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  1. Article ; Online: Lupus, antiphospholipid syndrome, and stroke: An attempt to crossmatch.

    El Hasbani, Georges / Uthman, Imad

    Lupus

    2023  Volume 32, Issue 5, Page(s) 593–602

    Abstract: Cerebrovascular accidents (CVAs) or strokes are part of the common thrombotic manifestations of Systemic Lupus Erythematosus (SLEs) and Antiphospholipid syndrome (APS). Such neurological thrombotic events tend to occur in patients with SLE at a higher ... ...

    Abstract Cerebrovascular accidents (CVAs) or strokes are part of the common thrombotic manifestations of Systemic Lupus Erythematosus (SLEs) and Antiphospholipid syndrome (APS). Such neurological thrombotic events tend to occur in patients with SLE at a higher frequency when Antiphospholipid antibodies (aPLs) are present, and tend to involve the large cerebral vessels. The mechanism of stroke in SLE can be driven by complement deposition and neuroinflammation involving the blood-brain barrier although the traditional cardiovascular risk factors remain major contributing factors. Primary prevention with antiplatelet therapy and disease activity controlling agent is the basis of the management. Anticoagulation via warfarin had been a tool for secondary prevention, especially in stroke recurrence, although the debate continues regarding the target international normalized ratio (INR). The presence of either of the three criteria antiphospholipid antibodies (aPLs) and certain non-criteria aPL can be an independent risk factor for stroke. The exact mechanism for the involvement of the large cerebral arteries, especially in lupus anticoagulant (LAC) positive cases, is still to be deciphered. The data on the role of non-criteria aPL remain very limited and heterogenous, but IgA antibodies against β2GPI and the D4/5 subunit as well as aPS/PT IgG might have a contribution. Anticoagulation with warfarin has been recommended although the optimal dosing or the utility of combination with antiplatelet agents is still unknown. Minimal data is available for direct oral anticoagulants (DOACs).
    MeSH term(s) Humans ; Antiphospholipid Syndrome/complications ; Warfarin ; Lupus Erythematosus, Systemic/complications ; Antibodies, Antiphospholipid ; Lupus Coagulation Inhibitor ; Stroke/chemically induced ; Thrombosis/prevention & control ; Anticoagulants/adverse effects
    Chemical Substances Warfarin (5Q7ZVV76EI) ; Antibodies, Antiphospholipid ; Lupus Coagulation Inhibitor ; Anticoagulants
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/09612033231165151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3717: Show issues Location:
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  2. Article ; Online: ANCA-Associated Vasculitis following the First Dose of Pfizer-BioNTech COVID-19 Vaccine.

    El Hasbani, Georges / Uthman, Imad

    Nephron

    2022  Volume 147, Issue 2, Page(s) 103–107

    Abstract: Coronavirus disease (COVID-19) vaccine can alter the body's immunological balance leading to autoimmune disease in rare cases. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is one of the autoimmune diseases which have been rarely ... ...

    Abstract Coronavirus disease (COVID-19) vaccine can alter the body's immunological balance leading to autoimmune disease in rare cases. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is one of the autoimmune diseases which have been rarely reported to appear post-COVID-19 vaccine. Herein, we report the case of a 47-year-old woman who developed acute renal failure few days after receiving the first dose of the Pfizer-BioNTech COVID-19 vaccine. Corticosteroids along with azathioprine were used for the management.
    MeSH term(s) Female ; Humans ; Middle Aged ; BNT162 Vaccine ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/etiology ; Azathioprine
    Chemical Substances BNT162 Vaccine ; COVID-19 Vaccines ; Azathioprine (MRK240IY2L)
    Language English
    Publishing date 2022-07-18
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000525562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 169: Show issues Location:
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  3. Article ; Online: The Impact of Nicotine Use on Osteoarthritis.

    Hasbani, Georges El / Nassar, Joseph E / Uthman, Imad / Jawad, Ali Sm

    Current rheumatology reviews

    2024  

    Language English
    Publishing date 2024-03-21
    Publishing country United Arab Emirates
    Document type Editorial
    ISSN 1875-6360
    ISSN (online) 1875-6360
    DOI 10.2174/0115733971270925240318080227
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  4. Article: Erythema nodosum in Behçet's disease in remission: Think COVID-19?

    El Hasbani, Georges / Jawad, Ali Sm / Uthman, Imad

    SAGE open medical case reports

    2023  Volume 11, Page(s) 2050313X231154316

    Abstract: The coronavirus disease has several manifestations related to the activation of the immune system. Because of such activation, autoimmune diseases, including vasculitis, have been reported to occur. Behçet's disease, a variable vessel vasculitis, has ... ...

    Abstract The coronavirus disease has several manifestations related to the activation of the immune system. Because of such activation, autoimmune diseases, including vasculitis, have been reported to occur. Behçet's disease, a variable vessel vasculitis, has been discussed in the context of coronavirus disease. Rarely, the induction of Behçet's disease flare or exacerbation has been reported necessitating aggressive treatment. The presentation of Behçet's disease flares secondary to coronavirus disease is variable, including mucocutaneous lesions and eye or joint involvement. We highlight the case of a 35-year-old woman with pre-existing Behçet's disease in remission on colchicine presenting with new onset erythema nodosum-like lesions on her right shin being diagnosed with coronavirus disease infection a few days after. Despite treatment with systemic corticosteroid, the lesions did not resolve, necessitating the initiation of anti-interleukin-6 therapy.
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X231154316
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  5. Article ; Online: Sarcoidosis as a cause of chronic back pain: a case report.

