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Article ; Online: Frailty as a determinant of dental attendance among community-dwelling older adults.

Janssens, Barbara / Tsakos, Georgios / De Visschere, Luc / Verté, Dominique / De Witte, Nico

2022 Volume 40, Issue 3, Page(s) 363–371

Abstract: Objectives: The aim of this study was to assess the association between different levels of frailty and dental attendance among home-dwelling older adults, in Belgium.: Background: While many determinants of dental attendance among older adults have ... ...

Abstract	Objectives: The aim of this study was to assess the association between different levels of frailty and dental attendance among home-dwelling older adults, in Belgium. Background: While many determinants of dental attendance among older adults have been identified, no study has focused on the role of frailty. Materials and methods: This was a cross-sectional study on a random sample of home-dwelling adults aged 60 and over from two Belgian cities. Data were collected with a structured questionnaire through a participatory peer-research method. Time since the last dental attendance was the dependent variable. The independent variable was frailty, assessed with the Comprehensive Frailty Assessment Instrument, including physical, psychological, social, and environmental subdomains. Covariates were age, gender, having a partner, educational level, and household income, as well as self-perceived oral health. Data analysis included descriptive, bivariate (Chi-Square, ANOVA, and Kruskal-Wallis), and binomial logistic regression analyses. Results: The sample consisted of 1329 older adults with a mean age of 72.5 years (SD 8.9, range 60-103). In the low frailty group, 73% attended the dentist in the previous 12 months, while it was 62% and 54% in the medium and high frailty groups, respectively. In the fully adjusted model, the initial gradient in the relationship between overall frailty and dental attendance remained; those in the medium and the high frailty groups were respectively 1.46 (95% CI: 1.09, 1.95) and 1.67 (95% CI: 1.15, 2.43) times more likely to report no dental attendance in the previous year than the low frailty group. Similar associations could be seen in the physical and environmental frailty subdomains. Conclusion: Frailty is consistently associated with less favourable dental attendance, independent from age, gender, socioeconomic factors, family composition, and self-perceived oral health. Once frailty has been detected, good interprofessional communication and care are needed to avoid the drop-out of older adults from the oral healthcare system.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Frailty/epidemiology ; Independent Living ; Cross-Sectional Studies ; Socioeconomic Factors ; Frail Elderly/psychology
Language	English
Publishing date	2022-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	604810-9
ISSN	1741-2358 ; 0734-0664
ISSN (online)	1741-2358
ISSN	0734-0664
DOI	10.1111/ger.12664
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Article ; Online: The burden of nonalcoholic steatohepatitis (NASH) in the United States.

Tapper, Elliot B / Krieger, Nancy / Przybysz, Raymond / Way, Nate / Cai, Jennifer / Zappe, Dion / McKenna, Sarah Jane / Wall, Garth / Janssens, Nico / Balp, Maria-Magdalena

BMC gastroenterology

2023 Volume 23, Issue 1, Page(s) 109

Abstract: Background: There is limited data on the comparative economic and humanistic burden of non-alcoholic steatohepatitis (NASH) in the United States. The objective was to examine the burden of disease comparing NASH to a representative sample of the general ...

