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Article ; Online: Editorial Reflections on the Demise of Molecular Endocrinology and the Future of Molecular Hormone Action Research.

Means, Anthony R

Molecular endocrinology (Baltimore, Md.)

2016 Volume 30, Issue 10, Page(s) 1021–1022

MeSH term(s)	Animals ; Endocrinology/trends ; History, 20th Century ; History, 21st Century ; Hormones/metabolism ; Humans ; Male ; Molecular Biology/trends ; Periodicals as Topic/trends ; Rats ; Societies, Scientific/history
Chemical Substances	Hormones
Language	English
Publishing date	2016-10-03
Publishing country	United States
Document type	Editorial ; Historical Article
ZDB-ID	639167-9
ISSN	1944-9917 ; 0888-8809
ISSN (online)	1944-9917
ISSN	0888-8809
DOI	10.1210/me.2016-1131
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Book: Calcium regulation of cellular function

Means, Anthony R.

(Advances in second messenger and phosphoprotein research ; 30)

1995

Author's details	ed. Anthony R. Means
Series title	Advances in second messenger and phosphoprotein research ; 30
Collection
Keywords	Calcium / metabolism ; Cells / metabolism ; Calcium ; Zelle
Subject	Beiträge ; Einzelbeiträge ; Sammelwerk ; Calzium ; Kalzium
Language	English
Size	X, 404 S. : Ill., graph. Darst.
Publisher	Raven Press
Publishing place	New York
Publishing country	United States
Document type	Book
HBZ-ID	HT006486106
ISBN	0-7817-0233-X ; 978-0-7817-0233-1
Database	Catalogue ZB MED Medicine, Health

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Se 313 -30-	verfügbar in Königswinter	Königswinter

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Article ; Online: CaMKK2 as an emerging treatment target for bipolar disorder.

Kaiser, Jacqueline / Nay, Kevin / Horne, Christopher R / McAloon, Luke M / Fuller, Oliver K / Muller, Abbey G / Whyte, Douglas G / Means, Anthony R / Walder, Ken / Berk, Michael / Hannan, Anthony J / Murphy, James M / Febbraio, Mark A / Gundlach, Andrew L / Scott, John W

Molecular psychiatry

2023 Volume 28, Issue 11, Page(s) 4500–4511

Abstract: Current pharmacological treatments for bipolar disorder are inadequate and based on serendipitously discovered drugs often with limited efficacy, burdensome side-effects, and unclear mechanisms of action. Advances in drug development for the treatment of ...

Abstract	Current pharmacological treatments for bipolar disorder are inadequate and based on serendipitously discovered drugs often with limited efficacy, burdensome side-effects, and unclear mechanisms of action. Advances in drug development for the treatment of bipolar disorder remain incremental and have come largely from repurposing drugs used for other psychiatric conditions, a strategy that has failed to find truly revolutionary therapies, as it does not target the mood instability that characterises the condition. The lack of therapeutic innovation in the bipolar disorder field is largely due to a poor understanding of the underlying disease mechanisms and the consequent absence of validated drug targets. A compelling new treatment target is the Ca
MeSH term(s)	Animals ; Humans ; Mice ; Bipolar Disorder/drug therapy ; Bipolar Disorder/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism ; Mutation, Missense
Chemical Substances	Calcium-Calmodulin-Dependent Protein Kinase Kinase (EC 2.7.11.17) ; CAMKK2 protein, human (EC 2.7.11.17) ; Camkk2 protein, mouse (EC 2.7.11.17)
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-023-02260-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Effects of Capitate Height Alteration on Dorsal Intercalated Segment Instability.

Nayar, Suresh K / Marjoua, Youssra / Colon, Anthony F / Means, Kenneth R / Higgins, James P

Journal of wrist surgery

2019 Volume 9, Issue 1, Page(s) 29–33

Abstract: ... Question/ ... ...

Abstract	Question/Purpose
Language	English
Publishing date	2019-09-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2678060-4
ISSN	2163-3924 ; 2163-3916
ISSN (online)	2163-3924
ISSN	2163-3916
DOI	10.1055/s-0039-1697651
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Article: The Year in Basic Science: calmodulin kinase cascades.

Means, Anthony R

Molecular endocrinology (Baltimore, Md.)

