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Article ; Online: More effective vaccines and oral antivirals: Keys for the battle against Omicron.

Lu, Hongzhou

2022 Volume 16, Issue 1, Page(s) 1–3

Abstract: With the rapid roll out of vaccination programs and extraordinary non-pharmaceutical interventions (NPIs) by the government, China has maintained a "dynamic zero-COVID-19" policy over the last two years. However, the global pandemic and immune evasion of ...

Abstract	With the rapid roll out of vaccination programs and extraordinary non-pharmaceutical interventions (NPIs) by the government, China has maintained a "dynamic zero-COVID-19" policy over the last two years. However, the global pandemic and immune evasion of Omicron variant poses a huge challenge to China. Currently, about 87.69% of the Chinese population has been vaccinated, most with inactivated vaccines. Although seroepidemiological data on the vaccinated are lacking, published data suggested that even a homologous booster of an inactivated vaccine displayed very limited neutralizing activity against the Omicron variant and that neutralizing activity was significantly lower than that of a heterologous booster or mRNA vaccine alone. A great concern is whether the neutralizing antibodies induced by inactivated vaccines can provide sufficient protection against the Omicron variant since local transmission of the Omicron variant is now occurring in China. The era of extraordinary NPIs by governments and countries to control the transmission of SARS-CoV-2 is going to change. Omicron's immune evasion of neutralizing antibodies induced by current vaccines and the majority of existing therapeutic SARS-CoV-2 monoclonal antibodies (mAbs) suggest an urgent need for more effective vaccines and highly effective oral antivirals, which will be the keys for the battle against Omicron in the future.
MeSH term(s)	Antiviral Agents ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Humans ; SARS-CoV-2 ; Vaccines, Inactivated ; Vaccines, Synthetic ; mRNA Vaccines ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; COVID-19 Vaccines ; Vaccines, Inactivated ; Vaccines, Synthetic ; mRNA Vaccines
Language	English
Publishing date	2022-02-17
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2543899-2
ISSN	1881-7823 ; 1881-7823
ISSN (online)	1881-7823
ISSN	1881-7823
DOI	10.5582/bst.2022.01062
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review.

Zhao, Fang / Lu, Hongzhou

Bioscience trends

2024

Abstract: Antiretroviral therapy (ART) has significantly enhanced the outlook for people with HIV(PWH), yet certain ART medications can adversely affect the renal function of these patients. Of particular concern is the nephrotoxicity associated with tenofovir ... ...

Abstract	Antiretroviral therapy (ART) has significantly enhanced the outlook for people with HIV(PWH), yet certain ART medications can adversely affect the renal function of these patients. Of particular concern is the nephrotoxicity associated with tenofovir disoproxil fumarate (TDF). Compared to TDF, tenofovir alafenamide (TAF), another prodrug of tenofovir (TFV), results in lower TFV plasma levels, thereby alleviating the TFV-associated mitochondrial toxicity on proximal renal tubular cells. Currently, numerous clinical trials and real-world studies have demonstrated the favorable renal safety profile of ART regimens incorporating TAF for PWH. This paper seeks to consolidate the available evidence regarding the renal safety of TAF-based regimens in PWH, encompassing both the general PWH and those with renal impairment or predisposing factors, in order to offer recommendations and insights for TAF clinical application.
Language	English
Publishing date	2024-04-24
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2543899-2
ISSN	1881-7823 ; 1881-7823
ISSN (online)	1881-7823
ISSN	1881-7823
DOI	10.5582/bst.2024.01062
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; E-Book: Diagnostic imaging of drug resistant pulmonary tuberculosis

Lu, Pu-Xuan / Lu, Hong-zhou / Yi, Yong-xiang

2023

Author's details	Pu-Xuan Lu, Hong-zhou Lu, Yong-xiang Yi editors
Keywords	Radiology
Language	English
Size	1 Online-Ressource (xx, 267 Seiten), Illustrationen, Diagramme
Publisher	People's Medical Publishing House
Publishing place	Singapore
Publishing country	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT030697346
ISBN	978-981-99-8339-1 ; 9789819983384 ; 981-99-8339-8 ; 981998338X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Drug treatment options for the 2019-new coronavirus (2019-nCoV).