Abstract	Background: There is limited data on the comparative economic and humanistic burden of non-alcoholic steatohepatitis (NASH) in the United States. The objective was to examine the burden of disease comparing NASH to a representative sample of the general population and separately to a type 2 diabetes mellitus (T2DM) cohort by assessing health-related quality of life (HRQoL) measures, healthcare resource use (HRU) and work productivity and activity impairment (WPAI). Methods: Data came from the 2016 National Health and Wellness Survey, a nationally representative patient-reported outcomes survey conducted in the United States. Respondents with physician-diagnosed NASH, physician-diagnosed T2DM, and respondents from the general population were compared. Humanistic burden was examined with mental (MCS) and physical (PCS) component summary scores from the Short-Form (SF)-36v2, concomitant diagnosis of anxiety, depression, and sleep difficulties. Economic burden was analysed based on healthcare professional (HCP) and emergency room (ER) visits, hospitalizations in the past six months; absenteeism, presenteeism, overall work impairment, and activity impairment scores on WPAI questionnaire. Bivariate and multivariable analysis were conducted for each outcome and matched comparative group. Results: After adjusting for baseline demographics and characteristics, NASH (N = 136) compared to the matched general population cohort (N = 544), reported significantly lower (worse) mental (MCS 43.19 vs. 46.22, p = 0.010) and physical (PCS 42.04 vs. 47.10, p < 0.001) status, higher % with anxiety (37.5% vs 25.5%, p = 0.006) and depression (43.4% vs 30.1%, p = 0.004), more HCP visits (8.43 vs. 5.17), ER visits (0.73 vs. 0.38), and hospitalizations (0.43 vs. 0.2) all p's < 0.05, and higher WPAI scores (e.g. overall work impairment 39.64% vs. 26.19%, p = 0.011). NASH cohort did not differ from matched T2DM cohort (N = 272) on mental or work-related WPAI scores, but had significantly worse physical status (PCS 40.52 vs. 44.58, p = 0.001), higher % with anxiety (39.9% vs 27.8%, p = 0.043), more HCP visits (8.63 vs. 5.68, p = 0.003) and greater activity impairment (47.14% vs. 36.07%, p = 0.010). Conclusion: This real-world study suggests that burden of disease is higher for all outcomes assessed among NASH compared to matched general controls. When comparing to T2DM, NASH cohort has comparable mental and work-related impairment but worse physical status, daily activities impairment and more HRU.
MeSH term(s)	Humans ; United States ; Quality of Life ; Cost of Illness ; Non-alcoholic Fatty Liver Disease ; Diabetes Mellitus, Type 2 ; Surveys and Questionnaires ; Health Surveys
Language	English
Publishing date	2023-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-023-02726-2
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Article ; Online: Generation of an induced pluripotent stem cell line (MHHi018-A) from a patient with Cystic Fibrosis carrying p.Asn1303Lys (N1303K) mutation.

Merkert, Sylvia / Schubert, Madline / Haase, Alexandra / Janssens, Hettie M / Scholte, Bob / Lachmann, Nico / Göhring, Gudrun / Martin, Ulrich

Stem cell research

2020 Volume 44, Page(s) 101744

Abstract: Cystic Fibrosis (CF) is a genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene which encodes for a chloride ion channel regulating the balance of salt and water across secretory epithelia. Here we ... ...

Abstract	Cystic Fibrosis (CF) is a genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene which encodes for a chloride ion channel regulating the balance of salt and water across secretory epithelia. Here we generated an iPSC line from a CF patient homozygous for the p.Asn1303Lys mutation, a Class II folding defect mutation. This iPSC line provides a useful resource for disease modeling and to investigate the pharmacological response to CFTR modulators in iPSC derived epithelia.
MeSH term(s)	Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Homozygote ; Humans ; Induced Pluripotent Stem Cells ; Mutation
Chemical Substances	Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
Language	English
Publishing date	2020-03-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1876-7753
ISSN (online)	1876-7753
DOI	10.1016/j.scr.2020.101744
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Article ; Online: Generation of an induced pluripotent stem cell line (MHHi018-A) from a patient with Cystic Fibrosis carrying p.Asn1303Lys (N1303K) mutation

Sylvia Merkert / Madline Schubert / Alexandra Haase / Hettie M. Janssens / Bob Scholte / Nico Lachmann / Gudrun Göhring / Ulrich Martin

Stem Cell Research, Vol 44, Iss , Pp - (2020)

2020

Abstract	Cystic Fibrosis (CF) is a genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene which encodes for a chloride ion channel regulating the balance of salt and water across secretory epithelia. Here we generated an iPSC line from a CF patient homozygous for the p.Asn1303Lys mutation, a Class II folding defect mutation. This iPSC line provides a useful resource for disease modeling and to investigate the pharmacological response to CFTR modulators in iPSC derived epithelia.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: GPS tracking data of Western marsh harriers breeding in Belgium and the Netherlands.

Milotić, Tanja / Desmet, Peter / Anselin, Anny / Bruyn, Luc De / Regge, Nico De / Janssens, Kjell / Klaassen, Raymond / Koks, Ben / Schaub, Tonio / Schlaich, Almut / Spanoghe, Geert / T'Jollyn, Filiep / Vanoverbeke, Joost / Bouten, Willem

ZooKeys

2020 Volume 947, Page(s) 143–155

Abstract: In this data paper three datasets are described containing GPS tracking and acceleration data of Western marsh harriers ( ...