2008 Volume 22, Issue 12, Page(s) 2759–2765

Abstract: This article highlights studies published during the past year that represent significant scientific achievements in the world of calmodulin kinase cascades. Calmodulin is the primary receptor for calcium present in all cells. The binding of its calcium ... ...

Abstract	This article highlights studies published during the past year that represent significant scientific achievements in the world of calmodulin kinase cascades. Calmodulin is the primary receptor for calcium present in all cells. The binding of its calcium ligand results in a conformational change in calmodulin, which allows the calcium-calmodulin complex to interact with many different targets. In the studies to be summarized in this review, the particular calmodulin cascade involved is shown to be the pathway responsible for important biological responses, including long-term memory formation, dendritic cell survival, hypercapnia, neuronal migration, synapse formation, autophagy, fatty acid oxidation, and energy balance. In some cases, the pathway was previously unknown, and the identification of the calmodulin cascade represents the definition of roles. In other cases, manipulating the cascade has suggested therapeutic approaches to certain diseases, most significantly, type 2 diabetes and obesity.
MeSH term(s)	AMP-Activated Protein Kinases/physiology ; Animals ; Biomedical Research/trends ; Calcium-Calmodulin-Dependent Protein Kinases/physiology ; Cell Movement/physiology ; Cell Survival/physiology ; Energy Metabolism/physiology ; Fatty Acids/metabolism ; Humans ; Models, Biological ; Neurons/physiology ; Signal Transduction/physiology ; Synapses/metabolism ; Synapses/physiology
Chemical Substances	Fatty Acids ; Calcium-Calmodulin-Dependent Protein Kinases (EC 2.7.11.17) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2008-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	639167-9
ISSN	1944-9917 ; 0888-8809
ISSN (online)	1944-9917
ISSN	0888-8809
DOI	10.1210/me.2008-0312
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Article ; Online: The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft.

Marcelo, Kathrina L / Means, Anthony R / York, Brian

Trends in endocrinology and metabolism: TEM

2016 Volume 27, Issue 10, Page(s) 706–718

Abstract: Calcium (Ca(2+)) is an essential ligand that binds its primary intracellular receptor calmodulin (CaM) to trigger a variety of downstream processes and pathways. Central to the actions of Ca(2+)/CaM is the activation of a highly conserved Ca(2+)/CaM ... ...

Abstract	Calcium (Ca(2+)) is an essential ligand that binds its primary intracellular receptor calmodulin (CaM) to trigger a variety of downstream processes and pathways. Central to the actions of Ca(2+)/CaM is the activation of a highly conserved Ca(2+)/CaM kinase (CaMK) cascade that amplifies Ca(2+) signals through a series of subsequent phosphorylation events. Proper regulation of Ca(2+) flux is necessary for whole-body metabolism and disruption of Ca(2+) homeostasis has been linked to various metabolic diseases. Here we provide a synthesis of recent advances that highlight the roles of the Ca(2+)/CaMK axis in key metabolic tissues. An appreciation of this information is critical to understanding the mechanisms by which Ca(2+)/CaM-dependent signaling contributes to metabolic homeostasis and disease.
MeSH term(s)	Animals ; Calcium/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism ; Calmodulin/metabolism ; Humans ; Phosphorylation ; Signal Transduction/genetics ; Signal Transduction/physiology
Chemical Substances	Calmodulin ; Calcium-Calmodulin-Dependent Protein Kinase Kinase (EC 2.7.11.17) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2016-07-20
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2016.06.001
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Article ; Online: Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology.

Racioppi, Luigi / Means, Anthony R

The Journal of biological chemistry

2012 Volume 287, Issue 38, Page(s) 31658–31665

Abstract: Many cellular Ca(2+)-dependent signaling cascades utilize calmodulin (CaM) as the intracellular Ca(2+) receptor. Ca(2+)/CaM binds and activates a plethora of enzymes, including CaM kinases (CaMKs). CaMKK2 is one of the most versatile of the CaMKs and ... ...