Lu, Hongzhou

Bioscience trends

2020 Volume 14, Issue 1, Page(s) 69–71

Abstract: As of January 22, 2020, a total of 571 cases of the 2019-new coronavirus (2019-nCoV) have been reported in 25 provinces (districts and cities) in China. At present, there is no vaccine or antiviral treatment for human and animal coronavirus, so that ... ...

Abstract	As of January 22, 2020, a total of 571 cases of the 2019-new coronavirus (2019-nCoV) have been reported in 25 provinces (districts and cities) in China. At present, there is no vaccine or antiviral treatment for human and animal coronavirus, so that identifying the drug treatment options as soon as possible is critical for the response to the 2019-nCoV outbreak. Three general methods, which include existing broad-spectrum antiviral drugs using standard assays, screening of a chemical library containing many existing compounds or databases, and the redevelopment of new specific drugs based on the genome and biophysical understanding of individual coronaviruses, are used to discover the potential antiviral treatment of human pathogen coronavirus. Lopinavir /Ritonavir, Nucleoside analogues, Neuraminidase inhibitors, Remdesivir, peptide (EK1), abidol, RNA synthesis inhibitors (such as TDF, 3TC), anti-inflammatory drugs (such as hormones and other molecules), Chinese traditional medicine, such ShuFengJieDu Capsules and Lianhuaqingwen Capsule, could be the drug treatment options for 2019-nCoV. However, the efficacy and safety of these drugs for 2019- nCoV still need to be further confirmed by clinical experiments.
MeSH term(s)	Alanine/analogs & derivatives ; Alanine/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus ; Coronavirus Infections/drug therapy ; Drug Combinations ; Drug Discovery ; Humans ; Lopinavir/therapeutic use ; Neuraminidase/antagonists & inhibitors ; Nucleosides/therapeutic use ; Pneumonia, Viral/drug therapy ; Ribonucleotides/therapeutic use ; Ritonavir/therapeutic use
Chemical Substances	Antiviral Agents ; Drug Combinations ; Nucleosides ; Ribonucleotides ; lopinavir-ritonavir drug combination ; Lopinavir (2494G1JF75) ; remdesivir (3QKI37EEHE) ; Neuraminidase (EC 3.2.1.18) ; Ritonavir (O3J8G9O825) ; Alanine (OF5P57N2ZX)
Keywords	covid19
Language	English
Publishing date	2020-01-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2543899-2
ISSN	1881-7823 ; 1881-7815
ISSN (online)	1881-7823
ISSN	1881-7815
DOI	10.5582/bst.2020.01020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Attention should be paid to acute hepatitis of unknown etiology in children.

Chen, Guangbin / Lu, Hongzhou

Intractable & rare diseases research

2022 Volume 11, Issue 3, Page(s) 153–157

Abstract: Since April 5, 2022, an increase in cases of severe acute hepatitis of unknown etiology among children with no underlying conditions was first reported in the United Kingdom (UK). Testing excluded viral hepatitis types A, B, C, D, and E and other known ... ...

Abstract	Since April 5, 2022, an increase in cases of severe acute hepatitis of unknown etiology among children with no underlying conditions was first reported in the United Kingdom (UK). Testing excluded viral hepatitis types A, B, C, D, and E and other known common and uncommon infectious and non-infectious causes of acute hepatitis. As of May 26, 2022, 650 cases of acute hepatitis of unknown etiology in children have been reported in at least 33 countries worldwide, with 99 additional cases pending classification. Here, the current prevalence of this condition around the world, a hazard analysis, possible causes, the risk of an outbreak in China, and advice on prevention have been briefly reviewed.
Language	English
Publishing date	2022-09-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2672570-8
ISSN	2186-361X ; 2186-3644
ISSN (online)	2186-361X
ISSN	2186-3644
DOI	10.5582/irdr.2022.01069
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Article ; Online: Advances in Acute Severe Hepatitis of Unknown Etiology in Children

Xuefeng Zhou / Hongzhou Lu

Zoonoses, Vol 2, Iss 1, p

2022 Volume 981

Abstract: Since the International Health Regulations National Focal Point for the United Kingdom alerted the WHO of ten cases of acute severe hepatitis of unknown etiology in children on April 5, 2022, relevant cases have been reported worldwide. These patients ... ...

