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  1. Article ; Online: A

    Wong, Jaslyn E M M / Nadzieja, Marcin / Madsen, Lene H / Bücherl, Christoph A / Dam, Svend / Sandal, Niels N / Couto, Daniel / Derbyshire, Paul / Uldum-Berentsen, Mette / Schroeder, Sina / Schwämmle, Veit / Nogueira, Fábio C S / Asmussen, Mette H / Thirup, Søren / Radutoiu, Simona / Blaise, Mickaël / Andersen, Kasper R / Menke, Frank L H / Zipfel, Cyril /
    Stougaard, Jens

    Proceedings of the National Academy of Sciences of the United States of America

    2019  Volume 116, Issue 28, Page(s) 14339–14348

    Abstract: The establishment of nitrogen-fixing root nodules in legume-rhizobia symbiosis requires an intricate communication between the host plant and its symbiont. We are, however, limited in our understanding of the symbiosis signaling process. In particular, ... ...

    Abstract The establishment of nitrogen-fixing root nodules in legume-rhizobia symbiosis requires an intricate communication between the host plant and its symbiont. We are, however, limited in our understanding of the symbiosis signaling process. In particular, how membrane-localized receptors of legumes activate signal transduction following perception of rhizobial signaling molecules has mostly remained elusive. To address this, we performed a coimmunoprecipitation-based proteomics screen to identify proteins associated with Nod factor receptor 5 (NFR5) in
    MeSH term(s) Cytoplasm/enzymology ; Fabaceae/genetics ; Fabaceae/growth & development ; Fabaceae/microbiology ; Gene Expression Regulation, Plant/genetics ; Lipopolysaccharides/genetics ; Lotus/genetics ; Lotus/growth & development ; Lotus/microbiology ; Phosphotransferases/genetics ; Plant Root Nodulation/genetics ; Plant Roots/genetics ; Plant Roots/microbiology ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/growth & development ; Rhizobium/genetics ; Rhizobium/growth & development ; Root Nodules, Plant/genetics ; Root Nodules, Plant/growth & development ; Root Nodules, Plant/microbiology ; Symbiosis/genetics ; Nicotiana/genetics ; Nicotiana/growth & development ; Nicotiana/microbiology
    Chemical Substances Lipopolysaccharides ; Nod factor, Rhizobium leguminosarum ; Phosphotransferases (EC 2.7.-)
    Language English
    Publishing date 2019-06-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1815425116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  2. Article ; Online: The HPA Axis as Target for Depression.

    Menke, Andreas

    Current neuropharmacology

    2023  Volume 22, Issue 5, Page(s) 904–915

    Abstract: Major depressive disorder (MDD) is a stress-related mental disorder with a lifetime prevalence of 20% and, thus, is one of the most prevalent mental health disorders worldwide. Many studies with a large number of patients support the notion that ... ...

    Abstract Major depressive disorder (MDD) is a stress-related mental disorder with a lifetime prevalence of 20% and, thus, is one of the most prevalent mental health disorders worldwide. Many studies with a large number of patients support the notion that abnormalities of the hypothalamus-pituitaryadrenal (HPA) axis are crucial for the development of MDD. Therefore, a number of strategies and drugs have been investigated to target different components of the HPA axis: 1) corticotrophinreleasing hormone (CRH) 1 receptor antagonists; 2) vasopressin V
    MeSH term(s) Humans ; Depressive Disorder, Major/drug therapy ; Depression ; Hypothalamo-Hypophyseal System/metabolism ; Pituitary-Adrenal System/metabolism ; Corticotropin-Releasing Hormone/metabolism ; Corticotropin-Releasing Hormone/pharmacology ; Corticotropin-Releasing Hormone/therapeutic use
    Chemical Substances Corticotropin-Releasing Hormone (9015-71-8)
    Language English
    Publishing date 2023-08-15
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X21666230811141557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6150: Show issues Location:
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  3. Article ; Conference proceedings: Pharmacogenetic testing for selection of antidepressant treatment

    Menke, A.