Abstract	Many cellular Ca(2+)-dependent signaling cascades utilize calmodulin (CaM) as the intracellular Ca(2+) receptor. Ca(2+)/CaM binds and activates a plethora of enzymes, including CaM kinases (CaMKs). CaMKK2 is one of the most versatile of the CaMKs and will phosphorylate and activate CaMKI, CaMKIV, and AMP-activated protein kinase. Cell expression of CaMKK2 is limited, yet CaMKK2 is involved in regulating many important physiological and pathophysiological processes, including energy balance, adiposity, glucose homeostasis, hematopoiesis, inflammation, and cancer. Here, we explore known functions of CaMKK2 and discuss its potential as a target for therapeutic intervention.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Adipose Tissue/enzymology ; Adiposity ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism ; Female ; Gene Expression Regulation ; Glucose/metabolism ; Homeostasis ; Humans ; Inflammation/metabolism ; Liver/enzymology ; Macrophages/metabolism ; Male ; Mice ; Neurons/metabolism ; Phosphorylation ; Prostatic Neoplasms/enzymology ; Rats ; Signal Transduction ; Tissue Distribution
Chemical Substances	Calcium-Calmodulin-Dependent Protein Kinase Kinase (EC 2.7.11.17) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2012-07-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.R112.356485
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Article: Expansion and population structure of transplanted Aristida beyrichiana (wiregrass) tussocks: results of a 37‐year study

Laucevicius, Anthony M., Jr / Robertson, Kevin M. / Means, D. Bruce / Mitchell, Trina R. / Taylor, Porter B.

Restoration ecology. 2021 July, v. 29, no. 5

2021

Abstract: Aristida beyrichiana (wiregrass) is a foundation bunchgrass species in many southeastern U.S. native pine communities, but it has been dramatically reduced in extent. The potential for reintroduced wiregrass to reproduce and spread is not well studied ... ...

Abstract	Aristida beyrichiana (wiregrass) is a foundation bunchgrass species in many southeastern U.S. native pine communities, but it has been dramatically reduced in extent. The potential for reintroduced wiregrass to reproduce and spread is not well studied because of its slow growth and limited conditions for successful reproduction. We present a case study where tussocks of wiregrass were transplanted and recensused 18 and 37 years later to study their population dynamics. We remeasured a subset of tussocks to estimate diameter growth over 2 years. With frequent prescribed fires (1–3 year intervals, about half in April–July when flowering is induced), the initial population of 160 tussocks increased to 1,199 through seed dispersal and clonal fragmentation, and the total basal area approximately tripled. Relationships among tussock density, diameter, and basal area per m² and their changes over time suggest density‐dependent regulation of population structure, possibly from intraspecific competition and competitive exclusion. Tussock diameter growth averaged 0.9 cm per year over a 2‐year period and was independent of initial diameter. This study, the longest of a wiregrass population to date, suggests that a low‐density population established in native soil types has a slow but robust tendency to reproduce by seed and expand if provided frequent fire, including April–July burns, in a high light environment without soil disturbance. Wiregrass can be characterized as a competitive, late‐successional, dominant species in stable, climax‐like native savannas, promising long‐term success under appropriate conditions as part of restoration efforts.
Keywords	Aristida stricta ; case studies ; competitive exclusion ; disturbed soils ; dominant species ; ecological restoration ; intraspecific competition ; population dynamics ; population structure ; reproduction ; seed dispersal ; Southeastern United States
Language	English
Dates of publication	2021-07
Publishing place	Wiley Periodicals, Inc.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	914746-9
ISSN	1526-100X ; 1061-2971
ISSN (online)	1526-100X
ISSN	1061-2971
DOI	10.1111/rec.13404
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism.

Stork, Brittany A / Dean, Adam / Ortiz, Andrea R / Saha, Pradip / Putluri, Nagireddy / Planas-Silva, Maricarmen D / Mahmud, Iqbal / Rajapakshe, Kimal / Coarfa, Cristian / Knapp, Stefan / Lorenzi, Philip L / Kemp, Bruce E / Turk, Benjamin E / Scott, John W / Means, Anthony R / York, Brian

Molecular metabolism

2022 Volume 62, Page(s) 101513

Abstract: Objective: The liver is the primary internal metabolic organ that coordinates whole body energy homeostasis in response to feeding and fasting. Genetic ablation or pharmacological inhibition of calcium/calmodulin-dependent protein kinase kinase 2 ( ... ...