Abstract	Since the International Health Regulations National Focal Point for the United Kingdom alerted the WHO of ten cases of acute severe hepatitis of unknown etiology in children on April 5, 2022, relevant cases have been reported worldwide. These patients had acute hepatitis (negative for hepatitis viruses A–E) and elevated aminotransferase (AST) or alanine aminase (ALT) exceeding 500 U/L. Furthermore, severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and/or adenovirus type F41 have been detected in some cases. This unknown hepatitis has been hypothesized to be induced by a viral reservoir of novel coronavirus superantigen, which repeatedly stimulates the intestines and leads to a multisystem inflammatory syndrome in children (MIS-C), which causes immune abnormalities in the presence of human adenovirus. Although this hypothesis has not been confirmed by any in vivo experimental or clinical studies, it may provide ideas for possible intervention strategies.
Keywords	Infectious and parasitic diseases ; RC109-216 ; Veterinary medicine ; SF600-1100
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Compuscript Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The 4Rs approach to COVID-19 emergency management during the post-pandemic period: What lessons can be learned from Shenzhen, China?

Zhou, Rongfeng / Lu, Hongzhou

Infectious medicine

2022 Volume 1, Issue 4, Page(s) 272–275

Abstract: The Omicron variant of SARS-CoV-2 (or Omicron) is extremely contagious and has swept the world in a short period. Shenzhen-a new international city in China with a permanent population of 17.56 million and covering nearly 2000 square kilometers-was ... ...

Abstract	The Omicron variant of SARS-CoV-2 (or Omicron) is extremely contagious and has swept the world in a short period. Shenzhen-a new international city in China with a permanent population of 17.56 million and covering nearly 2000 square kilometers-was attacked by Omicron in 2022. However, the pandemic was controlled in a very short time as a result of prompt government reaction that prevented the variant's further spread. The total number of cases in this wave of the pandemic was more than 2600. Shenzhen's successful experience in tackling the Omicron wave deserves in-depth discussion. Proposed by American scholar Robert Heath, the 4Rs model aims to reduce the harm from a crisis through the measures of reduction, readiness, response, and recovery. This article presents the successful experience of Shenzhen's local government and the Third People's Hospital of Shenzhen, the only hospital in Shenzhen designated to use the 4Rs emergency management model for the treatment of COVID-19 during the 2022 Omicron wave of the pandemic.
Language	English
Publishing date	2022-11-18
Publishing country	China
Document type	Journal Article
ISSN	2772-431X
ISSN (online)	2772-431X
DOI	10.1016/j.imj.2022.10.004
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Article ; Online: Proposal to apply a "Positive Emotion, Engagement, Relationships, Meaning, and Accomplishment (PERMA)" based approach to manage the COVID-19-related mental health problems in the era of long COVID.

Sun, Kai / Zhou, Rongfeng / Xu, Fang / Lu, Hongzhou / Asakawa, Tetsuya

Global health & medicine

2024 Volume 6, Issue 2, Page(s) 160–163

Abstract: Long COVID (LC)-related health problems are highly concerned. Many patients seem to have "recovered" from an acute SARS-CoV-2 infection, however, they might experience various symptoms, almost involving all organs and systems. Of those, neuropsychiatric ... ...

Abstract	Long COVID (LC)-related health problems are highly concerned. Many patients seem to have "recovered" from an acute SARS-CoV-2 infection, however, they might experience various symptoms, almost involving all organs and systems. Of those, neuropsychiatric symptoms like depression, anxiety, and post-traumatic stress disorder (PTSD) are not rare. These problems significantly impact the quality of life (QOL) of patients, family, and caregivers, even lead a tragic suicide outcome. Other than the conventional psychological and medical approaches, here, we proposal a positive emotion, engagement, relationships, meaning, and accomplishment (PERMA)-based approach to fight against these COVID-19-related mental health problems (CRMHPs). This approach is characterized by positive psychological interventions and self-achievements, which has been proved to be a powerful tool against mood disorders in common people. Nowadays, abolishment of certain prophylactic measures (such as isolation, lockdown, compulsorily wearing a mask and maintaining social distance, measures to avoid crowding) enables us to have more opportunities to contact patients and implement the PERMA-based approach to the patients with CRMHPs. We believe that application of PERMA-based approach is conducive to alleviate the influence of the CRMHPs and improve their QOL.
Language	English
Publishing date	2024-01-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	3140544-7
ISSN	2434-9194 ; 2434-9194 ; 2434-9186
ISSN (online)	2434-9194
ISSN	2434-9194 ; 2434-9186
DOI	10.35772/ghm.2023.01102
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Article ; Online: Multispectral Depolarization based Living-skin Detection: A New Measurement Principle.