    Pharmacopsychiatry

    2024  Volume 57, Issue 02

    Event/congress XVth Symposium of the Task Force Therapeutic Drug Monitoring of the AGNP, Freiburg, Germany, 2024-03-20
    Language English
    Publishing date 2024-03-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 605670-2
    ISSN 1439-0795 ; 0176-3679 ; 0720-4280
    ISSN (online) 1439-0795
    ISSN 0176-3679 ; 0720-4280
    DOI 10.1055/s-0044-1779568
    Database Thieme publisher's database

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    Zs.A 481: Show issues Location:
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  4. Article: Corona und ADHS - Der psychosoziale Faktor der Pandemie

    Menke, Andreas

    Kompendium ZNS

    2022  Volume -, Issue Okt, Page(s) 27

    Language German
    Document type Article
    ZDB-ID 2966536-X
    ISSN 2628-3573
    Database Current Contents Medicine

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    Zs.A 7191: Show issues Location:
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  5. Article: Is the HPA Axis as Target for Depression Outdated, or Is There a New Hope?

    Menke, Andreas

    Frontiers in psychiatry

    2019  Volume 10, Page(s) 101

    Abstract: Major depressive disorder (MDD) is a very common stress-related mental disorder that carries a huge burden for affected patients and the society. It is associated with a high mortality that derives from suicidality and the development of serious medical ... ...

    Abstract Major depressive disorder (MDD) is a very common stress-related mental disorder that carries a huge burden for affected patients and the society. It is associated with a high mortality that derives from suicidality and the development of serious medical conditions such as heart diseases, diabetes, and stroke. Although a range of effective antidepressants are available, more than 50% of the patients do not respond to the first treatment they are prescribed and around 30% fail to respond even after several treatment attempts. The heterogeneous condition of MDD, the lack of biomarkers matching patients with the right treatments and the situation that almost all available drugs are only targeting the serotonin, norepinephrine, or dopamine signaling, without regulating other potentially dysregulated systems may explain the insufficient treatment status. The hypothalamic-pituitary-adrenal (HPA) axis is one of these other systems, there is numerous and robust evidence that it is implicated in MDD and other stress-related conditions, but up to date there is no specific drug targeting HPA axis components that is approved and no test that is routinely used in the clinical setting identifying patients for such a specific treatment. Is there still hope after these many years for a breakthrough of agents targeting the HPA axis? This review will cover tests detecting altered HPA axis function and the specific treatment options such as glucocorticoid receptor (GR) antagonists, corticotropin-releasing hormone 1 (CRH
    Language English
    Publishing date 2019-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2019.00101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Superior Ophthalmic Vein Thrombosis Associated With Asymptomatic COVID-19 Infection.

    Menke, Bryant A / Ryu, Christine / Chundury, Rao V

    Ophthalmic plastic and reconstructive surgery

    2024  Volume 40, Issue 2, Page(s) e41–e42

    Abstract: Superior ophthalmic vein thrombosis is a rare condition scarcely described in clinical literature with potentially severe consequences including permanent vision loss. This report details the case of a 70-year-old woman who presented with acute binocular ...

    Abstract Superior ophthalmic vein thrombosis is a rare condition scarcely described in clinical literature with potentially severe consequences including permanent vision loss. This report details the case of a 70-year-old woman who presented with acute binocular horizontal diplopia, relative proptosis of the OD by 4 mm, and pain OD. On exam, visual acuity was 20/20 OD and 20/30 OS with full extraocular movements. CT revealed proptosis OD with a thrombosed superior ophthalmic varix. Evaluation for etiology of hypercoagulability was unremarkable, although the patient did have an asymptomatic COVID-19 infection 1 month prior. To the authors' knowledge, this is the first reported case of superior ophthalmic vein thrombosis secondary to an asymptomatic COVID-19 infection.
    MeSH term(s) Female ; Humans ; Aged ; Venous Thrombosis/etiology ; Venous Thrombosis/complications ; COVID-19/complications ; Eye/blood supply ; Exophthalmos/etiology ; Thrombosis ; Diplopia/etiology ; Varicose Veins/complications
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632830-1
    ISSN 1537-2677 ; 0740-9303
    ISSN (online) 1537-2677
    ISSN 0740-9303
    DOI 10.1097/IOP.0000000000002540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2159: Show issues Location:
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  7. Book ; Thesis: Veränderungen der zerebralen Gefäßreaktivität nach Schädel-Hirn-Trauma