Abstract	In this data paper three datasets are described containing GPS tracking and acceleration data of Western marsh harriers (
Language	English
Publishing date	2020-07-08
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.947.52570
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Article ; Online: Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A.

Nature communications

2023 Volume 14, Issue 1, Page(s) 1143

Abstract: The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly understood. Here, we report molecular level details and structural mechanisms of PP2A-B56α ... ...

Abstract	The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly understood. Here, we report molecular level details and structural mechanisms of PP2A-B56α inhibition by an oncoprotein CIP2A. Upon direct binding to PP2A-B56α trimer, CIP2A displaces the PP2A-A subunit and thereby hijacks both the B56α, and the catalytic PP2Ac subunit to form a CIP2A-B56α-PP2Ac pseudotrimer. Further, CIP2A competes with B56α substrate binding by blocking the LxxIxE-motif substrate binding pocket on B56α. Relevant to oncogenic activity of CIP2A across human cancers, the N-terminal head domain-mediated interaction with B56α stabilizes CIP2A protein. Functionally, CRISPR/Cas9-mediated single amino acid mutagenesis of the head domain blunted MYC expression and MEK phosphorylation, and abrogated triple-negative breast cancer in vivo tumour growth. Collectively, we discover a unique multi-step hijack and mute protein complex regulation mechanism resulting in tumour suppressor PP2A-B56α inhibition. Further, the results unfold a structural determinant for the oncogenic activity of CIP2A, potentially facilitating therapeutic modulation of CIP2A in cancer and other diseases.
MeSH term(s)	Humans ; Amino Acids ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Catalytic Domain ; Phosphorylation ; Protein Phosphatase 2/genetics ; Protein Phosphatase 2/ultrastructure ; Protein Processing, Post-Translational ; Triple Negative Breast Neoplasms/metabolism
Chemical Substances	Amino Acids ; CIP2A protein, human ; PP2A-B56alpha protein, human (EC 3.1.3.16) ; Protein Phosphatase 2 (EC 3.1.3.16)
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-36693-9
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Article ; Online: Development of a novel machine learning model to predict presence of nonalcoholic steatohepatitis.

Docherty, Matt / Regnier, Stephane A / Capkun, Gorana / Balp, Maria-Magdalena / Ye, Qin / Janssens, Nico / Tietz, Andreas / Löffler, Jürgen / Cai, Jennifer / Pedrosa, Marcos C / Schattenberg, Jörn M

Journal of the American Medical Informatics Association : JAMIA

2021 Volume 28, Issue 6, Page(s) 1235–1241

Abstract: Objective: To develop a computer model to predict patients with nonalcoholic steatohepatitis (NASH) using machine learning (ML).: Materials and methods: This retrospective study utilized two databases: a) the National Institute of Diabetes and ... ...

Abstract	Objective: To develop a computer model to predict patients with nonalcoholic steatohepatitis (NASH) using machine learning (ML). Materials and methods: This retrospective study utilized two databases: a) the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) nonalcoholic fatty liver disease (NAFLD) adult database (2004-2009), and b) the Optum® de-identified Electronic Health Record dataset (2007-2018), a real-world dataset representative of common electronic health records in the United States. We developed an ML model to predict NASH, using confirmed NASH and non-NASH based on liver histology results in the NIDDK dataset to train the model. Results: Models were trained and tested on NIDDK NAFLD data (704 patients) and the best-performing models evaluated on Optum data (~3,000,000 patients). An eXtreme Gradient Boosting model (XGBoost) consisting of 14 features exhibited high performance as measured by area under the curve (0.82), sensitivity (81%), and precision (81%) in predicting NASH. Slightly reduced performance was observed with an abbreviated feature set of 5 variables (0.79, 80%, 80%, respectively). The full model demonstrated good performance (AUC 0.76) to predict NASH in Optum data. Discussion: The proposed model, named NASHmap, is the first ML model developed with confirmed NASH and non-NASH cases as determined through liver biopsy and validated on a large, real-world patient dataset. Both the 14 and 5-feature versions exhibit high performance. Conclusion: The NASHmap model is a convenient and high performing tool that could be used to identify patients likely to have NASH in clinical settings, allowing better patient management and optimal allocation of clinical resources.
MeSH term(s)	Adult ; Biopsy ; Humans ; Machine Learning ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Retrospective Studies ; United States/epidemiology
Language	English
Publishing date	2021-03-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1205156-1
ISSN	1527-974X ; 1067-5027
ISSN (online)	1527-974X
ISSN	1067-5027
DOI	10.1093/jamia/ocab003
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Article ; Online: Spatially explicit analysis identifies significant potential for bioenergy with carbon capture and storage in China.