Wang, Wenjin / Shu, Huaijing / Lu, Hongzhou / Xu, Ming / Ji, Xiangyang

IEEE transactions on bio-medical engineering

2024 Volume PP

Abstract: Camera-based photoplethysmographic imaging enabled the segmentation of living-skin tissues in a video, but it has inherent limitations to be used in real-life applications such as video health monitoring and face anti-spoofing. Inspired by the use of ... ...

Abstract	Camera-based photoplethysmographic imaging enabled the segmentation of living-skin tissues in a video, but it has inherent limitations to be used in real-life applications such as video health monitoring and face anti-spoofing. Inspired by the use of polarization for improving vital signs monitoring (i.e. specular reflection removal), we observed that skin tissues have an attractive property of wavelength-dependent depolarization due to its multi-layer structure containing different absorbing chromophores, i.e. polarized light photons with longer wavelengths (R) have deeper skin penetrability and thus experience thorougher depolarization than those with shorter wavelengths (G and B). Thus we proposed a novel dual-polarization setup and an elegant algorithm (named "MSD") that exploits the nature of multispectral depolarization of skin tissues to detect living-skin pixels, which only requires two images sampled at the parallel and cross polarizations to estimate the characteristic chromaticity changes (R/G) caused by tissue depolarization. Our proposal was verified in both the laboratory and hospital settings (ICU and NICU) focused on anti-spoofing and patient skin segmentation. The clinical experiments in ICU also indicate the potential of MSD for skin perfusion analysis, which may lead to a new diagnostic imaging approach in the future. The proposed MSD algorithm is extremely simple to implement (only 5 lines of Matlab code) and its performance is highly reproducible: https://github.com/contactless-healthcare/Multispectral-Depolarization-based-Living-skin-Detection.
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	160429-6
ISSN	1558-2531 ; 0018-9294
ISSN (online)	1558-2531
ISSN	0018-9294
DOI	10.1109/TBME.2024.3356410
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Article ; Online: Camera-Based Seismocardiogram for Heart Rate Variability Monitoring.

Liu, Lin / Yu, Dongfang / Lu, Hongzhou / Shan, Caifeng / Wang, Wenjin

IEEE journal of biomedical and health informatics

2024 Volume 28, Issue 5, Page(s) 2794–2805

Abstract: Heart rate variability (HRV) is a crucial metric that quantifies the variation between consecutive heartbeats, serving as a significant indicator of autonomic nervous system (ANS) activity. It has found widespread applications in clinical diagnosis, ... ...

Abstract	Heart rate variability (HRV) is a crucial metric that quantifies the variation between consecutive heartbeats, serving as a significant indicator of autonomic nervous system (ANS) activity. It has found widespread applications in clinical diagnosis, treatment, and prevention of cardiovascular diseases. In this study, we proposed an optical model for defocused speckle imaging, to simultaneously incorporate out-of-plane translation and rotation-induced motion for highly-sensitive non-contact seismocardiogram (SCG) measurement. Using electrocardiogram (ECG) signals as the gold standard, we evaluated the performance of photoplethysmogram (PPG) signals and speckle-based SCG signals in assessing HRV. The results indicated that the HRV parameters measured from SCG signals extracted from laser speckle videos showed higher consistency with the results obtained from the ECG signals compared to PPG signals. Additionally, we confirmed that even when clothing obstructed the measurement site, the efficacy of SCG signals extracted from the motion of laser speckle patterns persisted in assessing the HRV levels. This demonstrates the robustness of camera-based non-contact SCG in monitoring HRV, highlighting its potential as a reliable, non-contact alternative to traditional contact-PPG sensors.
MeSH term(s)	Humans ; Heart Rate/physiology ; Signal Processing, Computer-Assisted ; Electrocardiography/methods ; Adult ; Photoplethysmography/methods ; Male ; Female ; Young Adult
Language	English
Publishing date	2024-05-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2695320-1
ISSN	2168-2208 ; 2168-2194
ISSN (online)	2168-2208
ISSN	2168-2194
DOI	10.1109/JBHI.2024.3370394
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