Abstract	Objective: The liver is the primary internal metabolic organ that coordinates whole body energy homeostasis in response to feeding and fasting. Genetic ablation or pharmacological inhibition of calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) has been shown to significantly improve hepatic health and peripheral insulin sensitivity upon overnutrition with high fat diet. However, the precise molecular underpinnings that explain this metabolic protection have remained largely undefined. Methods: To characterize the role of CaMKK2 in hepatic metabolism, we developed and challenged liver-specific CaMKK2 knockout (CaMKK2 Results: Consistent with previous findings, we show that hepatic CaMKK2 ablation significantly improves indices of peripheral insulin sensitivity. Mechanistically, we found that CaMKK2 phosphorylates and regulates GAPDH to promote glucose metabolism and PEX3 to blunt peroxisomal fatty acid catabolism in the liver. Conclusion: CaMKK2 is a central metabolic fuel sensor in the liver that significantly contributes to whole body systems metabolism.
MeSH term(s)	Animals ; Calcium/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism ; Fatty Acids ; Glucose/metabolism ; Insulin Resistance/physiology ; Mice
Chemical Substances	Fatty Acids ; Calcium-Calmodulin-Dependent Protein Kinase Kinase (EC 2.7.11.17) ; Camkk2 protein, mouse (EC 2.7.11.17) ; Glucose (IY9XDZ35W2) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-05-11
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2708735-9
ISSN	2212-8778 ; 2212-8778
ISSN (online)	2212-8778
ISSN	2212-8778
DOI	10.1016/j.molmet.2022.101513
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Article ; Online: Gfer is a critical regulator of HSC proliferation.

Sankar, Uma / Means, Anthony R

Cell cycle (Georgetown, Tex.)

2011 Volume 10, Issue 14, Page(s) 2263–2268

Abstract: Hematopoietic stem cells (HSC) are a relatively quiescent pool of cells that perform the arduous task of replacing the short-lived mature cells of the peripheral blood. While a rapid expansion of HSCs under periods of hematological stress is warranted, ... ...

Abstract	Hematopoietic stem cells (HSC) are a relatively quiescent pool of cells that perform the arduous task of replacing the short-lived mature cells of the peripheral blood. While a rapid expansion of HSCs under periods of hematological stress is warranted, their enhanced proliferation during homeostasis leads to loss of function. We recently reported that in HSCs, the evolutionarily conserved growth factor erv1-like (Gfer) acts to counter jun activation domain-binding protein 1 (Jab1)-mediated nuclear export and destabilization of the cell cycle inhibitor, p27kip1, by directly binding to and sequestering the COP9 signalosome (CSN) subunit. Through this mechanism, Gfer promotes quiescence and maintains the functional integrity of HSCs. Here, we extend our study to demonstrate an association between Gfer and Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) in the regulation of HSC proliferation. Highly proliferative and functionally deficient Camk4-/- HSCs possess significantly lower levels of Gfer and p27kip1. Ectopic expression of Gfer restores quiescence and elevates p27kip1 expression in Camk4-/- HSCs. These results further substantiate a critical role for Gfer in the restriction of unwarranted proliferation in HSCs through the inhibition of Jab1 and subsequent stabilization and nuclear retention of p27kip1. This Gfer-mediated pro-quiescence mechanism could be therapeutically exploited in the treatment of hematological malignancies associated with elevated Jab1 and reduced p27kip1.
MeSH term(s)	Animals ; COP9 Signalosome Complex ; Calcium-Calmodulin-Dependent Protein Kinase Type 4/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Type 4/metabolism ; Cell Proliferation ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Cytochrome Reductases/chemistry ; Cytochrome Reductases/metabolism ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice ; Oxidoreductases Acting on Sulfur Group Donors ; Peptide Hydrolases/metabolism ; Protein Structure, Tertiary ; Proto-Oncogene Proteins c-bcl-2/metabolism
Chemical Substances	Intracellular Signaling Peptides and Proteins ; Proto-Oncogene Proteins c-bcl-2 ; Cyclin-Dependent Kinase Inhibitor p27 (147604-94-2) ; Cytochrome Reductases (EC 1.6.2.-) ; GFER protein, human (EC 1.8.-) ; Oxidoreductases Acting on Sulfur Group Donors (EC 1.8.-) ; Calcium-Calmodulin-Dependent Protein Kinase Type 4 (EC 2.7.11.17) ; Camk4 protein, mouse (EC 2.7.11.17) ; Peptide Hydrolases (EC 3.4.-) ; Cops5 protein, mouse (EC 3.4.-.-) ; COP9 Signalosome Complex (EC 3.4.19.12)
Language	English
Publishing date	2011-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.10.14.15919
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