Xing, Xiaofan / Wang, Rong / Bauer, Nico / Ciais, Philippe / Cao, Junji / Chen, Jianmin / Tang, Xu / Wang, Lin / Yang, Xin / Boucher, Olivier / Goll, Daniel / Peñuelas, Josep / Janssens, Ivan A / Balkanski, Yves / Clark, James / Ma, Jianmin / Pan, Bo / Zhang, Shicheng / Ye, Xingnan /

Wang, Yutao / Li, Qing / Luo, Gang / Shen, Guofeng / Li, Wei / Yang, Yechen / Xu, Siqing

Nature communications

2021 Volume 12, Issue 1, Page(s) 3159

Abstract: As China ramped-up coal power capacities rapidly while ... ...

Abstract	As China ramped-up coal power capacities rapidly while CO
Language	English
Publishing date	2021-05-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-23282-x
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Article ; Online: Occipital alpha power reveals fast attentional inhibition of incongruent distractors.

Janssens, Clio / De Loof, Esther / Boehler, C Nico / Pourtois, Gilles / Verguts, Tom

Psychophysiology

2017 Volume 55, Issue 3

Abstract: Recent associative models of cognitive control hypothesize that cognitive control can be learned (optimized) for task-specific settings via associations between perceptual, motor, and control representations, and, once learned, control can be implemented ...

Abstract	Recent associative models of cognitive control hypothesize that cognitive control can be learned (optimized) for task-specific settings via associations between perceptual, motor, and control representations, and, once learned, control can be implemented rapidly. Midfrontal brain areas signal the need for control, and control is subsequently implemented by biasing sensory representations, boosting or suppressing activity in brain areas processing task-relevant or task-irrelevant information. To assess the timescale of this process, we employed EEG. In order to pinpoint control implementation in specific sensory areas, we used a flanker task with incongruent flankers shown in only one hemifield (congruent flankers in the other hemifield) isolating their processing in the contralateral hemisphere. ERPs revealed fast modulations specifically in visual processing areas contralateral to the incongruent flankers. To test whether these modulations reflect increased or decreased processing of incongruent flankers, we investigated alpha power, a marker for attentional inhibition. Importantly, we show increased alpha power over visual areas processing incongruent flankers from 300 to 500 ms poststimulus onset. This suggests fast cognitive control by attentional inhibition for information disrupting goal-oriented actions. Additionally, we show that midfrontal theta earlier in the trial is also modulated by incongruency, and that theta power predicts subsequent alpha power modulations. This supports the hypothesis that midfrontal incongruency detection leads to control implementation, and reveals that these mechanisms take place on a fast, within-trial timescale.
MeSH term(s)	Alpha Rhythm ; Attention/physiology ; Executive Function/physiology ; Humans ; Occipital Lobe/physiology ; Pattern Recognition, Visual/physiology ; Psychomotor Performance
Language	English
Publishing date	2017-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209486-1
ISSN	1540-5958 ; 0048-5772
ISSN (online)	1540-5958
ISSN	0048-5772
DOI	10.1111/psyp.13011
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Article: Draft Genome Sequence of

Janssens, Thierry K S / de Boer, Tjalf E / Agamennone, Valeria / Zaagman, Niels / van Straalen, Nico M / Roelofs, Dick

Genome announcements

2017 Volume 5, Issue 19

Abstract: We present here the draft genome ... ...

Abstract	We present here the draft genome of
Language	English
Publishing date	2017-05-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2704277-7
ISSN	2169-8287
ISSN	2169-8287
DOI	10.1128/genomeA.00287-17
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