    Menke, Andreas

    Untersuchungen am Modell der Kälteläsion und des Weight-Drop-Trauma bei Ratten

    2005  

    Author's details vorgelegt von Andreas Menke
    Language German
    Size 141 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2005
    HBZ-ID HT014586589
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2005 E 2365 order for loan Magazin

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  8. Book ; Thesis: Der Einfluss des Wachstumsfaktors TGF-beta auf die Pathogenese von Pankreaserkrankungen

    Menke, André

    2004  

    Author's details vorgelegt von Andre Menke
    Language German ; English
    Size 39, [126] Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Habil.-Schr., 2004
    HBZ-ID HT014447916
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2005 E 900 order to use in reading room Magazin

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  9. Article: Precision pharmacotherapy: psychiatry's future direction in preventing, diagnosing, and treating mental disorders.

    Menke, Andreas

    Pharmacogenomics and personalized medicine

    2018  Volume 11, Page(s) 211–222

    Abstract: Mental disorders account for around one-third of disability worldwide and cause enormous personal and societal burden. Current pharmacotherapies and nonpharmacotherapies do help many patients, but there are still high rates of partial or no response, ... ...

    Abstract Mental disorders account for around one-third of disability worldwide and cause enormous personal and societal burden. Current pharmacotherapies and nonpharmacotherapies do help many patients, but there are still high rates of partial or no response, delayed effect, and unfavorable adverse effects. The current diagnostic taxonomy of mental disorders by the Diagnostic and Statistical Manual of Mental Disorders and the International Classification of Diseases relies on presenting signs and symptoms, but does not reflect evidence from neurobiological and behavioral systems. However, in the last decades, the understanding of biological mechanisms underlying mental disorders has grown and can be used for the development of precision medicine, that is, to deliver a patient-tailored individual treatment. Precision medicine may incorporate genetic variants contributing to the mental disorder and the response to pharmacotherapies, but also consider gene
    Language English
    Publishing date 2018-11-19
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508173-1
    ISSN 1178-7066
    ISSN 1178-7066
    DOI 10.2147/PGPM.S146110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: If you are learner-centered and you know it, raise your hand: Perspectives on and implementation of pedagogical changes by science instructors during the COVID-19 pandemic.

    Donham, Cristine / Hong, Hanbo / Signorini, Adriana / Menke, Erik / Kranzfelder, Petra

    Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

    2024  

    Abstract: Students at Minority-Serving Institutions (MSIs) faced significant hardships while trying to learn through emergency remote teaching (ERT) during the COVID-19 pandemic. Our research aims to investigate if science, technology, engineering, and mathematics ...

    Abstract Students at Minority-Serving Institutions (MSIs) faced significant hardships while trying to learn through emergency remote teaching (ERT) during the COVID-19 pandemic. Our research aims to investigate if science, technology, engineering, and mathematics (STEM) instructors thought about and enacted more learner-centered teaching practices to alleviate some of this stress encountered by their students. Using semi-structured interviews and classroom observations, we utilized inductive and deductive qualitative research methods to examine two questions: (1) To what extent were STEM instructor's perceived pedagogical changes learner-centered during ERT?; and (2) To what extent were STEM instructor's teaching behaviors and discourse practices learner-centered during ERT? Our findings revealed that during ERT, STEM instructors described using a variety of pedagogical changes that we identified as learner-centered under the Weimer framework, including ideas such as enacting flexible late policies and increased usage of formative assessment. Interestingly, we found that many of these learned-centered changes were happening outside of the classroom. Classroom observations assessing instructor behaviors and discourse demonstrated that STEM instructors enacted practices that aligned with Weimer's five constructs of learner-centered teaching. Our research highlights implications of learner-centered teaching practices for STEM instructors as well as researchers.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2039717-3
    ISSN 1539-3429 ; 1470-8175
    ISSN (online) 1539-3429
    ISSN 1470-8175
    DOI 10.1002/bmb.21826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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