated
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02803-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Pneumococcal Serotype 15C Capsule Is Partially O-Acetylated and Allows for Limited Evasion of 23-Valent Pneumococcal Polysaccharide Vaccine-Elicited Anti-Serotype 15B Antibodies.

    Spencer, Brady L / Shenoy, Anukul T / Orihuela, Carlos J / Nahm, Moon H

    Clinical and vaccine immunology : CVI

    2017  Volume 24, Issue 8

    Abstract: As a species, ...

    Abstract As a species,
    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2221082-9
    ISSN 1556-679X ; 1556-6811
    ISSN (online) 1556-679X
    ISSN 1556-6811
    DOI 10.1128/CVI.00099-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4000: Show issues Location:
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