    El Hasbani, Georges / Nicolas, Jessica / Najjar, Vicky / Jawad, Ali / Uthman, Imad

    Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG

    2024  Volume 41, Issue 1, Page(s) e2024007

    Abstract: While sarcoidosis is typically a multisystem disease, it can, in some instances, exclusively affect the vertebrae, leading to back pain. Additionally, sarcoidosis may manifest with inflammation of the sacroiliac joints, not meeting the criteria for ... ...

    Abstract While sarcoidosis is typically a multisystem disease, it can, in some instances, exclusively affect the vertebrae, leading to back pain. Additionally, sarcoidosis may manifest with inflammation of the sacroiliac joints, not meeting the criteria for spondyloarthritis, yet contributing to back pain. In this report, we present a case involving a previously healthy 55-year-old woman who sought medical attention due to chronic back pain. She was subsequently diagnosed with spinal sarcoidosis, based on MRI, PET scan, and biopsy results. Furthermore, treatment with prednisolone monotherapy demonstrated substantial improvement in her symptoms.
    Language English
    Publishing date 2024-03-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1339192-6
    ISSN 2532-179X ; 1124-0490
    ISSN (online) 2532-179X
    ISSN 1124-0490
    DOI 10.36141/svdld.v41i1.14813
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    Zs.A 2076: Show issues Location:
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  6. Article: Vacuolar Interface Dermatitis as a Histologic Reaction Pattern of Sjögren's Syndrome: A Case Report.

    El Hasbani, Georges / Kibbi, Abdul-Ghani / Jawad, Ali / Uthman, Imad

    Cureus

    2023  Volume 15, Issue 10, Page(s) e46412

    Abstract: Sjögren's syndrome (SS) has been widely known for its dry mouth and dry eyes presentation. Extraglandular disease manifestations may be protean and pose a challenge for clinicians, especially when the typical known manifestations are absent. Skin ... ...

    Abstract Sjögren's syndrome (SS) has been widely known for its dry mouth and dry eyes presentation. Extraglandular disease manifestations may be protean and pose a challenge for clinicians, especially when the typical known manifestations are absent. Skin involvement of SS is variable, and cutaneous signs and symptoms may be the initial presentation of this syndrome. Vacuolar interface dermatitis has been linked to dermatomyositis and systemic lupus erythematosus, but rarely to SS. Herein, we present the case of an 87-year-old man who presented for widespread itchy erythematous scaly plaques that were refractory to topical corticosteroids as well as discontinuation of possible offending medications. A biopsy demonstrated vacuolar interface dermatitis in the setting of strongly positive anti-SSA. Hydroxychloroquine treatment was effective in resolving the plaques.
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.46412
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  7. Article: Musculoskeletal Manifestations of Sarcoidosis.

    Hasbani, Georges El / Uthman, Imad / Jawad, Ali Sm

    Clinical medicine insights. Arthritis and musculoskeletal disorders

    2022  Volume 15, Page(s) 11795441211072475

    Abstract: Since its initial description in the late 19th century, sarcoidosis has been extensively studied. Although the general mechanism of immune activation is known, many details especially in the context of disease associations are still missing. One of such ... ...

    Abstract Since its initial description in the late 19th century, sarcoidosis has been extensively studied. Although the general mechanism of immune activation is known, many details especially in the context of disease associations are still missing. One of such associations is the musculoskeletal complications that are widely variable in terms of presentation and response to treatment. Sarcoidosis can involve the joints leading to acute and, less commonly chronic, arthritis. While acute arthritis is mostly self-resolving in nature, chronic arthritis may lead to deformity and destruction of the joint. Sarcoidosis can also involve the muscles, leading to different pathologies primarily categorized according to the clinical presentation, despite the efforts to find a new classification based on imaging, histological, and clinical findings. The bones can be directly and indirectly affected. Different types of bone lesions have been described, although around half of these patients remain asymptomatic. Osteoporosis, increased risk of fractures, hypercalcemia, and hypercalciuria are examples of the indirect effect of sarcoidosis on the bones, possibly contributed to elevated levels of calcitriol. Nevertheless, sarcoidosis can be associated with small-vessel, medium-vessel, and large vessel vasculitis, although it is frequently difficult to differentiate between the co-existence of a pure vasculitis and sarcoidosis and sarcoid vasculitis.
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2590933-2
    ISSN 1179-5441
    ISSN 1179-5441
    DOI 10.1177/11795441211072475
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  8. Article: The effect of wet-cupping therapy (hijama) in modulating autoimmune activity of Hashimoto's thyroiditis.: A pilot controlled study.

    Jawad, Ali S / El-Hasbani, Georges / Uthman, Imad

    Saudi medical journal

    2022  Volume 43, Issue 3, Page(s) 321

    MeSH term(s) Cupping Therapy ; Hashimoto Disease/therapy ; Humans ; Pilot Projects ; Thyroiditis, Autoimmune
    Language English
    Publishing date 2022-03-07
    Publishing country Saudi Arabia
    Document type Letter ; Comment
    ZDB-ID 392302-2
    ISSN 1658-3175 ; 0379-5284
    ISSN (online) 1658-3175
    ISSN 0379-5284
    DOI 10.15537/smj.2022.43.3.20220122
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    Zs.B 2330: Show issues Location:
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  9. Article: Axial and peripheral spondyloarthritis triggered by sars-cov-2 infection: a report of two cases.

    El Hasbani, G / Jawad, A / Uthman, I

    Reumatismo

    2021  Volume 73, Issue 1, Page(s) 59–63

    Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can show musculoskeletal symptoms such as peripheral arthritis. In rare cases, peripheral arthritis can develop after the resolution of SARS-CoV-2. We present two cases of ... ...

    Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can show musculoskeletal symptoms such as peripheral arthritis. In rare cases, peripheral arthritis can develop after the resolution of SARS-CoV-2. We present two cases of spondyloarthritis induced by SARS-CoV-2; one case with axial and peripheral spondyloarthritis and the other with peripheral spondyloarthritis. Both cases refer to Lebanese patients who were HLA-B27 positive. These two cases highlight the possible predisposition of HLA-B27 positive patients to the development of spondyloarthritis symptoms triggered by SARS-CoV-2.
    MeSH term(s) Adult ; Arthritis/diagnosis ; Arthritis/diagnostic imaging ; Arthritis/etiology ; C-Reactive Protein/analysis ; COVID-19/blood ; COVID-19/complications ; COVID-19/diagnosis ; Genetic Predisposition to Disease ; HLA-B27 Antigen/blood ; Humans ; Male ; Middle Aged ; Sacroiliac Joint/diagnostic imaging ; Sacroiliac Joint/pathology ; Spondylarthritis/blood ; Spondylarthritis/etiology ; Wrist Joint
    Chemical Substances HLA-B27 Antigen ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2021-04-19
    Publishing country Italy
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 414816-2
    ISSN 2240-2683 ; 0048-7449
    ISSN (online) 2240-2683
    ISSN 0048-7449
    DOI 10.4081/reumatismo.2021.1374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Strategies that nurses working irregular night shifts use to improve sleep quality: A qualitative study among good and poor sleepers.

    Albakri, Uthman / Smeets, Nick / Kant, IJmert / Meertens, Ree

    Journal of advanced nursing

    2023  Volume 80, Issue 5, Page(s) 2038–2050

    Abstract: Aims: To assess the sleep strategies that nurses working irregular night shifts use to improve their sleep quality, and to compare the strategies of good and poor sleepers to determine whether the differences between the two groups could provide ... ...

    Abstract Aims: To assess the sleep strategies that nurses working irregular night shifts use to improve their sleep quality, and to compare the strategies of good and poor sleepers to determine whether the differences between the two groups could provide insights into possible effective strategies.
    Design: A qualitative descriptive study.
    Methods: The study was conducted from September 2019 to January 2020. Thirty-four nurses working irregular night shifts participated; 17 were classified as good sleepers and 17 as poor sleepers based on the Sleep-Wake Experience List, a validated self-report instrument that measures one's sleep quality. Interviews were conducted using open questions to explore strategies around the night-shift set. The interviews were analysed using thematic analysis.
    Findings: Both groups described similar and different strategies that help them work and sleep well during and after night shifts. However, good sleepers mentioned a greater number of strategies and seemed to have thought about them more than poor sleepers. The most common strategies were having a clear structure, being organized-especially regarding sleeping time-maintaining a daily routine and adjusting their sleep environment.
    Conclusion: Healthcare institutions should consider offering education and training programs aimed at empowering nurses who work irregular night shifts. These programs should provide nurses with various sleep strategies to enhance their sleep quality and overall well-being.
    Implications for the profession: Nurses working irregular night shifts can possibly enhance their sleep quality by making personalized plans, for example, including a clear day structure, or an optimized sleep environment.
    Impact: The study focused on how nurses working night shifts could possibly enhance their sleep quality. The findings highlight the importance of providing nurses with diverse sleep strategies to improve sleep quality, helping them to identify what works best for them and consistently apply these strategies.
    Reporting method: The Consolidated Criteria for Reporting Qualitative Research guidelines were followed.
    Patient or public contribution: Nurses working irregular night shifts at Maastricht University Medical Center in Maastricht, the Netherlands, who agreed to participate in the study, engaged in a discussion to assess the relevance of sleep quality to their work. They were also encouraged to share their perspectives during the interviews.
    MeSH term(s) Humans ; Sleep Quality ; Sleep ; Self Report ; Occupations ; Netherlands ; Work Schedule Tolerance ; Nurses
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 197634-5
    ISSN 1365-2648 ; 0309-2402
    ISSN (online) 1365-2648
    ISSN 0309-2402
    DOI 10.1111/jan.15962
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